The Mycobacterium bovis BCG prime-Rv0577 DNA boost vaccination induces a durable Th1 immune response in mice.

abstract：:Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Liu J,Zhao Z,Wen L,Li H,Ren J,Liu H

更新日期：2018-03-01 00:00:00

abstract：:LRRC4 is a novel relatively specific gene, which displays significant down-regulation in primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this study, we investigated the growth inhibitory effect of LRRC4 on tumorigencity in vivo and on cell proliferation in vitro by a tetracycline-...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang QH,Wang LL,Cao L,Peng C,Li XL,Tang K,Li WF,Liao P,Wang JR,Li GY

更新日期：2005-08-01 00:00:00

abstract：:Dengue infection is a major cause of morbidity in tropical and subtropical regions, bringing nearly 40% of the world population at risk and causing more than 20,000 deaths per year. But there is neither a vaccine for dengue disease nor antiviral drugs to treat the infection. In recent years, dengue infection has been ...

journal_title：Acta biochimica et biophysica Sinica

authors： Qi RF,Zhang L,Chi CW

更新日期：2008-02-01 00:00:00

abstract：:Vascularization is one of the hotspots during the development of new therapeutic strategies for bone tissue engineering, which can alleviate hypoxic circumstance and prevent transplant failure. Vascular endothelial growth factor (VEGF) gene transfection using recombinant adenovirus (Ad) vector can effectively promote ...

journal_title：Acta biochimica et biophysica Sinica

authors： Song X,Shi L,Chen L,Liu X,Qu X,Wang K,Wei F

更新日期：2017-11-01 00:00:00

abstract：:Many N-methyl-d-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmitter system makes the glutamic acid receptor blockers inefficient and unsafe. Thus, regulating the downstre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tian Y,He Y,Song W,Zhang E,Xia X

更新日期：2017-09-01 00:00:00

abstract：:Luffin-a, a single-chain Type I ribosome-inactivating protein, which is known to be the most toxic of the luffin family and apparently possesses antitumor activity, was isolated from Luffa cylindrica seeds. In the present study, mature alpha-luffin was cloned from L. cylindrica and it was found that mature alpha-luffi...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Wang R,He W,He F,Huang G

更新日期：2010-08-01 00:00:00

abstract：:Carbon monoxide (CO) is often viewed as a lethal gas in light of its capacity to prevent oxygen uptake in hemoglobin; however, it also functions to regulate a variety of proteins and physiological processes. Here we show that CO is an important chemical cue, to which neurons respond strongly, and this response is then...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Liu B,Zhang Q,Wu X,Yu Y,Jesse FF,Li L

更新日期：2015-05-01 00:00:00

abstract：:Human-induced pluripotent stem (iPS) cells share the same key properties as embryonic stem cells, and may be generated from patient- or disease-specific sources, which makes them attractive for personalized medicine, drug screens, or cellular therapy. Long-term cultivation and maintenance of normal iPS cells in an und...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu T,Chen Q,Huang Y,Huang Q,Jiang L,Guo L

更新日期：2012-03-01 00:00:00

abstract：:Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation, phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics. Combinations of different modifications on the histone proteins, termed 'histone code' in many cases, extend the information potentia...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang X,Wen H,Shi X

更新日期：2012-01-01 00:00:00

abstract：:Hepatocellular carcinoma is a common malignant cancer with high incidence. And long non-coding RNAs (lncRNAs) play pivotal roles in the development of different types of cancers. In this study, we aimed to investigate the role of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of hepatocel...

journal_title：Acta biochimica et biophysica Sinica

authors： Dong H,Zhang Y,Xu Y,Ma R,Liu L,Luo C,Jiang W

更新日期：2019-06-20 00:00:00

abstract：:Sequence analysis of oxazolomycin (OZM) biosynthetic gene cluster from Streptomyces albus JA3453 revealed a gene, ozmH, encoding a hybrid polyketide and non-ribosomal peptide enzyme. Tandem ketosynthase (KS) domains (KS 10-1 and KS 10-2) were characterized and they show significant homology with known KSs. Using an al...

