当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat.

Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat.

Abstract：

:[3H]Paroxetine is a highly selective ligand for the 5-hydroxytryptamine transporter complex and the specific binding of this ligand to membrane fractions from cerebral cortex or hippocampus was studied in rats treated with specific inhibitors of the uptake of 5-hydroxytryptamine and monoamine oxidase inhibitors. The Kd and Bmax of the binding of [3H]paroxetine to cerebral cortical membranes of the rat was unaffected, compared to sham controls, by either acute or chronic administration with citalopram or chlorimipramine. Also, chronic treatment with chlorimipramine did not alter the parameters of the binding of [3H]paroxetine to hippocampal membranes from the rat compared to sham controls. Furthermore, chronic and acute treatments with clorgyline or deprenyl did not produce any significant changes in the Kd and Bmax of the binding of [3H]paroxetine to cerebral cortical membranes in the rat. These findings on the binding of [3H]paroxetine are discussed in light of previous equivocal results on the plasticity of neuronal binding sites for [3H]imipramine after various pharmacological treatments.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Graham D,Tahraoui L,Langer SZ

doi

10.1016/0028-3908(87)90252-8

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

1087-92

issue

8

eissn

0028-3908

issn

1873-7064

journal_volume

26

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • [¹²⁵I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors.

    abstract：:Recent genetic and pharmacological studies have implicated the α3, β4 and α5 subunits of the nicotinic acetylcholine receptor (nAChR) in dependence to nicotine and other abused drugs and nicotine withdrawal. The α3β4* nAChR subtype has been shown to co-assemble with the α5 or β3 nAChR subunits, and is found mainly in ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.09.023

    authors： Wu J,Perry DC,Bupp JE,Jiang F,Polgar WE,Toll L,Zaveri NT

    更新日期：2014-02-01 00:00:00

  • Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy.

    abstract：:miRNA-137 is an extremely abundant miRNA in the central nervous system and is thought to be closely related to synaptic plasticity. Here, we report a previously unrecognized role of miRNA-137 in epilepsy. The expression of miRNA-137 was decreased both in patients with temporal lobe epilepsy (TLE) and in two different ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.06.010

    authors： Wang W,Guo Y,He L,Chen C,Luo J,Ma Y,Li J,Yang Y,Yang Q,Du C,Zhang Y,Li Z,Xu X,Tian X,Wang X

    更新日期：2018-08-01 00:00:00

  • Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice.

    abstract：:Of the ionotropic glutamatergic receptors, the NMDA receptor is clearly implicated in the acute and chronic effects of ethanol; however, the role of the AMPA receptor in mediating the effects of ethanol in vivo is as yet unclear. Using mice deficient in the AMPA receptor subunit GluR1 (GluR1-/- mice), we investigated ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(03)00174-6

    authors： Cowen MS,Schroff KC,Gass P,Sprengel R,Spanagel R

    更新日期：2003-09-01 00:00:00

  • A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation.

    abstract：:Treatment-related sexual dysfunction is a common side effect of antidepressants and contributes to patient non-compliance or treatment cessation. However, the multimodal antidepressant, vortioxetine, demonstrates low sexual side effects in depressed patients. To investigate the mechanisms involved, sexual behavior was...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.04.017

    authors： Li Y,Pehrson AL,Oosting RS,Gulinello M,Olivier B,Sanchez C

    更新日期：2017-07-15 00:00:00

  • In vivo chronic nicotine exposure differentially and reversibly affects upregulation and stoichiometry of α4β2 nicotinic receptors in cortex and thalamus.

    abstract：:Studies with heterologous expression systems have shown that the α4β2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(α4)2(β2)3] or three [(α4)3(β2)2] copies of the α subunit in the receptor pentamer) which have different pharmacological and functional properties and are d...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.04.048

    authors： Fasoli F,Moretti M,Zoli M,Pistillo F,Crespi A,Clementi F,Mc Clure-Begley T,Marks MJ,Gotti C

    更新日期：2016-09-01 00:00:00

  • A potent factor in extracts of the skin of the Australian frog, Pseudophryne coriacea--II. Stimulation of the leech helical muscle in vitro and in vivo.

    abstract：:Extracts of the skin of Pseudophryne coriacea displayed a powerful stimulant action on the leech helical muscle, both in vitro and in vivo. In the isolated dorsal muscle, the extract caused the appearance of vigorous phasic movements, accompanied by rapid increase in tonus, up to intense spasm. Hyoscine, physostigmine...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90001-8

    authors： Falconieri Erspamer G,Farruggia G

    更新日期：1986-08-01 00:00:00

  • Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex.

    abstract：:Prenatal exposure to the CB1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone) mesylate (WIN) at a daily dose of 0.5 mg/kg, and Delta9-tetrahydrocannabinol (Delta9-THC) at a daily dose of 5 mg/kg, reduced dialysate glutamate levels in ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2007.05.019

    authors： Castaldo P,Magi S,Gaetani S,Cassano T,Ferraro L,Antonelli T,Amoroso S,Cuomo V

