Proconflict effect of GABA receptor complex antagonists. Reversal by diazepam.

abstract：:C57BL/6J mice were introduced to a nine arm radial maze without prior habituation and trained in the acquisition of a working memory task in 16 sessions, one session per day. In this maze mice need to climb onto an upward inclined bridge in order to reach and cross onto an arm. They received in each session an i.p. in...

journal_title：Neuropharmacology

authors： Ennaceur A,Michalikova S,van Rensburg R,Chazot PL

更新日期：2011-10-01 00:00:00

abstract：:Depolarizations provoked by acetylcholine (ACh) and three dicholines, succinylcholine (SCh), glutarylcholine (GCh) and azelainylcholine (AzCh) were measured in normal and 3-7 days denervated muscles of adult, and in normal muscles of 0-27 days old mice and rats. Soleus and flexor digitorum superficialis muscles were m...

journal_title：Neuropharmacology

authors： Lorković H

更新日期：1989-04-01 00:00:00

abstract：:In this study, we analysed the implication of superoxide (O2-.) and nitric oxide (NO.) free radicals and their resulting product peroxynitrite (ONOO-) in the neuronal death induced by the activation of the glutamatergic receptor of the N-methyl-D-aspartate (NMDA) subtype using cultured cerebellar granule cells. The NO...

journal_title：Neuropharmacology

authors： Lafon-Cazal M,Culcasi M,Gaven F,Pietri S,Bockaert J

更新日期：1993-11-01 00:00:00

abstract：:The relevance and property of studies related to stress effects on immune function are undisputable. All studies conducted on stress-immune relationships, however, provide from physical and/or psychological stressors. Indeed, as far as it is of our knowledge brain-innate immune responses were not analyzed after anxiog...

journal_title：Neuropharmacology

authors： Stankevicius D,Rodrigues-Costa EC,Camilo Flório J,Palermo-Neto J

更新日期：2008-02-01 00:00:00

abstract：:Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene, represents a compelling novel drug target for the treatment of schizophrenia. mGluR5 is a postsynaptic G-protein coupled glutamate receptor strongly linked with several critical cellular processes that are reported to be disrupted in schizop...

journal_title：Neuropharmacology

authors： Matosin N,Fernandez-Enright F,Lum JS,Newell KA

更新日期：2017-03-15 00:00:00

abstract：:Convection-enhanced delivery (CED) of GDNF and NTN was employed to determine the tissue clearance of these factors from the rat striatum and the response of the dopaminergic system to a single infusion. Two doses of GDNF (15 and 3 microg) and NTN (10 microg and 2 microg) were infused into the rat striatum. Animals wer...

journal_title：Neuropharmacology

authors： Hadaczek P,Johnston L,Forsayeth J,Bankiewicz KS

更新日期：2010-06-01 00:00:00

abstract：:In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice. Colitis was induced in CD1 male mice through the intake of 4% DSS in tap water for 7 days. Control...

journal_title：Neuropharmacology

authors： Costa R,Motta EM,Manjavachi MN,Cola M,Calixto JB

更新日期：2012-10-01 00:00:00

abstract：RATIONALE:Diabetes mellitus (DM) is a major risk factor for Alzheimer's disease and vascular dementia. Few animal models exist that focus on the metabolic contributions to dementia onset and progression. Thus, there is strong scientific rationale to explore the effects of streptozotocin (STZ), a diabetogenic compound, ...

journal_title：Neuropharmacology

authors： Murtishaw AS,Heaney CF,Bolton MM,Belmonte KCD,Langhardt MA,Kinney JW

更新日期：2018-07-15 00:00:00

abstract：:Mice deficient in the microtubule stabilizing protein STOP (stable tubule only polypeptide) show synaptic plasticity anomalies in hippocampus, dopamine hyper-reactivity in the limbic system and severe behavioral deficits. Some of these disturbances are alleviated by long-term antipsychotic treatment. Therefore, this m...

