Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist.

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:The in vitro and in vivo properties of L-655,708, a compound with higher affinity for GABA(A) receptors containing an alpha5 compared to an alpha1, alpha2 or alpha3 subunit have been examined further. This compound has weak partial inverse agonist efficacy at each of the four subtypes but, and consistent with the bind...

journal_title：Neuropharmacology

authors： Atack JR,Bayley PJ,Seabrook GR,Wafford KA,McKernan RM,Dawson GR

更新日期：2006-11-01 00:00:00

abstract：:Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be particularly susceptible to cravings and other components of the disease. While many brain regions are involved in AUD etiology, proper prefrontal cortex (PFC) function is particularly important for top-down craving management and the m...

journal_title：Neuropharmacology

authors： Joffe ME,Winder DG,Conn PJ

更新日期：2020-11-01 00:00:00

abstract：:In view of the involvement of noradrenaline (NA) in the regulation of adrenocortical secretion, its role in the rise of plasma corticosterone following neural stimuli was evaluated in rats. The injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) into the ventral noradrenergic bundle in the brain stem,...

journal_title：Neuropharmacology

authors： Feldman S,Conforti N,Melamed E

更新日期：1988-02-01 00:00:00

abstract：:The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals were treated with GBP or saline from P36 to P75 and spontaneou...

journal_title：Neuropharmacology

authors： Cilio MR,Bolanos AR,Liu Z,Schmid R,Yang Y,Stafstrom CE,Mikati MA,Holmes GL

更新日期：2001-01-01 00:00:00

abstract：:The bed nucleus of the stria terminalis was first described nearly a century ago and has since emerged as a region central to motivated behavior and affective states. The last several decades have firmly established a role for the BNST in drug-associated behavior and implicated this region in addiction-related process...

journal_title：Neuropharmacology

authors： Vranjkovic O,Pina M,Kash TL,Winder DG

更新日期：2017-08-01 00:00:00

abstract：:Nitric oxide synthase (NOS) enzyme activity was determined in a comprehensive selection of regions of the rat brain. The effects of lateral ventricular administration of N omega-nitro-L-arginine (L-NA, 30 micrograms) and its methyl ester (L-NAME, 3-100 micrograms) on NOS activity were examined in the ipsilateral and c...

journal_title：Neuropharmacology

authors： Salter M,Duffy C,Garthwaite J,Strijbos PJ

更新日期：1995-06-01 00:00:00

abstract：:A new in vivo pharmacological method for the quantitative evaluation of alpha 1-adrenoceptor agonists and antagonists has been developed. It consists of recording the myoclonic twitch activity (MTA) of the suprahyoideal muscle of rats anesthetized with urethane. In these animals, the isomers of amphetamine elicited my...

journal_title：Neuropharmacology

authors： Menon MK,Kodama CK,Kling AS,Fitten J

更新日期：1986-05-01 00:00:00

abstract：:Rats were pretreated twice daily for six consecutive days with either saline or 1.0, 5.0, or 10.0 mg/kg (+)-amphetamine. On the following day, single-unit recording techniques were used to identify serotonin-containing neurons in the dorsal raphe nucleus (DRN). Pretreatment with amphetamine did not alter the mean spon...

journal_title：Neuropharmacology

authors： Heidenreich BA,Basse-Tomusk AE,Rebec GV

更新日期：1987-07-01 00:00:00

abstract：:The sleeping time induced by thiopentone in rats was markedly prolonged by the (-)-isomer of propranolol while the (+)-isomer was virtually without effect. Since the two isomers are equipotent in their membrane-stabilizing effects but the (-)-isomer is about seven to ten times more potent than the (+)-isomer in beta-b...

journal_title：Neuropharmacology

authors： Mason ST,Angel A

更新日期：1983-09-01 00:00:00

abstract：:The Mouse Defense Test Battery (MDTB) has been designed to investigate defensive responses of Swiss-Webster mice confronted with a natural predator, a rat. These behaviors include flight, avoidance, defensive threat/attack responses, and risk assessment activities. Previous studies with the MDTB have suggested that th...

