Phylogenetic conservation of the benzodiazepine binding sites: pharmacological evidence.

abstract：:Neurotrophins jointly exert various functions in the nervous system, including neuronal differentiation, survival, and regulation of synaptic plasticity. However, the functional interactions of neurotrophins or mechanisms through which neurotrophins regulate each other are still not clear. In the present study, brain-...

journal_title：Neuropharmacology

authors： Xiong H,Futamura T,Jourdi H,Zhou H,Takei N,Diverse-Pierluissi M,Plevy S,Nawa H

更新日期：2002-06-01 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion channels. It is vital for neuromuscular transmission and an important regulator of neurotransmission. A variety of toxic compounds derived from diverse species target this receptor and have been of elemental importance in basic a...

journal_title：Neuropharmacology

authors： Dutertre S,Nicke A,Tsetlin VI

更新日期：2017-12-01 00:00:00

abstract：:Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

journal_title：Neuropharmacology

authors： Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

更新日期：1991-07-01 00:00:00

abstract：:D-Tubocurarine is a potent competitive antagonist of two members of the ligand-gated ion channel family, the muscle-type nicotinic acetylcholine receptor (AChR) and serotonin type-3 receptor (5HT3R). We have used a series of analogs of D-tubocurarine to determine the effects of methylation, stereoisomerization and hal...

journal_title：Neuropharmacology

authors： Yan D,Pedersen SE,White MM

更新日期：1998-01-01 00:00:00

abstract：:Sodium (Na) channel blockers are known to possess antihyperalgesic properties. We have designed and synthesized a novel Na channel antagonist, alpha-hydroxyphenylamide, and determined its ability to inhibit both TTX-sensitive (TTX-s) and TTX-resistant (TTX-r) Na currents from small dorsal root ganglion (DRG) neurons. ...

journal_title：Neuropharmacology

authors： Ko SH,Jochnowitz N,Lenkowski PW,Batts TW,Davis GC,Martin WJ,Brown ML,Patel MK

更新日期：2006-06-01 00:00:00

abstract：:A subgroup of anticonvulsant and neuroleptic drugs acts through the potentiation of GABA pathways. The regulatory role of GABA in neuronal circuit formation is related to its depolarizing action that supports activity-dependent synaptogenesis. We hypothesized that elevated levels of GABA in the immature brain modify s...

journal_title：Neuropharmacology

authors： Melamed O,Levav-Rabkin T,Zukerman C,Clarke G,Cryan JF,Dinan TG,Grossman Y,Golan HM

更新日期：2014-04-01 00:00:00

abstract：:This work reports the effect of chemokine fractalkine/CX3CL1, an endogenous small peptide highly expressed in the central nervous system, on evoked synaptic responses investigated in mouse CA1 stratum radiatum using an electrophysiological approach. We report that in acute mouse hippocampal slices, superfusion of CX3C...

journal_title：Neuropharmacology

authors： Bertollini C,Ragozzino D,Gross C,Limatola C,Eusebi F

更新日期：2006-09-01 00:00:00

abstract：:Electrophysiological studies suggest that 5-HT autoreceptor desensitization may be responsible for the delayed clinical efficacy of some antidepressant drugs, such as selective 5-HT reuptake inhibitors (SSRI) and certain MAO inhibitors (MAOI). In the present study we have used in vivo microdialysis to test this hypoth...

journal_title：Neuropharmacology

authors： Hjorth S,Auerbach SB

更新日期：1994-03-01 00:00:00

abstract：:Although sigma 1 (σ(1)) receptors and mitogen-activated protein kinases (MAPKs) are known modulators of neuroprotection, a role for MAPK signaling pathways in σ receptor-mediated neuroprotection has not been investigated in detail.The present study aims to investigate the possible link between σ(1) receptors and MAPKs...

journal_title：Neuropharmacology

authors： Tan F,Guio-Aguilar PL,Downes C,Zhang M,O'Donovan L,Callaway JK,Crack PJ

更新日期：2010-11-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA, half-maximal inhibitory concentration, IC50 = 9.9 microM) and (-)-baclofen (IC50 = 4.5 microM) but not 10(-4) M muscimol, exerted a presynaptic inhibitory effect on cholinergic transmission in field-stimulated guinea-pig taenia coli preparations, in vitro. The antagonism by 10(-5) M (1S,...

