Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity.

abstract：:The aim of this study was to investigate the facilitatory effects of subanalgesic or low doses of different drugs (acetylsalicylic acid, ibuprofen and morphine) on the antinociceptive responses induced by the endogenous opioid peptides, enkephalins, protected from their catabolism by the dual enkephalin-degrading enzy...

journal_title：Neuropharmacology

authors： Nieto MM,Wilson J,Walker J,Benavides J,Fournié-Zaluski MC,Roques BP,Noble F

更新日期：2001-09-01 00:00:00

abstract：:The effects of high-K, glutamate and glutamate receptor agonists on the efflux of Ca2+ were studied in cultured primary astrocytes, prepared from the brains of newborn rats. An increase in efflux of 45Ca2+ of produced by a large extracellular concentration of K+ was effectively inhibited by verapamil, a blocker of vol...

journal_title：Neuropharmacology

authors： Holopainen I,Akerman KE

更新日期：1990-08-01 00:00:00

abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

journal_title：Neuropharmacology

authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

更新日期：2020-09-15 00:00:00

abstract：:Based on significant amount of evidence, it is now generally believed, that one underlying cause for neurodegenerative diseases, could be dysregulation in inflammatory processes. The actual mechanisms involved are not yet well understood. Several studies have demonstrated the potent analgesic and anti-inflammatory act...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Jabbur SJ,Dardenne M,Saadé NE

更新日期：2011-02-01 00:00:00

abstract：:The effect of the D1 dopamine receptor antagonist SCH 23390 on sleep patterns was studied in rats by means of the electroencephalographic (EEG) technique. Haloperidol, an established D2 antagonist neuroleptic, was used for comparison. Over a very small dose range (0.003-0.03 mg/kg, subcutaneously), SCH 23390 significa...

journal_title：Neuropharmacology

authors： Trampus M,Ongini E

更新日期：1990-10-01 00:00:00

abstract：:We have used whole-cell patch clamp electrophysiology to characterise the actions of the P2 antagonist, cibacron blue, on the rat recombinant P2X4 receptor, stably expressed in human embryonic kidney 293 (HEK293) cells. In single cells, adenosine triphosphate (ATP) evoked inward currents, but the response was subject ...

journal_title：Neuropharmacology

authors： Miller KJ,Michel AD,Chessell IP,Humphrey PP

更新日期：1998-12-01 00:00:00

abstract：:Morphine was shown to enhance dopamine release in the rat olfactory tubercle, nucleus accumbens, prefrontal cortex and pyriform cortex, as assessed by increased 3-methoxytyramine (3-MT) levels and 3-MT accumulation after pargyline treatment. In contrast, both 3-MT levels and accumulation after pargyline were unaffecte...

journal_title：Neuropharmacology

authors： Wood PL,Rao TS

更新日期：1991-04-01 00:00:00

abstract：:Cannabinoid CB2 receptors (CB2Rs) are emerging as important therapeutic targets in brain disorders that typically involve neurometabolic alterations. We here addressed the possible role of CB2Rs in the regulation of glucose uptake in the mouse brain. To that aim, we have undertaken 1) measurement of (3)H-deoxyglucose ...

journal_title：Neuropharmacology

authors： Köfalvi A,Lemos C,Martín-Moreno AM,Pinheiro BS,García-García L,Pozo MA,Valério-Fernandes Â,Beleza RO,Agostinho P,Rodrigues RJ,Pasquaré SJ,Cunha RA,de Ceballos ML

更新日期：2016-11-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is characterized by avoidance of trauma-associated stimuli and amygdala hyperreactivity, and is highly co-morbid with alcohol use disorder (AUD). Our lab uses a predator odor (bobcat urine) stress model that produces conditioned avoidance of an odor-paired context in a subset of r...

journal_title：Neuropharmacology

authors： Weera MM,Schreiber AL,Avegno EM,Gilpin NW

更新日期：2020-04-01 00:00:00

abstract：:Disruptions in synaptic plasticity in the dorsal striatum may contribute to the pathophysiology underlying Parkinson's disease. Here we report a novel, chemically-induced form of plasticity induced by application of the potassium channel blocker tetraethylammonium (TEA) in the dorsolateral striatum of the adult rat. T...