journal_title：Neuropharmacology

authors： Griebel G,Blanchard DC,Jung A,Lee JC,Masuda CK,Blanchard RJ

更新日期：1995-12-01 00:00:00

abstract：:Methamphetamine is a neurotoxic drug of abuse known to cause cell death both in vitro and in vivo. Nevertheless, the molecular and cellular mechanisms involved in this process remain to be clarified. Herein, we show that methamphetamine-induced apoptosis is associated with early (2 h) overexpression of bax, decreases ...

journal_title：Neuropharmacology

authors： Deng X,Cai NS,McCoy MT,Chen W,Trush MA,Cadet JL

更新日期：2002-05-01 00:00:00

abstract：:In a cell line (C2D7) stably expressing the human N-type calcium channel encoded by the subunits alpha1B-a, beta1b, alpha2bdelta, we have analysed the Ca2+ currents produced by a range of action potential-like voltage protocols (APVPs). Such protocols consistently produced robust inward currents that could be eliminat...

journal_title：Neuropharmacology

authors： McNaughton NC,Bleakman D,Randall AD

更新日期：1998-01-01 00:00:00

abstract：:A history of intermittent exposures to drugs of abuse can cause long-term changes in acute behavioural responses to a subsequent drug exposure. In drug-naive rats, morphine can elicit intermittent cataleptic postures followed by sustained increases in locomotor activity. Chronic intermittent morphine treatment can red...

journal_title：Neuropharmacology

authors： Hamlin AS,McNally GP,Westbrook RF,Osborne PB

更新日期：2009-03-01 00:00:00

abstract：:Trace amines are biological compounds that are still awaiting identification of their role in neuronal function. Using intracellular electrophysiological recordings, we investigated the depressant action of two trace amines (beta-phenylethylamine and tyramine) on the firing activity of dopaminergic neurons of the subs...

journal_title：Neuropharmacology

authors： Geracitano R,Federici M,Prisco S,Bernardi G,Mercuri NB

更新日期：2004-05-01 00:00:00

abstract：:The increased pro-inflammatory cytokine production was previously observed in Alzheimer's disease (AD). We sought to explore whether acetylcholinesterase inhibitor (AChEI) therapy ameliorates clinical symptoms in AD through down-regulation of inflammation. Expression and release of monocyte chemotactic protein-1 (MCP-...

journal_title：Neuropharmacology

authors： Reale M,Iarlori C,Gambi F,Feliciani C,Isabella L,Gambi D

更新日期：2006-04-01 00:00:00

abstract：:Hippocampal damage produces spatial memory impairment and hyperactivity in animals, while reductions in hippocampal size have been associated with memory deficits in humans. There are no known treatments for the behavioral changes specifically related to reduced hippocampal size. The purpose of this study was to deter...

journal_title：Neuropharmacology

authors： Bardgett ME,Baum KT,O'Connell SM,Lee NM,Hon JC

更新日期：2006-12-01 00:00:00

abstract：:Human studies suggest that a variety of prenatal stressors are related to high risk for cognitive and behavioral abnormalities associated with psychiatric illness (Markham and Koenig, 2011). Recently, a downregulation in the expression of GABAergic genes (i.e., glutamic acid decarboxylase 67 and reelin) associated wit...

journal_title：Neuropharmacology

authors： Matrisciano F,Tueting P,Dalal I,Kadriu B,Grayson DR,Davis JM,Nicoletti F,Guidotti A

更新日期：2013-05-01 00:00:00

abstract：:The purpose of this experiment was to study the electrophysiological interactions between phencyclidine and NMDA receptor agonists. Drugs were directly applied to cerebellar Purkinje neurons of urethane-anesthetized rats, through a multibarreled pipette by pressure ejection. Neuronal activity was recorded extracellula...

journal_title：Neuropharmacology

authors： Wang Y,Lee HK

更新日期：1991-09-01 00:00:00

abstract：:An earlier finding that three systems were responsible for the uptake of gamma-aminobutyric acid by synaptosomes was corroborated. In addition, the existence of three uptake systems for RS-nipecotic acid and beta-alanine was demonstrated. We have called these systems high affinity, medium affinity and low affinity upt...

