Interaction between plasminogen activator inhibitor type-2 and pre-mRNA processing factor 8.

abstract：:MicroRNAs (miRNAs) function as negative regulators of gene expression involved in cancer metastasis. The aim of this study is to investigate the potential roles of miR-218 in non-small cell lung cancer and validate its regulation mechanism. Functional studies showed that miR-218 overexpression inhibited cell migration...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang C,Ge S,Hu C,Yang N,Zhang J

更新日期：2013-12-01 00:00:00

abstract：:Some barley mutants can synthesize neither anthocyanins nor proanthocyanidins in the seed coat, which is related to several genes in locus Ant13, but the exact model of action remains unknown. We used the cDNA microarray technology with barley transcription-deficient mutant (ant13-152) that does not synthesize proanth...

journal_title：Acta biochimica et biophysica Sinica

authors： Pang JS,He MY,Liu B

更新日期：2004-10-01 00:00:00

abstract：:Tuberculosis remains a major global health problem and effective vaccines are urgently needed. In this study, we used the combined DNA- and protein-based vaccines of immunodominant antigen Rv0577 to boost BCG and evaluated their immunogenicity in BALB/c mice. Our data suggest that the booster vaccine may substantially...

journal_title：Acta biochimica et biophysica Sinica

authors： Gu D,Chen W,Mi Y,Gong X,Luo T,Bao L

更新日期：2016-04-01 00:00:00

abstract：:Heterotrimeric G-proteins localized in the plasma membrane convey the signals from G-protein-coupled receptors (GPCRs) to different effectors. At least some types of G-protein α subunits have been shown to be partly released from plasma membranes and to move into the cytosol after receptor activation by the agonists. ...

journal_title：Acta biochimica et biophysica Sinica

authors： Drastichova Z,Novotny J

更新日期：2012-08-01 00:00:00

abstract：:Osteoarthritis (OA) is an age-related joint disease that is characterized by the degeneration of articular chondrocytes. Nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is associated with inflammation response. We investigated the role of PARP-1 in interleukin-1β (IL-1β)-stimulated human articular chondrocytes a...

journal_title：Acta biochimica et biophysica Sinica

authors： Sun Y,Zhou L,Lv D,Liu H,He T,Wang X

更新日期：2015-06-01 00:00:00

abstract：:Increasing evidence has been accumulated indicating the important role of epigenetic regulation in tumor genesis. Previously, we observed that the transfection of hepatitis C virus core (HCVc) protein led to malignant transformation in normal biliary cells, and that tumor suppressor gene RASSF1A was downregulated in m...

journal_title：Acta biochimica et biophysica Sinica

authors： Guo N,Chen R,Li Z,Liu Y,Cheng D,Zhou Q,Zhou J,Lin Q

更新日期：2011-05-01 00:00:00

abstract：:OsEBP-89 gene encodes an ethylene responsive element binding protein (EREBP) transcription factor from rice (Oryza sativa). Northern blot analysis revealed that OsEBP-89 was expressed in root, stem, seeds, flowers and leaves of rice. Histochemical assay showed that GUS expressed mainly in phloem of vascular tissues of...

journal_title：Acta biochimica et biophysica Sinica

authors： Shen H,Wang ZY

更新日期：2004-01-01 00:00:00

abstract：:Cotton fiber developmental transition from elongation to secondary cell wall biosynthesis is a critical growth shifting phase that affects fiber final length, strength, and other properties. Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotto...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhou X,Hu W,Li B,Yang Y,Zhang Y,Thow K,Fan L,Qu Y

更新日期：2019-11-18 00:00:00

abstract：:The natural alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy and bioavailability, several derivatives have been designed and synthesized and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, fi...

journal_title：Acta biochimica et biophysica Sinica

authors： Guamán Ortiz LM,Croce AL,Aredia F,Sapienza S,Fiorillo G,Syeda TM,Buzzetti F,Lombardi P,Scovassi AI

更新日期：2015-10-01 00:00:00

abstract：:At initial stages in the Rhizobium legume symbiosis, most nodulation genes are controlled by NodD protein and plant inducers. Some genetic studies and other reports have suggested that NodD may be activated by its direct interaction with plant inducers. However, there has been no molecular evidence of such an inducing...

