Role of sensory deficits in motor impairments after injury to primary motor cortex.

abstract：:There has been increasing interest in the rostromedial tegmental nucleus (RMTg), given its potential regulatory role in many aversion-related behaviors. The RMTg contains mostly GABAergic neurons, sends a dense inhibitory projection to dopamine neurons in the midbrain, and is rich with μ-opioid receptors (MOR). Like m...

journal_title：Neuropharmacology

authors： Fu R,Chen X,Zuo W,Li J,Kang S,Zhou LH,Siegel A,Bekker A,Ye JH

更新日期：2016-08-01 00:00:00

abstract：:Histamine is an aminergic neurotransmitter, which regulates wakefulness, arousal and attention in the central nervous system. Histamine receptors have been the target of efforts to develop pro-cognitive drugs to treat disorders such as Alzheimer's disease and schizophrenia. Cognitive functions including attention are ...

journal_title：Neuropharmacology

authors： Andersson R,Galter D,Papadia D,Fisahn A

更新日期：2017-05-15 00:00:00

abstract：:Brain injury generates the release of a multitude of factors including extracellular nucleotides, which exhibit bi-functional properties and contribute to both detrimental actions in the acute phase and also protective and reparative actions in the later recovery phase to allow neuroregeneration. A promising strategy ...

journal_title：Neuropharmacology

authors： Miras-Portugal MT,Gomez-Villafuertes R,Gualix J,Diaz-Hernandez JI,Artalejo AR,Ortega F,Delicado EG,Perez-Sen R

更新日期：2016-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) through the activation of its receptor (TrkB-FL) exert well-described neuroprotective effects playing a major role in hippocampal synaptic transmission and plasticity such as long-term potentiation (LTP), a molecular surrogate for learning and memory. Impairments in BDNF signal...

journal_title：Neuropharmacology

authors： Jerónimo-Santos A,Batalha VL,Müller CE,Baqi Y,Sebastião AM,Lopes LV,Diógenes MJ

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hyperdopaminergic signaling and an upregulated brain arachidonic acid (AA) cascade may contribute to bipolar disorder (BD). Lithium and carbamazepine, FDA-approved for the treatment of BD, attenuate brain dopaminergic D(2)-like (D(2), D(3), and D(4)) receptor signaling involving AA when given c...

journal_title：Neuropharmacology

authors： Ramadan E,Basselin M,Taha AY,Cheon Y,Chang L,Chen M,Rapoport SI

更新日期：2011-12-01 00:00:00

abstract：:Morphine was shown to enhance dopamine release in the rat olfactory tubercle, nucleus accumbens, prefrontal cortex and pyriform cortex, as assessed by increased 3-methoxytyramine (3-MT) levels and 3-MT accumulation after pargyline treatment. In contrast, both 3-MT levels and accumulation after pargyline were unaffecte...

journal_title：Neuropharmacology

authors： Wood PL,Rao TS

更新日期：1991-04-01 00:00:00

abstract：:NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely th...

journal_title：Neuropharmacology

authors： Zhou Q,Sheng M

更新日期：2013-11-01 00:00:00

abstract：:The effects of prostaglandin (PG) E(1) on NO neurotoxicity were examined using rat cultured spinal neurons. Rat cultured spinal neurons exposed to the NO donor, 2,2'-(hydroxynitrosohydrazono) bis-ethanamine (NOC18), showed neurotoxic effects that were accompanied by apoptotic nuclear change, free radical generation, a...

journal_title：Neuropharmacology

authors： Kikuchi S,Shinpo K,Niino M,Tsuji S,Iwabuchi K,Onoé K,Tashiro K

更新日期：2002-04-01 00:00:00

abstract：:In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice. Colitis was induced in CD1 male mice through the intake of 4% DSS in tap water for 7 days. Control...

journal_title：Neuropharmacology

authors： Costa R,Motta EM,Manjavachi MN,Cola M,Calixto JB

更新日期：2012-10-01 00:00:00

abstract：:Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexa...

journal_title：Neuropharmacology

authors： Barthó L,Holzer P,Lembeck F

更新日期：1987-11-01 00:00:00

abstract：:Selective central benzodiazepine agonists, such as clonazepam, are known to modify serotonin and 5-hydroxyindoleacetic content in the brain. In order to further study the effect of this benzodiazepine on serotonin turnover rate, rats received clonazepam, 10 mg/kg for 10 days, and the concentrations of serotonin and 5-...

journal_title：Neuropharmacology

authors： Lima L,Trejo E,Urbina M

更新日期：1995-10-01 00:00:00

abstract：:A functional balance between excitatory and inhibitory control over dopamine (DA)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin(2C) receptor (5-HT(2C)R) located within the ventral tegmental area and the nucleus accumbens (NAc). The 5-HT(2C)R located in the medial prefrontal cor...

journal_title：Neuropharmacology

authors： Leggio GM,Cathala A,Moison D,Cunningham KA,Piazza PV,Spampinato U

更新日期：2009-02-01 00:00:00

abstract：:Long-term potentiation (LTP) resembles memory in that it is initially unstable and then, over about 30 min, becomes increasingly resistant to disruption. Here we present an hypothesis to account for this initial consolidation effect and consider implications that follow from it. Anatomical studies indicate that LTP is...

journal_title：Neuropharmacology

authors： Lynch G,Rex CS,Gall CM

更新日期：2007-01-01 00:00:00

abstract：:Protein phosphorylation, controlled by the coordinated actions of phosphatases and kinases, is an important regulatory mechanism in synaptic transmission and other neurophysiological processes. Ionotropic glutamate receptors are known targets of phosphorylation on serine, threonine and tyrosine residues, with function...

