Effects of apomorphine and methamphetamine on a quickly-learned conditioned-suppression response in rats.

abstract：:Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery is a pivotal player in the ...

journal_title：Neuropharmacology

authors： Fitzpatrick JK,Downer EJ

更新日期：2017-02-01 00:00:00

abstract：:Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...

journal_title：Neuropharmacology

authors： Simon OR,Schramm LP

更新日期：1983-03-01 00:00:00

abstract：:Microglial cells killed neurons damaged following incubation with sub-lethal concentrations of peptides derived from either the human prion protein (HuPrP82-146) or amyloid-beta1-42 (a peptide found in Alzheimer's disease). HuPrP82-146 or amyloid-beta1-42 induced phenotypic changes in neurons that caused them to bind ...

journal_title：Neuropharmacology

authors： Bate C,Kempster S,Williams A

更新日期：2006-02-01 00:00:00

abstract：:The effects of a variety of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on behaviour in 5- and 20-day old rat pups have been investigated. Increased locomotion and head-weaving responses were induced in both age groups by 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 5-HT1A agonist); 5-MeODMT (5-...

journal_title：Neuropharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-06-01 00:00:00

abstract：:Benzodiazepines (BZDs) are widely used in the treatment of a variety of neurological and psychiatric conditions including anxiety, insomnia and epilepsy. BZDs are thought to act predominantly by affecting the gating of GABAA receptor channels, resulting in enhanced GABA-mediated currents in neurons. However, mutations...

journal_title：Neuropharmacology

authors： Lévi S,Le Roux N,Eugène E,Poncer JC

更新日期：2015-01-01 00:00:00

abstract：:The hypothesis that aberrant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activity contributes to epileptogenesis and neurodegeneration has prompted the search for AMPA receptor antagonists as potential therapeutics to treat these conditions. We describe the functional characterization of a...

journal_title：Neuropharmacology

authors： Lazzaro JT,Paternain AV,Lerma J,Chenard BL,Ewing FE,Huang J,Welch WM,Ganong AH,Menniti FS

更新日期：2002-02-01 00:00:00

abstract：:Changes in brain reward and control systems of frontal cortical areas including the orbitofrontal cortex (OFC) are associated with alcohol use disorders (AUD). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors have been used to treat a number of neuropsychiatric diseases, inclu...

journal_title：Neuropharmacology

authors： Nimitvilai S,Lopez MF,Woodward JJ

更新日期：2018-07-15 00:00:00

abstract：:Schizophrenic patients have been shown to exhibit abnormal cortical gamma band oscillation (GBO), which is thought to be related to the symptoms of schizophrenia, including cognitive impairment. Recently, non-competitive NMDA receptor (NMDAr) antagonists such as MK-801 and ketamine have been reported to increase the b...

journal_title：Neuropharmacology

authors： Hiyoshi T,Kambe D,Karasawa J,Chaki S

更新日期：2014-10-01 00:00:00

abstract：:Spinal metabotropic serotonin receptors encode transient experiences into long-lasting changes in motor behavior (i.e. motor plasticity). While interactions between serotonin receptor subtypes are known to regulate plasticity, the significance of molecular divergence in downstream G protein coupled receptor signaling ...

journal_title：Neuropharmacology

authors： Fields DP,Mitchell GS

更新日期：2017-02-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) antagonist ifenprodil and several structurally related compounds are highly selective for the NR2B-containing receptor subtype. This selectivity could provide an explanation for the reported difference of the analgesic and side-effect profile of ifenprodil-like compounds from other NMDA...

journal_title：Neuropharmacology

authors： Chizh BA,Reissmüller E,Schlütz H,Scheede M,Haase G,Englberger W

更新日期：2001-01-01 00:00:00

abstract：:Protein phosphorylation, controlled by the coordinated actions of phosphatases and kinases, is an important regulatory mechanism in synaptic transmission and other neurophysiological processes. Ionotropic glutamate receptors are known targets of phosphorylation on serine, threonine and tyrosine residues, with function...

journal_title：Neuropharmacology

authors： Orlando LR,Dunah AW,Standaert DG,Young AB

更新日期：2002-08-01 00:00:00

abstract：:Chlorpromazine, given either subcutaneously (0.375 mg/kg) or unilaterally into the preoptic/anterior hypothalamic area through a chronically implanted cannula (20 micrograms), was found to enhance the hypothermic response to delta-9-tetrahydrocannabinol (THC; 5 mg/kg i.p.) in unrestrained adult male MF1 mice, kept at ...