journal_title：Neuropharmacology

authors： Bouvrais-Veret C,Weiss S,Andrieux A,Schweitzer A,McIntosh JM,Job D,Giros B,Martres MP

更新日期：2007-06-01 00:00:00

abstract：:Due to the claim that lithium (Li+) reduces morphine self-administration in dependent rats, the effects of acute and chronic Li+ treatments on naloxone-precipitated withdrawal syndrome and physical dependence development to morphine in mice chronically treated with morphine, were evaluated. Morphine dependency was ind...

journal_title：Neuropharmacology

authors： Dehpour AR,Farsam H,Azizabadi-Farahani M

更新日期：1995-01-01 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibit...

journal_title：Neuropharmacology

authors： Samuels BA,Leonardo ED,Gadient R,Williams A,Zhou J,David DJ,Gardier AM,Wong EH,Hen R

更新日期：2011-09-01 00:00:00

abstract：:Glutamatergic neurotransmission in the central nucleus of the amygdala (CeA) plays an important role in many behaviors including anxiety, memory consolidation and cardiovascular responses. While these behaviors can be modulated by corticotropin releasing factor (CRF) and catecholamine signaling, the mechanism(s) by wh...

journal_title：Neuropharmacology

authors： Silberman Y,Winder DG

更新日期：2013-07-01 00:00:00

abstract：:The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG prefere...

journal_title：Neuropharmacology

authors： Jane DE,Jones PL,Pook PC,Salt TE,Sunter DC,Watkins JC

更新日期：1993-07-01 00:00:00

abstract：:The contribution of metabotropic glutamate receptors (mGluRs) to the modulation of nociception by the periaqueductal gray (PAG) matter was investigated in mice. Intra-PAG microinjection of (IS,3R)-ACPD, an agonist of groups I and II mGluRs, as well as (S)-3,5-DHPG, a selective agonist of group I mGluRs, increased the ...

journal_title：Neuropharmacology

authors： Maione S,Marabese I,Leyva J,Palazzo E,de Novellis V,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:The effects of intracerebroventricular administration of morphine, the selective mu-agonist DAMGO, the delta-agonist DPDPE, the kappa-preferring peptide dynorphin A(1-13) and the kappa-agonist U50,488H on locomotor behaviour in the guinea pig were investigated. Morphine (total dose = 0.01, 0.1, 1, 10, 200 nmol), DAMGO...

journal_title：Neuropharmacology

authors： Bot G,Chahl LA,Brent PJ,Johnston PA

更新日期：1992-09-01 00:00:00

abstract：:Calcium modulates the 5-HT3 receptor response by reducing peak current amplitude and increasing rates of activation, deactivation and desensitisation, but the binding site(s) and mechanism(s) of this modulation are unknown. Here we study residues that may be involved in calcium binding in two partially overlapping reg...

journal_title：Neuropharmacology

authors： Thompson AJ,Lummis SC

更新日期：2009-01-01 00:00:00

abstract：:Maternal aggression is highly expressed during lactation and serves to protect the developing young from intruders that may injure the offspring. One neurochemical modulator of maternal aggression appears to be arginine vasopressin (AVP). Earlier research supports a role for AVP in maternal aggression in rats as treat...

journal_title：Neuropharmacology

authors： Nephew BC,Byrnes EM,Bridges RS

更新日期：2010-01-01 00:00:00

abstract：:Etomidate and propofol have clearly distinguishable effects on the central nervous system. However, studies in knock-in mice provided evidence that these agents produce anesthesia via largely overlapping molecular targets, namely GABA(A) receptors containing beta3 subunits. Here the authors address the question as to ...

journal_title：Neuropharmacology

authors： Drexler B,Jurd R,Rudolph U,Antkowiak B

更新日期：2009-09-01 00:00:00

abstract：:A study has been undertaken to identify the category of receptors mediating the inhibitory effects of adenosine on evoked activity in slices of olfactory cortex in the rat. The approach has been to measure the relative potencies of adenosine and a range of structural analogues [2-chloroadenosine, 2' deoxyadenosine, cy...

