Post-ischemic administration [correction of administeration] but not pre-ischemic administration [correction of administeration] of NG-nitro-L-arginine prevents spatial memory impairments and apoptosis by an inhibition of a delayed increase in NOx- in the

abstract：:The present studies examined the relationship between protein kinase C (PKC) and L-type voltage-dependent calcium channels in modulating the release of neurotransmitter from K(+)-depolarized rat spinal cord synaptosomes. Activators of PKC, such as phorbol 12-myristate 13-acetate (PMA), mezerein and oleoyl acetylglycer...

journal_title：Neuropharmacology

authors： Gandhi VC,Jones DJ

更新日期：1992-11-01 00:00:00

abstract：:A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 microns) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected ...

journal_title：Neuropharmacology

authors： Welzl H,Kuhn G,Huston JP

更新日期：1989-10-01 00:00:00

abstract：:Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors at synapses within the nucleus accumbens. Exposure to cocaine can lead to protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and this phosphorylation event ...

journal_title：Neuropharmacology

authors： Briand LA,Deutschmann AU,Ellis AS,Fosnocht AQ

更新日期：2016-12-01 00:00:00

abstract：:The gender difference in behavioral and hormonal response to stress is well known, but the underlying mechanism remains elusive. Arginine-vasopressin (AVP) and corticotrophin-releasing hormone (CRH) are two major regulatory peptides in the brain involved in stress regulation. Their response to stress has been shown to...

journal_title：Neuropharmacology

authors： Huang Q,Zhu H,Fischer DF,Zhou JN

更新日期：2008-06-01 00:00:00

abstract：:Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of side effects has hampered clinical progression. As separate inhibitio...

journal_title：Neuropharmacology

authors： Paes D,Xie K,Wheeler DG,Zook D,Prickaerts J,Peters M

更新日期：2021-02-15 00:00:00

abstract：:The nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate hydrochloride (MNPC) is a potent inhibitor of uptake of GABA in vitro and should be able to penetrate into the brain much more readily than the parent compound nipecotic acid. A study of the effects of MNPC on convulsions induced by chemicals which ...

journal_title：Neuropharmacology

authors： Hinko CN,Seibert K,Crider AM

更新日期：1984-09-01 00:00:00

abstract：:Neonatal maternal deprivation permanently modifies the hypothalamo-pituitary-adrenal (HPA) axis and other neurobiological and behavioural parameters in rats. The HPA axis plays a central role in the control of feeding, and participates in the anorexigenic action of dexfenfluramine and restraint stress, and in the orex...

journal_title：Neuropharmacology

authors： Penke Z,Fernette B,Nyakas C,Max JP,Burlet A

更新日期：2002-03-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:The effect of trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-benzene-acetamide methane sulfonate (U-50,488H), a kappa-opiate agonist-induced tolerance and abstinence on 5-HT1A receptors was determined in regions of the brain and spinal cord of the rat. The administration of U-50,488H (25 mg/kg, i....

journal_title：Neuropharmacology

authors： Reddy VP,Bhargava HN

更新日期：1992-12-01 00:00:00

abstract：:Lesions of the ventral hippocampus (VH) in neonatal rats result in post-pubertal alterations in a number of cognitive, social and motor behaviors that bear some analogy to schizophrenia. Increased sensitivity to stress and psychostimulants and prefrontal functional changes in the lesioned animals suggest an involvemen...

journal_title：Neuropharmacology

authors： Bhardwaj SK,Quirion R,Srivastava LK

更新日期：2004-01-01 00:00:00

abstract：:Bilateral injection of gamma-aminobutyric acid (GABA, 10-300 micrograms) into the substantia nigra (pars reticulata) of rats produced stereotyped sniffing and had an analgesic-like effect on the hot-plate but not on the tail-flick test. These effects of GABA (30 micrograms) were suppressed by simultaneous administrati...

journal_title：Neuropharmacology

authors： Baumeister AA,Hawkins MF,Anderson-Moore LL,Anticich TG,Higgins TD,Griffin P

