New microbiota found in sputum from patients with community-acquired pneumonia.

abstract：:It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA) exert different effects on the biological function of the vascular endothelial cell (EC), resulting in altered regulation of angiogenesis. However, the specific mechanism is still unclear. Our study focused on the effects of nHA ...

journal_title：Acta biochimica et biophysica Sinica

authors： Mo W,Yang C,Liu Y,He Y,Wang Y,Gao F

更新日期：2011-12-01 00:00:00

abstract：:Abnormal development of central nervous system (CNS) caused by neural tube defects is not only a major contributor in the prevalence of stillbirths and neonatal deaths but also causes lifelong physical disability in surviving infants. Due to insufficient known investigated causes, CNS developmental abnormality has bro...

journal_title：Acta biochimica et biophysica Sinica

authors： Jia S,Zhang L,Zhang K,Wang L,Khan A,Zhang J,Sun Y,Wang Y,Song M,Lyu Y,Li M,Lu X,Niu B,Liu Z,Xie J

更新日期：2020-06-20 00:00:00

abstract：:LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which ...

journal_title：Acta biochimica et biophysica Sinica

authors： Feng Q,Yang J,Luo P,Zhang WJ,Zou QM

更新日期：2005-02-01 00:00:00

abstract：:Metformin, a first line medication for type II diabetes, initially entered the spotlight as a promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk and improved clinical outcomes in diabetic patients taking metformin. To uncover the anti-cancer mechanisms of metformin, preclinical stu...

journal_title：Acta biochimica et biophysica Sinica

authors： Saini N,Yang X

更新日期：2018-02-01 00:00:00

abstract：:MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleo...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang B,Qin W,Zhao B,Shi Y,Yao C,Li J,Xiao H,Jin Y

更新日期：2009-06-01 00:00:00

abstract：:Alteration in cellular energy metabolism plays a critical role in the development and progression of cancer. Leptin is a hormone secreted by adipose tissue. Recent reports have shown that leptin can induce cancer cell proliferation and regulate cell energy metabolism, but the regulatory mechanism is still unclear. Her...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu Q,Sun Y,Fei Z,Yang Z,Duan K,Zi J,Cui Q,Yu M,Xiong W

更新日期：2019-07-10 00:00:00

abstract：:MicroRNAs are highly conserved endogenous small noncoding RNAs and demonstrated to play important roles in the metastatic cascade of papillary thyroid carcinoma (PTC), including the process of anoikis resistance. In this study, the correlation between miRNA-363-3p (miR-363-3p) expression and PTC metastasis was analyze...

journal_title：Acta biochimica et biophysica Sinica

authors： Pan Y,Zhu X,Wang K,Chen Y

更新日期：2019-08-05 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis, species of the fungal genus Cordyceps. It has traditionally been a prized Chinese folk medicine for the human well-being. However, the actions of cordycepin against renal isc...

journal_title：Acta biochimica et biophysica Sinica

authors： Han F,Dou M,Wang Y,Xu C,Li Y,Ding X,Xue W,Zheng J,Tian P,Ding C

更新日期：2020-02-03 00:00:00

abstract：:Recent studies have demonstrated that the expression of the long non-coding RNA (lncRNA) AFAP1-AS1 in pancreatic cancer is negatively correlated with survival and prognosis. However, the effects of oridonin and lncRNA AFAP1-AS1 on the epithelial-to-mesenchymal transition (EMT) and migration of pancreatic cancer cells ...

journal_title：Acta biochimica et biophysica Sinica

authors： Lou S,Xu J,Wang B,Li S,Ren J,Hu Z,Xu B,Luo F

更新日期：2019-08-05 00:00:00

abstract：:To test the hypothesis that hypoxia inducible factor-1 alpha (HIF-1alpha) up-regulated the expression of heme oxygenase-1 (HO-1) gene in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension, 8 male Wistar rats in each of 5 groups were exposed to hypoxia for 0, 3, 7, 14 or 21 d, respectively. Mean pul...

