Neonatal maternal deprivation modifies feeding in response to pharmacological and behavioural factors in adult rats.

abstract：:Glibenclamide (GBC), a sulfonylurea receptor 1 blocker, emerges recently as a promising neuron protectant in various neurological disorders. This study aimed to determine whether GBC improves survival and neurological outcome of status epilepticus (SE). Male Sprague-Dawley rats successfully undergoing SE for 2.5 h (n ...

journal_title：Neuropharmacology

authors： Lin Z,Huang H,Gu Y,Huang K,Hu Y,Ji Z,Wu Y,Wang S,Yang T,Pan S

更新日期：2017-07-15 00:00:00

abstract：:Hydrogen sulfide (H2S) is a crucial signaling molecule involved in several physiological and pathological processes. Nonetheless, the role of this gasotransmitter in the pathogenesis and treatment of neuropathic pain is controversial. The aim of the present study was to investigate the pain relieving profile of a seri...

journal_title：Neuropharmacology

authors： Di Cesare Mannelli L,Lucarini E,Micheli L,Mosca I,Ambrosino P,Soldovieri MV,Martelli A,Testai L,Taglialatela M,Calderone V,Ghelardini C

更新日期：2017-07-15 00:00:00

abstract：:Rat striatal slices, preincubated with [3H]dopamine (DA) and [14C]choline, were superfused continuously. Detection of radioactivity was used to monitor the release of the neurotransmitters DA and acetylcholine (ACh). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (...

journal_title：Neuropharmacology

authors： Jin S

更新日期：1997-11-01 00:00:00

abstract：:Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that controls neural circuits involved in the cognitive, emotional, and motor aspects of goal-directed behavior. Accordingly, perturbations in DA neurotransmission play a central role in several neuropsychiatric disorders. Somewhat surprisi...

journal_title：Neuropharmacology

authors： Covey DP,Mateo Y,Sulzer D,Cheer JF,Lovinger DM

更新日期：2017-09-15 00:00:00

abstract：:Neural sensorimotor gating mechanisms prevent the interruption of ongoing information processing routines by ensuing stimuli to permit mental integration and adaptive behavior. Prepulse inhibition (PPI), an operational measure of sensorimotor gating, is now being investigated using murine models to exploit transgenic ...

journal_title：Neuropharmacology

authors： Dulawa SC,Geyer MA

更新日期：2000-08-23 00:00:00

abstract：:Lithium has been proven to be effective in the therapy of bipolar disorder, but its mechanism of pharmacological action is not clearly defined. We examined the effects of lithium on voltage-dependent Na(+) channels, nicotinic acetylcholine receptors, and voltage-dependent Ca(2+) channels, as well as catecholamine secr...

journal_title：Neuropharmacology

authors： Yanagita T,Maruta T,Uezono Y,Satoh S,Yoshikawa N,Nemoto T,Kobayashi H,Wada A

更新日期：2007-12-01 00:00:00

abstract：:These experiments examined the effects of lithium and imipramine on the regulation by norepinephrine in vivo of (Na+, K+)-ATPase in brain and heart. The binding of ouabain and the activity of K+-phosphatase were used as indices of (Na+, K+)-ATPase. In the cerebral cortex, imipramine prevented, and lithium reduced, the...

journal_title：Neuropharmacology

authors： Swann AC

更新日期：1988-03-01 00:00:00

abstract：:The present study evaluated whether hypolocomotion elicited by subcutaneous administration of the non-specific 5-HT/preferential 5-HT(2C) receptor agonist mCPP during novelty exposure was due to an enhanced anxiety-like state. The effects of mCPP on exploratory behavior during exposure to a new environment (novelty) w...

journal_title：Neuropharmacology

authors： Stiedl O,Misane I,Koch M,Pattij T,Meyer M,Ogren SO

更新日期：2007-03-01 00:00:00

abstract：:Prenatal exposure to the CB1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone) mesylate (WIN) at a daily dose of 0.5 mg/kg, and Delta9-tetrahydrocannabinol (Delta9-THC) at a daily dose of 5 mg/kg, reduced dialysate glutamate levels in ...