journal_title：Neuropharmacology

authors： Collins GG,Anson J

更新日期：1985-11-01 00:00:00

abstract：:A challenge for theories of general anesthesia is the existence of compounds predicted to be anesthetics but which, instead, do not produce anesthesia and often elicit other behavioral effects such as convulsions. This study focused on flurothyl (bis[2,2, 2-trifluoroethyl] ether), a potent volatile convulsant, and its...

journal_title：Neuropharmacology

authors： Krasowski MD

更新日期：2000-04-27 00:00:00

abstract：:Opioid drugs such as heroin interact directly with opioid receptors whilst other addictive drugs, including marijuana, alcohol and nicotine indirectly activate endogenous opioid systems to contribute to their rewarding properties. The opioid system therefore plays a key role in addiction neurobiology and continues to ...

journal_title：Neuropharmacology

authors： Kieffer BL,Evans CJ

更新日期：2009-01-01 00:00:00

abstract：:Amphetamine-type stimulants (ATS) are the second most consumed illicit drug worldwide and lack good treatments for associated substance use disorders, lagging behind other addictive drugs. For this reason, a deeper understanding of the pharmacodynamics of ATS is required. The present study seeks to determine amphetami...

journal_title：Neuropharmacology

authors： Garton DR,Ross SG,Maldonado-Hernández R,Quick M,Lasalde-Dominicci JA,Lizardi-Ortiz JE

更新日期：2019-01-01 00:00:00

abstract：:This study was performed to investigate the effects of exercise on the synthesis of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the brain of the trained rat. The consequences on the relationships between these two systems were also examined. The sum of the levels of free 3,4-dihydroxyphenyl acetic acid (DOPAC) plu...

journal_title：Neuropharmacology

authors： Chaouloff F,Laude D,Merino D,Serrurrier B,Guezennec Y,Elghozi JL

更新日期：1987-08-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors play several essential roles in the physiology and pathophysiology of the brain. Their activation results in long-term changes in glutamatergic synaptic transmission in several brain areas, but excessive activation of these receptors induces neurotoxicity. Some of NMDA-mediated ac...

journal_title：Neuropharmacology

authors： Schotanus SM,Fredholm BB,Chergui K

更新日期：2006-08-01 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (K(ATP)) in learning and memory. After confirming expression of the Kir6.2 subunit in the CA3 region of C57BL/6J mice, we performed intra-hippocampal pharmacological injections of specific openers and blockers of K(ATP) channels. The ...

journal_title：Neuropharmacology

authors： Betourne A,Bertholet AM,Labroue E,Halley H,Sun HS,Lorsignol A,Feng ZP,French RJ,Penicaud L,Lassalle JM,Frances B

更新日期：2009-03-01 00:00:00

abstract：:The pharmacological profile of (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) and of other group 1 metabotropic glutamate (mGlu) receptor agents were studied in BHK cells transfected with mGlu receptor subtypes or in native receptors in brain slices by measuring second messenger responses. The mGlu receptor...

journal_title：Neuropharmacology

authors： Mannaioni G,Attucci S,Missanelli A,Pellicciari R,Corradetti R,Moroni F

更新日期：1999-07-01 00:00:00

abstract：:The effect of 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (CHEB) on the isolated spinal cord of the immature rat was examined using extracellular recording. At concentrations less than 20 microM CHEB increased the monosynaptic reflex (MSR) but depressed the reflex at greater concentrations (30-100 microM). At c...

journal_title：Neuropharmacology

authors： Nicholson GM,Spence I,Johnston GA

更新日期：1985-06-01 00:00:00

abstract：:The guinea-pig substantia nigra receives a 5-hydroxytryptaminergic (5-HT ergic) projection from the dorsal raphé nucleus. In this study we have attempted to identify the 5-HT receptor subtype mediating release of acetylcholinesterase (AChE) from nigral neurones, measured by assay of perfusate obtained via chronically ...

journal_title：Neuropharmacology

authors： Dickie BG,Greenfield SA

更新日期：1995-09-01 00:00:00