Abstract:
:Intraventricular administration of substance P (SP), of the heptapeptide SP5-11 and of DiMe-C7, a stable analogue of SP5-11 induced locomotor activation in rats and in mice. The activating effect of substance P was longer-lasting in mice than in rats, whereas the effect of the two heptapeptides appears to be more marked in rats than in mice. The locomotor stimulation induced by substance P was blocked by naloxone and by the specific antiserum against met-enkephalin, suggesting that this effect is possibly mediated by released of this opioid peptide. Since the activating effect of substance P was also blocked by haloperidol, it is proposed that substance P produces behavioural excitation by activating dopaminergic systems, implicated in the control of locomotion, through interposed enkephalinergic neurones.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Naranjo JR,Del Rio Jdoi
10.1016/0028-3908(84)90234-xsubject
Has Abstractpub_date
1984-10-01 00:00:00pages
1167-71issue
10eissn
0028-3908issn
1873-7064journal_volume
23pub_type
杂志文章abstract::The consumption of saline and water in a two-bottle test of salt-preference was measured after the administration of sulpiride, a dopamine receptor antagonist and of naloxone, an antagonist at opiate receptors. The two drugs were injected alone, or in combination. Three concentrations of saline (0.125, 0.6 and 1.7% Na...
journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
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更新日期:2004-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2016.09.010
更新日期:2016-12-01 00:00:00
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journal_title:Neuropharmacology
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