Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo.

abstract：:It has been shown that Fructus Ligustri Lucidi (FLL), a promising traditional Chinese medicine, can inhibit the growth of tumors. However, the effective component and molecular mechanism of FLL act to inhibit tumor proliferation are unclear. In this study, we demonstrated that oleanolic acid (OA), a principal chemical...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang P,Li H,Chen D,Ni J,Kang Y,Wang S

更新日期：2007-10-01 00:00:00

abstract：:Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li Y,Liu J,Zhao Z,Wen L,Li H,Ren J,Liu H

更新日期：2018-03-01 00:00:00

abstract：:Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the kil...

journal_title：Acta biochimica et biophysica Sinica

authors： Huang HF,Chen YZ,Wu Y

更新日期：2005-07-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is one of the deadliest malignant tumors, and many genes play important roles in its development. The hepatocyte nuclear factor-1a (HNF-1a) gene encodes HNF-1a, which is a transcriptional activator. HNF-1a regulates the tissue-specific expression of multiple genes, especially in pancre...

journal_title：Acta biochimica et biophysica Sinica

authors： Fan Z,Fan K,Deng S,Gong Y,Qian Y,Huang Q,Yang C,Cheng H,Jin K,Luo G,Liu C,Yu X

更新日期：2020-03-18 00:00:00

abstract：:PKZ, protein kinase containing Z-DNA domains, is a novel member of the vertebrate eIF2α kinase family. Containing a catalytic domain in C-terminus and two Z-DNA binding domains (Zα1 and Zα2) in N-terminus, PKZ can be activated through the binding of Zα to Z-DNA. However, the regulatory function of PKZ Zα remains to be...

journal_title：Acta biochimica et biophysica Sinica

authors： Lu P,Deng S,Wu C,Zhu Y,Liu Y,Lin G,Yan Y,Hu C

更新日期：2013-12-01 00:00:00

abstract：:LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which ...

journal_title：Acta biochimica et biophysica Sinica

authors： Feng Q,Yang J,Luo P,Zhang WJ,Zou QM

更新日期：2005-02-01 00:00:00

abstract：:The major goal of researchers and oncologists is to develop promising ground for novel therapeutic strategies to prevent recurrence or relapse of cancer. Recent evidences suggest that a subset of cells called cancer stem cells (CSCs) are present within the tumor mass which possess tumorigenic capacity and may be respo...

journal_title：Acta biochimica et biophysica Sinica

authors： Bhattacharyya S,Khanduja KL

更新日期：2010-04-01 00:00:00

abstract：:Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% of primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been de...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou W,Feng X,Li H,Wang L,Zhu B,Liu W,Zhao M,Yao K,Ren C

更新日期：2009-01-01 00:00:00

abstract：:Hepatocellular carcinoma is a common malignant cancer with high incidence. And long non-coding RNAs (lncRNAs) play pivotal roles in the development of different types of cancers. In this study, we aimed to investigate the role of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of hepatocel...

journal_title：Acta biochimica et biophysica Sinica

authors： Dong H,Zhang Y,Xu Y,Ma R,Liu L,Luo C,Jiang W

更新日期：2019-06-20 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a fascinating target for cancer therapy due to its significant role in the crossroad of multiple signaling pathways associated with cell proliferation and regulation. Hsp90 inhibitors have the potential to be developed into anti-cancer drugs. Here, we identified nicotinic-mycoepoxydien...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Xiao S,Chen J,Wang M,Zheng Z,Song S,Zhang L

更新日期：2015-06-01 00:00:00

abstract：:Tuberculosis remains a major global health problem and effective vaccines are urgently needed. In this study, we used the combined DNA- and protein-based vaccines of immunodominant antigen Rv0577 to boost BCG and evaluated their immunogenicity in BALB/c mice. Our data suggest that the booster vaccine may substantially...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu D,Chen W,Mi Y,Gong X,Luo T,Bao L

