Protein kinase C modulates the release of [3H]5-hydroxytryptamine in the spinal cord of the rat: the role of L-type voltage-dependent calcium channels.

abstract：:Long-term consumption of ethanol affects cortical areas that are important for learning and memory, cognition, and decision-making. Deficits in cortical function may contribute to alcohol-abuse disorders by impeding an individual's ability to control drinking. Previous studies from this laboratory show that acute etha...

journal_title：Neuropharmacology

authors： den Hartog C,Zamudio-Bulcock P,Nimitvilai S,Gilstrap M,Eaton B,Fedarovich H,Motts A,Woodward JJ

更新日期：2016-08-01 00:00:00

abstract：:Depotentiation, the reversal of long-term potentiation (LTP), can be induced by activation of metabotropic glutamate receptors (mGluRs) or NMDA receptors (NMDARs). Although NMDAR-dependent depotentiation is due to a protein phosphatase-dependent erasure of LTP, the notion that mGluR-dependent depotentiation also invol...

journal_title：Neuropharmacology

authors： Delgado JY,O'dell TJ

更新日期：2005-06-01 00:00:00

abstract：:An infusion of dopamine for 13 days into the nucleus accumbens of rat caused biphasic peaks of hyperactivity responding during infusion and an enhanced locomotor responsiveness to the dopamine agonist (-)N-n-propylnorapomorphine [(-)NPA] after the infusion when rats where initially preselected as low activity responde...

journal_title：Neuropharmacology

authors： Costall B,Domeney AM,Naylor RJ

更新日期：1985-03-01 00:00:00

abstract：:The dopaminergic receptors of planaria have been studied with pharmacological and biochemical criteria. Dopamine D1 selective agonists (CY 208243 (10 micrograms/ml) and SKF 38393 (10 micrograms/ml] induced in planaria typical screw-like hyperkinesias, that were inhibited by a D1 antagonist (SCH 23390 (10 micrograms/ml...

journal_title：Neuropharmacology

authors： Venturini G,Stocchi F,Margotta V,Ruggieri S,Bravi D,Bellantuono P,Palladini G

更新日期：1989-12-01 00:00:00

abstract：:Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation ...

journal_title：Neuropharmacology

authors： Yanai J,Rogel-Fuchs Y,Pick CG,Slotkin T,Seidler FJ,Zahalka EA,Newman ME

更新日期：1993-02-01 00:00:00

abstract：:The role of dopamine in spinal motor transmission was investigated using spinal reflexes in acutely spinalized rats. Intravenous administration of a relatively high dose of the dopamine receptor agonist apomorphine-HCl (3 mg/kg) or the D2 receptor agonist bromocriptine mesylate (1 mg/kg) reduced the amplitude of the m...

journal_title：Neuropharmacology

authors： Kamijo N,Nagao T,Ono H

更新日期：1993-08-01 00:00:00

abstract：:The function of 5-HT1A autoreceptors was examined by measuring the ability of the 5-HT1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, att...

journal_title：Neuropharmacology

authors： Kreiss DS,Lucki I

更新日期：1992-10-01 00:00:00

abstract：:The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse. Oxytocin and the dipeptides attenuated the development of acute and chroni...

journal_title：Neuropharmacology

authors： Kovács GL,Horváth Z,Sarnyai Z,Faludi M,Telegdy G

更新日期：1985-05-01 00:00:00

abstract：:Though amyloid precursor protein (APP) can potentially be cleaved to generate the pathological amyloid β peptide (Aβ), APP itself plays an important role in regulating neuronal activity. APP deficiency causes functional impairment in cholinergic synaptic transmission and cognitive performance. However, the mechanisms ...

journal_title：Neuropharmacology

authors： Cai ZL,Zhang JJ,Chen M,Wang JZ,Xiao P,Yang L,Long C

更新日期：2016-11-01 00:00:00

abstract：:Rodents emit ultrasonic vocalizations (USVs) to communicate the presence of positive or negative emotional states and to coordinate social interactions. On this basis, USVs are increasingly being used as a behavioral readout in rodent studies of affect, motivation and social behavior. Notably, several investigations h...

