Abstract：
:Long-term memory formation requires the coordinated regulation of gene expression. Until recently nucleosome remodeling, one of the major epigenetic mechanisms for controlling gene expression, had been largely unexplored in the field of neuroscience. Nucleosome remodeling is carried out by chromatin remodeling complexes (CRCs) that interact with DNA and histones to physically alter chromatin structure and ultimately regulate gene expression. Human exome sequencing and gene wide association studies have linked mutations in CRC subunits to intellectual disability disorders, autism spectrum disorder and schizophrenia. However, how mutations in CRC subunits were related to human cognitive disorders was unknown. There appears to be both developmental and adult specific roles for the neuron specific CRC nBAF (neuronal Brg1/hBrm Associated Factor). nBAF regulates gene expression required for dendritic arborization during development, and in the adult, contributes to long-term potentiation, a form of synaptic plasticity, and long-term memory. We propose that the nBAF complex is a novel epigenetic mechanism for regulating transcription required for long-lasting forms of synaptic plasticity and memory processes and that impaired nBAF function may result in human cognitive disorders.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Vogel-Ciernia A,Wood MAdoi
10.1016/j.neuropharm.2013.10.002subject
Has Abstractpub_date
2014-05-01 00:00:00pages
18-27eissn
0028-3908issn
1873-7064pii
S0028-3908(13)00475-9journal_volume
80pub_type
杂志文章,评审abstract：:Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the "therapeutic window" may be widened beyond the first few hour after stroke and an e...
journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1987-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2015.08.015
更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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更新日期：2018-07-15 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/s0028-3908(98)00135-x
更新日期：1998-10-01 00:00:00
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