更新日期：2016-04-01 00:00:00

abstract：:Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased and down-regulation of ASS1 was closely corre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tao X,Zuo Q,Ruan H,Wang H,Jin H,Cheng Z,Lv Y,Qin W,Wang C

更新日期：2019-03-01 00:00:00

abstract：:The present study aims to characterize the effect of chronic intermittent hypoxia and HIF1α on the non-alcoholic steatohepatitis (NASH) process in mice, and to explore the role of the Treg/Th17 balance in the formation of NASH inflammation and fibrosis. To achieve this purpose, simple steatosis was induced in mice by ...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu J,Li W,Zhu W,He W,Zhao H,Xiang Y,Liu C,Wu W

更新日期：2018-12-01 00:00:00

abstract：:Thyroid cancer is one of the common malignancies of the endocrine system and the number of thyroid cancer cases is increasing constantly. Significant work has focused on the molecular mechanisms of thyroid cancer, but many mechanisms remain undiscovered. In this study, we employed a comprehensive analysis of whole-tra...

journal_title：Acta biochimica et biophysica Sinica

authors： Guan Y,Bhandari A,Xia E,Kong L,Zhang X,Wang O

更新日期：2020-02-03 00:00:00

abstract：:Erythrocyte senescence is characterized by exposure of cell surface epitopes on cell membrane proteins leading to immune mediated removal of red blood cells. One mechanism for antigen formation is tyrosine phosphorylation (Tyr-P) of the transmembrane protein band 3 by Syk kinase. Our aim was to test the hypothesis tha...

journal_title：Acta biochimica et biophysica Sinica

authors： Bordin L,Fiore C,Bragadin M,Brunati AM,Clari G

更新日期：2009-10-01 00:00:00

abstract：:Luffin-a, a single-chain Type I ribosome-inactivating protein, which is known to be the most toxic of the luffin family and apparently possesses antitumor activity, was isolated from Luffa cylindrica seeds. In the present study, mature alpha-luffin was cloned from L. cylindrica and it was found that mature alpha-luffi...

journal_title：Acta biochimica et biophysica Sinica

authors： Liu L,Wang R,He W,He F,Huang G

更新日期：2010-08-01 00:00:00

abstract：:Epigenetic regulation of gene expression is a dynamic and reversible process with DNA methylation, histone modifications, and chromatin remodeling. Recently, groundbreaking studies have demonstrated the importance of DNA and chromatin regulatory proteins from different aspects, including stem cell, development, and tu...

journal_title：Acta biochimica et biophysica Sinica

authors： Ning B,Li W,Zhao W,Wang R

更新日期：2016-01-01 00:00:00

abstract：:N6-methyladenosine (m6A), a methylation in the N6 position of adenosine especially in the mRNA, exerts diverse physiological and pathological functions. However, the precise role of m6A methylation in hypoxic preconditioning (HPC) is still unknown. Here, we observed that HPC treatment protected H9c2 cells against H2O2...

journal_title：Acta biochimica et biophysica Sinica

authors： Su Y,Xu R,Zhang R,Qu Y,Zuo W,Ji Z,Geng H,Pan M,Ma G

更新日期：2020-12-29 00:00:00

abstract：:Community-acquired pneumonia (CAP) is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients in the acute stages is a kind of accessible sample reflecting its features. In our study, we analyzed 45 sputum samples from 45 patients with CAP. Eighte...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen C,Shen T,Tian F,Lin P,Li Q,Cui Z,Zhang Y,Xue M,Ye J,Guo X,Zhou Y

更新日期：2013-12-01 00:00:00

abstract：:Metallothionein 2A (MT2A) is a small stress response protein that can be induced by exposure to toxic metals. It is highly expressed in breast cancer cells. In this study, the cDNA encoding the human MT2A protein was expressed as glutathione S-transferase (GST) fusion protein in Escherichia coli. Recombinant MT2A prot...

