Abstract:
:Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation, phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics. Combinations of different modifications on the histone proteins, termed 'histone code' in many cases, extend the information potential of the genetic code by regulating DNA at the epigenetic level. Many PTMs occur on non-histone proteins as well as histones, regulating protein-protein interactions, stability, localization, and/or enzymatic activities of proteins involved in diverse cellular processes. Although protein phosphorylation, ubiquitylation, and acetylation have been extensively studied, only a few proteins other than histones have been reported that can be modified by lysine methylation. This review summarizes the current progress on lysine methylation of non-histone proteins, and we propose that lysine methylation, like phosphorylation and acetylation, is a common PTM that regulates proteins in diverse cellular processes.
journal_name
Acta Biochim Biophys Sin (Shanghai)journal_title
Acta biochimica et biophysica Sinicaauthors
Zhang X,Wen H,Shi Xdoi
10.1093/abbs/gmr100subject
Has Abstractpub_date
2012-01-01 00:00:00pages
14-27issue
1eissn
1672-9145issn
1745-7270pii
gmr100journal_volume
44pub_type
杂志文章,评审abstract::MicroRNAs (miRNAs) function as key regulators of gene expression in various cancers. In this study, the aim is to explore the roles and regulation mechanism of miR-181c in neuroblastoma (NB) cells. We found that miR-181c was downregulated in metastatic NB tissues, compared with primary NB tissues. Then functional stud...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmt124
更新日期:2014-01-01 00:00:00
abstract::Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFα mRNA degradation. Moreover, T0901317 destabilized TNFα...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmw136
更新日期:2017-03-01 00:00:00
abstract::Renal ischemia/reperfusion (I/R) is a common cause of acute renal failure in many clinical settings. Our study aimed to elucidate the role of lentiviral vector-mediated KSR1 gene silencing in inflammatory factor expression and proliferation of renal tubular epithelial cells (RTECs) in a rat model of I/R injury. Male S...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmy071
更新日期:2018-08-01 00:00:00
abstract::At initial stages in the Rhizobium legume symbiosis, most nodulation genes are controlled by NodD protein and plant inducers. Some genetic studies and other reports have suggested that NodD may be activated by its direct interaction with plant inducers. However, there has been no molecular evidence of such an inducing...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Human glioma is the most common primary brain tumor and is associated with high morbidity and mortality. Aberrant expressions of microRNAs (miRNAs) are involved in glioma progression. In the present study, we aimed to elucidate the roles of miR-4530 in the pathogenesis of gliomas. miR-4530 expression was examined in h...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmaa126
更新日期:2020-12-29 00:00:00
abstract::Cortactin, an actin-binding protein and a substrate of Src, is encoded by the EMS1 oncogene. Cortactin is known to activate Arp2/3 complex-mediated actin polymerization and interact with dynamin, a large GTPase and proline rich domain-containing protein. Transferrin endocytosis was significantly reduced in cells by kn...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1111/j.1745-7270.2006.00141.x
更新日期:2006-02-01 00:00:00
abstract::Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported to interact with proteins containing the polyglutamine (polyQ) domain. The present study was undertaken to evaluate the potential contributions of the polyQ and polyproline (polyP) domains to the co-localization of mutant huntingtin (htt) and GAPDH. Ov...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1111/j.1745-7270.2007.00352.x
更新日期:2007-11-01 00:00:00
abstract::Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that the transfection of hepatitis C virus core (HCVc) protein led to malignant transformation in normal biliary cells, and that tumor suppressor gene RASSF1A was downregulated in m...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmr021
更新日期:2011-05-01 00:00:00
abstract::Several studies have shown that combination treatment with natural products and chemotherapy agents can improve the sensitivity and cytotoxicity of chemotherapy agents. Resveratrol, a natural product, has many biological effects including antitumor and antiviral activities, as well as vascular protective effect. The a...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmw026
更新日期:2016-06-01 00:00:00
abstract::Dementia, a devastating neurological disorder commonly found in the elderly, is characterized by severe cognitive and memory impairment. Ample clinical and epidemiological evidence has depicted a close association between dementia and heart failure. While cerebral blood under perfusion and neurohormonal activation due...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章,评审
doi:10.1093/abbs/gmz115
更新日期:2020-01-02 00:00:00
abstract::Hyperglycemia-mediated reactive oxygen species (ROS) accumulation plays an important role in hyperglycemia-induced endothelial injury. Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibition participates in hyperglycemia-induc...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmaa023
更新日期:2020-05-26 00:00:00
abstract::Gastric ulcers (GUs) are common pathologies that affect many people around the world. Excessive alcohol consumption is one of the main causes of GUs; however, there are still lack of effective drugs for the prevention or therapy of GUs. In this study, we evaluated the protective effects and possible mechanisms of kaem...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmy002
更新日期:2018-03-01 00:00:00
