Intrathecal neostigmine reduces the zymosan-induced inflammatory response in a mouse air pouch model via adrenomedullary activity: involvement of spinal muscarinic type 2 receptors.

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:Rats exhibited a marked suppression of motor activity when placed in the same chamber where they had been given electric shocks. Administration of apomorphine-HCl (0.1, 0.5 and 1.0 mg/kg, i.p.) attenuated the conditioned suppression, dose-dependently, but did not facilitate motor activity of control (i.e. non-shocked)...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1983-07-01 00:00:00

abstract：:Neural uptake of glutamate is executed by the structurally related members of the SLC1A family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2. These plasma membrane proteins ensure supply of glutamate, aspartate and some neutral amino acids, including glutamine and cysteine, for synthetic,...

journal_title：Neuropharmacology

authors： Gegelashvili G,Bjerrum OJ

更新日期：2019-12-15 00:00:00

abstract：:Neural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote aversion, while dopamine was viewed as interacting with reward behavior, and KOR acti...

journal_title：Neuropharmacology

authors： Pirino BE,Spodnick MB,Gargiulo AT,Curtis GR,Barson JR,Karkhanis AN

更新日期：2020-12-15 00:00:00

abstract：:Allopregnanolone (ALLO), a potent positive-allosteric modulator of the action of GABA at GABA(A) receptors, is synthesized in the brain from progesterone by the sequential action of two enzymes: 5alpha-reductase and 3alpha-hydroxysteroidoxidoreductase. The concentration of ALLO in various parts of the mouse brain vari...

journal_title：Neuropharmacology

authors： Pinna G,Uzunova V,Matsumoto K,Puia G,Mienville JM,Costa E,Guidotti A

更新日期：2000-01-28 00:00:00

abstract：:Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly...

journal_title：Neuropharmacology

authors： Iwakabe H,Katsuura G,Ishibashi C,Nakanishi S

更新日期：1997-02-01 00:00:00

abstract：:Here, we define a protophenotype as an endophenotype that has been conserved during evolution. Social feeding in Caenorhabditis elegans may be an example of a protophenotype related to asociality in schizophrenia. It is regulated by the highly conserved neuropeptide Y receptor, NPR-1, and we speculated that social fee...

journal_title：Neuropharmacology

authors： Dwyer DS,Awatramani P,Thakur R,Seeni R,Aamodt EJ

更新日期：2015-05-01 00:00:00

abstract：:Orexin contributes to the expression of the cardiovascular and behavioural response of some forms of stress, including novelty stress. Thus, Almorexant, a dual receptor antagonist that blocks the two known orexin receptors, Ox1R and Ox2R, reduces these responses. However, it is not known if the reduction results from ...

journal_title：Neuropharmacology

authors： Beig MI,Dampney BW,Carrive P

更新日期：2015-02-01 00:00:00

abstract：:The cognitive impairments and negative symptoms experienced by schizophrenia patients still await effective treatment. Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) have gain considerable attention in this regard. It has been recently proposed that positive allosteric modulators (PAMs) of α7 nAChRs may represen...

journal_title：Neuropharmacology

authors： Potasiewicz A,Hołuj M,Kos T,Popik P,Arias HR,Nikiforuk A

更新日期：2017-02-01 00:00:00

abstract：:D-Tubocurarine is a potent competitive antagonist of two members of the ligand-gated ion channel family, the muscle-type nicotinic acetylcholine receptor (AChR) and serotonin type-3 receptor (5HT3R). We have used a series of analogs of D-tubocurarine to determine the effects of methylation, stereoisomerization and hal...

journal_title：Neuropharmacology

authors： Yan D,Pedersen SE,White MM

更新日期：1998-01-01 00:00:00

abstract：:The ability of (-)N-n-propylnorapomorphine and selective D1 and D2 dopamine receptor agonists and antagonists to modify the release of [3H]dopamine, induced by potassium from the nucleus accumbens, was studied using an in vitro superfusion technique. (-)N-n-Propylnorapomorphine, in picomolar concentrations, inhibited ...