更新日期：1988-08-01 00:00:00

abstract：:Anti-emetic drugs such as the tachykinin NK(1) receptor antagonists are useful to control emesis induced by diverse challenges. Evidence suggests pungent capsaicin-like TRPV1 activators also have broad inhibitory anti-emetic activity. However, pungent compounds are associated with undesirable effects including adverse...

journal_title：Neuropharmacology

authors： Chu KM,Ngan MP,Wai MK,Yeung CK,Andrews PL,Percie du Sert N,Rudd JA

更新日期：2010-02-01 00:00:00

abstract：:The activity of tianeptine (2.5 and 5.0 mg/kg twice daily, i.p.) and of sertraline (5.0 mg/kg, twice daily, i.p.) were assessed in three animal models of depression. In the Behavioural Despair Test, acute treatment with sertraline or tianeptine (5.0 mg/kg) significantly reduced the immobility time. In the olfactory bu...

journal_title：Neuropharmacology

authors： Kelly JP,Leonard BE

更新日期：1994-08-01 00:00:00

abstract：:Prenatal cocaine exposure has been reported to result in abnormal neurobehavioral development, both in animals and humans. In this study, outbred CD-1 mice were exposed in utero to cocaine hydrochloride administered daily as i.p. injections to dams from day 10 of gestation to day 16, at the dose 0, 5 or 50 mg/kg. Coca...

journal_title：Neuropharmacology

authors： Laviola G,Fiore M,Loggi G,Alleva E

更新日期：1994-06-01 00:00:00

abstract：:Although depression is a severe and life-threatening psychiatric illness, its pathogenesis still is essentially unknown. Recent studies highlighted the influence of environmental stress factors on an individual's genetic predisposition to develop mood disorders. In the present study, we employed a well-validated stres...

journal_title：Neuropharmacology

authors： Mallei A,Giambelli R,Gass P,Racagni G,Mathé AA,Vollmayr B,Popoli M

更新日期：2011-06-01 00:00:00

abstract：:We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid (3-MATIDA) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a, mGlu2, mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist-induced depolarizations in mouse cortical w...

journal_title：Neuropharmacology

authors： Moroni F,Attucci S,Cozzi A,Meli E,Picca R,Scheideler MA,Pellicciari R,Noe C,Sarichelou I,Pellegrini-Giampietro DE

更新日期：2002-05-01 00:00:00

abstract：:We investigated the effects of salvinorin A on the basal and the 12 mM K(+)-evoked release of preloaded [(3)H]noradenaline ([(3)H]NA) and [(3)H]serotonin ([(3)H]5-HT) from mouse hippocampal nerve terminals (synaptosomes), as well as on the basal and 12mM K(+)-evoked release of preloaded [(3)H]dopamine ([(3)H]DA) from ...

journal_title：Neuropharmacology

authors： Grilli M,Neri E,Zappettini S,Massa F,Bisio A,Romussi G,Marchi M,Pittaluga A

更新日期：2009-10-01 00:00:00

abstract：:The effects of the anxiolytic benzodiazepine flurazepam and the anxiogenic beta-carboline N-methyl-beta-carboline-3-carboxylate (FG 7142) were measured in unanaesthetised rats. Changes in motor activity, using a Doppler-shift microwave device, and in the extracellular concentration of ascorbate in the striatum and nuc...

journal_title：Neuropharmacology

authors： Brose N,O'Neill RD,Boutelle MG,Fillenz M

更新日期：1989-05-01 00:00:00

abstract：:Changes in brain reward and control systems of frontal cortical areas including the orbitofrontal cortex (OFC) are associated with alcohol use disorders (AUD). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors have been used to treat a number of neuropsychiatric diseases, inclu...

journal_title：Neuropharmacology

authors： Nimitvilai S,Lopez MF,Woodward JJ

更新日期：2018-07-15 00:00:00

abstract：:In this study, we investigated whether resveratrol could protect against ischemic injury by improving brain energy metabolism and alleviating oxidative stress. Male rats were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol treatment (resveratrol-treated group, 30 m...

