LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125.

abstract：:The development and strategic application of effective anticancer therapies have turned out to be one of the most critical approaches of managing human cancers. Nevertheless, drug resistance is the major obstacle for clinical management of these diseases especially ovarian cancer. In the past years, substantial studie...

journal_title：Acta biochimica et biophysica Sinica

authors： Yung MM,Ngan HY,Chan DW

更新日期：2016-04-01 00:00:00

abstract：:A number of significant studies in the field of cell biology have revealed another pattern of intracellular signal transduction in which cells transmit information through the dynamics of key signaling molecules. Dynamical properties of p53 have been demonstrated to be the key factor in dictating cell fate, including ...

journal_title：Acta biochimica et biophysica Sinica

authors： Shi G,Wang Q,Zhou X,Li J,Liu H,Gu J,Wang H,Wu Y,Ding L,Ni S,Tang Z

更新日期：2017-04-01 00:00:00

abstract：:Gastric ulcers (GUs) are common pathologies that affect many people around the world. Excessive alcohol consumption is one of the main causes of GUs; however, there are still lack of effective drugs for the prevention or therapy of GUs. In this study, we evaluated the protective effects and possible mechanisms of kaem...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Q,Hu X,Xuan Y,Ying J,Fei Y,Rong J,Zhang Y,Zhang J,Liu C,Liu Z

更新日期：2018-03-01 00:00:00

abstract：:Nocardia, Rhodococcus and Streptomyces, all members of the actinomycetes family, are Gram-positive eubacteria with high G+C content and able to form mycelium. We report here a newly identified plasmid pXT107 of Nocardia sp. 107, one of the smallest circular plasmids found in Nocardia. The complete nucleotide sequence ...

journal_title：Acta biochimica et biophysica Sinica

authors： Xia HY,Tian YQ,Zhang R,Lin KC,Qin ZJ

更新日期：2006-09-01 00:00:00

abstract：:Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC), and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis. In this study, we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC. The results showed that miR-1827 l...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo X,Wang Z,Sun Q,Sun C,Hua H,Huang Q

更新日期：2020-10-19 00:00:00

abstract：:Previous studies have indicated that noggin exerts its neural inducing effect by binding and antagonizing bone morphogenetic protein 4 (BMP4). In order to further clarify the relationship between the structure and the function of noggin, and elucidate the possible mechanism responsible for noggin-BMP4 interaction, we ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu WD,Feng XL,Ren CP,Shi JL,Yang XY,Zhao M,Zhou L,Lan K,Yao KT

更新日期：2005-03-01 00:00:00

abstract：:The study was undertaken to examine the effects of C-peptide on glomerular volume (V(GLOM)), mesangial matrix synthesis, and degradation in streptozotocin (STZ)-diabetic rats with poor or moderate glycemic control. Series 1 (poor glycemic control) included groups of healthy rats, hyperglycemic rats, diabetic insulin-t...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun W,Gao X,Zhao X,Cui D,Xia Q

更新日期：2010-12-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DPPIV), which belongs to the prolyl oligopeptidase family of serine proteases, is known to have a variety of regulatory biological functions and has been shown to be implicated in type 2 diabetes. It is therefore important to develop selective human DPPIV (hDPPIV) inhibitors. In this study, we...

journal_title：Acta biochimica et biophysica Sinica

authors： Hiramatsu H,Kyono K,Yamamoto A,Saeki K,Shima H,Sugiyama S,Inaka K,Shimizu R

更新日期：2007-05-01 00:00:00

abstract：:Heart failure (HF) induced by ischemia myocardial infarction (MI) is one of the major causes of morbidity and mortality all around the world. Atorvastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, has been demonstrated to benefit patients with ischemic or non-ischemic-induced HF, but the mechanism is st...

journal_title：Acta biochimica et biophysica Sinica

authors： Su J,Fang M,Tian B,Luo J,Jin C,Wang X,Ning Z,Li X

更新日期：2018-12-01 00:00:00

abstract：:MicroRNAs are highly conserved endogenous small noncoding RNAs and demonstrated to play important roles in the metastatic cascade of papillary thyroid carcinoma (PTC), including the process of anoikis resistance. In this study, the correlation between miRNA-363-3p (miR-363-3p) expression and PTC metastasis was analyze...

journal_title：Acta biochimica et biophysica Sinica

authors： Pan Y,Zhu X,Wang K,Chen Y

更新日期：2019-08-05 00:00:00

abstract：:The effect of the guanosine triphosphatase activating proteins (GAPs) on spermatogenesis has been studied for years, though no GAPs have been explored in epididymis, an essential organ for sperm maturation. In this study, a new GAP member, designated as MacGAP, was cloned in human epididymis. The MacGAP gene encodes a...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Liu Q,Liu S,Zhang J,Zhang Y

更新日期：2008-10-01 00:00:00

abstract：:Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not b...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen S,Wu Z,Ke Y,Shu P,Chen C,Lin R,Shi Q

更新日期：2019-11-18 00:00:00

abstract：:Emodin, a natural anthraquinone extracted from the Chinese herbs rhubarb and giant knotweed rhizome, has been reported to enhance osteoblast differentiation. However, the mechanisms underlying its ability to regulate osteogenesis are unclear. The objective of this study was to determine the role of emodin in osteoblas...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen X,Zhang S,Chen X,Hu Y,Wu J,Chen S,Chang J,Wang G,Gao Y

更新日期：2017-10-01 00:00:00

abstract：:Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the kil...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang HF,Chen YZ,Wu Y

更新日期：2005-07-01 00:00:00

abstract：:Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation, phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics. Combinations of different modifications on the histone proteins, termed 'histone code' in many cases, extend the information potentia...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang X,Wen H,Shi X