journal_title：Neuropharmacology

authors： Barnes JM,Barnes NM,Costall B,Naylor RJ

更新日期：1990-04-01 00:00:00

abstract：:The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have previously been identified in the genetically epilepsy-prone rat (GEPR) brain. In vitro binding of [3H]8-OH-DPAT (0.16-10.3 nM) to 5-HT1A receptor sites was foun...

journal_title：Neuropharmacology

authors： Statnick MA,Dailey JW,Jobe PC,Browning RA

更新日期：1996-01-01 00:00:00

abstract：:Stress-related psychiatric disorders, including anxiety, are complex diseases that have genetic, and environmental causes. Stressful experiences increase the release of prefrontal amygdala neurotransmitters, a response that is relevant to cognitive, emotional, and behavioral coping. Moreover, exposure to stress elicit...

journal_title：Neuropharmacology

authors： Andolina D,Di Segni M,Bisicchia E,D'Alessandro F,Cestari V,Ventura A,Concepcion C,Puglisi-Allegra S,Ventura R

更新日期：2016-08-01 00:00:00

abstract：:Recent observations from synaptosome preparations have questioned the tetrodotoxin (TTX) insensitivity of nicotine-evoked release in the striatum, a characteristic previously considered diagnostic of presynaptically located nicotinic acetylcholine receptors (nAChRs). Therefore, we have undertaken a comparison of nicot...

journal_title：Neuropharmacology

authors： Marshall D,Soliakov L,Redfern P,Wonnacott S

更新日期：1996-01-01 00:00:00

abstract：:Radioligand binding studies were performed in membranes of human cerebellum using [125I][Tyr3]octreotide also known as [125I]204-090, [125I]LTT-SRIF-28 ([Leu8, D-Trp22, 125I-Tyr25]SRIF-28) and [125I]CGP 23996 ([125I]c[Asu-Lys-Asn-Phe-Trp-Lys-Thr-Tyr-Thr-Ser]) to characterize the nature of cerebellar somatostatin recep...

journal_title：Neuropharmacology

authors： Piwko C,Thoss VS,Probst A,Hoyer D

更新日期：1996-06-01 00:00:00

abstract：:NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular source driving the working memory deficits caused by NMDAr hypofunc...

journal_title：Neuropharmacology

authors： Sokolenko E,Nithianantharajah J,Jones NC

更新日期：2020-07-01 00:00:00

abstract：:In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio). Release of DA per surviving neurone was assesse...

journal_title：Neuropharmacology

authors： Hefti F,Enz A,Melamed E

更新日期：1985-01-01 00:00:00

abstract：:The effects of chronic administration of the nonselective monoamine oxidase (MAO) inhibitor, phenelzine, and two selective inhibitors, clorgyline, and pargyline on adrenergic receptor binding and MAO activity were studied in the rat brain. Chronic but not acute administration of both phenelzine and the MAO-A inhibitor...

journal_title：Neuropharmacology

authors： Cohen RM,Campbell IC,Dauphin M,Tallman JF,Murphy DL

更新日期：1982-04-01 00:00:00

abstract：:The surface expression and metabolic turnover time of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors are important factors in determining the involvement of these proteins in synaptic function. We used the membrane-impermeant chemical crosslinking reagent BS3 and subsequent immunoblot analysis t...

journal_title：Neuropharmacology

authors： Archibald K,Perry MJ,Molnár E,Henley JM

更新日期：1998-10-01 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:Schizophrenic patients have been shown to exhibit abnormal cortical gamma band oscillation (GBO), which is thought to be related to the symptoms of schizophrenia, including cognitive impairment. Recently, non-competitive NMDA receptor (NMDAr) antagonists such as MK-801 and ketamine have been reported to increase the b...

