The effects of anxiolytic and anxiogenic benzodiazepine receptor ligands on motor activity and levels of ascorbic acid in the nucleus accumbens and striatum of the rat.

abstract：:The role of the adenosine A(2A) receptor in the hypnotic effects of ethanol was assessed in mice. The duration of the loss of righting reflex following acute ethanol administration was shorter for A(2A) receptor-deficient mice (A(2A)R KO) than for wild-type mice (A(2A)R WT), whereas the fall in body temperature was no...

journal_title：Neuropharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2003-12-01 00:00:00

abstract：:Behavioral sensitization, or augmented locomotor response to successive drug exposures, results from neuroadaptive changes contributing to addiction. Both the medial prefrontal cortex (mPFC) and ventral tegmental area (VTA) influence behavioral sensitization and display increased immediate-early gene and BDNF expressi...

journal_title：Neuropharmacology

authors： Fanous S,Lacagnina MJ,Nikulina EM,Hammer RP Jr

更新日期：2011-09-01 00:00:00

abstract：:The effect of clonidine (0.1 mg/kg, i.p.), as a three-injection course, on behaviour in the forced swimming test was studied in rats injected intracerebroventricularly (i.c.v.) with 150 micrograms 5,7-dihydroxy-tryptamine (5,7-DHT) to destroy serotonin (5-HT) neurones or treated with 100 mg/kg (i.p.) (+/-)-sulpiride o...

journal_title：Neuropharmacology

authors： Cervo L,Rossi C,Samanin R

更新日期：1992-04-01 00:00:00

abstract：:The effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-HT1A, 5-HT1B, 5-HT2A and 5-HT3, in various brain regions in the rat. In addition, t...

journal_title：Neuropharmacology

authors： Gozlan H,Laporte AM,Thibault S,Schechter LE,Bolaños F,Hamon M

更新日期：1994-03-01 00:00:00

abstract：:Changes in astroglial volume were studied after incubating primary cultures from the cerebral cortex of newborn rats for 5 hr in taurine, glutamate or gamma-aminobutyric acid (GABA), alone or together with monoamine receptor agonists. Control cell volume was 2.2 microliters/mg protein. In the presence of taurine or gl...

journal_title：Neuropharmacology

authors： Hansson E,Rönnbäck L

更新日期：1992-01-01 00:00:00

abstract：:Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in maintaining wakefulness (W) under behavioral challenges. Since the central actions of HA are mediated by several receptor subtypes, it remains to b...

journal_title：Neuropharmacology

authors： Parmentier R,Zhao Y,Perier M,Akaoka H,Lintunen M,Hou Y,Panula P,Watanabe T,Franco P,Lin JS

更新日期：2016-07-01 00:00:00

abstract：:Memory reactivation has been shown to open a time window for memory modulation. The majority of the methodological or pharmacological approaches target disruption of reconsolidation to weaken aversive memories. However, methods to improve appetitive memory persistence through reconsolidation or to reverse drug-induced...

journal_title：Neuropharmacology

authors： Wang SH

更新日期：2018-10-01 00:00:00

abstract：:The increased pro-inflammatory cytokine production was previously observed in Alzheimer's disease (AD). We sought to explore whether acetylcholinesterase inhibitor (AChEI) therapy ameliorates clinical symptoms in AD through down-regulation of inflammation. Expression and release of monocyte chemotactic protein-1 (MCP-...

journal_title：Neuropharmacology

authors： Reale M,Iarlori C,Gambi F,Feliciani C,Isabella L,Gambi D

更新日期：2006-04-01 00:00:00

abstract：:Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capabilit...

journal_title：Neuropharmacology

authors： Parker CC,Chen H,Flagel SB,Geurts AM,Richards JB,Robinson TE,Solberg Woods LC,Palmer AA

更新日期：2014-01-01 00:00:00

abstract：:Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of side effects has hampered clinical progression. As separate inhibitio...