更新日期：2012-01-01 00:00:00

abstract：:Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activation by the agonists. ...

journal_title：Acta biochimica et biophysica Sinica

authors： Drastichova Z,Novotny J

更新日期：2012-08-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is indispensable for the development and maintenance of brown adipose tissue (BAT), and its activity is inhibited due to obesity. The isocitrate dehydrogenase 2 (IDH2) is a mitochondrial enzyme responsible for the production of α-ketoglutarate, a key intermediate metabolite integrat...

journal_title：Acta biochimica et biophysica Sinica

authors： Cao Y,Liu X,Zhao J,Du M

更新日期：2021-01-12 00:00:00

abstract：:Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that som...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu X,Shao X,Guo ZY,Chi CW

更新日期：2010-07-01 00:00:00

abstract：:A gene encoding a special thermophilic multifunctional amylase OPMA-N was cloned from Bacillus sp. ZW2531-1. OPMA-N has an additional 124-residue N-terminal domain compared with typical amylases and forms a relatively independent domain with a β-pleated sheet and random coil structure. Here we reported an unusual subs...

journal_title：Acta biochimica et biophysica Sinica

authors： Li F,Zhu X,Li Y,Cao H,Zhang Y

更新日期：2011-04-01 00:00:00

abstract：:G-quadruplexes are higher-order nucleic acid structures formed in G-rich sequences in DNA or RNA. G-quadruplexes are distributed in many locations in the human genome, including promoter regions, and are viewed as promising therapeutic targets. Uncoupling protein-1 (UCP1) is a mitochondrial thermogenic gene critical f...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao Y,Uhler JP

更新日期：2018-07-01 00:00:00

abstract：:Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Leptin is a hormone secreted by adipose tissue. Recent reports have shown that leptin can induce cancer cell proliferation and regulate cell energy metabolism, but the regulatory mechanism is still unclear. Her...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Q,Sun Y,Fei Z,Yang Z,Duan K,Zi J,Cui Q,Yu M,Xiong W

更新日期：2019-07-10 00:00:00

abstract：:Reactive oxygen species (ROS), including H(2)O(2), play a critical role in the pathophysiology of osteoporosis. Therefore, agents or antioxidants that can inhibit ROS production have a high clinical value in the treatment of osteoporosis. Curculigoside (CUR), one of the main bioactive phenolic compounds isolated from ...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Y,Zhao L,Wang Y,Xu J,Nie Y,Guo Y,Tong Y,Qin L,Zhang Q

更新日期：2012-05-01 00:00:00

abstract：:To explore new targets for hepatoma research, we used a surface display library to screen novel tumor cell-specific peptides. The bacterial FliTrx system was screened with living normal liver cell line L02 and hepatoma cell line HepG2 successively to search for hepatoma-specific peptides. Three clones (Hep1, Hep2, and...

journal_title：Acta biochimica et biophysica Sinica

authors： Li W,Lei P,Yu B,Wu S,Peng J,Zhao X,Zhu H,Kirschfink M,Shen G

更新日期：2008-05-01 00:00:00

abstract：:LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which ...

journal_title：Acta biochimica et biophysica Sinica

authors： Feng Q,Yang J,Luo P,Zhang WJ,Zou QM

更新日期：2005-02-01 00:00:00

abstract：:The diamagnetic levitation as a novel ground-based model for simulating a reduced gravity environment has been widely applied in many fields. In this study, a special designed superconducting magnet, which can produce three apparent gravity levels (0, 1, and 2 g), namely high magneto-gravitational environment (HMGE), ...

journal_title：Acta biochimica et biophysica Sinica

authors： Qian A,Di S,Gao X,Zhang W,Tian Z,Li J,Hu L,Yang P,Yin D,Shang P

更新日期：2009-07-01 00:00:00

abstract：:Hyperglycemia-mediated reactive oxygen species (ROS) accumulation plays an important role in hyperglycemia-induced endothelial injury. Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibition participates in hyperglycemia-induc...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen X,Qi J,Wu Q,Jiang H,Wang J,Chen W,Mao A,Zhu M

更新日期：2020-05-26 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal isc...

journal_title：Acta biochimica et biophysica Sinica

authors： Han F,Dou M,Wang Y,Xu C,Li Y,Ding X,Xue W,Zheng J,Tian P,Ding C

更新日期：2020-02-03 00:00:00

abstract：:CYP6F1 (GenBank/EMBL accession No. AY662654), a novel gene with a complete encoding sequence in the cytochrome P450 family 6, was cloned and sequenced from deltamethrin-resistant 4th instar larvae of Culex pipiens pallens. The cDNA sequence of CYP6F1 has an open reading frame of 1527 bp, which encodes a putative prote...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong MQ,Gu Y,Hu XB,Sun Y,Ma L,Li XL,Sun LX,Sun J,Qian J,Zhu CL

更新日期：2005-05-01 00:00:00

abstract：:Osteoarthritis (OA) is an age-related joint disease that is characterized by the degeneration of articular chondrocytes. Nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is associated with inflammation response. We investigated the role of PARP-1 in interleukin-1β (IL-1β)-stimulated human articular chondrocytes a...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Zhou L,Lv D,Liu H,He T,Wang X

更新日期：2015-06-01 00:00:00

abstract：:Dementia, a devastating neurological disorder commonly found in the elderly, is characterized by severe cognitive and memory impairment. Ample clinical and epidemiological evidence has depicted a close association between dementia and heart failure. While cerebral blood under perfusion and neurohormonal activation due...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang M,Li C,Zhang Y,Ren J

更新日期：2020-01-02 00:00:00