当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells.

Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells.

Abstract：

:Bradykinin interacts with the bradykinin B2 receptor on dorsal root ganglion (DRG) neurons, setting off a series of reactions inside the cells that ultimately make the vanilloid receptor 1 more sensitive to a normal stimulus by activating various enzymes coupled with second messenger signaling cascades. Zaltoprofen, a propionic acid derivative non-steroidal anti-inflammatory drug (NSAID), was proved to inhibit bradykinin-induced pain responses in vivo experimental systems more potently than indomethacin or other NSAIDs, but the molecular mechanisms underlying its action are not yet fully understood. Currently it appears unlikely that zaltoprofen binds to specific sites on the protein of the bradykinin B2 receptor, hence we have examined the effect of zaltoprofen on bradykinin-induced responses of adult DRG neurons to investigate possible interaction sites. Compared with several other NSAIDs, such as indomethacin, loxoprofen and diclofenac, zaltoprofen most potently inhibits bradykinin-enhancement of capsaicin-induced 45Ca2+ uptake into DRG neurons. Zaltoprofen also significantly inhibits bradykinin-induced 12-lipoxygenase (12-LOX) activity and the slow bradykinin-induced onset of substance P release from DRG neurons. These data indicate zaltoprofen may produce its analgesic effects through the inhibition of bradykinin B2 receptor-mediated bradykinin responses of not only cyclooxygenases (COXs) but also bradykinin induced 12-LOX inhibitors.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Tang HB,Inoue A,Oshita K,Hirate K,Nakata Y

doi

10.1016/j.neuropharm.2005.01.011

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1035-42

issue

7

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(05)00045-6

journal_volume

48

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex.

    abstract：:Akt is a serine/threonine kinase, which is dramatically reduced in the prefrontal cortex (PFC) of patients with schizophrenia, and a deficiency in Akt1 results in PFC function abnormalities. Although the importance of Akt in dopamine (DA) transmission is well established, how impaired Akt signaling affects the DA modu...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.05.002

    authors： Li YC,Yang SS,Gao WJ

    更新日期：2016-09-01 00:00:00

  • Tolerance to the behavioural effect of serotonergic (5-HT1B) agonists in the isolation-induced social behavioural deficit test.

    abstract：:In mice, isolation-induced social behavioural deficits are attenuated by stimulants of 5-HT1B receptors, such as TFMPP or CGS 120 66B. Repeated treatment with RU 24969 (5 mg/kg, daily, for 3 days) reduced the effect of TFMPP and that of other 5-HT1B agonists (CGS 120 66B, m-CPP, RU 24969). Similarly, repeated treatmen...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(91)90082-m

    authors： Frances H,Monier C

    更新日期：1991-06-01 00:00:00

  • Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.

    abstract：:Acamprosate is clinically used to treat alcohol-dependent patients. While the molecular and pharmacological mechanisms of acamprosate remain unclear, it has been shown to regulate γ-aminobutyric acid (GABA) or glutamate levels in the cortex and striatum. To investigate the effect of acamprosate on brain metabolites in...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.02.022

    authors： Hinton DJ,Lee MR,Jacobson TL,Mishra PK,Frye MA,Mrazek DA,Macura SI,Choi DS

    更新日期：2012-06-01 00:00:00

  • Hypothesis: cannabinoid therapy for the treatment of gliomas?

    abstract：:Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most frequent class of malignant primary brain tumours and one of the most aggressive forms of cancer. Current therapeutic strategies for the treatment of glioblastoma multiforme are usually ineffective or just palliative. During the last ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2004.04.016

    authors： Velasco G,Galve-Roperh I,Sánchez C,Blázquez C,Guzmán M

    更新日期：2004-09-01 00:00:00

  • Neuroprotection by Paeoniflorin in the MPTP mouse model of Parkinson's disease.

    abstract：:Paeoniflorin (PF) is a major bioactive ingredient in Radix Paeonia alba roots that has low toxicity and has been shown to have neuroprotective effects. Our in vitro experiments suggested that PF affords a significant neuroprotective effect against MPP+-induced damage and apoptosis in PC12 cells through Bcl-2/Bax/caspa...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.01.009

    authors： Zheng M,Liu C,Fan Y,Yan P,Shi D,Zhang Y

    更新日期：2017-04-01 00:00:00

  • Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway.