journal_title：Neuropharmacology

authors： Paes D,Xie K,Wheeler DG,Zook D,Prickaerts J,Peters M

更新日期：2021-02-15 00:00:00

abstract：:The identification and characterization of amyloid-beta (Abeta) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD. In the last decade, research in this area has focused on developing a better understanding of the principles that go...

journal_title：Neuropharmacology

authors： Tarawneh R,Holtzman DM

更新日期：2010-09-01 00:00:00

abstract：:The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamin...

journal_title：Neuropharmacology

authors： Langer I,Vertongen P,Perret J,Waelbroeck M,Robberecht P

更新日期：2003-01-01 00:00:00

abstract：:This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generat...

journal_title：Neuropharmacology

authors： Pang TY,Hannan AJ

更新日期：2013-01-01 00:00:00

abstract：:Histamine H3 receptor (H3R) antagonists are currently being investigated for the possible therapeutic use in various cognitive deficits such as those in schizophrenia, attention deficit hyperactivity disorder and Alzheimer's disease. Our previous studies suggest a role for H3Rs in ethanol-related behaviors in rat and ...

journal_title：Neuropharmacology

authors： Nuutinen S,Vanhanen J,Pigni MC,Panula P

更新日期：2011-06-01 00:00:00

abstract：:High performance liquid chromatography with electrochemical detection (HPLC-EC) was adapted for the analysis of metabolites of monoamines (MA) in the developing brain of the rat. 3-Methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG), dihydroxy phenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxy-3-indoleaceti...

journal_title：Neuropharmacology

authors： Ribary U,Schlumpf M,Lichtensteiger W

更新日期：1986-09-01 00:00:00

abstract：:The neurochemical basis for the clinical observation that some patients receiving a large dose of haloperidol exhibit no extrapyramidal side effects was investigated in rats. Haloperidol at doses of 1, 2.5, 5, 7.5 and 10 mg/kg (i.p.) caused a dose-dependent decrease in the duration of catalepsy. Haloperidol at a dose ...

journal_title：Neuropharmacology

authors： Toru M,Takashima M

更新日期：1985-03-01 00:00:00

abstract：:Flavopiridol was developed as a drug for cancer therapy due to its ability to inhibit cell cycle progression by targeting cyclin-dependent kinases (CDKs). In this study, we show that flavopiridol may also have a neuroprotective action. We show that at therapeutic dosage (or at micromolar range), flavopiridol almost co...

journal_title：Neuropharmacology

authors： Jorda EG,Verdaguer E,Canudas AM,Jiménez A,Bruna A,Caelles C,Bravo R,Escubedo E,Pubill D,Camarasa J,Pallàs M,Camins A

更新日期：2003-10-01 00:00:00

abstract：:In this study, we analysed the implication of superoxide (O2-.) and nitric oxide (NO.) free radicals and their resulting product peroxynitrite (ONOO-) in the neuronal death induced by the activation of the glutamatergic receptor of the N-methyl-D-aspartate (NMDA) subtype using cultured cerebellar granule cells. The NO...

journal_title：Neuropharmacology

authors： Lafon-Cazal M,Culcasi M,Gaven F,Pietri S,Bockaert J

更新日期：1993-11-01 00:00:00

abstract：:Recent studies suggest a role for the arachidonic acid-derived epoxyeicosatrienoic acids (EETs) in attenuating epileptic seizures. However, their effect on neurotransmission has never been investigated in detail. Here, we studied how 11,12- and 14,15 EET affect excitability and excitatory neurotransmission in mouse hi...

journal_title：Neuropharmacology

authors： Mule NK,Orjuela Leon AC,Falck JR,Arand M,Marowsky A

更新日期：2017-09-01 00:00:00

abstract：:Putative kappa binding was investigated in homogenates of the brain of the rat using [3H]ethylketocylazocine and [3H]diprenorphine under conditions where mu and delta sites were blocked. Under blocked conditions, the binding of [3H]ethylketocyclazocine labelled a single site, as defined by kinetic and equilibrium anal...

