Tolerance to the behavioural effect of serotonergic (5-HT1B) agonists in the isolation-induced social behavioural deficit test.

abstract：:G protein regulated inward rectifying potassium channels (GIRKs) are activated by G protein coupled receptors (GPCRs) via the G protein betagamma subunits. However, little is known about the effects of different GPCRs on the deactivation kinetics of transmitter-mediated GIRK currents. In the present study we investiga...

journal_title：Neuropharmacology

authors： Mark MD,Ruppersberg JP,Herlitze S

更新日期：2000-09-01 00:00:00

abstract：:Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring spike and wave discharges (SWDs) in the WAG/Rij rat model of absence e...

journal_title：Neuropharmacology

authors： D'Amore V,Santolini I,van Rijn CM,Biagioni F,Molinaro G,Prete A,Conn PJ,Lindsley CW,Zhou Y,Vinson PN,Rodriguez AL,Jones CK,Stauffer SR,Nicoletti F,van Luijtelaar G,Ngomba RT

更新日期：2013-03-01 00:00:00

abstract：:In view of the involvement of noradrenaline (NA) in the regulation of adrenocortical secretion, its role in the rise of plasma corticosterone following neural stimuli was evaluated in rats. The injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) into the ventral noradrenergic bundle in the brain stem,...

journal_title：Neuropharmacology

authors： Feldman S,Conforti N,Melamed E

更新日期：1988-02-01 00:00:00

abstract：:Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist a...

journal_title：Neuropharmacology

authors： Shueb SS,Erb SJ,Lunzer MM,Speltz R,Harding-Rose C,Akgün E,Simone DA,Portoghese PS

更新日期：2019-12-01 00:00:00

abstract：:Somatostatin (SRIF) is involved in a variety of physiological functions via the activation of five subtypes of specific receptors (sst1-5). Here, we investigated the effects of SRIF on AMPA receptor (AMPAR)-mediated currents (AMPA currents) in isolated rat retinal ganglion cells (GCs) using patch-clamp techniques. Imm...

journal_title：Neuropharmacology

authors： Deng QQ,Sheng WL,Zhang G,Weng SJ,Yang XL,Zhong YM

更新日期：2016-08-01 00:00:00

abstract：:Intracerebroventricular administration of neurotensin (NT) suppresses locomotor activity. However, the brain regions that mediate the locomotor depressant effect of NT and receptor subtype-specific mechanisms involved are unclear. Using a brain-penetrating, selective NT receptor type 1 (NTS1) agonist PD149163, we inve...

journal_title：Neuropharmacology

authors： Vadnie CA,Hinton DJ,Choi S,Choi Y,Ruby CL,Oliveros A,Prieto ML,Park JH,Choi DS

更新日期：2014-10-01 00:00:00

abstract：:The mechanisms underlying lateralization and progression of motor symptoms from unilateral to bilateral in Parkinson's disease (PD) remain to be elucidated. In addition, the molecular mechanisms involved in levodopa-induced dyskinesias (LIDs) depending on lateralization and disease progression from unilaterally to bil...

journal_title：Neuropharmacology

authors： Marin C,Bonastre M,Mengod G,Cortés R,Rodríguez-Oroz MC

更新日期：2015-10-01 00:00:00

abstract：:Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and has recently been shown effective for the treatment of childhood seizures caused by Dravet and Lennox-Gastaut syndromes. Given evidence for activity to mitigate effects of CNS insu...

journal_title：Neuropharmacology

authors： Alalawi A,Dodu JC,Woolley-Roberts M,Brodie J,Di Marzo V,Soderstrom K

更新日期：2019-11-01 00:00:00

abstract：:Recent genetic and pharmacological studies have implicated the α3, β4 and α5 subunits of the nicotinic acetylcholine receptor (nAChR) in dependence to nicotine and other abused drugs and nicotine withdrawal. The α3β4* nAChR subtype has been shown to co-assemble with the α5 or β3 nAChR subunits, and is found mainly in ...

journal_title：Neuropharmacology

authors： Wu J,Perry DC,Bupp JE,Jiang F,Polgar WE,Toll L,Zaveri NT

更新日期：2014-02-01 00:00:00

abstract：:Extrapyramidal syndromes (EPS) caused by antipsychotic therapy are currently treated with anticholinergics that lack selectivity for the five muscarinic receptor subtypes. Since these receptors are heterogeneously expressed among the different classes of striatal neurons and their afferents, it can be expected that th...

