Actions of morphine and met-enkephalin-amide on nociceptor driven neurones in substantia gelatinosa and deeper dorsal horn.

abstract：:The identification of a second 5-HT(3) (5-HT(3B)) subunit provides an explanation for 5-HT(3) receptor heterogeneity. We investigated whether introduction of recombinant 5-HT(3B) subunits would alter the functional properties of mouse neuroblastoma 5-HT(3) receptors. RT-PCR analysis revealed that NB41A3 cells contain ...

journal_title：Neuropharmacology

authors： Stewart A,Davies PA,Kirkness EF,Safa P,Hales TG

更新日期：2003-02-01 00:00:00

abstract：:In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmit...

journal_title：Neuropharmacology

authors： Ikemoto S,Bonci A

更新日期：2014-01-01 00:00:00

abstract：:PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A(-/-)) were characterized both behaviorally and neurochemically. PDE10A(-/-...

journal_title：Neuropharmacology

authors： Siuciak JA,McCarthy SA,Chapin DS,Fujiwara RA,James LC,Williams RD,Stock JL,McNeish JD,Strick CA,Menniti FS,Schmidt CJ

更新日期：2006-08-01 00:00:00

abstract：:We have recently reported that intraperitoneal (i.p.) injection of thymulin at low doses (50 ng) resulted in thermal and mechanical hyperalgesia and upregulation of the level of interleukin-1beta in the liver. In this study, we demonstrate that such injections of thymulin result in a significant elevation in the level...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Dardenne M,Kanaan SA,Atweh SF,Jabbur SJ,Saadé NE

更新日期：2000-07-10 00:00:00

abstract：:The responses of the guinea-pig ileum myenteric plexus-longitudinal muscle to the food, drug and cosmetic dye erythrosin B (FD & C Red No. 3) were examined in acetylcholine- and electrically-stimulated preparations. Erythrosin B (10(-6)-10(-4)) reduced the amplitude of the mechanical responses produced by both stimuli...

journal_title：Neuropharmacology

authors： Kaplita PV,Bolger GT,Triggle DJ

更新日期：1983-02-01 00:00:00

abstract：:Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques. Application of carbachol activates an inward calcium channel, through an action on muscarinic receptors. The influx of calcium activ...

journal_title：Neuropharmacology

authors： Hedlund B

更新日期：1987-10-01 00:00:00

abstract：:This study utilised the selective 5-ht(5A) receptor antagonist, SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), to investigate 5-ht5A receptor function in guinea pig brain. SB-699551-A competitively antagonised 5-HT-stimulate...

journal_title：Neuropharmacology

authors： Thomas DR,Soffin EM,Roberts C,Kew JN,de la Flor RM,Dawson LA,Fry VA,Coggon SA,Faedo S,Hayes PD,Corbett DF,Davies CH,Hagan JJ

更新日期：2006-09-01 00:00:00

abstract：:The uptake of norepinephrine into cortical punches from the brain of the rat was studied in the presence of buffer and plasma from patients containing bupropion and its metabolites. Even though bupropion and its metabolite (compound II) were equipotent in inhibiting the uptake of NE in buffer, compound II was twice as...

journal_title：Neuropharmacology

authors： Perumal AS,Smith TM,Suckow RF,Cooper TB

更新日期：1986-02-01 00:00:00

abstract：:Despite evidence from psychiatry and psychology clinics pointing to altered cognition and decision making following the consumption of cannabis, the effects of cannabis derivatives are still under dispute and the mechanisms of cannabinoid effects on cognition are not known. In this study, we used effort-based and dela...

journal_title：Neuropharmacology

authors： Fatahi Z,Reisi Z,Rainer G,Haghparast A,Khani A

更新日期：2018-05-01 00:00:00

abstract：:The heart rate of the anaesthetized rabbit was slowed by electrical stimulation of the hypothalamus with 7-9 sec trains of 250-330 microA pulses, duration 1 msec, frequency 60 Hz. This vagally-mediated cardio-decelerator response was attenuated in a dose-dependent manner after intravenous administration of phenoxybenz...