journal_title：Acta biochimica et biophysica Sinica

authors： Marikar FM,Sun QM,Hua ZC

更新日期：2006-05-01 00:00:00

abstract：:HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. The expressions of HEATR1 in GC tissues were analyzed using The ...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao J,Zhu Y,Fu Q,Zhu Y,Zhao G

更新日期：2020-09-08 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the key devastating bacterial pathogen responsible for tuberculosis. Increasing emergence of multi-drug-resistant, extensively drug-resistant, and rifampicin/isoniazid-resistant strains of Mtb makes the discovery of validated drug targets an urgent priority. As a vital translational...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang J,Hong J,Luo L,Liu K,Meng C,Ji ZL,Lin D

更新日期：2019-02-01 00:00:00

abstract：:OsEBP-89 gene encodes an ethylene responsive element binding protein (EREBP) transcription factor from rice (Oryza sativa). Northern blot analysis revealed that OsEBP-89 was expressed in root, stem, seeds, flowers and leaves of rice. Histochemical assay showed that GUS expressed mainly in phloem of vascular tissues of...

journal_title：Acta biochimica et biophysica Sinica

authors： Shen H,Wang ZY

更新日期：2004-01-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that som...

journal_title：Acta biochimica et biophysica Sinica

authors： Wu X,Shao X,Guo ZY,Chi CW

更新日期：2010-07-01 00:00:00

abstract：:To explore new targets for hepatoma research, we used a surface display library to screen novel tumor cell-specific peptides. The bacterial FliTrx system was screened with living normal liver cell line L02 and hepatoma cell line HepG2 successively to search for hepatoma-specific peptides. Three clones (Hep1, Hep2, and...

journal_title：Acta biochimica et biophysica Sinica

authors： Li W,Lei P,Yu B,Wu S,Peng J,Zhao X,Zhu H,Kirschfink M,Shen G

更新日期：2008-05-01 00:00:00

abstract：:Emodin, a natural anthraquinone extracted from the Chinese herbs rhubarb and giant knotweed rhizome, has been reported to enhance osteoblast differentiation. However, the mechanisms underlying its ability to regulate osteogenesis are unclear. The objective of this study was to determine the role of emodin in osteoblas...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen X,Zhang S,Chen X,Hu Y,Wu J,Chen S,Chang J,Wang G,Gao Y

更新日期：2017-10-01 00:00:00

abstract：:Many N-methyl-d-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glutamate excitotoxicity in clinics. However, the universality of the glutamic acid neurotransmitter system makes the glutamic acid receptor blockers inefficient and unsafe. Thus, regulating the downstre...

journal_title：Acta biochimica et biophysica Sinica

authors： Tian Y,He Y,Song W,Zhang E,Xia X

更新日期：2017-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell apoptosis. Zinc finger E-box binding homeobox factor 1 (ZEB1) is a crucial mediator of epithelial-mesenchymal transition (EMT). It induces mali...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao L,Li R,Xu S,Li Y,Zhao P,Dong W,Liu Z,Zhao Q,Tan B

更新日期：2018-02-01 00:00:00

abstract：:Although viral vectors are efficient systems to transfer foreign genes into cells or target tissues, safety issues remain in relation to human gene therapy. Microbubbles currently used as ultrasound contrast agents have been applied in transfection of genes. This study was designed to test the transfection efficiency ...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo DP,Li XY,Sun P,Wang ZG,Chen XY,Chen Q,Fan LM,Zhang B,Shao LZ,Li XR

更新日期：2004-12-01 00:00:00

abstract：:Two full-length cDNAs, named CaM1a and CaM1b, encoding the highly conserved calmodulin1 (CaM1) proteins, were isolated from the cDNA library of amphioxus Branchiostoma belcheri tsingtauense. There are only two nucleotide differences between them, producing one amino acid difference between CaM1a and CaM1b. Comparison ...

journal_title：Acta biochimica et biophysica Sinica

authors： Luan J,Liu Z,Zhang S,Li H,Fan C,Li L

更新日期：2007-04-01 00:00:00