Abstract:
:In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% above levels of their lean littermates. This increased number of hypothalamic [3H] (+)-amphetamine binding sites appeared during the onset of obesity and then remained elevated following the most prominent weight gain. Since ob/ob mice are markedly hyperglycemic throughout their life, the increase in [3H] (+)-amphetamine binding site density in the hypothalamus may be secondary to elevated blood glucose.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Hauger R,Hulihan-Giblin B,Paul SMdoi
10.1016/0028-3908(86)90260-1subject
Has Abstractpub_date
1986-03-01 00:00:00pages
327-30issue
3eissn
0028-3908issn
1873-7064journal_volume
25pub_type
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