journal_title：Neuropharmacology

authors： Simola N,Granon S

更新日期：2019-11-15 00:00:00

abstract：:Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression of various cancers. However, the molecular mechanism and pathological role of bradykinin recept...

journal_title：Neuropharmacology

authors： Liu YS,Hsu JW,Lin HY,Lai SW,Huang BR,Tsai CF,Lu DY

更新日期：2019-01-01 00:00:00

abstract：:Compelling evidence has shown that in hippocampus tumor necrosis factor alpha (TNF-alpha) at pathological concentration inhibits long-term potentiation (LTP), a synaptic model of learning and memory. In the present work we investigated the role of TNF-alpha in LTP of C-fiber evoked field potentials in spinal dorsal ho...

journal_title：Neuropharmacology

authors： Liu YL,Zhou LJ,Hu NW,Xu JT,Wu CY,Zhang T,Li YY,Liu XG

更新日期：2007-03-01 00:00:00

abstract：:Similar to patients with ventromedial prefrontal cortex (VMPC) lesions, substance abusers show altered decision-making, characterized by a tendency to choose the immediate reward, at the expense of negative future consequences. The somatic marker model proposes that decision-making depends on neural substrates that re...

journal_title：Neuropharmacology

authors： Verdejo-García A,Bechara A

更新日期：2009-01-01 00:00:00

abstract：:The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception. To this purpo...

journal_title：Neuropharmacology

authors： Casarrubea M,Sorbera F,Santangelo A,Crescimanno G

更新日期：2012-08-01 00:00:00

abstract：:Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...

journal_title：Neuropharmacology

authors： Lamont JS,Kula NS,Baldessarini RJ

更新日期：1987-06-01 00:00:00

abstract：:Sensory gating can be assessed in rodents and humans using an auditory conditioning (C)-test (T) paradigm, with schizophrenic patients exhibiting a loss of gating. Dysregulation of the endocannabinoid system has been proposed to be involved in the pathogenesis of schizophrenia. We studied auditory gating and the effec...

journal_title：Neuropharmacology

authors： Dissanayake DW,Zachariou M,Marsden CA,Mason R

更新日期：2008-12-01 00:00:00

abstract：:4-Aminopyridine (4-AP) stimulated the release of [3H]dopamine from striatal synaptosomes in the rat. At a concentration of 200 microM, 4-aminopyridine increased the spontaneous efflux of dopamine by 170%. The effect of 4-aminopyridine was calcium-dependent, being abolished when calcium was omitted from the incubation ...

journal_title：Neuropharmacology

authors： Arzate ME,Morán J,Pasantes-Morales H

更新日期：1986-07-01 00:00:00

abstract：:Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, rapamycin remarkably ...

journal_title：Neuropharmacology

authors： Xu C,Wang X,Zhu Y,Dong X,Liu C,Zhang H,Liu L,Huang S,Chen L

更新日期：2016-06-01 00:00:00

abstract：:We investigated block of voltage-dependent Ca channels in freshly dissociated rat central and peripheral neurons by the synthetic peptide omega-Aga-IVA. Synthetic omega-Aga-IVA blocked approximately 90% of the high-threshold Ca current in cerebellar Purkinje neurons with an estimated Kd of approximately 1.5 nM, slight...

journal_title：Neuropharmacology

authors： Mintz IM,Bean BP

更新日期：1993-11-01 00:00:00

abstract：:The guinea-pig substantia nigra receives a 5-hydroxytryptaminergic (5-HT ergic) projection from the dorsal raphé nucleus. In this study we have attempted to identify the 5-HT receptor subtype mediating release of acetylcholinesterase (AChE) from nigral neurones, measured by assay of perfusate obtained via chronically ...

journal_title：Neuropharmacology

authors： Dickie BG,Greenfield SA

更新日期：1995-09-01 00:00:00

abstract：:The identification and characterization of amyloid-beta (Abeta) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD. In the last decade, research in this area has focused on developing a better understanding of the principles that go...

