Blast-induced "PTSD": Evidence from an animal model.

abstract：:Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR, M1 - M5, which are expressed throughout the central nervous system (CNS) on numerous cell types and represent promising treatment targets fo...

journal_title：Neuropharmacology

authors： Lebois EP,Thorn C,Edgerton JR,Popiolek M,Xi S

更新日期：2018-07-01 00:00:00

abstract：:This study shows that the selective GABAB antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benz...

journal_title：Neuropharmacology

authors： Jackson HC,Nutt DJ

更新日期：1991-05-01 00:00:00

abstract：:Central sensitization represents a key mechanism mediating chronic pain, a major clinical problem lacking effective treatment options. LIM-domain kinases (LIMKs) selectively regulate several substrates, e.g. cofilin and cAMP response element-binding protein (CREB), that profoundly affect neural activities, such as syn...

journal_title：Neuropharmacology

authors： Yang X,He G,Zhang X,Chen L,Kong Y,Xie W,Jia Z,Liu WT,Zhou Z

更新日期：2017-10-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the preferential dopamine D3 receptor agonists, PD128,907 (0.16 mg/kg, i.p.) and 7-OH-DPAT (0.16 mg/kg, i.p.). PD128,907 and 7-OH-DPAT showed "full" (> or = 80%) and mutual generalization. Chemically-diverse, preferential D3 versus D2 agonists, ...

journal_title：Neuropharmacology

authors： Millan MJ,Girardon S,Monneyron S,Dekeyne A

更新日期：2000-02-14 00:00:00

abstract：:Family, twin and adoption studies demonstrate clearly that alcohol dependence and alcohol use disorders are phenotypically complex and heritable. The heritability of alcohol use disorders is estimated at approximately 50-60% of the total phenotypic variability. Vulnerability to alcohol use disorders can be due to mult...

journal_title：Neuropharmacology

authors： Reilly MT,Noronha A,Goldman D,Koob GF

更新日期：2017-08-01 00:00:00

abstract：:Neural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote aversion, while dopamine was viewed as interacting with reward behavior, and KOR acti...

journal_title：Neuropharmacology

authors： Pirino BE,Spodnick MB,Gargiulo AT,Curtis GR,Barson JR,Karkhanis AN

更新日期：2020-12-15 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) administration of NT on the activity of midbrain DA neurons were studied in rats using single unit recording techniques. NT (i.c.v., 50 micrograms) was found to have no significant effect on the spontaneous activity of DA cells. On the other hand, NT treatment significan...

journal_title：Neuropharmacology

authors： Shi WS,Bunney BS

更新日期：1990-11-01 00:00:00

abstract：:Long-term potentiation (LTP) resembles memory in that it is initially unstable and then, over about 30 min, becomes increasingly resistant to disruption. Here we present an hypothesis to account for this initial consolidation effect and consider implications that follow from it. Anatomical studies indicate that LTP is...

journal_title：Neuropharmacology

authors： Lynch G,Rex CS,Gall CM

更新日期：2007-01-01 00:00:00

abstract：RATIONALE:Diabetes mellitus (DM) is a major risk factor for Alzheimer's disease and vascular dementia. Few animal models exist that focus on the metabolic contributions to dementia onset and progression. Thus, there is strong scientific rationale to explore the effects of streptozotocin (STZ), a diabetogenic compound, ...

journal_title：Neuropharmacology

authors： Murtishaw AS,Heaney CF,Bolton MM,Belmonte KCD,Langhardt MA,Kinney JW

更新日期：2018-07-15 00:00:00

abstract：:We have used patch-clamp recording from cultured neurones, immunohistochemistry and gene deletion techniques to characterize the P2X receptors present in mouse otic ganglion neurones, and demonstrated the presence of similar receptors in rat neurones. All neurones from wild-type (WT) mice responded to ATP (EC(50) 109 ...

journal_title：Neuropharmacology

authors： Ma B,Ruan HZ,Cockayne DA,Ford AP,Burnstock G,Dunn PM

更新日期：2004-06-01 00:00:00

abstract：:The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest...

journal_title：Neuropharmacology

authors： Long SK,Evans RH,Cull L,Krijzer F,Bevan P

更新日期：1988-05-01 00:00:00

abstract：:The present study measured oxygen consumption and core body temperature following central injections of bombesin (1.0 microgram) in food-deprived rats. Oxygen consumption did not differ for bombesin- and control-injected rats while mean core body temperature decreased significantly following bombesin administrations. ...

journal_title：Neuropharmacology

authors： Babcock AM,Wunder BA

更新日期：1984-11-01 00:00:00

abstract：:Acromelic acid, a kainate derivative of natural origin, markedly increased intracellular Ca2+ concentration ([Ca2+]i) in cultured rat spinal neurons in a concentration dependent manner; the half effective concentration (EC50) was 1.3 microM. Acromelic acid was more potent in increasing [Ca2+]i than any other glutamate...

journal_title：Neuropharmacology

authors： Ogata T,Nakamura Y,Tsuji K,Shibata T,Kataoka K,Ishida M,Shinozaki H

更新日期：1994-09-01 00:00:00

abstract：:Amphetamine (AMPH) acts as a substrate of the dopamine transporter (DAT) and causes a dramatic increase in extracellular dopamine (DA). Upon entering DA neurons, AMPH promotes DA efflux via DAT through a mechanism implicating depletion of DA from vesicular stores, activation of kinase pathways and transporter phosphor...

journal_title：Neuropharmacology

authors： Runegaard AH,Dencker D,Wörtwein G,Gether U

更新日期：2019-12-15 00:00:00

abstract：:In three experiments, rats were injected once daily with 5.0 mg/kg apomorphine or vehicle and tested for locomotor activity for 10-14 days. In each experiment, apomorphine produced behavioral sensitization, characterized by a progressively greater increase in locomotor activity with each succeeding injection. On day 1...