journal_title：Acta biochimica et biophysica Sinica

authors： Li F,Hou B,Chen L,Yao Z,Hong G

更新日期：2008-09-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients in the acute stages is a kind of accessible sample reflecting its features. In our study, we analyzed 45 sputum samples from 45 patients with CAP. Eighte...

journal_title：Acta biochimica et biophysica Sinica

authors： Chen C,Shen T,Tian F,Lin P,Li Q,Cui Z,Zhang Y,Xue M,Ye J,Guo X,Zhou Y

更新日期：2013-12-01 00:00:00

abstract：:Hyperglycemia, a diagnostic characteristic of diabetes mellitus, is detrimental to pancreatic β cells. Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a prot...

journal_title：Acta biochimica et biophysica Sinica

authors： Lai D,Huang M,Zhao L,Tian Y,Li Y,Liu D,Wu Y,Deng F

更新日期：2019-12-13 00:00:00

abstract：:In order to obtain the recombinant human PACAP efficiently by intein-mediated single column purification, a gene encoding human PACAP was synthesized and cloned into Escherichia coli expression vector pKYB. The recombinant vector pKY-PAC was transferred into E. coli ER2566 cells and the target protein was over-express...

journal_title：Acta biochimica et biophysica Sinica

authors： Yu RJ,Hong A,Dai Y,Gao Y

更新日期：2004-11-01 00:00:00

abstract：:Many harpins have been found in plant pathogen bacteria that can elicit disease and insect resistance in plants, and promote plant growth. In this work, we overexpressed and purified Xanthomonas oryzae pv. oryzae harpin, harpin(Xoo), in Escherichia coli BL21/pGEX-hpa1. Harpin(Xoo) was fused to the C-terminus of glutat...

journal_title：Acta biochimica et biophysica Sinica

authors： Li M,Shao M,Lu XZ,Wang JS

更新日期：2005-10-01 00:00:00

abstract：:To investigate whether apelin-13 induced THP-1 monocytes (MCs) adhesion to ECV304 human umbilical vein endothelial cells (HUVECs) via 14-3-3 signaling transduction pathway and the potential novel physiological function and signaling transduction pathway of apelin-APJ, HUVECs ECV304 were cultured in DMEM and MCs THP-1 ...

journal_title：Acta biochimica et biophysica Sinica

authors： Li X,Zhang X,Li F,Chen L,Li L,Qin X,Gao J,Su T,Zeng Y,Liao D

更新日期：2010-06-15 00:00:00

abstract：:Human glioma is the most common primary brain tumor and is associated with high morbidity and mortality. Aberrant expressions of microRNAs (miRNAs) are involved in glioma progression. In the present study, we aimed to elucidate the roles of miR-4530 in the pathogenesis of gliomas. miR-4530 expression was examined in h...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang T,Zhang Y,Cui B,Wang M,Li Y,Gao K

更新日期：2020-12-29 00:00:00

abstract：:Vascularization is one of the hotspots during the development of new therapeutic strategies for bone tissue engineering, which can alleviate hypoxic circumstance and prevent transplant failure. Vascular endothelial growth factor (VEGF) gene transfection using recombinant adenovirus (Ad) vector can effectively promote ...

journal_title：Acta biochimica et biophysica Sinica

authors： Song X,Shi L,Chen L,Liu X,Qu X,Wang K,Wei F

更新日期：2017-11-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy), which is an independent risk factor for atherosclerosis, might cause dysregulation of gene expression, but the characteristics and key links involved in its pathogenic mechanisms are still poorly understood. The objective of the present study was to investigate the effect of HHcy on DNA me...

journal_title：Acta biochimica et biophysica Sinica

authors： Jiang Y,Sun T,Xiong J,Cao J,Li G,Wang S

更新日期：2007-09-01 00:00:00

abstract：:Caveolin-1 is regulated by estrogen in vascular smooth muscle cells. Raloxifene, a selective estrogen receptor modulator that possibly has cardioprotective properties without an increased risk of cancer or other side effects of estrogen, may be used in women with risk of coronary artery disease. However, the relations...

journal_title：Acta biochimica et biophysica Sinica

authors： Yang FL,He H,Liu XX,Tu B,Zeng XW,Su JX,Wang X,Hu Q

更新日期：2006-11-01 00:00:00

abstract：:Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang Z,Wang M,Wang C,Lu B