journal_title：Acta biochimica et biophysica Sinica

authors： Li QF,Dai AG

更新日期：2004-02-01 00:00:00

abstract：:hPFTAIRE1 is a Cdc2-related kinase family member. To search its substrates and regulatory proteins, hPFTAIRE1 was fused to LexA and used as a bait to screen a human brain LexA two-hybrid library. In this screening, seven hPFTAIRE1 interacting proteins, including promyelocytic leukemia zinc finger (PLZF), were obtained...

journal_title：Acta biochimica et biophysica Sinica

authors： Gao YK,Jiang M,Yang T,Chen JY

更新日期：2006-03-01 00:00:00

abstract：:To explore new targets for hepatoma research, we used a surface display library to screen novel tumor cell-specific peptides. The bacterial FliTrx system was screened with living normal liver cell line L02 and hepatoma cell line HepG2 successively to search for hepatoma-specific peptides. Three clones (Hep1, Hep2, and...

journal_title：Acta biochimica et biophysica Sinica

authors： Li W,Lei P,Yu B,Wu S,Peng J,Zhao X,Zhu H,Kirschfink M,Shen G

更新日期：2008-05-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPAR-γ) is expressed in pancreatic β cells and is involved in insulin secretion. However, the precise mechanisms remain unclear. Calcium/calmodulin-dependent serine protein kinase (CASK), which plays a vital role in the anchoring of insulin granules on pancreatic β cell me...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang K,Yuan Q,Xie J,Yuan L,Wang Y

更新日期：2019-07-10 00:00:00

abstract：:The destruction of proteins via the ubiquitin-proteasome system is a multi-step, complex process involving polyubiquitination of substrate proteins, followed by proteolytic degradation by the macromolecular 26S proteasome complex. Inhibitors of the proteasome promote the accumulation of proteins that are deleterious t...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu H,Wang T,Xin Z,Zhan Y,Gu G,Li X,Wang X,Yang S,Liu C

更新日期：2019-09-06 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a fascinating target for cancer therapy due to its significant role in the crossroad of multiple signaling pathways associated with cell proliferation and regulation. Hsp90 inhibitors have the potential to be developed into anti-cancer drugs. Here, we identified nicotinic-mycoepoxydien...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Xiao S,Chen J,Wang M,Zheng Z,Song S,Zhang L

更新日期：2015-06-01 00:00:00

abstract：:Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activation by the agonists. ...

journal_title：Acta biochimica et biophysica Sinica

authors： Drastichova Z,Novotny J

更新日期：2012-08-01 00:00:00

abstract：:Heart failure (HF) induced by ischemia myocardial infarction (MI) is one of the major causes of morbidity and mortality all around the world. Atorvastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, has been demonstrated to benefit patients with ischemic or non-ischemic-induced HF, but the mechanism is st...

journal_title：Acta biochimica et biophysica Sinica

authors： Su J,Fang M,Tian B,Luo J,Jin C,Wang X,Ning Z,Li X

更新日期：2018-12-01 00:00:00

abstract：:Kaempferol is a flavonoid that has been reported to exhibit antitumor activity in various malignant tumors. However, the role of kaempferol on cholangiocarcinoma (CCA) is largely unknown. In this article, we found that kaempferol inhibited proliferation, reduced colony formation ability, and induced apoptosis in HCCC9...

journal_title：Acta biochimica et biophysica Sinica

authors： Qin Y,Cui W,Yang X,Tong B

更新日期：2016-03-01 00:00:00

abstract：:Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan TJ,Han LH,Cong RS,Liang J

更新日期：2005-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in post-transcriptional gene silencing of target messenger RNAs, which are involved in virtually all biological processes. Previously, we have demonstrated that spheroid body-forming cells from the MKN-45 cancer cell line possessed gastric cancer stem cell (CSC) properties. In t...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Ma L,Wang Z,Wang L,Liu C,Chen R,Zhang J

更新日期：2014-02-01 00:00:00

abstract：:Galectin-3 (Gal-3) which shows affinity of β-galactosides is a cancer-related protein. Thus, it is important to understand its ligand binding mechanism and then design its specific inhibitor. It was suggested that the positions of water molecules in Gal-3 ligand-binding site could be replaced by appropriate chemical g...

