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Inhibition of baclofen-induced hypothermia in mice by the novel GABAB antagonist CGP 35348.

Abstract：

:This study shows that the selective GABAB antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benzodiazepine agonist loprazolam (3 mg/kg i.p.); the alpha 2-agonist UK 14,304 (1 mg/kg i.p.) nor the mu-opioid agonist morphine (30 mg/kg i.p.). These findings, showing selective antagonism of GABAB receptors by CGP 35348, confirm that this compound may be a valuable tool for exploration of GABAB receptor function in vivo.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Jackson HC,Nutt DJ

doi

10.1016/0028-3908(91)90018-7

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

535-8

issue

5

eissn

0028-3908

issn

1873-7064

journal_volume

30

pub_type

杂志文章

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