journal_title：Acta biochimica et biophysica Sinica

authors： Song D,Coughlin J,Ju J,Zhou X,Shen B,Zhao C,Deng Z

更新日期：2008-04-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is the most common category and disease entity of non-Hodgkin lymphoma. Osalmide and pterostilbene are natural products with anticancer activities via different mechanism. In this study, using a new synthetic strategy for the two natural products, we obtained the compound DCZ0801,...

journal_title：Acta biochimica et biophysica Sinica

authors： Xi M,He W,Li B,Zhou J,Xu Z,Wu H,Zhang Y,Song D,Hu L,Lu Y,Bu W,Kong Y,Chen G,Chang S,Shi J,Zhu W

更新日期：2020-04-20 00:00:00

abstract：:Acyl-coenzymeA:cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in intestine and fetal liver of healthy human. Our previous studies have shown that in monocytic cells the low-level expression of human ACAT2 gene with specific CpG-hypomethylated promoter is regulated by the CCAAT/enhancer binding protein (...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo D,Zhang X,Li Q,Qian L,Xu J,Lu M,Hu X,Zhu M,Chang CC,Song B,Chang T,Xiong Y,Li B

更新日期：2016-11-01 00:00:00

abstract：:MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated...

journal_title：Acta biochimica et biophysica Sinica

authors： Hu H,Li S,Liu J,Ni B

更新日期：2012-05-01 00:00:00

abstract：:CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative prote...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong MQ,Gu Y,Hu XB,Sun Y,Ma L,Li XL,Sun LX,Sun J,Qian J,Zhu CL

更新日期：2005-05-01 00:00:00

abstract：:A number of significant studies in the field of cell biology have revealed another pattern of intracellular signal transduction in which cells transmit information through the dynamics of key signaling molecules. Dynamical properties of p53 have been demonstrated to be the key factor in dictating cell fate, including ...

journal_title：Acta biochimica et biophysica Sinica

authors： Shi G,Wang Q,Zhou X,Li J,Liu H,Gu J,Wang H,Wu Y,Ding L,Ni S,Tang Z

更新日期：2017-04-01 00:00:00

abstract：:Gastric ulcers (GUs) are common pathologies that affect many people around the world. Excessive alcohol consumption is one of the main causes of GUs; however, there are still lack of effective drugs for the prevention or therapy of GUs. In this study, we evaluated the protective effects and possible mechanisms of kaem...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Q,Hu X,Xuan Y,Ying J,Fei Y,Rong J,Zhang Y,Zhang J,Liu C,Liu Z

更新日期：2018-03-01 00:00:00

abstract：:MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleo...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang B,Qin W,Zhao B,Shi Y,Yao C,Li J,Xiao H,Jin Y

更新日期：2009-06-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported to interact with proteins containing the polyglutamine (polyQ) domain. The present study was undertaken to evaluate the potential contributions of the polyQ and polyproline (polyP) domains to the co-localization of mutant huntingtin (htt) and GAPDH. Ov...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu J,Lin F,Qin Z

更新日期：2007-11-01 00:00:00

abstract：:Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased and down-regulation of ASS1 was closely corre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tao X,Zuo Q,Ruan H,Wang H,Jin H,Cheng Z,Lv Y,Qin W,Wang C

更新日期：2019-03-01 00:00:00

abstract：:The subfamily of voltage-dependent potassium (Kv) channel interacting protein 4 (KChIP4) is made up of the auxiliary interacting protein of voltage-dependent potassium channels. In this study, the structure of four splicing variants of the human KChIP4 gene was analyzed. Three of the four isoforms of the KChIP4 gene, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Deng XY,Cai F,Xia K,Pan Q,Long ZG,Wu LQ,Liang DS,Dai HP,Zhang ZH,Xia JH