journal_title：Neuropharmacology

authors： Erosa-Rivero HB,Bata-García JL,Alvarez-Cervera FJ,Heredia-López FJ,Góngora-Alfaro JL

更新日期：2014-06-01 00:00:00

abstract：:The effect of in vivo administration of the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on striatal and extrastriatal D-1 and D-2 dopamine (DA) receptors was investigated in the rat. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline treatment reduced specific [3H]SCH 23390 (7-chloro-8-hydroxy-2...

journal_title：Neuropharmacology

authors： Gnanalingham KK,Hunter AJ,Jenner P,Marsden CD

更新日期：1994-05-01 00:00:00

abstract：:Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In orde...

journal_title：Neuropharmacology

authors： Mäger I,Meyer AH,Li J,Lenter M,Hildebrandt T,Leparc G,Wood MJA

更新日期：2017-07-01 00:00:00

abstract：:Neonatal administration of monosodium glutamate (MSG) destroyed perikarya in the arcuate nucleus and median eminence, including those that contain met-enkephalin and beta-endorphin and it increased the density of opiate receptors in the midbrain. Treatment with glutamate decreased the analgesic response on the jump te...

journal_title：Neuropharmacology

authors： Badillo-Martinez D,Kirchgessner AL,Butler PD,Bodnar RJ

更新日期：1984-10-01 00:00:00

abstract：:The central nucleus of the amygdala (CeA) is a component of the limbic fear-anxiety circuit, and has also been implicated in regulation of the hypothalamic-pituitary-adrenal (HPA) stress axis. The CeA receives dense noradrenergic innervation, and is rich in expression of alpha(1)-adrenergic receptors. We hypothesized ...

journal_title：Neuropharmacology

authors： Cecchi M,Khoshbouei H,Morilak DA

更新日期：2002-12-01 00:00:00

abstract：:Nicotine improves endotoxic manifestations of hypotension and cardiac autonomic dysfunction in rats. Here, we test the hypothesis that brainstem antiinflammatory pathways of α7/α4β2 nicotinic acetylcholine receptors (nAChRs) modulate endotoxic cardiovascular derangements. Pharmacologic and molecular studies were perfo...

journal_title：Neuropharmacology

authors： Sallam MY,El-Gowilly SM,Fouda MA,Abd-Alhaseeb MM,El-Mas MM

更新日期：2019-10-01 00:00:00

abstract：:The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG prefere...

journal_title：Neuropharmacology

authors： Jane DE,Jones PL,Pook PC,Salt TE,Sunter DC,Watkins JC

更新日期：1993-07-01 00:00:00

abstract：:The effects of phospholipase A2, cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase inhibitors on acute opiate withdrawal induced by selective mu, kappa and delta receptor agonists was investigated in vitro. After a 4 min in vitro exposure to D-Ala2-N-methyl-Phe-Gly5-ol)enkephalin (DAMGO; a highly selective mu ago...

journal_title：Neuropharmacology

authors： Capasso A

更新日期：1999-06-01 00:00:00

abstract：:The effect of injection of inhibitors of GABA-transaminase into the nucleus tractus solitarius (NTS) on arterial pressure was examined in anesthetized rats. Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS, a response...

journal_title：Neuropharmacology

authors： Tsukamoto K,Sved AF

更新日期：1993-06-01 00:00:00

abstract：:The selective benzodiazepine antagonist RO 15-1788, labelled with carbon 11 [11C] RO 15-1788, as a specific marker, together with positron emission tomography, allows the in vivo study of benzodiazepine receptors in primates. In addition, when coupled with recordings of electroencephalographic activity, this method of...

journal_title：Neuropharmacology

authors： Hantraye P,Brouillet E,Guibert B,Chavoix C,Fukuda H,Prenant C,Crouzel M,Naquet R,Maziere M

更新日期：1987-10-01 00:00:00

abstract：:The pharmacological profile of (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) and of other group 1 metabotropic glutamate (mGlu) receptor agents were studied in BHK cells transfected with mGlu receptor subtypes or in native receptors in brain slices by measuring second messenger responses. The mGlu receptor...

journal_title：Neuropharmacology

authors： Mannaioni G,Attucci S,Missanelli A,Pellicciari R,Corradetti R,Moroni F

更新日期：1999-07-01 00:00:00

abstract：:Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capabilit...

journal_title：Neuropharmacology

authors： Parker CC,Chen H,Flagel SB,Geurts AM,Richards JB,Robinson TE,Solberg Woods LC,Palmer AA