journal_title：Neuropharmacology

authors： Evans MH,Sutton MR,Williamson NM

更新日期：1983-01-01 00:00:00

abstract：:The consumption of saline and water in a two-bottle test of salt-preference was measured after the administration of sulpiride, a dopamine receptor antagonist and of naloxone, an antagonist at opiate receptors. The two drugs were injected alone, or in combination. Three concentrations of saline (0.125, 0.6 and 1.7% Na...

journal_title：Neuropharmacology

authors： Gilbert DB,Cooper SJ

更新日期：1986-07-01 00:00:00

abstract：:Amyloid-beta (Abeta) deposition is a defining feature of Alzheimer's disease (AD). The toxicity of Abeta aggregation is thought to contribute to clinical deficits including progressive memory loss and cognitive dysfunction. Therefore, Abeta peptide has become the focus of many therapeutic approaches for the treatment ...

journal_title：Neuropharmacology

authors： Dong J,Revilla-Sanchez R,Moss S,Haydon PG

更新日期：2010-09-01 00:00:00

abstract：:The accumulation of β-amyloid (Aβ) is one of the hallmarks of Alzheimer disease (AD). Beyond the inflammatory reactions promoted by Aβ, it has been demonstrated that the prokineticin (PK) system, composed of the chemokine prokineticin 2 (PK2) and its receptors, is involved in Aβ toxicity. In this study we have analyze...

journal_title：Neuropharmacology

authors： Caioli S,Severini C,Ciotti T,Florenzano F,Pimpinella D,Petrocchi Passeri P,Balboni G,Polisca P,Lattanzi R,Nisticò R,Negri L,Zona C

更新日期：2017-04-01 00:00:00

abstract：:Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. Male Wistar rats were exposed to an l-try...

journal_title：Neuropharmacology

authors： Koot S,Zoratto F,Cassano T,Colangeli R,Laviola G,van den Bos R,Adriani W

更新日期：2012-03-01 00:00:00

abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

journal_title：Neuropharmacology

authors： Laviolette SR

更新日期：2021-02-15 00:00:00

abstract：:A new in vivo pharmacological method for the quantitative evaluation of alpha 1-adrenoceptor agonists and antagonists has been developed. It consists of recording the myoclonic twitch activity (MTA) of the suprahyoideal muscle of rats anesthetized with urethane. In these animals, the isomers of amphetamine elicited my...

journal_title：Neuropharmacology

authors： Menon MK,Kodama CK,Kling AS,Fitten J

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Nucleus accumbens (NAc) and prefrontal cortex (PFC) dopaminergic and glutamatergic systems are involved in fear/anxiety-related behaviors; meanwhile NAc dopaminergic system activity is mediated by PFC via NAc glutamatergic projections. This study has investigated the involvement of NAc shell dopaminergic sys...

journal_title：Neuropharmacology

authors： Ahmadi H,Nasehi M,Rostami P,Zarrindast MR

更新日期：2013-08-01 00:00:00

abstract：:Rat striatal slices, preincubated with [3H]dopamine (DA) and [14C]choline, were superfused continuously. Detection of radioactivity was used to monitor the release of the neurotransmitters DA and acetylcholine (ACh). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (...

journal_title：Neuropharmacology

authors： Jin S

更新日期：1997-11-01 00:00:00

abstract：:The effect of drugs which down-regulate the function of GABA at the level of the GABA/benzodiazepine receptor complex was studied on the conflict test in the rat. The GABA receptor antagonist, bicuculline, and the blockers of the GABA-receptor-coupled chloride channel, picrotoxin and pentylenetetrazol, produced a dose...

journal_title：Neuropharmacology

authors： Corda MG,Biggio G

更新日期：1986-05-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVES:Recombinant tissue plasminogen activator (rtPA) is widely used for patients with thromboembolic disease, and increasing evidence indicates that it can directly induce neurotoxicity independent of its thrombolysis property. Here, we aimed to confirm the long-term effect of rtPA on animal's behavior, and inves...