更新日期：2005-04-01 00:00:00

abstract：:Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role of RhoA in the mechanisms underlying growth, migration, and invasion of squamous cell carcinoma of tongue (TSCC). Stable RhoA knockdown of TSCC cell lines SCC-4 and CAL2...

journal_title：Acta biochimica et biophysica Sinica

authors： Yan G,Zou R,Chen Z,Fan B,Wang Z,Wang Y,Yin X,Zhang D,Tong L,Yang F,Jiang W,Fu W,Zheng J,Bergo MO,Dalin M,Zheng J,Chen S,Zhou J

更新日期：2014-08-01 00:00:00

abstract：:It has been reported that oncostatin M (OSM) could initiate cardiomyocyte dedifferentiation both in vivo and in vitro. OSM-induced cardiomyocyte dedifferentiation might be a new target for the treatment of diabetic cardiomyopathy (DCM). This study was designed to determine the role of OSM in cardiomyocyte dedifferenti...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang X,Ma S,Zhang R,Li S,Zhu D,Han D,Li X,Li C,Yan W,Sun D,Xu B,Wang Y,Cao F

更新日期：2016-03-01 00:00:00

abstract：:Nuclear factor kappa B (NF-κB) plays a prominent role in the pathogenesis of infectious diseases. Staphylococcus aureus (S. aureus), which can attach to and invade human osteoblasts, is the most common causative agent of osteomyelitis. To determine whether S. aureus can activate NF-κB in human osteoblasts and explore ...

journal_title：Acta biochimica et biophysica Sinica

authors： Ning R,Zhang X,Guo X,Li Q

更新日期：2010-12-01 00:00:00

abstract：:The mechanisms of chronic neuropathic pain are not clear. Serum microRNAs (miRNAs) might show a special feature for chronic nervous lesions. However, little is known about the changes in circulating miRNAs for the neuropathic pain. Therefore, changes in the circulating miRNAs expression profile for the neuropathic pai...

journal_title：Acta biochimica et biophysica Sinica

authors： Xu Y,Zhang X,Pu S,Wu J,Lv Y,Du D

更新日期：2014-11-01 00:00:00

abstract：:LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which ...

journal_title：Acta biochimica et biophysica Sinica

authors： Feng Q,Yang J,Luo P,Zhang WJ,Zou QM

更新日期：2005-02-01 00:00:00

abstract：:We previously identified a matrix protein, MSI7, from pearl oyster Pinctada fucata. According to the structural analysis, the DGD site in the N-terminal of MSI7 is crucial for its role in the shell formation. In this study, we expressed a series of recombinant MSI7 proteins, including the wild-type and several mutants...

journal_title：Acta biochimica et biophysica Sinica

authors： Feng Q,Fang Z,Yan Z,Xing R,Xie L,Zhang R

更新日期：2009-11-01 00:00:00

abstract：:Receptor of human interleukin 4 (hIL4R) has been found to be present on many types of cancer, so it may be a good target for cancer therapy. Here, fusion toxin gene DT4H has been constructed by fusing DNA sequence encoding the first 389 amino acids of diphtherial toxin (DT), which can not bind its own receptor, to hum...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang YJ,Hu XB,Li SX,Tian LP,Yang SL,Gong Y

更新日期：2004-06-01 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal isc...

journal_title：Acta biochimica et biophysica Sinica

authors： Han F,Dou M,Wang Y,Xu C,Li Y,Ding X,Xue W,Zheng J,Tian P,Ding C

更新日期：2020-02-03 00:00:00

abstract：:Edaravone is a novel free radical scavenger that exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Recently, it was reported that edaravone could alleviate the pathology and cognitive deficits of Alzheimer's disease patients. However, its relevance t...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Lu F,Li W,Qin L,Yao Y,Ge X,Yu Q,Liang X,Zhao D,Li X,Zhang J

更新日期：2017-01-01 00:00:00