journal_title：Neuropharmacology

authors： Castaldo P,Magi S,Gaetani S,Cassano T,Ferraro L,Antonelli T,Amoroso S,Cuomo V

更新日期：2007-09-01 00:00:00

abstract：:PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A(-/-)) were characterized both behaviorally and neurochemically. PDE10A(-/-...

journal_title：Neuropharmacology

authors： Siuciak JA,McCarthy SA,Chapin DS,Fujiwara RA,James LC,Williams RD,Stock JL,McNeish JD,Strick CA,Menniti FS,Schmidt CJ

更新日期：2006-08-01 00:00:00

abstract：:Administration of 0.13% lead acetate solution as drinking fluid to breeding mice was without significant effect on the numbers of live or dead births or on weight of pups at 1 day. The appearance of fur was delayed and the body weights at 21 days and 31-38 weeks were smaller than in controls. On weaning, the treated o...

journal_title：Neuropharmacology

authors： Donald JM,Cutler MG,Moore MR,Bradley M

更新日期：1986-02-01 00:00:00

abstract：:Remifentanil is a powerful mu-opioid (MOP) receptor agonist used in anaesthesia with a very short half-life. However, per-operative perfusion of remifentanil was shown to increase morphine consumption during post-operative period to relieve pain. In the present study, we aimed to describe the cellular mechanisms respo...

journal_title：Neuropharmacology

authors： Nowoczyn M,Marie N,Coulbault L,Hervault M,Davis A,Hanouz JL,Allouche S

更新日期：2013-10-01 00:00:00

abstract：:The sedative effect of SCH 34826, an enkephalinase inhibitor, was evaluated by studying electroencephalographic (EEG) activity, behaviour and the sleep-waking cycle in the rat. The reference opioid, morphine, was used for comparison. After administration of morphine (10 mg/kg s.c.) the rats were motionless and stuporo...

journal_title：Neuropharmacology

authors： Trampus M,Conti A,Marzanatti M,Monopoli A,Ongini E

更新日期：1990-03-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to clarify the dose response for inhibition of catechol-O-methyltransferase (COMT) by opicapone, a third generation COMT inhibitor, after acute and repeated administration to the cynomolgus monkey with pharmacokinetic evaluation at the higher dose. METHODS:Three cynomolgus monkeys...

journal_title：Neuropharmacology

authors： Kitajima T,Mizote S,Bonifácio MJ,Umemura T,Yoneda K,Moser P,Soares-da-Silva P,Tanaka M

更新日期：2018-12-01 00:00:00

abstract：:To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator) were administered to 6-hydroxydopamine hemilesioned rats, a model of...

journal_title：Neuropharmacology

authors： Pisanò CA,Brugnoli A,Novello S,Caccia C,Keywood C,Melloni E,Vailati S,Padoani G,Morari M

更新日期：2020-05-01 00:00:00

abstract：:The present study used pharmacological and gene ablation techniques to examine the involvement of kappa opioid receptors (KOPr) in modulating the convulsant effects of two mechanistically different drugs: cocaine and pentylenetetrazol (PTZ; GABA-A receptor antagonist) in mice. Systemic administration of the selective ...

journal_title：Neuropharmacology

authors： Kaminski RM,Witkin JM,Shippenberg TS

更新日期：2007-03-01 00:00:00

abstract：:Depotentiation, the reversal of long-term potentiation (LTP), can be induced by activation of metabotropic glutamate receptors (mGluRs) or NMDA receptors (NMDARs). Although NMDAR-dependent depotentiation is due to a protein phosphatase-dependent erasure of LTP, the notion that mGluR-dependent depotentiation also invol...

journal_title：Neuropharmacology

authors： Delgado JY,O'dell TJ

更新日期：2005-06-01 00:00:00

abstract：:The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...