    abstract：:The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic target of rapamycin (mTOR) signaling pathway has been associated with several pathologies in the central nervous system (CNS), including epilepsy. There is evidence supporting the hypothesis that the PI3Kγ signaling pathway may mediate the...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108156

    authors： Lima IVA,Bellozi PMQ,Batista EM,Vilela LR,Brandão IL,Ribeiro FM,Moraes MFD,Moreira FA,de Oliveira ACP

    更新日期：2020-10-01 00:00:00

  • Chronic exposure to anabolic androgenic steroids alters activity and synaptic function in neuroendocrine control regions of the female mouse.

    abstract：:Disruption of reproductive function is a hallmark of abuse of anabolic androgenic steroids (AAS) in female subjects. To understand the central actions of AAS, patch clamp recordings were made in estrous, diestrous and AAS-treated mice from gonadotropin releasing hormone (GnRH) neurons, neurons in the medial preoptic a...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.05.008

    authors： Penatti CA,Oberlander JG,Davis MC,Porter DM,Henderson LP

    更新日期：2011-09-01 00:00:00

  • Transitions near the open state in Shaker K(+)-channel: probing with temperature.

    abstract：:Ionic currents from non-inactivating Shaker K(+)-channels were expressed in Xenopus oocytes and recorded with the cut-open oocyte voltage clamp technique. Kinetic properties of ionic currents were studied between 1.4 and 19 degrees C. The forward step of the last transition (...C --> O) of the activation pathway, just...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(96)00111-6

    authors： Rodríguez BM,Bezanilla F

    更新日期：1996-01-01 00:00:00

  • Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.

    abstract：:Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clustered at the edges of postsynaptic densities of excitatory ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.08.015

    authors： Meera P,Dodson PD,Karakossian MH,Otis TS

    更新日期：2005-11-01 00:00:00

  • Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.

    abstract：:The identification of a second 5-HT(3) (5-HT(3B)) subunit provides an explanation for 5-HT(3) receptor heterogeneity. We investigated whether introduction of recombinant 5-HT(3B) subunits would alter the functional properties of mouse neuroblastoma 5-HT(3) receptors. RT-PCR analysis revealed that NB41A3 cells contain ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00376-3

    authors： Stewart A,Davies PA,Kirkness EF,Safa P,Hales TG

    更新日期：2003-02-01 00:00:00

  • Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats.

    abstract：:Tobacco addiction is a chronic disorder that is characterized by craving for tobacco products, withdrawal upon smoking cessation, and relapse after periods of abstinence. Previous studies demonstrated that systemic administration of α2-adrenergic receptor agonists attenuates stress-induced reinstatement of drug seekin...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2010.09.013

    authors： Yamada H,Bruijnzeel AW

    更新日期：2011-02-01 00:00:00

  • Diazepam binding inhibitor (DBI) increases after acute stress in rat.

    abstract：:Diazepam binding inhibitor (DBI) acts in brain by binding to GABAA/benzodiazepine receptors (GBR) and to mitochondrial benzodiazepine receptors (MBR). Because DBI acting at MBR, has been shown to be an effector of ACTH-induced steroidogenesis and stress is known to change the level of GBR and MBR, the model of acute n...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(11)80015-8

    authors： Ferrarese C,Mennini T,Pecora N,Pierpaoli C,Frigo M,Marzorati C,Gobbi M,Bizzi A,Codegoni A,Garattini S

    更新日期：1991-12-01 00:00:00

  • Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine.

    abstract：:A history of intermittent exposures to drugs of abuse can cause long-term changes in acute behavioural responses to a subsequent drug exposure. In drug-naive rats, morphine can elicit intermittent cataleptic postures followed by sustained increases in locomotor activity. Chronic intermittent morphine treatment can red...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2009.01.003

    authors： Hamlin AS,McNally GP,Westbrook RF,Osborne PB

    更新日期：2009-03-01 00:00:00

  • Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain.