更新日期：2014-01-01 00:00:00

abstract：:Several lines of evidence suggest a tight functional coupling between N-methyl-D-aspartate (NMDA) and phencyclidine (PCP) receptors. The effects of PCP receptor agonists (PCP, dexoxadrol, ketamine and MK-801) and NMDA receptor antagonists, cis-4-phosphonomethyl-2-piperidine carboxylic acid (CGS-19755) and 3-(2-carboxy...

journal_title：Neuropharmacology

authors： Rao TS,Kim HS,Lehmann J,Martin LL,Wood PL

更新日期：1990-03-01 00:00:00

abstract：:We used rats with a sciatic nerve chronic constrictive injury (CCI) and combined behavioural, molecular and morphological approaches to assess the involvement of mGlu5 receptors in neuropathic pain-associated hyperalgesia and spinal cord neuron apoptosis. Mechanical and thermal hyperalgesia developed 2-3 days after su...

journal_title：Neuropharmacology

authors： de Novellis V,Siniscalco D,Galderisi U,Fuccio C,Nolano M,Santoro L,Cascino A,Roth KA,Rossi F,Maione S

更新日期：2004-03-01 00:00:00

abstract：:The incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are growth factors that have shown neuroprotective effects in animal models of Parkinson's and Alzheimer's disease. In addition, the GLP-1 mimetic exendin-4 has shown protective effects in a clinical trial in Parkinson...

journal_title：Neuropharmacology

authors： Jalewa J,Sharma MK,Gengler S,Hölscher C

更新日期：2017-05-01 00:00:00

abstract：:The voltage-dependent calcium channels (VDCCs) involved in K(+)-induced transmitter release have been studied. A maximally effective concentration of the N-type VDCC inhibitor, omega-conotoxin GVIA (GVIA) blocked the release of 5-HT (30%), DA (30%) and ACh (60%) but not that of GABA or glutamate. The O, P and Q-type V...

journal_title：Neuropharmacology

authors： Harvey J,Wedley S,Findlay JD,Sidell MR,Pullar IA

更新日期：1996-04-01 00:00:00

abstract：:A pharmacological study using monkeys, in which parkinsonism was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was undertaken to elucidate the mechanism underlying urinary bladder dysfunctions in Parkinson's disease. Under ketamine anesthesia, cystometrograms showed that, in MPTP-treated monkeys, a c...

journal_title：Neuropharmacology

authors： Yoshimura N,Mizuta E,Kuno S,Sasa M,Yoshida O

更新日期：1993-04-01 00:00:00

abstract：:Chronic activity perturbations in neurons induce homeostatic plasticity through modulation of synaptic strength or other intrinsic properties to maintain the correct physiological range of excitability. Although similar plasticity can also occur at the population level, what molecular mechanisms are involved remain un...

journal_title：Neuropharmacology

authors： Jewett KA,Lee KY,Eagleman DE,Soriano S,Tsai NP

更新日期：2018-08-01 00:00:00

abstract：:3,4-methylenedioxypyrovalerone (MDPV) is a synthetic cathinone with cocaine-like properties. In a previous work, we exposed adolescent mice to MDPV, finding sensitization to cocaine effects, and a higher vulnerability to cocaine abuse in adulthood. Here we sought to determine if such MDPV schedule induces additional b...

journal_title：Neuropharmacology

authors： Duart-Castells L,López-Arnau R,Buenrostro-Jáuregui M,Muñoz-Villegas P,Valverde O,Camarasa J,Pubill D,Escubedo E

更新日期：2019-01-01 00:00:00

abstract：:Anxiety disorders contribute to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The hippocampus is important for anxiety modulation. However, the mechanisms that control the neuronal activity of the hippocampus in anxiety are still not clear. We found that E...

journal_title：Neuropharmacology

authors： Chen M,Shu S,Yan HH,Pei L,Wang ZF,Wan Q,Bi LL

更新日期：2017-05-15 00:00:00

abstract：:Centrally-administered opioid peptides produce elevations in levels of catecholamines in plasma in conscious rats. To investigate the opioid receptor involved in mediating this response, morphine (3.5-105 nmol), [D-Ala2-D-Leu5]enkephalin (DADL, 1.05-35 nmol) and U50, 488H (35-1160 nmol), relatively selective ligands f...

journal_title：Neuropharmacology

authors： Conway EL,Brown MJ,Dollery CT

更新日期：1984-11-01 00:00:00