journal_title：Acta biochimica et biophysica Sinica

authors： Su J,Zhang T,Wang P,Liu F,Tai G,Zhou Y

更新日期：2015-03-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality in the world. Ischemia/reperfusion (I/R) injury-induced cardiomyocytes death is the main obstacle that limits the heart function recovery of the AMI patients. Reactive oxygen species (ROS) generated by mitochondria is the main path...

journal_title：Acta biochimica et biophysica Sinica

authors： Li L,Zhang M,Chen W,Wang R,Ye Z,Wang Y,Li X,Cai C

更新日期：2018-10-01 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) is fatal and there is currently no effective clinical treatment. The antibiotic doxycycline has shown anti-cancer effect in several kinds of solid tumors including prostate cancer. In this study, a combination of doxycycline and doxorubicin was used to investigate the synerg...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhu C,Yan X,Yu A,Wang Y

更新日期：2017-11-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is one of the deadliest malignant tumors, and many genes play important roles in its development. The hepatocyte nuclear factor-1a (HNF-1a) gene encodes HNF-1a, which is a transcriptional activator. HNF-1a regulates the tissue-specific expression of multiple genes, especially in pancre...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan Z,Fan K,Deng S,Gong Y,Qian Y,Huang Q,Yang C,Cheng H,Jin K,Luo G,Liu C,Yu X

更新日期：2020-03-18 00:00:00

abstract：:N6-methyladenosine (m6A), a methylation in the N6 position of adenosine especially in the mRNA, exerts diverse physiological and pathological functions. However, the precise role of m6A methylation in hypoxic preconditioning (HPC) is still unknown. Here, we observed that HPC treatment protected H9c2 cells against H2O2...

journal_title：Acta biochimica et biophysica Sinica

authors： Su Y,Xu R,Zhang R,Qu Y,Zuo W,Ji Z,Geng H,Pan M,Ma G

更新日期：2020-12-29 00:00:00

abstract：:In this study, a mistletoe lectin (ML) was purified from Chinese mistletoe and the effect of this 60 kDa Chinese ML on human gammadelta T cell cytotoxicity, apoptosis and modulation of the cytokine network was studied. The cytotoxic properties of delta T cells was evaluated by using a (51)Cr release test and employed ...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong F,Ma Y,Ma A,Yu Q,Zhang J,Nie H,Chen X,Shen B,Li N,Zhang D

更新日期：2007-06-01 00:00:00

abstract：:Hepatocellular carcinoma is a common malignant cancer with high incidence. And long non-coding RNAs (lncRNAs) play pivotal roles in the development of different types of cancers. In this study, we aimed to investigate the role of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of hepatocel...

journal_title：Acta biochimica et biophysica Sinica

authors： Dong H,Zhang Y,Xu Y,Ma R,Liu L,Luo C,Jiang W

更新日期：2019-06-20 00:00:00

abstract：:In this study, we confirmed that sesamin, an active lignan isolated from sesame seed and oil, is a novel skin-tanning compound. The melanin content and tyrosinase activity were increased by sesamin in a dose-dependent manner in B16 melanoma cells. The mRNA and protein levels of tyrosinase were also enhanced after the ...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Z,Li S,Liu Y,Deng P,Huang J,He G

更新日期：2011-10-01 00:00:00

abstract：:Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role of RhoA in the mechanisms underlying growth, migration, and invasion of squamous cell carcinoma of tongue (TSCC). Stable RhoA knockdown of TSCC cell lines SCC-4 and CAL2...

journal_title：Acta biochimica et biophysica Sinica

authors： Yan G,Zou R,Chen Z,Fan B,Wang Z,Wang Y,Yin X,Zhang D,Tong L,Yang F,Jiang W,Fu W,Zheng J,Bergo MO,Dalin M,Zheng J,Chen S,Zhou J

更新日期：2014-08-01 00:00:00

abstract：:Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tu...

journal_title：Acta biochimica et biophysica Sinica

authors： Ning B,Li W,Zhao W,Wang R

更新日期：2016-01-01 00:00:00