更新日期：2019-02-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human malignant diseases and the sixth leading cause of cancer-related deaths in China. Gemcitabine is the only first-line chemotherapeutic agent used for the palliative treatment of patients with PDAC, but chemo-resistance limits their efficacy. Here, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Yao J,Li Z,Wang X,Xu P,Zhao L,Qian J

更新日期：2016-02-01 00:00:00

abstract：:The subfamily of voltage-dependent potassium (Kv) channel interacting protein 4 (KChIP4) is made up of the auxiliary interacting protein of voltage-dependent potassium channels. In this study, the structure of four splicing variants of the human KChIP4 gene was analyzed. Three of the four isoforms of the KChIP4 gene, ...

journal_title：Acta biochimica et biophysica Sinica

authors： Deng XY,Cai F,Xia K,Pan Q,Long ZG,Wu LQ,Liang DS,Dai HP,Zhang ZH,Xia JH

更新日期：2005-04-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cell lines, suggesting its great potential in cancer therapy. Many components in TRAIL-mediated signaling pathway have been identified, but how they interact with each other to determine the network dynamics and final apoptosis remain...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang T,Wu M,Chen Q,Sun Z

更新日期：2010-02-01 00:00:00

abstract：:In this study, we identified five miRNAs highly expressed in the small-cell lung cancer (SCLC) cell line NCI-H209. Among them, the expression levels of miR-375 were dramatically elevated in all SCLC cell lines examined, coincident with the expression of the transcription factor achaete-scute complex homolog 1 (ASCL1)....

journal_title：Acta biochimica et biophysica Sinica

authors： Zhao H,Zhu L,Jin Y,Ji H,Yan X,Zhu X

更新日期：2012-02-01 00:00:00

abstract：:Gallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found th...

journal_title：Acta biochimica et biophysica Sinica

authors： Wang H,Dong F,Wang Y,Wang X,Hong D,Liu Y,Zhou J

更新日期：2020-02-03 00:00:00

abstract：:Thyroid cancer is one of the common malignancies of the endocrine system and the number of thyroid cancer cases is increasing constantly. Significant work has focused on the molecular mechanisms of thyroid cancer, but many mechanisms remain undiscovered. In this study, we employed a comprehensive analysis of whole-tra...

journal_title：Acta biochimica et biophysica Sinica

authors： Guan Y,Bhandari A,Xia E,Kong L,Zhang X,Wang O

更新日期：2020-02-03 00:00:00

abstract：:Recent studies have suggested that antibodies can catalyze the generation of unknown oxidants including hydrogen peroxide (H2O2) and ozone (O3) from singlet oxygen (1O2) and water. This study is aimed to detect the effect of antibody-catalyzed water oxidation on atherosclerosis. Our results showed that both H2O2 and O...

journal_title：Acta biochimica et biophysica Sinica

authors： Peng KJ,Huang YS,An LN,Han XQ,Zhang JG,Wang QL,Sun J,Wang SR

更新日期：2006-06-01 00:00:00

abstract：:Mediator complex subunit 1 (Med1)/Thyroid hormone receptor-associated protein 220 (TRAP220), an essential component of thyroid hormone receptor-associated proteins (TRAP)/mediator, plays important roles in hormone responses and tumorigenesis. However, the role of Med1 in the DNA damage response has not been studied. I...

journal_title：Acta biochimica et biophysica Sinica

authors： Kim HJ,Yun J

更新日期：2017-06-01 00:00:00

abstract：:In this study, a mistletoe lectin (ML) was purified from Chinese mistletoe and the effect of this 60 kDa Chinese ML on human gammadelta T cell cytotoxicity, apoptosis and modulation of the cytokine network was studied. The cytotoxic properties of delta T cells was evaluated by using a (51)Cr release test and employed ...

journal_title：Acta biochimica et biophysica Sinica

authors： Gong F,Ma Y,Ma A,Yu Q,Zhang J,Nie H,Chen X,Shen B,Li N,Zhang D

更新日期：2007-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPAR-γ) is expressed in pancreatic β cells and is involved in insulin secretion. However, the precise mechanisms remain unclear. Calcium/calmodulin-dependent serine protein kinase (CASK), which plays a vital role in the anchoring of insulin granules on pancreatic β cell me...

journal_title：Acta biochimica et biophysica Sinica

authors： Zhang K,Yuan Q,Xie J,Yuan L,Wang Y

更新日期：2019-07-10 00:00:00