journal_title：Neuropharmacology

authors： Rowlett JK,Mattingly BA,Bardo MT

更新日期：1991-02-01 00:00:00

abstract：:The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...

journal_title：Neuropharmacology

authors： Lopatář J,Dale N,Frenguelli BG

更新日期：2015-06-01 00:00:00

abstract：:Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms. Mice with periarticular injections of complete Fr...

journal_title：Neuropharmacology

authors： Montilla-García Á,Tejada MÁ,Perazzoli G,Entrena JM,Portillo-Salido E,Fernández-Segura E,Cañizares FJ,Cobos EJ

更新日期：2017-10-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the control of cellular excitability. HCN2, a subgroup of the HCN family channels, are heavily expressed in small dorsal root ganglia (DRG) neurons and their activation seems to be important in the determination of pain intensity. In...

journal_title：Neuropharmacology

authors： Resta F,Masi A,Sili M,Laurino A,Moroni F,Mannaioni G

更新日期：2016-09-01 00:00:00

abstract：:The loci coeruleus of freely moving cats were perfused bilaterally with acetylcholine at a dose of 0.001 microgram/microliter per min, while the animals were recorded polygraphically. The controls consisted of experiments in which no perfusions were done, and experiments in which the loci coeruleus were perfused bilat...

journal_title：Neuropharmacology

authors： Masserano JM,King C

更新日期：1982-11-01 00:00:00

abstract：:After a focal ischemic lesion in the hand representation of the primary motor cortex in squirrel monkeys, manual skill was mildly and transiently impaired on a reach-and-retrieval task. Performance was significantly poorer during weeks 1 and 3 post-lesion, but was normal by week 4. An unusual behavioral event was also...

journal_title：Neuropharmacology

authors： Nudo RJ,Friel KM,Delia SW

更新日期：2000-03-03 00:00:00

abstract：:The effects of a variety of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on behaviour in 5- and 20-day old rat pups have been investigated. Increased locomotion and head-weaving responses were induced in both age groups by 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 5-HT1A agonist); 5-MeODMT (5-...

journal_title：Neuropharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-06-01 00:00:00

abstract：:The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats. Initially, tonic-clonic seizures were induced in 90% of the animals. Of those animals responding with tonic-clonic seizures, 42% had hindlimb extension (extensors); the remainder showed on...

journal_title：Neuropharmacology

authors： Peterson SL,Trzeciakowski JP,St Mary JS

更新日期：1985-10-01 00:00:00

abstract：:The effects of microiontophoretically-applied and pneumatically-applied morphine on the spontaneous discharge of Purkinje cells in the cerebellum of the anesthetized cat were examined. Microiontophoretic application of morphine produced both inhibitory and excitatory responses of the Purkinje cells. Pneumatic applicat...

journal_title：Neuropharmacology

authors： Taguchi K,Suzuki Y

更新日期：1989-03-01 00:00:00

abstract：:Mechanisms underlying stress-induced depression and antidepressant drug action were shown to involve alterations in serotonergic (5-HT) neurotransmission and expression of genes coding for proteins associated with neurotrophic signaling pathways and cell-survival in the hippocampus and cortex. Expression of these gene...

journal_title：Neuropharmacology

authors： Shishkina GT,Kalinina TS,Berezova IV,Dygalo NN

更新日期：2012-01-01 00:00:00

abstract：:Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...

journal_title：Neuropharmacology

authors： Simon OR,Schramm LP

更新日期：1983-03-01 00:00:00

abstract：:Intraperitoneal administration of 5-10 mg/kg of THIP (4,5,6,7 tetrahydroxyisoxazolo (4,5,c) pyridine 3-ol) induced a transient, reliable model of bilaterally synchronous spikes and waves in rats. The paroxysmal bursts elicited by THIP had similar topographical distribution to the spontaneously-occurring spike and wave...

journal_title：Neuropharmacology

authors： Fariello RG,Golden GT

更新日期：1987-02-01 00:00:00

abstract：:In human populations, there is a well-defined sequence of involvement in drugs of abuse, in which the use of nicotine or alcohol precedes the use of marijuana, which in turn, precedes the use of cocaine. The term "Gateway Hypothesis" describes this developmental sequence of drug involvement. In prior work, we have dev...

journal_title：Neuropharmacology

authors： Huang YY,Kandel DB,Kandel ER,Levine A

更新日期：2013-11-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. Using rat striatal synaptosomes loaded with [3H]dopamine, we have characterized the action of the selective nicotinic agonist, (+/-)anatoxin-a, with respect to [3H]dopamine release, in order to explore the mecha...

journal_title：Neuropharmacology

authors： Soliakov L,Gallagher T,Wonnacott S

更新日期：1995-11-01 00:00:00

abstract：:Benzodiazepines (BZDs) and barbiturates exert their CNS actions by binding to GABA-A receptors (GABARs). The structural mechanisms by which these drugs allosterically modulate GABAR function, to either enhance or inhibit GABA-gated current, are poorly understood. Here, we used the substituted cysteine accessibility me...

journal_title：Neuropharmacology

authors： Sancar F,Czajkowski C

更新日期：2011-02-01 00:00:00

abstract：:We have recently reported that intraperitoneal (i.p.) injection of thymulin at low doses (50 ng) resulted in thermal and mechanical hyperalgesia and upregulation of the level of interleukin-1beta in the liver. In this study, we demonstrate that such injections of thymulin result in a significant elevation in the level...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Dardenne M,Kanaan SA,Atweh SF,Jabbur SJ,Saadé NE

更新日期：2000-07-10 00:00:00