Abstract：
:Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associated with both sporadic and familial Parkinson's disease (PD). Pathogenic mutations are localized to the catalytic domains of LRRK2, including kinase and GTPase domains. Altered catalytic activity correlates with neurotoxicity, indicating that targeting those activities may provide clues as to novel therapeutic strategies for LRRK2-linked PD. However, the cellular readout of such altered catalytic activities remains largely unknown. Recent cell biological studies have started to highlight possible early cellular events which are altered in the presence of pathogenic LRRK2 and may ultimately lead to neuronal demise, and these studies link altered LRRK2 function to various abnormal endolysosomal vesicular trafficking events. This review examines our current knowledge of LRRK2 neurobiology and how pathogenic mutations may lead to neurodegeneration in PD.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Gómez-Suaga P,Fdez E,Fernández B,Martínez-Salvador M,Blanca Ramírez M,Madero-Pérez J,Rivero-Ríos P,Fuentes JM,Hilfiker Sdoi
10.1016/j.neuropharm.2014.05.020subject
Has Abstractpub_date
2014-10-01 00:00:00pages
45-56eissn
0028-3908issn
1873-7064pii
S0028-3908(14)00187-7journal_volume
85pub_type
杂志文章,评审abstract：:Compelling evidence has shown that in hippocampus tumor necrosis factor alpha (TNF-alpha) at pathological concentration inhibits long-term potentiation (LTP), a synaptic model of learning and memory. In the present work we investigated the role of TNF-alpha in LTP of C-fiber evoked field potentials in spinal dorsal ho...
journal_title：Neuropharmacology
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更新日期：2012-02-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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更新日期：2016-12-01 00:00:00
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更新日期：2008-05-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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更新日期：2012-04-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：2014-04-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：2006-03-01 00:00:00
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更新日期：2007-03-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2008.08.015
更新日期：2009-01-01 00:00:00