journal_title：Neuropharmacology

authors： Tarawneh R,Holtzman DM

更新日期：2010-09-01 00:00:00

abstract：:Parkinson's disease (PD) shows a complex etiology, where both genetic and environmental factors contribute to initiation and advance of pathology. Mitochondrial dysfunction and mutation of genes implicated in mitochondria quality control are recognized contributors to etiopathology and progression of PD. Here we repor...

journal_title：Neuropharmacology

authors： Moisoi N,Fedele V,Edwards J,Martins LM

更新日期：2014-02-01 00:00:00

abstract：:Thiamethoxam (TMX) is a second-generation neonicotinoid which is known to induce toxic effects on insects and mammalians. Recently, it has been proposed that TMX is a poor agonist of insect nicotinic acetylcholine receptors (nAChRs) on isolated cell bodies. Here, we have studied its effect on synaptic transmission. Ou...

journal_title：Neuropharmacology

authors： Thany SH

更新日期：2011-03-01 00:00:00

abstract：:Research on the nicotinic cholinergic system function in the brain was previously mainly derived from animal studies, yet, research in humans is growing. Up to date, findings allow significant advances on the understanding of nicotinic cholinergic effects on human cognition, emotion and behavior using a range of funct...

journal_title：Neuropharmacology

authors： Nees F

更新日期：2015-09-01 00:00:00

abstract：:The involvement of metabotropic glutamate receptor group II (mGluRII) in the induction of long-term depression (LTD) was investigated in the medial perforant path of the rat dentate gyrus, a region with a very high density of mGluRII. Perfusion of either of two potent mGluRII agonists, (2S,1R,2R,3R)-2-(2S, 1'R, 2'R, 3...

journal_title：Neuropharmacology

authors： Huang L,Killbride J,Rowan MJ,Anwyl R

更新日期：1999-01-01 00:00:00

abstract：:Excessive glutamate-mediated synaptic transmission and secondary excitotoxicity have been proposed as key determinants of neurodegeneration in many neurological diseases. Soluble mediators of inflammation have recently gained attention owing to their ability to enhance glutamate transmission and affect synaptic sensit...

journal_title：Neuropharmacology

authors： Rossi S,Motta C,Musella A,Centonze D

更新日期：2015-09-01 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH) were examined on the monosynaptic reflex and on the activity of motoneurons in the spinal cord of the neonatal rat to elucidate the mechanism of action of TRH and its ability to reverse the spinal depression caused by phencyclidine and ketamine. Phencyclidine (2-32 mi...

journal_title：Neuropharmacology

authors： Ohno Y,Warnick JE

更新日期：1988-10-01 00:00:00

abstract：:The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have previously been identified in the genetically epilepsy-prone rat (GEPR) brain. In vitro binding of [3H]8-OH-DPAT (0.16-10.3 nM) to 5-HT1A receptor sites was foun...

journal_title：Neuropharmacology

authors： Statnick MA,Dailey JW,Jobe PC,Browning RA

更新日期：1996-01-01 00:00:00

abstract：:The effects of short- and long-term exposure of cells to elevated cyclic adenosine monophosphate (c-AMP), using dibutyryl-c-AMP, 8-bromo-c-AMP, cholera toxin or forskolin, or cyclic guanosine monophosphate (c-GMP), using dibutyryl-c-GMP or 8-bromo-c-GMP, on the activity and expression of the noradrenaline transporter ...

journal_title：Neuropharmacology

authors： Bryan-Lluka LJ,Paczkowski FA,Bönisch H

更新日期：2001-03-01 00:00:00

abstract：:gamma-Aminobutyric acid type A (GABA(A)) receptors are an important target for general anesthetics in the central nervous system. Site-directed mutagenesis techniques have identified amino acid residues that are important for the positive modulation of GABA(A) receptors by general anesthetics. In the present study, we...

journal_title：Neuropharmacology

authors： Krasowski MD,Nishikawa K,Nikolaeva N,Lin A,Harrison NL

更新日期：2001-12-01 00:00:00