journal_title：Neuropharmacology

authors： Orlando LR,Dunah AW,Standaert DG,Young AB

更新日期：2002-08-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1G93A mice. Recordi...

journal_title：Neuropharmacology

authors： Rei N,Rombo DM,Ferreira MF,Baqi Y,Müller CE,Ribeiro JA,Sebastião AM,Vaz SH

更新日期：2020-07-01 00:00:00

abstract：:It has been shown that endogenous adenosine 5'-triphosphate (ATP) as well as its exogenously applied structural analogue, 2-methylthio ATP (2-MeSATP), facilitate the release of dopamine from axon terminals in the rat nucleus accumbens (NAc) by activating ATP-sensitive P2 receptors. In the present study, reversed micro...

journal_title：Neuropharmacology

authors： Krügel U,Kittner H,Franke H,Illes P

更新日期：2001-06-01 00:00:00

abstract：:Transmission at the parallel fibre-Purkinje neurone synapse of the cerebellum can be depressed by a number of presynaptic receptors: endocannabinoid (CB1), metabotropic glutamate (mGluR4), adenosine (A1) and GABA (GABA(B)), which have been implicated in both short- and long-term synaptic plasticity. Stimulation of par...

journal_title：Neuropharmacology

authors： Bellamy TC

更新日期：2007-02-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a group of inter-connected subnuclei that play critical roles in stress-reward interactions. An interesting feature of this brain region is the massive noradrenergic input that it receives. Important roles for norepinephrine in this region have been documented in a num...

journal_title：Neuropharmacology

authors： Flavin SA,Winder DG

更新日期：2013-07-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00

abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

journal_title：Neuropharmacology

authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

更新日期：2013-10-01 00:00:00

abstract：:In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% ...

journal_title：Neuropharmacology

authors： Hauger R,Hulihan-Giblin B,Paul SM

更新日期：1986-03-01 00:00:00

abstract：:The present study investigated the metabolism of serotonin (5-HT) in rats made hypertensive by treatment with DOCA/NaCl. 5-Hydroxytryptamine and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were significantly elevated in a number of regions of the brain in rats treated for 2 weeks with DOCA/NaCl. Elevatio...

journal_title：Neuropharmacology

authors： Dawson R Jr,Nagamhama S,Oparil S

更新日期：1988-04-01 00:00:00

abstract：:Intracerebroventricular administration of neurotensin (NT) suppresses locomotor activity. However, the brain regions that mediate the locomotor depressant effect of NT and receptor subtype-specific mechanisms involved are unclear. Using a brain-penetrating, selective NT receptor type 1 (NTS1) agonist PD149163, we inve...

journal_title：Neuropharmacology

authors： Vadnie CA,Hinton DJ,Choi S,Choi Y,Ruby CL,Oliveros A,Prieto ML,Park JH,Choi DS

更新日期：2014-10-01 00:00:00

abstract：:The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-me...

journal_title：Neuropharmacology

authors： Lanza M,Bonnafous C,Colombo S,Revel L,Makovec F

更新日期：1997-08-01 00:00:00

abstract：:A major mouse model widely adopted in recent years to induce pronounced ethanol intake is the ethanol vapor model known as "CIE" or "Chronic Intermittent Ethanol." One critical question concerning this model is whether the rapid induction of high blood ethanol levels for such short time periods is sufficient to induce...

journal_title：Neuropharmacology

authors： Renteria R,Maier EY,Buske TR,Morrisett RA

更新日期：2017-01-01 00:00:00

abstract：:The uptake of norepinephrine into cortical punches from the brain of the rat was studied in the presence of buffer and plasma from patients containing bupropion and its metabolites. Even though bupropion and its metabolite (compound II) were equipotent in inhibiting the uptake of NE in buffer, compound II was twice as...

journal_title：Neuropharmacology

authors： Perumal AS,Smith TM,Suckow RF,Cooper TB

更新日期：1986-02-01 00:00:00

abstract：:Melanopsin-dependent phototransduction in intrinsically photosensitive retinal ganglion cells (ipRGCs) involves a Gq-coupled phospholipase C (PLC) signaling cascade. Acetylcholine, released in the mammalian retina by starburst amacrine cells, can also activate Gq-PLC pathways through certain muscarinic acetylcholine r...

journal_title：Neuropharmacology

authors： Sodhi P,Hartwick AT

更新日期：2016-09-01 00:00:00

abstract：:Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated. This study investigated whether varenicline and nicotine could attenuate the ataxia induced in rats f...

journal_title：Neuropharmacology

authors： Wecker L,Engberg ME,Philpot RM,Lambert CS,Kang CW,Antilla JC,Bickford PC,Hudson CE,Zesiewicz TA,Rowell PP

更新日期：2013-10-01 00:00:00

abstract：:Destruction of the ventral noradrenergic pathway elicited by administration of 6-hydroxydopamine (6-OHDA, 5 micrograms into each side of the ventral pons) reduced the content of norepinephrine (NE) in the anterior hypothalamus (-80%) and induced an increase in arterial blood pressure (ABP) and in heart rate. These hyp...

journal_title：Neuropharmacology

authors： Benarroch EE,Balda MS,Finkielman S,Nahmod VE

更新日期：1983-01-01 00:00:00

abstract：:This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generat...

journal_title：Neuropharmacology

authors： Pang TY,Hannan AJ

更新日期：2013-01-01 00:00:00