    更新日期：2007-09-01 00:00:00

  • Interferon modifies morphine withdrawal phenomena in rodents.

    abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(83)90157-0

    authors： Dafny N

    更新日期：1983-05-01 00:00:00

  • Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.

    abstract：:The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG prefere...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(93)90088-k

    authors： Jane DE,Jones PL,Pook PC,Salt TE,Sunter DC,Watkins JC

    更新日期：1993-07-01 00:00:00

  • Alpha 2C-adrenoceptor mediated regulation of cortical EEG arousal.

    abstract：:Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (alpha(2)-AR) subtypes in these functions is not clear. We investigated the role of alpha(2C)-ARs in the modulation of baseline cortical EEG activity and EEG responses to the alpha(2)-AR selective agonist, de...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00305-2

    authors： Puoliväli J,Björklund M,Holmberg M,Ihalainen JA,Scheinin M,Tanila H

    更新日期：2002-12-01 00:00:00

  • Efflux of 45calcium from cultured primary astrocytes: effects of glutamate receptor agonists and antagonists.

    abstract：:The effects of high-K, glutamate and glutamate receptor agonists on the efflux of Ca2+ were studied in cultured primary astrocytes, prepared from the brains of newborn rats. An increase in efflux of 45Ca2+ of produced by a large extracellular concentration of K+ was effectively inhibited by verapamil, a blocker of vol...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(90)90123-9

    authors： Holopainen I,Akerman KE

    更新日期：1990-08-01 00:00:00

  • Voluntary wheel running effects on intra-accumbens opioid driven diet preferences in male and female rats.

    abstract：:Palatability driven feeding and voluntary physical activity are mediated by and influence similar neural mechanisms, notably through the actions of opioids within the nucleus accumbens. Recent studies suggest that access to a voluntary running wheel results in sex dependent behavioral and physiological adaptations rel...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.05.017

    authors： Lee JR,Tapia MA,Weise VN,Bathe EL,Vieira-Potter VJ,Booth FW,Will MJ

    更新日期：2019-09-01 00:00:00

  • Toll-like receptor signalling as a cannabinoid target in Multiple Sclerosis.

    abstract：:Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery is a pivotal player in the ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2016.04.009

    authors： Fitzpatrick JK,Downer EJ

    更新日期：2017-02-01 00:00:00

  • In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice.

    abstract：:The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was ev...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.04.020

    authors： Higgs J,Wasowski C,Loscalzo LM,Marder M

    更新日期：2013-09-01 00:00:00

  • Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist.

    abstract：:Alcohol produces many subjective and objective effects in man including pleasure, sedation, anxiolysis, plus impaired eye movements and memory. In human volunteers we have used a newly available GABA-A/benzodiazepine receptor inverse agonist that is selective for the alpha5 subtype (a5IA) to evaluate the role of this ...

    journal_title：Neuropharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.neuropharm.2007.08.008

    authors： Nutt DJ,Besson M,Wilson SJ,Dawson GR,Lingford-Hughes AR

    更新日期：2007-12-01 00:00:00

  • Repeated administration of triiodothyronine (T3) to rats enhances nigrostriatal and mesolimbic dopaminergic behavioural responses.

    abstract：:A once daily injection to rats of triiodothyronine (T3; 100 micrograms/kg s.c.) for 10 days enhanced the locomotor responses of rats pretreated with tranylcypromine (5 mg/kg) to an injection into the nucleus accumbens of dopamine (5 micrograms bilaterally), when tested 24 hr after the last T3 administration. This trea...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(82)90156-3

    authors： Heal DJ,Atterwill CK

    更新日期：1982-02-01 00:00:00

  • A bradycardiac agent ZD7288 blocks the hyperpolarization-activated current (I(h)) in retinal rod photoreceptors.

    abstract：:Recently it has been reported that "I(f) channel blockers", which block the hyperpolarization-activated inward current (I(f)) in heart sino atrial node cells, also block the hyperpolarization-activated inward current (I(h)) in other tissues. Here we compared the effects of one of these agents, ZD7288 [4-(N-ethyl-N-phe...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00207-5

    authors： Satoh TO,Yamada M

    更新日期：2000-04-27 00:00:00

  • Intrathecal neostigmine reduces the zymosan-induced inflammatory response in a mouse air pouch model via adrenomedullary activity: involvement of spinal muscarinic type 2 receptors.

    abstract：:Intrathecal (IT) injection of neostigmine (a cholinesterase inhibitor) has been reported to produce a significant anti-nociceptive effect in a number of inflammatory pain models. However, a potential anti-inflammatory effect of IT neostigmine in these models has not been investigated. In the present study, we have exa...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2004.12.024

    authors： Yoon SY,Kwon YB,Kim HW,Roh DH,Kang SY,Kim CY,Han HJ,Kim KW,Yang IS,Beitz AJ,Lee JH