journal_title：Neuropharmacology

authors： Pertwee RG,Hedley D,McQueen AS,Gentleman SM

更新日期：1988-02-01 00:00:00

abstract：:Bradykinin interacts with the bradykinin B2 receptor on dorsal root ganglion (DRG) neurons, setting off a series of reactions inside the cells that ultimately make the vanilloid receptor 1 more sensitive to a normal stimulus by activating various enzymes coupled with second messenger signaling cascades. Zaltoprofen, a...

journal_title：Neuropharmacology

authors： Tang HB,Inoue A,Oshita K,Hirate K,Nakata Y

更新日期：2005-06-01 00:00:00

abstract：:This study shows that the selective GABAB antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benz...

journal_title：Neuropharmacology

authors： Jackson HC,Nutt DJ

更新日期：1991-05-01 00:00:00

abstract：:We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid (3-MATIDA) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a, mGlu2, mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist-induced depolarizations in mouse cortical w...

journal_title：Neuropharmacology

authors： Moroni F,Attucci S,Cozzi A,Meli E,Picca R,Scheideler MA,Pellicciari R,Noe C,Sarichelou I,Pellegrini-Giampietro DE

更新日期：2002-05-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) acts as a neuroprotective agent against various insults, however, the underlying mechanism has not been fully elucidated yet. Here, we report that Rg1 protects primary rat cerebrocortical neurons against β-amyloid peptide₂₅₋₃₅ (Aβ₂₅₋₃₅) injury via estrogen receptor α (ERα) and glucocorticoid rece...

journal_title：Neuropharmacology

authors： Wu J,Pan Z,Wang Z,Zhu W,Shen Y,Cui R,Lin J,Yu H,Wang Q,Qian J,Yu Y,Zhu D,Lou Y

更新日期：2012-09-01 00:00:00

abstract：:GABAA and glycine receptors are close relatives in the "gene superfamily" of ligand-gated ion channels, but have distinctly different pharmacology. For example, barbiturates have two effects on GABAA receptors (GABAA-R): at low micromolar concentrations (2-5 microM), the anesthetic barbiturate methohexital potentiates...

journal_title：Neuropharmacology

authors： Koltchine VV,Ye Q,Finn SE,Harrison NL

更新日期：1996-01-01 00:00:00

abstract：:A neuronal nicotinic acetylcholine receptor (nAChR) subunit, Dalpha4, has been identified and cloned from the fruit fly Drosophila melanogaster, together with several alternatively spliced transcripts. Intron-exon boundaries within the gene encoding Dalpha4 (nAcRalpha-80B) have been identified by comparison of cDNA an...

journal_title：Neuropharmacology

authors： Lansdell SJ,Millar NS

更新日期：2000-10-01 00:00:00

abstract：:Nitric oxide synthase (NOS) enzyme activity was determined in a comprehensive selection of regions of the rat brain. The effects of lateral ventricular administration of N omega-nitro-L-arginine (L-NA, 30 micrograms) and its methyl ester (L-NAME, 3-100 micrograms) on NOS activity were examined in the ipsilateral and c...

journal_title：Neuropharmacology

authors： Salter M,Duffy C,Garthwaite J,Strijbos PJ

更新日期：1995-06-01 00:00:00

abstract：:BU99006 is an irreversible I(2) ligand which selectively inactivates I(2) binding sites, making it an ideal tool with which to study I(2) site mechanism. We sought to determine the effects of BU99006 on I(2) binding in relation to monoamine oxidase (MAO), and the time course of these effects. In vitro, rat brain membr...

journal_title：Neuropharmacology

authors： Paterson LM,Tyacke RJ,Robinson ES,Nutt DJ,Hudson AL

更新日期：2007-02-01 00:00:00

abstract：:Neurons in thalamic midline and paraventricular nuclei (PVT) display a unique slow afterhyperpolarizing potential (sAHP) following the low threshold spike (LTS) generated by activation of their low voltage Ca(2+) channels. We evaluated the conductances underlying this sAHP using whole-cell patch-clamp recordings in ra...