    abstract：:Recently, the presence of two high affinity binding sites for phencyclidine were described in guinea pig brain, with one site coupled to the glutamate excitatory amino acid receptor, specifically activated by N-methyl-D-aspartate (NMDA) (site 1) and the other site associated with the dopamine (DA) reuptake carrier (si...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(90)90154-j

    authors： Reid AA,Mattson MV,de Costa BR,Thurkauf A,Jacobson AE,Monn JA,Rice KC,Rothman RB

    更新日期：1990-09-01 00:00:00

  • Concentrations of histamine in the hypothalamus of the rat: effect of extraction volume and interpretation of the effects of acutely-administered morphine.

    abstract：:The effect of varying the ratio of extraction volume to tissue weight (EVR) on the apparent concentration of histamine (HA) in the hypothalamus of the rat was examined. Increasing the weight of tissue (by pooling 1, 2 or 3 hypothalami), in a constant extraction volume, resulted in progressive decreases in apparent con...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(87)90263-2

    authors： Lewis SJ,Verberne AJ,Fennessy MR,Jarrott B

    更新日期：1987-08-01 00:00:00

  • Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function.

    abstract：:ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the pathophysiology of various neurological diseases such as epilepsy, Alzheimer's disease and stroke. GABA transporters (GATs) facilitate the termi...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2019.05.021

    authors： Kickinger S,Hellsberg E,Frølund B,Schousboe A,Ecker GF,Wellendorph P

    更新日期：2019-12-15 00:00:00

  • Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.

    abstract：:Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to inflammation and glutamate-directed excitotoxicity. Social isolation rearing (SIR) in rats induces ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.02.021

    authors： Möller M,Du Preez JL,Emsley R,Harvey BH

    更新日期：2012-06-01 00:00:00

  • 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide.

    abstract：:24S-hydroxycholesterol (24S-HC) is a brain-derived product of lipid metabolism present in the systemic circulation, where its level can change significantly in response to physiological and pathophysiological conditions. Here, using electrophysiological and optical approaches, we have found a high sensitivity to 24S-H...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.01.030

    authors： Kasimov MR,Fatkhrakhmanova MR,Mukhutdinova KA,Petrov AM

    更新日期：2017-05-01 00:00:00

  • Is there a role for neurotrophic factors and their receptors in augmenting the neuroprotective effect of (-)-epigallocatechin-3-gallate treatment of sciatic nerve crush injury?

    abstract：:This study analyzed and compared the effects of EGCG treatment on the expression of NTFs and NTF receptors expression in the sciatic nerve and the L3-L6 spinal cord segments at the early phase of regeneration following sciatic nerve crush injury. Analysis of BDNF, GDNF and NT3 neurotropic factors and Trk-B, Trk-C and ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.10.029

    authors： Renno WM,Khan KM,Benov L

    更新日期：2016-03-01 00:00:00

  • Interplay between PACAP and NO in mouse ileum.

    abstract：:We investigated the possibility that pituitary adenylate cyclase activating peptide (PACAP) has a role in the control of contractility in the mouse ileum. PACAP-(1-27) produced tetrodotoxin (TTX)-insensitive, concentration-dependent reduction of the amplitude of the spontaneous contractions of longitudinal muscle up t...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2003.09.011

    authors： Zizzo MG,Mulè F,Serio R

    更新日期：2004-03-01 00:00:00

  • Inhibitory effects of trace amines on rat midbrain dopaminergic neurons.

    abstract：:Trace amines are biological compounds that are still awaiting identification of their role in neuronal function. Using intracellular electrophysiological recordings, we investigated the depressant action of two trace amines (beta-phenylethylamine and tyramine) on the firing activity of dopaminergic neurons of the subs...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2003.11.031

    authors： Geracitano R,Federici M,Prisco S,Bernardi G,Mercuri NB

    更新日期：2004-05-01 00:00:00

  • Inhibitors of neuropeptide peptidases engaged in pain and drug dependence.

    abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2020.108137

    authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

    更新日期：2020-09-15 00:00:00

  • Effects of intracerebroventricularly administered mu-, delta- and kappa-opioid agonists on locomotor activity of the guinea pig and the pharmacology of the locomotor response to U50,488H.

    abstract：:The effects of intracerebroventricular administration of morphine, the selective mu-agonist DAMGO, the delta-agonist DPDPE, the kappa-preferring peptide dynorphin A(1-13) and the kappa-agonist U50,488H on locomotor behaviour in the guinea pig were investigated. Morphine (total dose = 0.01, 0.1, 1, 10, 200 nmol), DAMGO...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(92)90118-9

    authors： Bot G,Chahl LA,Brent PJ,Johnston PA

    更新日期：1992-09-01 00:00:00

  • The effects of a photosensitive nitric oxide donor on basal and electrically-stimulated dopamine efflux from the rat striatum in vitro.

    abstract：:The reported effects of nitric oxide (NO) on dopamine release from the striatum are variable and its precise effect on striatal nerve terminals is unclear. In the present study a novel method of applying NO to brain tissue in situ was employed. Photo-activation of Roussin's Black Salt (RBS), retained in isolated perfu...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(94)90037-x

    authors： Black MD,Matthews EK,Humphrey PP

    更新日期：1994-11-01 00:00:00

  • GABAB, not GABAA receptors play a role in cortical postictal refractoriness.

    abstract：:Postictal refractoriness may be taken as an expression of lasting activity of inhibitory systems arresting seizures. We tested drugs interfering with GABAergic inhibitory system in pairs of cortical epileptic afterdischarges induced with 1-min interval in rats. Under control conditions the second stimulation failed to...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2014.09.007

    authors： Mareš P,Kubová H

    更新日期：2015-01-01 00:00:00

  • Nucleotides in neuroregeneration and neuroprotection.

    abstract：:Brain injury generates the release of a multitude of factors including extracellular nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions in the acute phase and also protective and reparative actions in the later recovery phase to allow neuroregeneration. A promising strategy ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2015.09.002

    authors： Miras-Portugal MT,Gomez-Villafuertes R,Gualix J,Diaz-Hernandez JI,Artalejo AR,Ortega F,Delicado EG,Perez-Sen R

    更新日期：2016-05-01 00:00:00

  • Effects of amphetamines and small related molecules on recovery after stroke in animals and man.

    abstract：:Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the "therapeutic window" may be widened beyond the first few hour after stroke and an e...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0028-3908(99)00249-x

    authors： Goldstein LB

    更新日期：2000-03-03 00:00:00

  • Attenuation of withdrawal-induced hyperactivity of locus coeruleus neurones by inhibitors of nitric oxide synthase in morphine-dependent rats.

    abstract：:Electrophysiological, biochemical, and behavioural studies have suggested that opiate withdrawal is mediated, at least in part, by a hyperactivity of locus coeruleus (LC) neurones. The aim of this study was to evaluate, using single-unit extracellular recordings, the role of NO in the opiate withdrawal-induced hyperac...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(98)00063-x

    authors： Pineda J,Torrecilla M,Martín-Ruiz R,Ugedo L

    更新日期：1998-06-01 00:00:00

  • The THIP-induced model of bilateral synchronous spike and wave in rodents.

    abstract：:Intraperitoneal administration of 5-10 mg/kg of THIP (4,5,6,7 tetrahydroxyisoxazolo (4,5,c) pyridine 3-ol) induced a transient, reliable model of bilaterally synchronous spikes and waves in rats. The paroxysmal bursts elicited by THIP had similar topographical distribution to the spontaneously-occurring spike and wave...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(87)90204-8

    authors： Fariello RG,Golden GT

    更新日期：1987-02-01 00:00:00

  • Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action.

    abstract：:GABA(B) receptor antagonists have been shown to have antidepressant-like properties in animal models and thus, could represent a novel approach for the treatment of depression. The neurobiological mechanisms underlying these effects are currently unknown. Adult hippocampal neurogenesis (the birth of new neurons) is th...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2012.06.066

    authors： Felice D,O'Leary OF,Pizzo RC,Cryan JF

    更新日期：2012-12-01 00:00:00