    更新日期：2005-09-01 00:00:00

  • The noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits.

    abstract：:Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90150-0

    authors： Scheller MS,Zornow MH,Fleischer JE,Shearman GT,Greber TF

    更新日期：1989-07-01 00:00:00

  • Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla.

    abstract：:The endocannabinoid system (ECS) comprises the cannabinoid receptors CB1 and CB2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. Recently, a novel class of negative allosteric CB1 receptor peptide ligands, hemopressin-like pepti...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.03.021

    authors： Hofer SC,Ralvenius WT,Gachet MS,Fritschy JM,Zeilhofer HU,Gertsch J

    更新日期：2015-11-01 00:00:00

  • Influence of the intracellular GluN2 C-terminal domain on NMDA receptor function.

    abstract：:Excitatory neurotransmission mediated by N-methyl-d-aspartate receptors (NMDARs) is fundamental to learning and memory and, when impaired, causes certain neurological disorders. NMDARs are heterotetrameric complexes composed of two GluN1 [NR1] and two GluN2(A-D) [NR2(A-D)] subunits. The GluN2 subunit is responsible fo...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.12.018

    authors： Punnakkal P,Jendritza P,Köhr G

    更新日期：2012-04-01 00:00:00

  • Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats.

    abstract：BACKGROUND AND OBJECTIVE:Hyperdopaminergic signaling and an upregulated brain arachidonic acid (AA) cascade may contribute to bipolar disorder (BD). Lithium and carbamazepine, FDA-approved for the treatment of BD, attenuate brain dopaminergic D(2)-like (D(2), D(3), and D(4)) receptor signaling involving AA when given c...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.07.025

    authors： Ramadan E,Basselin M,Taha AY,Cheon Y,Chang L,Chen M,Rapoport SI

    更新日期：2011-12-01 00:00:00

  • 5-(4-hydroxy-3-dimethoxybenzylidene)-rhodanine (RD-1)-improved mitochondrial function prevents anxiety- and depressive-like states induced by chronic corticosterone injections in mice.

    abstract：:Most current pharmacologic antidepressant treatments target monoaminergic systems confronts some problems such as low rate of remission and high risk for relapse indicating new therapeutic strategy is urgently need. Evidences showed that impairments in mitochondrial function were associated with the pathogenesis of mo...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.02.031

    authors： Yang N,Ren Z,Zheng J,Feng L,Li D,Gao K,Zhang L,Liu Y,Zuo P

    更新日期：2016-06-01 00:00:00

  • Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling.

    abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.10.029

    authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

    更新日期：2017-02-01 00:00:00

  • Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation.

    abstract：:At times of an aging population and increasing prevalence of neurodegenerative disorders, effective medical treatments remain limited. Therefore, there is an urgent need for new therapies to treat Alzheimer's disease (AD). Deep brain stimulation (DBS) is thought to address the neuronal network dysfunction of this diso...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2019.107860

    authors： Jakobs M,Lee DJ,Lozano AM

    更新日期：2020-07-01 00:00:00

  • Parallel kinase cascades are involved in the induction of LTP at hippocampal CA1 synapses.

    abstract：:To identify the enzymes involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at CA1 synapses of two-week-old rats we have tested various kinase inhibitors. Surprisingly, given the large body of evidence supporting a role for calcium/calmodulin-dependent protein kinas...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(03)00336-8

    authors： Wikström MA,Matthews P,Roberts D,Collingridge GL,Bortolotto ZA

    更新日期：2003-11-01 00:00:00

  • Orexin/hypocretin is necessary for context-driven cocaine-seeking.

    abstract：:Orexin/hypocretin signaling at the orexin 1 receptor (OX(1)R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats s...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2009.06.042

    authors： Smith RJ,Tahsili-Fahadan P,Aston-Jones G

    更新日期：2010-01-01 00:00:00

  • THC and gabapentin interactions in a mouse neuropathic pain model.

    abstract：:Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the profile of THC could be improved by co-administering it with the first-...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.10.006

    authors： Atwal N,Casey SL,Mitchell VA,Vaughan CW

    更新日期：2019-01-01 00:00:00

  • Mu opioid receptor modulation in the nucleus accumbens lowers voluntary wheel running in rats bred for high running motivation.

    abstract：:The exact role of opioid receptor signaling in mediating voluntary wheel running is unclear. To provide additional understanding, female rats selectively bred for motivation of low (LVR) versus high voluntary running (HVR) behaviors were used. Aims of this study were 1) to identify intrinsic differences in nucleus acc...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.05.022

    authors： Ruegsegger GN,Toedebusch RG,Will MJ,Booth FW

    更新日期：2015-10-01 00:00:00

  • Fluoxetine and vitamin C synergistically inhibits blood-spinal cord barrier disruption and improves functional recovery after spinal cord injury.

    abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.05.018

    authors： Lee JY,Choi HY,Yune TY

    更新日期：2016-10-01 00:00:00