Abstract:
:Edaravone is a novel free radical scavenger that exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Recently, it was reported that edaravone could alleviate the pathology and cognitive deficits of Alzheimer's disease patients. However, its relevance to vascular dementia (VaD) is not clear. In this study, we partially occluded the bilateral carotid arteries of rats surgically to induce chronic cerebral hypoperfusion (CCH), a well-known rat model of VaD. Water maze and step-down inhibitory test were used to evaluate the memory deficit. The activities of superoxide dismutase (SOD) and lactate dehydrogenase (LDH), the content of malondialdehyde (MDA) and total reactive oxygen species were measured to evaluate the oxidative stress level. Western blot analysis was used to evaluate the synaptic protein expression. It was found that treatment with edaravone for a 5-week period was able to reverse both spatial and fear-memory deficits in rats with CCH. Edaravone significantly reduced the level of oxidative stress in the brains of rats with CCH by increasing SOD activity and decreasing the content of MDA, LDH, and total reactive oxygen species. Furthermore, edaravone treatment also restored the levels of multiple synaptic proteins in the hippocampi of rats with CCH. Our data provide direct evidence supporting the neuroprotective effects of edaravone in VaD. We propose that the alleviation of oxidative stress and restoration of synaptic proteins play important roles in neuroprotection.
journal_name
Acta Biochim Biophys Sin (Shanghai)journal_title
Acta biochimica et biophysica Sinicaauthors
Li X,Lu F,Li W,Qin L,Yao Y,Ge X,Yu Q,Liang X,Zhao D,Li X,Zhang Jdoi
10.1093/abbs/gmw116subject
Has Abstractpub_date
2017-01-01 00:00:00pages
83-89issue
1eissn
1672-9145issn
1745-7270pii
gmw116journal_volume
49pub_type
杂志文章abstract::To investigate whether apelin-13 induced THP-1 monocytes (MCs) adhesion to ECV304 human umbilical vein endothelial cells (HUVECs) via 14-3-3 signaling transduction pathway and the potential novel physiological function and signaling transduction pathway of apelin-APJ, HUVECs ECV304 were cultured in DMEM and MCs THP-1 ...
journal_title:Acta biochimica et biophysica Sinica
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abstract::Hypopharyngeal carcinoma (HC) is one of the most malignant tumors in the upper aerodigestive tract. Currently, there are no effective treatments for HC. Gold nanoparticles (AuNPs) are a promising tool that can be used for plasmonic photothermal therapy (PPTT), which refers to the use of electromagnetic radiation, most...
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pub_type: 杂志文章,评审
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journal_title:Acta biochimica et biophysica Sinica
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pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
abstract::Mycobacterium tuberculosis (Mtb) is the key devastating bacterial pathogen responsible for tuberculosis. Increasing emergence of multi-drug-resistant, extensively drug-resistant, and rifampicin/isoniazid-resistant strains of Mtb makes the discovery of validated drug targets an urgent priority. As a vital translational...
journal_title:Acta biochimica et biophysica Sinica
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更新日期:2019-02-01 00:00:00
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journal_title:Acta biochimica et biophysica Sinica
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更新日期:2016-11-01 00:00:00
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journal_title:Acta biochimica et biophysica Sinica
pub_type: 杂志文章
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journal_title:Acta biochimica et biophysica Sinica
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更新日期:2005-03-01 00:00:00
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journal_title:Acta biochimica et biophysica Sinica
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abstract::Although Ca(V)1.3 channels are known to be essential for neuronal excitation and signal transduction in the auditory system, their expression patterns in the cochlea are still not fully understood, particularly in the regions where non-sensory cells are located. We performed immunohistochemistry, western blotting and ...
journal_title:Acta biochimica et biophysica Sinica
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abstract::Gliomas are the most common brain tumors of the central nervous system. In this study, we investigated the molecular mechanisms and biological function of SIRT6 in human gliomas. The expression levels of SIRT6 in glioma tissues and cells were analyzed by qRT-PCR and western blot analysis. CCK8 and clonogenicity assays...
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journal_title:Acta biochimica et biophysica Sinica
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更新日期:2006-04-01 00:00:00
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journal_title:Acta biochimica et biophysica Sinica
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abstract::In this study, we identified five miRNAs highly expressed in the small-cell lung cancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1)....
journal_title:Acta biochimica et biophysica Sinica
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abstract::A number of significant studies in the field of cell biology have revealed another pattern of intracellular signal transduction in which cells transmit information through the dynamics of key signaling molecules. Dynamical properties of p53 have been demonstrated to be the key factor in dictating cell fate, including ...
journal_title:Acta biochimica et biophysica Sinica
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更新日期:2017-04-01 00:00:00