Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:Stimulation of cannabinoid CB1 receptors or inhibition of nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (dlPAG) decreases anxiety-like behavior. Moreover, activation of CB1 receptors attenuates flight responses induced by nitric oxide (NO) donors in the dlPAG, suggesting that endocannabinoids and...

journal_title：Neuropharmacology

authors： Lisboa SF,Magesto AC,Aguiar JC,Resstel LB,Guimarães FS

更新日期：2013-12-01 00:00:00

abstract：:Alternative splicing of the dopamine D2 receptor gene produces two distinct isoforms referred to as D2long (D2L) and D2short (D2S). In mesencephalic dopamine neurons, inhibition of the firing rate through activation of somatodendritic D2 receptors and blockade of neurotransmitter release through stimulation of termina...

journal_title：Neuropharmacology

authors： Jomphe C,Tiberi M,Trudeau LE

更新日期：2006-04-01 00:00:00

abstract：:It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast howe...

journal_title：Neuropharmacology

authors： Massey PV,Warburton EC,Wynick D,Brown MW,Bashir ZI

更新日期：2003-01-01 00:00:00

abstract：:Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exert beneficial effects in models of cardiac and renal disease, as well as hemorrhagic stroke. Here, we hypothesize that C21 may exer...

journal_title：Neuropharmacology

authors： Joseph JP,Mecca AP,Regenhardt RW,Bennion DM,Rodríguez V,Desland F,Patel NA,Pioquinto DJ,Unger T,Katovich MJ,Steckelings UM,Sumners C

更新日期：2014-06-01 00:00:00

abstract：:The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studies already indicating which subtype mediates the anxiolytic and anti-p...

journal_title：Neuropharmacology

authors： Sanger H,Hanna L,Colvin EM,Grubisha O,Ursu D,Heinz BA,Findlay JD,Vivier RG,Sher E,Lodge D,Monn JA,Broad LM

更新日期：2013-03-01 00:00:00

abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

journal_title：Neuropharmacology

authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

更新日期：2020-09-15 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH) were examined on the monosynaptic reflex and on the activity of motoneurons in the spinal cord of the neonatal rat to elucidate the mechanism of action of TRH and its ability to reverse the spinal depression caused by phencyclidine and ketamine. Phencyclidine (2-32 mi...

journal_title：Neuropharmacology

authors： Ohno Y,Warnick JE

更新日期：1988-10-01 00:00:00

abstract：RATIONALE:Diabetes mellitus (DM) is a major risk factor for Alzheimer's disease and vascular dementia. Few animal models exist that focus on the metabolic contributions to dementia onset and progression. Thus, there is strong scientific rationale to explore the effects of streptozotocin (STZ), a diabetogenic compound, ...

journal_title：Neuropharmacology

authors： Murtishaw AS,Heaney CF,Bolton MM,Belmonte KCD,Langhardt MA,Kinney JW

更新日期：2018-07-15 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) and TRH analogues have been reported to be neuroprotective in experimental models of spinal cord injury and head injury. We have previously shown that a diketopiperazine structurally related to the TRH metabolite cyclo-his-pro reduces neuronal cell death in vitro and in vivo. Here w...

journal_title：Neuropharmacology

authors： Faden AI,Movsesyan VA,Knoblach SM,Ahmed F,Cernak I

更新日期：2005-09-01 00:00:00

abstract：:Following intraperitoneal administration, the selective cAMP phosphodiesterase (PDE) inhibitors rolipram, ICI 63 197 and Ro 20-1724 were investigated in mice in comparison with imipramine for their effectiveness in two classical test models for prediction of clinical antidepressant activity: antagonism of reserpine-in...

journal_title：Neuropharmacology

authors： Wachtel H

更新日期：1983-03-01 00:00:00

abstract：:A subgroup of anticonvulsant and neuroleptic drugs acts through the potentiation of GABA pathways. The regulatory role of GABA in neuronal circuit formation is related to its depolarizing action that supports activity-dependent synaptogenesis. We hypothesized that elevated levels of GABA in the immature brain modify s...