journal_title：Neuropharmacology

authors： Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

更新日期：2018-10-01 00:00:00

abstract：:The effects of high-K, glutamate and glutamate receptor agonists on the efflux of Ca2+ were studied in cultured primary astrocytes, prepared from the brains of newborn rats. An increase in efflux of 45Ca2+ of produced by a large extracellular concentration of K+ was effectively inhibited by verapamil, a blocker of vol...

journal_title：Neuropharmacology

authors： Holopainen I,Akerman KE

更新日期：1990-08-01 00:00:00

abstract：:Long-term potentiation (LTP) resembles memory in that it is initially unstable and then, over about 30 min, becomes increasingly resistant to disruption. Here we present an hypothesis to account for this initial consolidation effect and consider implications that follow from it. Anatomical studies indicate that LTP is...

journal_title：Neuropharmacology

authors： Lynch G,Rex CS,Gall CM

更新日期：2007-01-01 00:00:00

abstract：:Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects resulting from concurrent administration of low doses of mu- and CB1-agonists may produce analgesia with fewer side effects. Synergism potentially results from interact...

journal_title：Neuropharmacology

authors： Seely KA,Brents LK,Franks LN,Rajasekaran M,Zimmerman SM,Fantegrossi WE,Prather PL

更新日期：2012-10-01 00:00:00

abstract：:Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intr...

journal_title：Neuropharmacology

authors： Gareri P,Condorelli D,Belluardo N,Russo E,Loiacono A,Barresi V,Trovato-Salinaro A,Mirone MB,Ferreri Ibbadu G,De Sarro G

更新日期：2004-12-01 00:00:00

abstract：:The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...

journal_title：Neuropharmacology

authors： Lopatář J,Dale N,Frenguelli BG

更新日期：2015-06-01 00:00:00

abstract：:Cholecystokinin (CCK) is the most abundant neuropeptide in the central nervous system. In the hippocampal CA1 region, CCK is co-localized with GABA in a subset of interneurons that synapse on pyramidal cell somata and apical dendrites. CCK-containing interneurons also uniquely express a high level of the cannabinoid r...

journal_title：Neuropharmacology

authors： Karson MA,Whittington KC,Alger BE

更新日期：2008-01-01 00:00:00

abstract：:Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capabilit...

journal_title：Neuropharmacology

authors： Parker CC,Chen H,Flagel SB,Geurts AM,Richards JB,Robinson TE,Solberg Woods LC,Palmer AA

更新日期：2014-01-01 00:00:00

abstract：:A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan has been the co-occurrence of blast-related mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI might coexist due to additive effects of independent psychological and physical traum...

journal_title：Neuropharmacology

authors： Perez-Garcia G,Gama Sosa MA,De Gasperi R,Tschiffely AE,McCarron RM,Hof PR,Gandy S,Ahlers ST,Elder GA

更新日期：2019-02-01 00:00:00

abstract：:The autoradiographic distribution of binding sites for [3H]AMPA, [3H]kainate, [3H]MK-801 and [3H]L-glutamate and the in situ hybridization of GluR-A, GluR-B, GluR-C and GluR-D in rat spinal cord sections were determined. All of the radioligands had similar localisations with the dorsal horn being the most intensely la...

journal_title：Neuropharmacology

authors： Henley JM,Jenkins R,Hunt SP

更新日期：1993-01-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:The United States is in the midst of an opiate epidemic, with abuse of prescription and illegal opioids increasing steadily over the past decade. While it is clear that there is a genetic component to opioid addiction, there is a significant portion of heritability that cannot be explained by genetics alone. The curre...

journal_title：Neuropharmacology

authors： Vassoler FM,Oliver DJ,Wyse C,Blau A,Shtutman M,Turner JR,Byrnes EM

更新日期：2017-02-01 00:00:00

abstract：:The present studies examined the relationship between protein kinase C (PKC) and L-type voltage-dependent calcium channels in modulating the release of neurotransmitter from K(+)-depolarized rat spinal cord synaptosomes. Activators of PKC, such as phorbol 12-myristate 13-acetate (PMA), mezerein and oleoyl acetylglycer...

journal_title：Neuropharmacology

authors： Gandhi VC,Jones DJ

更新日期：1992-11-01 00:00:00