abstract::Carbon monoxide (CO) is often viewed as a lethal gas in light of its capacity to prevent oxygen uptake in hemoglobin; however, it also functions to regulate a variety of proteins and physiological processes. Here we show that CO is an important chemical cue, to which neurons respond strongly, and this response is then...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmv017
更新日期:2015-05-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human malignant diseases and the sixth leading cause of cancer-related deaths in China. Gemcitabine is the only first-line chemotherapeutic agent used for the palliative treatment of patients with PDAC, but chemo-resistance limits their efficacy. Here, ...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmv129
更新日期:2016-02-01 00:00:00
abstract::Abnormal development of central nervous system (CNS) caused by neural tube defects is not only a major contributor in the prevalence of stillbirths and neonatal deaths but also causes lifelong physical disability in surviving infants. Due to insufficient known investigated causes, CNS developmental abnormality has bro...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmaa037
更新日期:2020-06-20 00:00:00
abstract::TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cell lines, suggesting its great potential in cancer therapy. Many components in TRAIL-mediated signaling pathway have been identified, but how they interact with each other to determine the network dynamics and final apoptosis remain...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmp114
更新日期:2010-02-01 00:00:00
abstract::Allergic protein TBb, a major allergen in tartary buckwheat, was divided into four epitope-containing fragments and was named F1, F2, F3, and F4, respectively. Results of immunological assays revealed that F2 had the strongest IgE-binding activity to patient's sera, which indicated that it might contain the linear IgE...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmr036
更新日期:2011-06-01 00:00:00
abstract::The aim of this study was to establish and apply a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) for rubella virus (RV) RNA. First, the primer and TaqMan probe concentrations, as well as reaction temperatures were optimized to establish an efficient real-time quantitative RT-PCR assay...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1111/j.1745-7270.2006.00213.x
更新日期:2006-10-01 00:00:00
abstract::Previous studies have indicated that noggin exerts its neural inducing effect by binding and antagonizing bone morphogenetic protein 4 (BMP4). In order to further clarify the relationship between the structure and the function of noggin, and elucidate the possible mechanism responsible for noggin-BMP4 interaction, we ...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role of RhoA in the mechanisms underlying growth, migration, and invasion of squamous cell carcinoma of tongue (TSCC). Stable RhoA knockdown of TSCC cell lines SCC-4 and CAL2...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmu051
更新日期:2014-08-01 00:00:00
abstract::Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmy161
更新日期:2019-02-01 00:00:00
abstract::Activation of the P2X7 receptor leads to a rapid, bidirectional flux of cations, causing broad range of biological responses including cytotoxicity. However, the mechanism of P2X7-mediated cytotoxicity remains largely unexplored. In our previous study, the lack of P2X7-mediated calcium response under normal conditions...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmp016
更新日期:2009-05-01 00:00:00
abstract::The study was undertaken to examine the effects of C-peptide on glomerular volume (V(GLOM)), mesangial matrix synthesis, and degradation in streptozotocin (STZ)-diabetic rats with poor or moderate glycemic control. Series 1 (poor glycemic control) included groups of healthy rats, hyperglycemic rats, diabetic insulin-t...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmq100
更新日期:2010-12-01 00:00:00
abstract::Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found th...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmz148
更新日期:2020-02-03 00:00:00
abstract::Many N-methyl-d-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmitter system makes the glutamic acid receptor blockers inefficient and unsafe. Thus, regulating the downstre...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmx082
更新日期:2017-09-01 00:00:00
abstract::We cloned and isolated a cysteine-rich protein, designated Mr30, from Conus marmoreus. Mr30 belongs to the cysteine-rich secretory protein family that is highly homologous to Tex31 previously obtained from Conus textile and reported as a protease responsible for processing of pro-conotoxins. Mr30, purified by a proced...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1111/j.1745-7270.2008.00385.x
更新日期:2008-02-01 00:00:00
abstract::Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal isc...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmz145
更新日期:2020-02-03 00:00:00
abstract::The destruction of proteins via the ubiquitin-proteasome system is a multi-step, complex process involving polyubiquitination of substrate proteins, followed by proteolytic degradation by the macromolecular 26S proteasome complex. Inhibitors of the proteasome promote the accumulation of proteins that are deleterious t...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gmz093
更新日期:2019-09-06 00:00:00
abstract::Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章,评审
doi:10.1111/j.1745-7270.2005.00108.x
更新日期:2005-11-01 00:00:00
abstract::Neuron restrictive silencer factor (NRSF), also known as repressor element-1 silencing transcription factor, has been reported to modulate neuronal excitability and acts as endogenous anticonvulsant in kainic acid-induced or kindling-evoked seizure activity. However, whether NRSF functions in pentylenetetrazol (PTZ)-i...
journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
doi:10.1093/abbs/gms023
更新日期:2012-06-01 00:00:00