journal_title：Neuropharmacology

authors： Melamed O,Levav-Rabkin T,Zukerman C,Clarke G,Cryan JF,Dinan TG,Grossman Y,Golan HM

更新日期：2014-04-01 00:00:00

abstract：:(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats ...

journal_title：Neuropharmacology

authors： Bruno V,Battaglia G,Kingston A,O'Neill MJ,Catania MV,Di Grezia R,Nicoletti F

更新日期：1999-02-01 00:00:00

abstract：:The effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-HT1A, 5-HT1B, 5-HT2A and 5-HT3, in various brain regions in the rat. In addition, t...

journal_title：Neuropharmacology

authors： Gozlan H,Laporte AM,Thibault S,Schechter LE,Bolaños F,Hamon M

更新日期：1994-03-01 00:00:00

abstract：:Participation of opiate, serotonergic and noradrenergic components in the antinociceptive action of intrathecally administered morphine was evaluated by measuring the ability of subcutaneously administered doses of naloxone, methysergide and phentolamine to alter analgesia. Morphine produced a dose-dependent elevation...

journal_title：Neuropharmacology

authors： Crisp T,Smith DJ

更新日期：1989-10-01 00:00:00

abstract：:Tityustoxin (TsTx) inhibited high affinity choline uptake (HAChU) in cortical slices of the rat brain. The effect was dependent on the concentration of tityustoxin, energy source, incubation time, temperature, and the pH of the incubation medium. The inhibitory effect was dependent upon the presence of sodium and calc...

journal_title：Neuropharmacology

authors： Macedo TM,Gomez MV

更新日期：1983-02-01 00:00:00

abstract：:Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associated with both sporadic and familial Parkinson's disease (PD). Pathogenic mutations are localized to the catalytic domains of LRRK2, including kinase and GTPase domains. Altered catalytic activity correlates with neurotoxicity, indicating that targeting...

journal_title：Neuropharmacology

authors： Gómez-Suaga P,Fdez E,Fernández B,Martínez-Salvador M,Blanca Ramírez M,Madero-Pérez J,Rivero-Ríos P,Fuentes JM,Hilfiker S

更新日期：2014-10-01 00:00:00

abstract：:The kinetics of synaptic currents is largely determined by the postsynaptic receptor gating and the concentration time course of synaptic neurotransmitter. While the analysis of current responses to rapid agonist application provides the means to study the ligand-gated receptor gating, no direct tools are available to...

journal_title：Neuropharmacology

authors： Mozrzymas JW

更新日期：2004-12-01 00:00:00

abstract：:We have previously shown that animals acquired robust conditioned place preference (CPP) to either social interaction alone or cocaine alone. Recently it has been reported that drugs of abuse abnormally activated p38, a member of mitogen-activated protein kinase family, in the nucleus accumbens. In this study, we aime...

journal_title：Neuropharmacology

authors： Salti A,Kummer KK,Sadangi C,Dechant G,Saria A,El Rawas R

更新日期：2015-12-01 00:00:00

abstract：:The long held view is cocaine's pharmacological effects are mediated by monoamine reuptake inhibition. However, drugs with rapid brain penetration like sibutramine, bupropion, mazindol and tesofensine, which are equal to or more potent than cocaine as dopamine reuptake inhibitors, produce no discernable subjective eff...

journal_title：Neuropharmacology

authors： Heal DJ,Gosden J,Smith SL

更新日期：2014-12-01 00:00:00

abstract：:Improgan is a chemical congener of the H2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To ...

journal_title：Neuropharmacology

authors： Hough LB,de Esch IJ,Janssen E,Phillips J,Svokos K,Kern B,Trachler J,Abood ME,Leurs R,Nalwalk JW