journal_title：Neuropharmacology

authors： Kolaj M,Zhang L,Renaud LP

更新日期：2014-11-01 00:00:00

abstract：:Some phytochemical-derived synthetic compounds have been shown to improve neurological disorders, especially in ischemic stroke. In this study, we identified a novel biscoumarin compound, known as COM 3, which had substantial antioxidant effects in neurons. Next, we found that COM 3 occupies a critical binding site be...

journal_title：Neuropharmacology

authors： Wang J,Zhang W,Lv C,Wang Y,Ma B,Zhang H,Fan Z,Li M,Li X

更新日期：2020-05-01 00:00:00

abstract：:Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In orde...

journal_title：Neuropharmacology

authors： Mäger I,Meyer AH,Li J,Lenter M,Hildebrandt T,Leparc G,Wood MJA

更新日期：2017-07-01 00:00:00

abstract：:Benzodiazepines (BZDs) and barbiturates exert their CNS actions by binding to GABA-A receptors (GABARs). The structural mechanisms by which these drugs allosterically modulate GABAR function, to either enhance or inhibit GABA-gated current, are poorly understood. Here, we used the substituted cysteine accessibility me...

journal_title：Neuropharmacology

authors： Sancar F,Czajkowski C

更新日期：2011-02-01 00:00:00

abstract：:Time-effects of morphine, methadone, meperidine and pentazocine upon locomotor activity were investigated in naive and in post-dependent rats. Dependence was induced by daily injection of 20 mg/kg (i.p.) of morphine for 30 days. Tests were run starting from 1 month after withdrawal from morphine. Morphine produced a g...

journal_title：Neuropharmacology

authors： Bartoletti M,Gaiardi M,Gubellini C,Bacchi A,Babbini M

更新日期：1985-09-01 00:00:00

abstract：:An earlier finding that three systems were responsible for the uptake of gamma-aminobutyric acid by synaptosomes was corroborated. In addition, the existence of three uptake systems for RS-nipecotic acid and beta-alanine was demonstrated. We have called these systems high affinity, medium affinity and low affinity upt...

journal_title：Neuropharmacology

authors： Sidhu HS,Wood JD

更新日期：1986-05-01 00:00:00

abstract：:The majority of existing research on the function of metabotropic glutamate (mGlu) receptor 1 focuses on G protein-mediated outcomes. However, similar to other G protein-coupled receptors (GPCR), it is becoming apparent that mGlu1 receptor signaling is multi-dimensional and does not always involve G protein activation...

journal_title：Neuropharmacology

authors： Hathaway HA,Pshenichkin S,Grajkowska E,Gelb T,Emery AC,Wolfe BB,Wroblewski JT

更新日期：2015-06-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) acts in brain by binding to GABAA/benzodiazepine receptors (GBR) and to mitochondrial benzodiazepine receptors (MBR). Because DBI acting at MBR, has been shown to be an effector of ACTH-induced steroidogenesis and stress is known to change the level of GBR and MBR, the model of acute n...

journal_title：Neuropharmacology

authors： Ferrarese C,Mennini T,Pecora N,Pierpaoli C,Frigo M,Marzorati C,Gobbi M,Bizzi A,Codegoni A,Garattini S

更新日期：1991-12-01 00:00:00

abstract：:The hypoactivity in rats induced by small doses of apomorphine, injected bilaterally into the nucleus accumbens area of the brain, could be antagonized by pretreatment with the neuroleptic-like neuropeptide des-enkephalin-gamma-endorphin (DE gamma E, beta-endorphin 6-17) as well as with the neuroleptic drugs haloperid...

journal_title：Neuropharmacology

authors： Van Ree JM,Caffé AR,Wolterink G

更新日期：1982-11-01 00:00:00

abstract：:Methylphenidate (MPH, Ritalin©) is widely used in the treatment of Attention Deficit Hyperactivity Disorder and recently as a drug of abuse. Although the effect of MPH has been studied in brain regions such as striatum and prefrontal cortex (PFC), the hippocampus has received relatively little attention. It is known t...

journal_title：Neuropharmacology

authors： Rozas C,Carvallo C,Contreras D,Carreño M,Ugarte G,Delgado R,Zeise ML,Morales B

更新日期：2015-12-01 00:00:00