journal_title：Neuropharmacology

authors： Norman ED,Egli RE,Colbran RJ,Winder DG

更新日期：2005-02-01 00:00:00

abstract：:The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...

journal_title：Neuropharmacology

authors： Lopatář J,Dale N,Frenguelli BG

更新日期：2015-06-01 00:00:00

abstract：:The exact role of opioid receptor signaling in mediating voluntary wheel running is unclear. To provide additional understanding, female rats selectively bred for motivation of low (LVR) versus high voluntary running (HVR) behaviors were used. Aims of this study were 1) to identify intrinsic differences in nucleus acc...

journal_title：Neuropharmacology

authors： Ruegsegger GN,Toedebusch RG,Will MJ,Booth FW

更新日期：2015-10-01 00:00:00

abstract：:Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood. A gr...

journal_title：Neuropharmacology

authors： Bryleva EY,Brundin L

更新日期：2017-01-01 00:00:00

abstract：:Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and LY2365109 {[2-(4-benzo[1,3]dioxol-5-yl-2-tert-butylphenoxy)ethyl]-methylamino}-acetic acid in...

journal_title：Neuropharmacology

authors： Perry KW,Falcone JF,Fell MJ,Ryder JW,Yu H,Love PL,Katner J,Gordon KD,Wade MR,Man T,Nomikos GG,Phebus LA,Cauvin AJ,Johnson KW,Jones CK,Hoffmann BJ,Sandusky GE,Walter MW,Porter WJ,Yang L,Merchant KM,Shannon HE,S

更新日期：2008-10-01 00:00:00

abstract：:Alcohol produces many subjective and objective effects in man including pleasure, sedation, anxiolysis, plus impaired eye movements and memory. In human volunteers we have used a newly available GABA-A/benzodiazepine receptor inverse agonist that is selective for the alpha5 subtype (a5IA) to evaluate the role of this ...

journal_title：Neuropharmacology

authors： Nutt DJ,Besson M,Wilson SJ,Dawson GR,Lingford-Hughes AR

更新日期：2007-12-01 00:00:00

abstract：:Rats exhibited a marked suppression of motor activity when placed in the same chamber where they had been given electric shocks. Administration of apomorphine-HCl (0.1, 0.5 and 1.0 mg/kg, i.p.) attenuated the conditioned suppression, dose-dependently, but did not facilitate motor activity of control (i.e. non-shocked)...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1983-07-01 00:00:00

abstract：:Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the "therapeutic window" may be widened beyond the first few hour after stroke and an e...

journal_title：Neuropharmacology

authors： Goldstein LB

更新日期：2000-03-03 00:00:00

abstract：:A new in vivo pharmacological method for the quantitative evaluation of alpha 1-adrenoceptor agonists and antagonists has been developed. It consists of recording the myoclonic twitch activity (MTA) of the suprahyoideal muscle of rats anesthetized with urethane. In these animals, the isomers of amphetamine elicited my...

journal_title：Neuropharmacology

authors： Menon MK,Kodama CK,Kling AS,Fitten J

更新日期：1986-05-01 00:00:00

abstract：:Alternative splicing of the dopamine D2 receptor gene produces two distinct isoforms referred to as D2long (D2L) and D2short (D2S). In mesencephalic dopamine neurons, inhibition of the firing rate through activation of somatodendritic D2 receptors and blockade of neurotransmitter release through stimulation of termina...

journal_title：Neuropharmacology

authors： Jomphe C,Tiberi M,Trudeau LE

更新日期：2006-04-01 00:00:00

abstract：:The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although the underlying mechanisms and/or therapeutic target are not yet clear. In this study, we investigated the involvement of the glutamatergic neuronal system in the ...

journal_title：Neuropharmacology

authors： Hasegawa S,Yoshimi A,Mouri A,Uchida Y,Hida H,Mishina M,Yamada K,Ozaki N,Nabeshima T,Noda Y