journal_title：Neuropharmacology

authors： Hiyoshi T,Kambe D,Karasawa J,Chaki S

更新日期：2014-10-01 00:00:00

abstract：:Since its characterisation in 2001, the mGlu8-selective agonist DCPG has been widely used to explore the potential functional role of this group III mGlu receptor within the central nervous system. This research has implicated mGlu8 receptors in a number of disease states and conditions such as epilepsy and anxiety, s...

journal_title：Neuropharmacology

authors： Mercier MS,Lodge D,Fang G,Nicolas CS,Collett VJ,Jane DE,Collingridge GL,Bortolotto ZA

更新日期：2013-04-01 00:00:00

abstract：:The role of the stress-induced increase in the uptake of tryptophan in brain in opioid-induced analgesia was investigated by modifying the uptake of amino acid in brain with injections of competing amino acids. Blockade of analgesia by valine (200 mg/kg, i.p.) alone, and by valine and tyrosine (100 mg/kg, i.p.), but n...

journal_title：Neuropharmacology

authors： Kelly SJ,Franklin KB

更新日期：1985-11-01 00:00:00

abstract：:The effects of a stimulation of dopamine D1 receptors by using (+/-)SKF 38393 on the cortical EEG in rats which were chronically implanted with electrodes were studied. Administration of SKF 38393 (3 or 9 mg/kg, s.c.) produced alterations suggesting an arousal in the EEG: the power in all of the frequency bands decrea...

journal_title：Neuropharmacology

authors： Kropf W,Kuschinsky K

更新日期：1993-05-01 00:00:00

abstract：:Dopamine (DA)-replacement therapy utilizing l-DOPA is the gold standard symptomatic treatment for Parkinson's disease (PD). A critical complication of this therapy is the development of l-DOPA-induced dyskinesia (LID). The endogenous opioid peptides, including enkephalins and dynorphin, are co-transmitters of dopamine...

journal_title：Neuropharmacology

authors： Flores AJ,Bartlett MJ,Root BK,Parent KL,Heien ML,Porreca F,Polt R,Sherman SJ,Falk T

更新日期：2018-10-01 00:00:00

abstract：:Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the "therapeutic window" may be widened beyond the first few hour after stroke and an e...

journal_title：Neuropharmacology

authors： Goldstein LB

更新日期：2000-03-03 00:00:00

abstract：:Conantokin-G (Con-G), a gamma-carboxylglutamate (Gla) containing peptide derived from the venom of the marine cone snail Conus geographus, acts as a selective and potent inhibitor of N-methyl-D-aspartate (NMDA) receptors. Here, the effect of Con-G on recombinant NMDA receptors carrying point mutations within the glyci...

journal_title：Neuropharmacology

authors： Wittekindt B,Malany S,Schemm R,Otvos L,Maccecchini ML,Laube B,Betz H

更新日期：2001-11-01 00:00:00

abstract：:Both short-term (48 h) exposure to the neuroactive steroid 3alpha,5alpha[beta]-THP and its withdrawal increase expression of the benzodiazepine (BDZ)-insensitive GABAA receptor (GABAR) alpha4 subunit in hippocampus. This increase in alpha4 subunit expression was associated with a relative insensitivity of CA1 hippocam...

journal_title：Neuropharmacology

authors： Smith SS,Gong QH

更新日期：2004-07-01 00:00:00

abstract：:Purines are ubiquitous endogenous metabolites, and their roles as signalling molecules, especially in the case of adenosine and ATP, are well documented. The release of purines is increased when cells are highly activated, stressed or damaged, and this is known to have profound effects on various organ systems. Recent...

journal_title：Neuropharmacology

authors： Chow SC,Kass GE,Orrenius S

更新日期：1997-09-01 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function as excitatory glycine receptors that respond to agonist application only with a very low efficacy. Binding of glycine to the high-affinity GluN3 subunits triggers channel opening, whereas glycine binding to the low-affi...

journal_title：Neuropharmacology

authors： Mesic I,Madry C,Geider K,Bernhard M,Betz H,Laube B

更新日期：2016-06-01 00:00:00