journal_title：Neuropharmacology

authors： Dong MX,Li CM,Shen P,Hu QC,Wei YD,Ren YF,Yu J,Gui SW,Liu YY,Pan JX,Xie P

更新日期：2018-01-01 00:00:00

abstract：:Based on significant amount of evidence, it is now generally believed, that one underlying cause for neurodegenerative diseases, could be dysregulation in inflammatory processes. The actual mechanisms involved are not yet well understood. Several studies have demonstrated the potent analgesic and anti-inflammatory act...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Jabbur SJ,Dardenne M,Saadé NE

更新日期：2011-02-01 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibit...

journal_title：Neuropharmacology

authors： Samuels BA,Leonardo ED,Gadient R,Williams A,Zhou J,David DJ,Gardier AM,Wong EH,Hen R

更新日期：2011-09-01 00:00:00

abstract：:Protein phosphorylation, controlled by the coordinated actions of phosphatases and kinases, is an important regulatory mechanism in synaptic transmission and other neurophysiological processes. Ionotropic glutamate receptors are known targets of phosphorylation on serine, threonine and tyrosine residues, with function...

journal_title：Neuropharmacology

authors： Orlando LR,Dunah AW,Standaert DG,Young AB

更新日期：2002-08-01 00:00:00

abstract：:Ketogenesis is a metabolic process wherein ketone bodies are produced from the breakdown of fatty acids. In humans, fatty acid catabolism results in the production of acetyl-CoA which can then be used to synthesize three ketone bodies: acetoacetate, acetone, and β-hydroxybutyrate. Ketogenesis occurs at a higher rate i...

journal_title：Neuropharmacology

authors： Pflanz NC,Daszkowski AW,James KA,Mihic SJ

更新日期：2019-04-01 00:00:00

abstract：:In this study, we evaluated the gastric effects of methylnaltrexone, an opioid receptor antagonist that does not cross the blood-brain barrier in vivo, on mu, kappa and delta opioid agonists induced brainstem unitary responses in an in vitro neonatal rat brainstem-gastric preparation. Single units in the medial subnuc...

journal_title：Neuropharmacology

authors： Yuan CS,Foss JF

更新日期：1999-03-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a group of inter-connected subnuclei that play critical roles in stress-reward interactions. An interesting feature of this brain region is the massive noradrenergic input that it receives. Important roles for norepinephrine in this region have been documented in a num...

journal_title：Neuropharmacology

authors： Flavin SA,Winder DG

更新日期：2013-07-01 00:00:00

abstract：:Extracts of the skin of Pseudophryne coriacea displayed a powerful stimulant action on the leech helical muscle, both in vitro and in vivo. In the isolated dorsal muscle, the extract caused the appearance of vigorous phasic movements, accompanied by rapid increase in tonus, up to intense spasm. Hyoscine, physostigmine...

journal_title：Neuropharmacology

authors： Falconieri Erspamer G,Farruggia G

更新日期：1986-08-01 00:00:00

abstract：:A neuronal nicotinic acetylcholine receptor (nAChR) subunit, Dalpha4, has been identified and cloned from the fruit fly Drosophila melanogaster, together with several alternatively spliced transcripts. Intron-exon boundaries within the gene encoding Dalpha4 (nAcRalpha-80B) have been identified by comparison of cDNA an...

journal_title：Neuropharmacology

authors： Lansdell SJ,Millar NS

更新日期：2000-10-01 00:00:00

abstract：:Cocaine produces a motor-stimulant response in part by its actions within the mesolimbic dopamine system. Repeated exposure to cocaine induces an augmented motor activity response which is termed behavioral sensitization, or reverse tolerance. Previous studies have suggested that sensitization may result from increase...

journal_title：Neuropharmacology

authors： Steketee JD

更新日期：1993-12-01 00:00:00