更新日期：2006-09-01 00:00:00

abstract：:In slices of the hypothalamus of the rat, prelabelled with [3H]5-hydroxytryptamine ([3H]5-HT), dihydroergocristine (DHEC) decreased in a concentration-dependent manner (0.01-1 microM) the release of [3H]transmitter elicited by stimulation. In the presence of phentolamine (1 microM), sulpiride (1 microM), atropine (1 m...

journal_title：Neuropharmacology

authors： Moret C,Briley M

更新日期：1986-02-01 00:00:00

abstract：:Stimulus evoked neurotransmitter release requires that Na(+) channel-dependent nerve terminal depolarization be transduced into synaptic vesicle exocytosis. Inhaled anesthetics block presynaptic Na(+) channels and selectively inhibit glutamate over GABA release from isolated nerve terminals, indicating mechanistic dif...

journal_title：Neuropharmacology

authors： Westphalen RI,Kwak NB,Daniels K,Hemmings HC Jr

更新日期：2011-09-01 00:00:00

abstract：:Urocortin 3 (Ucn3) is an anorexigenic neuropeptide with high affinity for the type 2 corticotropin-releasing factor receptor (CRF₂-R). How the expression of hypothalamic Ucn3 is regulated by fasting and refeeding in genetically obese (fa/fa) Zucker rats is not known. Obese Zucker rats develop early hyperphagia associa...

journal_title：Neuropharmacology

authors： Poulin AM,Lenglos C,Mitra A,Timofeeva E

更新日期：2012-07-01 00:00:00

abstract：:The effect of nifedipine, a calcium channel antagonist, on changes in the density of glucocorticoid (GR) and/or mineralocorticoid receptors (MR), induced by long-term treatment with antidepressant drugs (imipramine and amitriptyline) or electroconvulsive shock (ECS) was investigated in the rat hippocampus. Long-term t...

journal_title：Neuropharmacology

authors： Przegaliński E,Budziszewska B,Siwanowicz J,Jaworska L

更新日期：1993-12-01 00:00:00

abstract：:A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

journal_title：Neuropharmacology

authors： Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

更新日期：2019-03-01 00:00:00

abstract：:Drug addiction continues to be an important public health problem, with an estimated 22.6 million current illicit drug users in the United States alone. For many addictions, including cocaine, methamphetamine, and marijuana addiction, there are no approved pharmacological treatments. Behavioral treatments are effectiv...

journal_title：Neuropharmacology

authors： Sofuoglu M,DeVito EE,Waters AJ,Carroll KM

更新日期：2013-01-01 00:00:00

abstract：:Group III metabotropic glutamate receptors (mGluR4,7,8) are widely distributed in the basal ganglia. Injection of group III mGluR agonists into the striatopallidal complex alleviates parkinsonian symptoms in 6-hydroxydopamine-treated rats. In vitro rodent studies have suggested that this may be partly due to modulatio...

journal_title：Neuropharmacology

authors： Bogenpohl J,Galvan A,Hu X,Wichmann T,Smith Y

更新日期：2013-03-01 00:00:00

abstract：:Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) expressed in several mammalian brain areas and activated by "trace amines" (TAs). TAs role is unknown; however, discovery of their receptors provided an opportunity to investigate their functions. In vivo evidence has indicated an inhibit...

journal_title：Neuropharmacology

authors： Leo D,Mus L,Espinoza S,Hoener MC,Sotnikova TD,Gainetdinov RR

更新日期：2014-06-01 00:00:00

abstract：:5-HT(7) receptor mRNA and protein are localised in the dorsal raphe nucleus (DRN) on non-serotonergic neurones. The effect of 5-HT(7) receptor antagonism on 5-HT efflux was measured from guinea-pig DRN slices, using the technique of fast cyclic voltammetry. The 5-HT(7) receptor antagonist, SB-269970-A, significantly i...

journal_title：Neuropharmacology

authors： Roberts C,Thomas DR,Bate ST,Kew JN

更新日期：2004-06-01 00:00:00