journal_title：Neuropharmacology

authors： Li H,Yan Z,Zhu J,Yang J,He J

更新日期：2011-02-01 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function as excitatory glycine receptors that respond to agonist application only with a very low efficacy. Binding of glycine to the high-affinity GluN3 subunits triggers channel opening, whereas glycine binding to the low-affi...

journal_title：Neuropharmacology

authors： Mesic I,Madry C,Geider K,Bernhard M,Betz H,Laube B

更新日期：2016-06-01 00:00:00

abstract：:Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, rapamycin remarkably ...

journal_title：Neuropharmacology

authors： Xu C,Wang X,Zhu Y,Dong X,Liu C,Zhang H,Liu L,Huang S,Chen L

更新日期：2016-06-01 00:00:00

abstract：:Reserpine (5 mg/kg s.c.) was given to rats kept under a reversed light-dark cycle and 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) determined in frontal cortex tissue and dialysate at various times after drug treatment. The decline and return of spontaneous locomotor activity was also measured. ...

journal_title：Neuropharmacology

authors： Heslop KE,Curzon G

更新日期：1994-03-01 00:00:00

abstract：:N-Ethyl-maleimide (NEM, 2.5 x 10(-5) M) inhibited the compound action potential of the phrenic nerve and increased the spontaneous release of transmitter from the nerve terminals, recorded as miniature endplate potentials. The first effect was the cause of a blockade of the phrenic nerve diaphragm preparation, during ...

journal_title：Neuropharmacology

authors： Røed A

更新日期：1989-08-01 00:00:00

abstract：:The loss of synapses and a corresponding reduction in synaptic proteins are histopathological features of Alzheimer's disease that correlate strongly with dementia. Here we report that stable Aβ oligomers secreted by 7PA2 cells reduced the amount of synaptophysin, a protein used as an indicator of synapse density, in ...

journal_title：Neuropharmacology

authors： Bate C,Williams A

更新日期：2011-12-01 00:00:00

abstract：:There is evidence that adenosine is an endogenous neuroprotective substance in the gerbil and that propentofylline, a novel xanthine derivative that acts as a transport inhibitor, exerts part of its neuroprotective activity in this species by enhancing adenosine actions. Using autoradiography we have examined the dist...

journal_title：Neuropharmacology

authors： Parkinson FE,Johansson B,Lindström K,Fredholm BB

更新日期：1996-01-01 00:00:00

abstract：:Venlafaxine, a novel 2-phenyl-2-(1-hydroxycycloalkyl) ethylamine, is a potent inhibitor of 5-hydroxytryptamine and noradrenaline reuptake and exhibits a profile of activity in pre-clinical in vitro biochemical studies predictive of antidepressant activity. The studies described here examined the effects of acute and c...

journal_title：Neuropharmacology

authors： Mitchell PJ,Fletcher A

更新日期：1993-10-01 00:00:00

abstract：:The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...

journal_title：Neuropharmacology

authors： Pallotta M,Segieth J,Sadideen F,Whitton PS

更新日期：2001-09-01 00:00:00

abstract：:γ-Aminobutyric acid B (GABAB) receptors and their ligands are postulated as potential therapeutic targets for the treatment of several brain disorders, including drug dependence. Over the past fifteen years positive allosteric modulators (PAMs) have emerged that enhance the effects of GABA at GABAB receptors and which...

journal_title：Neuropharmacology

authors： Filip M,Frankowska M,Sadakierska-Chudy A,Suder A,Szumiec L,Mierzejewski P,Bienkowski P,Przegaliński E,Cryan JF

更新日期：2015-01-01 00:00:00

abstract：:Caretakers and clinicians alike have long recognized that individuals with autism spectrum disorder (ASD) can have altered sensory processing, which can contribute to its core symptoms. However, the pathobiology of sensory alterations in ASD is poorly understood. Here we examined nocifensive behavior in ASD mouse mode...

journal_title：Neuropharmacology

authors： Wang L,Almeida LE,Nettleton M,Khaibullina A,Albani S,Kamimura S,Nouraie M,Quezado ZM

更新日期：2016-12-01 00:00:00