journal_title：Neuropharmacology

authors： Sidhu HS,Wood JD

更新日期：1986-05-01 00:00:00

abstract：:A functional balance between excitatory and inhibitory control over dopamine (DA)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin(2C) receptor (5-HT(2C)R) located within the ventral tegmental area and the nucleus accumbens (NAc). The 5-HT(2C)R located in the medial prefrontal cor...

journal_title：Neuropharmacology

authors： Leggio GM,Cathala A,Moison D,Cunningham KA,Piazza PV,Spampinato U

更新日期：2009-02-01 00:00:00

abstract：:To study the effects of maternal alcohol ingestion on brain adenylate cyclase in offspring, rats were given ethanol in the drinking water before, during and after gestation. Fifteen-day-old pups from alcoholic mothers had reduced body and wet brain weight and protein content with normal concentrations of DNA and RNA i...

journal_title：Neuropharmacology

authors： Salinas M,Fernández T

更新日期：1983-11-01 00:00:00

abstract：:Neurones isolated from the CA1 region of rat hippocampal slices by the "vibrodissociation" method were voltage-clamped in the whole-cell configuration. The currents through N-methyl-D-aspartate (NMDA) channels were recorded in response to the rapid application (solution exchange time <30 msec) of 100 microM aspartate ...

journal_title：Neuropharmacology

authors： Sobolevsky A,Koshelev S,Khodorov BI

更新日期：1997-03-01 00:00:00

abstract：:Clinically, it is suggested that chronic pain might induce mood disorders like depression and anxiety. Based on this antidepressant drugs have emerged as a new therapy for pain. In this study, the effect of acute and subchronic treatments with 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) on behavioral cha...

journal_title：Neuropharmacology

authors： Gai BM,Bortolatto CF,Brüning CA,Zborowski VA,Stein AL,Zeni G,Nogueira CW

更新日期：2014-04-01 00:00:00

abstract：:A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

journal_title：Neuropharmacology

authors： Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

更新日期：2019-03-01 00:00:00

abstract：:The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats. Initially, tonic-clonic seizures were induced in 90% of the animals. Of those animals responding with tonic-clonic seizures, 42% had hindlimb extension (extensors); the remainder showed on...

journal_title：Neuropharmacology

authors： Peterson SL,Trzeciakowski JP,St Mary JS

更新日期：1985-10-01 00:00:00

abstract：:Although sigma 1 (σ(1)) receptors and mitogen-activated protein kinases (MAPKs) are known modulators of neuroprotection, a role for MAPK signaling pathways in σ receptor-mediated neuroprotection has not been investigated in detail.The present study aims to investigate the possible link between σ(1) receptors and MAPKs...

journal_title：Neuropharmacology

authors： Tan F,Guio-Aguilar PL,Downes C,Zhang M,O'Donovan L,Callaway JK,Crack PJ

更新日期：2010-11-01 00:00:00

abstract：:ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the pathophysiology of various neurological diseases such as epilepsy, Alzheimer's disease and stroke. GABA transporters (GATs) facilitate the termi...

journal_title：Neuropharmacology

authors： Kickinger S,Hellsberg E,Frølund B,Schousboe A,Ecker GF,Wellendorph P

更新日期：2019-12-15 00:00:00

abstract：:The homotrimeric P2X3 subtype, one of the seven members of the ATP-gated P2X receptor family, plays a role in sensory neurotransmission, including nociception. To overcome the bias resulting from fast desensitization of the P2X3 receptor in dose-response analyses, a non-desensitizing P2X2-X3 receptor chimera has been ...

journal_title：Neuropharmacology

authors： Hausmann R,Bahrenberg G,Kuhlmann D,Schumacher M,Braam U,Bieler D,Schlusche I,Schmalzing G

更新日期：2014-04-01 00:00:00

abstract：:GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GABA binding site affects this transition. However, description of flippi...

journal_title：Neuropharmacology

authors： Kisiel M,Jatczak M,Brodzki M,Mozrzymas JW

更新日期：2018-03-15 00:00:00