journal_title：Neuropharmacology

authors： Rónai AZ,Kardos J,Simonyi M

更新日期：1987-11-01 00:00:00

abstract：:Nicotine improves endotoxic manifestations of hypotension and cardiac autonomic dysfunction in rats. Here, we test the hypothesis that brainstem antiinflammatory pathways of α7/α4β2 nicotinic acetylcholine receptors (nAChRs) modulate endotoxic cardiovascular derangements. Pharmacologic and molecular studies were perfo...

journal_title：Neuropharmacology

authors： Sallam MY,El-Gowilly SM,Fouda MA,Abd-Alhaseeb MM,El-Mas MM

更新日期：2019-10-01 00:00:00

abstract：:The effect of injection of inhibitors of GABA-transaminase into the nucleus tractus solitarius (NTS) on arterial pressure was examined in anesthetized rats. Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS, a response...

journal_title：Neuropharmacology

authors： Tsukamoto K,Sved AF

更新日期：1993-06-01 00:00:00

abstract：:Ketogenesis is a metabolic process wherein ketone bodies are produced from the breakdown of fatty acids. In humans, fatty acid catabolism results in the production of acetyl-CoA which can then be used to synthesize three ketone bodies: acetoacetate, acetone, and β-hydroxybutyrate. Ketogenesis occurs at a higher rate i...

journal_title：Neuropharmacology

authors： Pflanz NC,Daszkowski AW,James KA,Mihic SJ

更新日期：2019-04-01 00:00:00

abstract：:Opioids are thought to increase the excitability of hippocampal pyramidal cells by decreasing release of neurotransmitter from inhibitory interneurons. This study compared the actions of the opioid agonist normorphine, and the GABA receptor antagonist bicuculline, on the responses of CA1 pyramidal cells to afferent st...

journal_title：Neuropharmacology

authors： Swearengen E,Chavkin C

更新日期：1989-07-01 00:00:00

abstract：:The effects of various benzodiazepine receptor ligands on the GABA autoreceptor have been studied in slices of cerebral cortex of the rat. The GABAA receptor agonist muscimol inhibited the K+-stimulated release of [3H]GABA with a pIC25 of 7.65 +/- 0.11. This effect was antagonised by the GABAA receptor antagonist bicu...

journal_title：Neuropharmacology

authors： Ennis C,Minchin MC

更新日期：1988-10-01 00:00:00

abstract：:Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects resulting from concurrent administration of low doses of mu- and CB1-agonists may produce analgesia with fewer side effects. Synergism potentially results from interact...

journal_title：Neuropharmacology

authors： Seely KA,Brents LK,Franks LN,Rajasekaran M,Zimmerman SM,Fantegrossi WE,Prather PL

更新日期：2012-10-01 00:00:00

abstract：:The autoradiographic distribution of binding sites for [3H]AMPA, [3H]kainate, [3H]MK-801 and [3H]L-glutamate and the in situ hybridization of GluR-A, GluR-B, GluR-C and GluR-D in rat spinal cord sections were determined. All of the radioligands had similar localisations with the dorsal horn being the most intensely la...

journal_title：Neuropharmacology

authors： Henley JM,Jenkins R,Hunt SP

更新日期：1993-01-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a crucial signaling molecule involved in several physiological and pathological processes. Nonetheless, the role of this gasotransmitter in the pathogenesis and treatment of neuropathic pain is controversial. The aim of the present study was to investigate the pain relieving profile of a seri...

journal_title：Neuropharmacology

authors： Di Cesare Mannelli L,Lucarini E,Micheli L,Mosca I,Ambrosino P,Soldovieri MV,Martelli A,Testai L,Taglialatela M,Calderone V,Ghelardini C

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesized that chronic alcoh...