journal_title：Neuropharmacology

authors： Weyhenmeyer JA,Mack KJ

更新日期：1985-02-01 00:00:00

abstract：:The effects of a stimulation of dopamine D1 receptors by using (+/-)SKF 38393 on the cortical EEG in rats which were chronically implanted with electrodes were studied. Administration of SKF 38393 (3 or 9 mg/kg, s.c.) produced alterations suggesting an arousal in the EEG: the power in all of the frequency bands decrea...

journal_title：Neuropharmacology

authors： Kropf W,Kuschinsky K

更新日期：1993-05-01 00:00:00

abstract：:ORL-1 agonists have been proposed as potential therapeutics for substance abuse based on their propensity to counter the effects of mu opioid agonists in several systems, and to inhibit mesolimbic dopamine release, while mostly being devoid of aversive properties. In support of this, ORL-1 agonists have been shown to ...

journal_title：Neuropharmacology

authors： Shoblock JR,Wichmann J,Maidment NT

更新日期：2005-09-01 00:00:00

abstract：:Central sensitization represents a key mechanism mediating chronic pain, a major clinical problem lacking effective treatment options. LIM-domain kinases (LIMKs) selectively regulate several substrates, e.g. cofilin and cAMP response element-binding protein (CREB), that profoundly affect neural activities, such as syn...

journal_title：Neuropharmacology

authors： Yang X,He G,Zhang X,Chen L,Kong Y,Xie W,Jia Z,Liu WT,Zhou Z

更新日期：2017-10-01 00:00:00

abstract：:Following its binding to somatodendritic receptors, the neuropeptide neurotensin (NT) internalizes via a clathrin-mediated process. In the present study, we investigated whether NT also internalizes presynaptically using synaptosomes from rat neostriatum, a region in which NT1 receptors are virtually all presynaptic. ...

journal_title：Neuropharmacology

authors： Nguyen HM,Cahill CM,McPherson PS,Beaudet A

更新日期：2002-06-01 00:00:00

abstract：:Chronic nicotine administration in animals, and smoking in humans, causes up-regulation of α4β2* neuronal nicotinic receptors (nAChRs), which has been hypothesized to contribute to the addictive actions of nicotine. We used a rat model to test whether such up-regulatory effects differ in adolescents versus adults, and...

journal_title：Neuropharmacology

authors： Hoegberg BG,Lomazzo E,Lee NH,Perry DC

更新日期：2015-12-01 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibit...

journal_title：Neuropharmacology

authors： Samuels BA,Leonardo ED,Gadient R,Williams A,Zhou J,David DJ,Gardier AM,Wong EH,Hen R

更新日期：2011-09-01 00:00:00

abstract：:Nitronyl nitroxides (NN) effectively decompose free radicals (. As brain endothelium, forming the blood-brain barrier (BBB), is both the main source and the target of reactive species during cerebral oxidative stress, we studied the effect of NN on brain endothelial cells injured by the mediator of oxidative stress H(...

journal_title：Neuropharmacology

authors： Blasig IE,Mertsch K,Haseloff RF

更新日期：2002-11-01 00:00:00

abstract：:The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest...

journal_title：Neuropharmacology

authors： Long SK,Evans RH,Cull L,Krijzer F,Bevan P

更新日期：1988-05-01 00:00:00

abstract：:Radioligand binding studies were performed in membranes of human cerebellum using [125I][Tyr3]octreotide also known as [125I]204-090, [125I]LTT-SRIF-28 ([Leu8, D-Trp22, 125I-Tyr25]SRIF-28) and [125I]CGP 23996 ([125I]c[Asu-Lys-Asn-Phe-Trp-Lys-Thr-Tyr-Thr-Ser]) to characterize the nature of cerebellar somatostatin recep...

journal_title：Neuropharmacology

authors： Piwko C,Thoss VS,Probst A,Hoyer D

更新日期：1996-06-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00