更新日期：2019-04-01 00:00:00

abstract：:Data have been collected indicating possible functions for histamine in brain but there are only a very few data, collected exclusively with behavioural tests, about the effects of histamine on the perception of the pain, an important aspect in the homeostasis of the human body. The purpose of the present study was to...

journal_title：Neuropharmacology

authors： Braga PC,Sibilia V,Guidobono E,Pecile A,Netti C

更新日期：1992-09-01 00:00:00

abstract：:Venlafaxine, a novel 2-phenyl-2-(1-hydroxycycloalkyl) ethylamine, is a potent inhibitor of 5-hydroxytryptamine and noradrenaline reuptake and exhibits a profile of activity in pre-clinical in vitro biochemical studies predictive of antidepressant activity. The studies described here examined the effects of acute and c...

journal_title：Neuropharmacology

authors： Mitchell PJ,Fletcher A

更新日期：1993-10-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:The rat hemisected spinal cord preparation was used to assess the role of different adrenoceptor subtypes on the modulation of nociceptive reflexes. These were elicited by trains of high intensity electrical stimuli delivered to a lumbar dorsal root. Responses were recorded from the corresponding ventral root in AC- a...

journal_title：Neuropharmacology

authors： Hedo G,Lopez-Garcia JA

更新日期：2001-12-01 00:00:00

abstract：:The secreted glycoprotein Dickkopf-1 (Dkk1), an antagonist of the Wnt/β-catenin pathway, has been implicated in many neurodegenerative diseases. However, it is unknown whether Dkk1 is involved in the pathogenesis of Parkinson's disease (PD). In this study, we discovered that Dkk1 was induced in MPP(+)-treated PC12 cel...

journal_title：Neuropharmacology

authors： Dun Y,Yang Y,Xiong Z,Feng M,Zhang Y,Wang M,Xiang J,Li G,Ma R

更新日期：2013-04-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the preferential dopamine D3 receptor agonists, PD128,907 (0.16 mg/kg, i.p.) and 7-OH-DPAT (0.16 mg/kg, i.p.). PD128,907 and 7-OH-DPAT showed "full" (> or = 80%) and mutual generalization. Chemically-diverse, preferential D3 versus D2 agonists, ...

journal_title：Neuropharmacology

authors： Millan MJ,Girardon S,Monneyron S,Dekeyne A

更新日期：2000-02-14 00:00:00

abstract：:Depression is a leading cause of mortality and morbidity. Selective serotonin reuptake inhibitors, such as fluoxetine, are the most commonly prescribed antidepressant medication. SSRIs produce their therapeutic effects by elevating extracellular concentrations of serotonin. Although this elevation occurs rapidly, ther...

journal_title：Neuropharmacology

authors： Van Dyke AM,Francis TC,Chen H,Bailey AM,Thompson SM

更新日期：2019-05-15 00:00:00

abstract：:A history of intermittent exposures to drugs of abuse can cause long-term changes in acute behavioural responses to a subsequent drug exposure. In drug-naive rats, morphine can elicit intermittent cataleptic postures followed by sustained increases in locomotor activity. Chronic intermittent morphine treatment can red...

journal_title：Neuropharmacology

authors： Hamlin AS,McNally GP,Westbrook RF,Osborne PB

更新日期：2009-03-01 00:00:00

abstract：:Prenatal hypoxia ischemia is a major cause of neurodevelopmental impairment in the newborn, associated with risk for motor, behavioral and cognitive impaired outcomes. We used an established mouse model of maternal hypoxia to examine the immediate molecular responses of signaling pathways associated with both cell dea...

journal_title：Neuropharmacology

authors： Golan MH,Mane R,Molczadzki G,Zuckerman M,Kaplan-Louson V,Huleihel M,Perez-Polo JR

更新日期：2009-10-01 00:00:00

abstract：:We have previously shown that animals acquired robust conditioned place preference (CPP) to either social interaction alone or cocaine alone. Recently it has been reported that drugs of abuse abnormally activated p38, a member of mitogen-activated protein kinase family, in the nucleus accumbens. In this study, we aime...

journal_title：Neuropharmacology

authors： Salti A,Kummer KK,Sadangi C,Dechant G,Saria A,El Rawas R

更新日期：2015-12-01 00:00:00