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Electrophysiological interactions between NMDA and phencyclidine/sigma receptor agonists and antagonists in Purkinje neurons in the cerebellum of the rat.

Abstract：

:The purpose of this experiment was to study the electrophysiological interactions between phencyclidine and NMDA receptor agonists. Drugs were directly applied to cerebellar Purkinje neurons of urethane-anesthetized rats, through a multibarreled pipette by pressure ejection. Neuronal activity was recorded extracellularly. In almost all the cells encountered, NMDA-induced responses were stereospecifically blocked by phencyclidine/sigma agonists, such as: (+)PCMP[1-(1-phenyl cyclohexyl)-3-methyl piperidine] or dexoxadrol. However, quisqualate-mediated excitation was also antagonized by (+)PCMP, although quisqualate had a lower sensitivity to (+)PCMP than NMDA did. It was previously found that metaphit irreversibly blocked phencyclidine-induced responses in the cerebellum. It was found that metaphit attenuated phencyclidine-induced antagonism of NMDA responses. In conclusion, these findings suggested that phencyclidine/sigma agonists antagonized effects of NMDA and quisqualate, whereas the presence of an intact phencyclidine/sigma receptor was not essential for the NMDA-mediated response in the cerebellum.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Wang Y,Lee HK

doi

10.1016/0028-3908(91)90112-o

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

985-94

issue

9

eissn

0028-3908

issn

1873-7064

journal_volume

30

pub_type

杂志文章

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