Abstract:
:The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, five compounds were identified to be able to heavily affect the proliferation of human HCT116 and SW613-B3 colon carcinoma cell lines. Remarkably, these active compounds exhibit high fluorescence emission property and ability to induce autophagy.
journal_name
Acta Biochim Biophys Sin (Shanghai)journal_title
Acta biochimica et biophysica Sinicaauthors
Guamán Ortiz LM,Croce AL,Aredia F,Sapienza S,Fiorillo G,Syeda TM,Buzzetti F,Lombardi P,Scovassi AIdoi
10.1093/abbs/gmv077subject
Has Abstractpub_date
2015-10-01 00:00:00pages
824-33issue
10eissn
1672-9145issn
1745-7270pii
gmv077journal_volume
47pub_type
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