journal_title：Neuropharmacology

authors： Sharma R,Sahota P,Thakkar MM

更新日期：2020-12-01 00:00:00

abstract：:Of the ionotropic glutamatergic receptors, the NMDA receptor is clearly implicated in the acute and chronic effects of ethanol; however, the role of the AMPA receptor in mediating the effects of ethanol in vivo is as yet unclear. Using mice deficient in the AMPA receptor subunit GluR1 (GluR1-/- mice), we investigated ...

journal_title：Neuropharmacology

authors： Cowen MS,Schroff KC,Gass P,Sprengel R,Spanagel R

更新日期：2003-09-01 00:00:00

abstract：:It is estimated that up to 30% of epilepsy patients are poorly treated with available anti-epileptic drugs (AEDs). Thus, there is a medical need for new AEDs with novel mechanisms of action to serve as alternate or adjunct therapy for the treatment of drug-resistant or refractory epilepsy. One potential anti-epileptic...

journal_title：Neuropharmacology

authors： Wickenden AD

更新日期：2002-12-01 00:00:00

abstract：:Disruptions in synaptic plasticity in the dorsal striatum may contribute to the pathophysiology underlying Parkinson's disease. Here we report a novel, chemically-induced form of plasticity induced by application of the potassium channel blocker tetraethylammonium (TEA) in the dorsolateral striatum of the adult rat. T...

journal_title：Neuropharmacology

authors： Norman ED,Egli RE,Colbran RJ,Winder DG

更新日期：2005-02-01 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid (3-MATIDA) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a, mGlu2, mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist-induced depolarizations in mouse cortical w...

journal_title：Neuropharmacology

authors： Moroni F,Attucci S,Cozzi A,Meli E,Picca R,Scheideler MA,Pellicciari R,Noe C,Sarichelou I,Pellegrini-Giampietro DE

更新日期：2002-05-01 00:00:00

abstract：:NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular source driving the working memory deficits caused by NMDAr hypofunc...

journal_title：Neuropharmacology

authors： Sokolenko E,Nithianantharajah J,Jones NC

更新日期：2020-07-01 00:00:00

abstract：:The majority of existing research on the function of metabotropic glutamate (mGlu) receptor 1 focuses on G protein-mediated outcomes. However, similar to other G protein-coupled receptors (GPCR), it is becoming apparent that mGlu1 receptor signaling is multi-dimensional and does not always involve G protein activation...

journal_title：Neuropharmacology

authors： Hathaway HA,Pshenichkin S,Grajkowska E,Gelb T,Emery AC,Wolfe BB,Wroblewski JT

更新日期：2015-06-01 00:00:00

abstract：:Glibenclamide (GBC), a sulfonylurea receptor 1 blocker, emerges recently as a promising neuron protectant in various neurological disorders. This study aimed to determine whether GBC improves survival and neurological outcome of status epilepticus (SE). Male Sprague-Dawley rats successfully undergoing SE for 2.5 h (n ...

journal_title：Neuropharmacology

authors： Lin Z,Huang H,Gu Y,Huang K,Hu Y,Ji Z,Wu Y,Wang S,Yang T,Pan S

更新日期：2017-07-15 00:00:00

abstract：:PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A(-/-)) were characterized both behaviorally and neurochemically. PDE10A(-/-...

journal_title：Neuropharmacology

authors： Siuciak JA,McCarthy SA,Chapin DS,Fujiwara RA,James LC,Williams RD,Stock JL,McNeish JD,Strick CA,Menniti FS,Schmidt CJ

更新日期：2006-08-01 00:00:00

abstract：:The role of the sympathetic nervous system in the mediation of cardiovascular function, following administration of histamine centrally was investigated. Intracerebroventricular (i.c.v.) injections of histamine into the lateral ventricle of conscious rats caused a dose-dependent increase in blood pressure as well as a...

journal_title：Neuropharmacology

authors： Klein MC,Gertner SB

更新日期：1983-09-01 00:00:00

abstract：:Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, rapamycin remarkably ...

journal_title：Neuropharmacology

authors： Xu C,Wang X,Zhu Y,Dong X,Liu C,Zhang H,Liu L,Huang S,Chen L

更新日期：2016-06-01 00:00:00