Modeling treatment-resistant depression.

abstract：:The effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), an activator of soluble guanylyl cyclase, on ionic currents have been assessed in rat pituitary GH(3) lactotrophs. In GH(3) cells bathed in normal Tyrode's solution, YC-1 (1 microM) reversibly suppressed the amplitude of the Ca(2+)-activated K(+) c...

journal_title：Neuropharmacology

authors： Wu SN,Hwang T,Teng CM,Li HF,Jan CR

更新日期：2000-07-24 00:00:00

abstract：:Hippocampal volume reductions and functional impairments are reliable findings in posttraumatic stress disorder (PTSD) imaging studies. However, it is not clear if and how hippocampal dysfunction contributes to the etiology and maintenance of PTSD. Individuals with PTSD are often described as showing fear responses to...

journal_title：Neuropharmacology

authors： Acheson DT,Gresack JE,Risbrough VB

更新日期：2012-02-01 00:00:00

abstract：:Anesthetics exposure to neonates leads to impairment of hippocampal synaptic plasticity and cognitive functions later in life. This phenomenon complies with the concept of metaplasticity: a priming stimulation can affect induction of synaptic plasticity mins or days later. We aimed to understand whether small conducta...

journal_title：Neuropharmacology

authors： Yu X,Zhang F,Shi J

更新日期：2018-10-01 00:00:00

abstract：:The exact role of opioid receptor signaling in mediating voluntary wheel running is unclear. To provide additional understanding, female rats selectively bred for motivation of low (LVR) versus high voluntary running (HVR) behaviors were used. Aims of this study were 1) to identify intrinsic differences in nucleus acc...

journal_title：Neuropharmacology

authors： Ruegsegger GN,Toedebusch RG,Will MJ,Booth FW

更新日期：2015-10-01 00:00:00

abstract：:Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of with...

journal_title：Neuropharmacology

authors： Kim R,Sepulveda-Orengo MT,Healey KL,Williams EA,Reissner KJ

更新日期：2018-01-01 00:00:00

abstract：:Depolarizing, hyperpolarizing and biphasic muscarinic responses have been described in hippocampal inhibitory interneurons, but the receptor subtypes and activity patterns required to synaptically activate muscarinic responses in interneurons have not been completely characterized. Using optogenetics combined with who...

journal_title：Neuropharmacology

authors： Bell LA,Bell KA,McQuiston AR

更新日期：2013-10-01 00:00:00

abstract：:We have previously demonstrated that an acute dose of Δ9-tetrahydrocanninbinol (THC), administered prior to extinction learning, facilitates later recall of extinction learning and modulates the underlying neural circuitry, including the ventromedial prefrontal cortex (vmPFC), hippocampus (HPC), and amygdala (AMYG). I...

journal_title：Neuropharmacology

authors： Rabinak CA,Peters C,Marusak HA,Ghosh S,Phan KL

更新日期：2018-12-01 00:00:00

abstract：:Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation provides a potential therapeutic strategy for cognitive disorders involving aberrant neuroplastic...

journal_title：Neuropharmacology

authors： Fass DM,Reis SA,Ghosh B,Hennig KM,Joseph NF,Zhao WN,Nieland TJ,Guan JS,Kuhnle CE,Tang W,Barker DD,Mazitschek R,Schreiber SL,Tsai LH,Haggarty SJ

更新日期：2013-01-01 00:00:00

abstract：:The aim of the present study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, ad...

journal_title：Neuropharmacology

authors： Ingram N,Martin S,Wang JH,van der Laan S,Loiacono R,van den Buuse M

更新日期：2005-01-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a forebrain structure implicated in physiological and behavioral responses to emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully known. Here, we investigated the involvement of BNST cholinergic neu...

journal_title：Neuropharmacology

authors： Gouveia MK,Miguel TT,Busnardo C,Scopinho AA,Corrêa FM,Nunes-de-Souza RL,Crestani CC

更新日期：2016-02-01 00:00:00

abstract：:Seldom does a single individual have such a profound effect on the development of a scientific discipline as Erminio Costa had on neuropharmacology. During nearly sixty years of research, Costa and his collaborators helped established many of the basic principles of the pharmacodynamic actions of psychotherapeutics. H...

journal_title：Neuropharmacology

authors： Enna SJ

更新日期：2011-06-01 00:00:00

abstract：:Mutations in hundreds of genes contribute to cognitive and behavioral dysfunction associated with developmental brain disorders (DBDs). Due to the sheer number of risk factors available for study combined with the cost of developing new animal models, it remains an open question how genes should be prioritized for in-...

journal_title：Neuropharmacology

authors： Ogden KK,Ozkan ED,Rumbaugh G

更新日期：2016-01-01 00:00:00

abstract：:Pyrethroids, widely used insecticides with low acute toxicity in mammals, affect sodium channels in neurons. In a primary culture of rat cortical neurons, deltamethrin (DM), a type II pyrethroid, markedly enhanced the expression of brain-derived neurotrophic factor (BDNF) exon IV-IX (Bdnf eIV-IX) mRNA. In this study, ...

journal_title：Neuropharmacology

authors： Ihara D,Fukuchi M,Honma D,Takasaki I,Ishikawa M,Tabuchi A,Tsuda M

更新日期：2012-02-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is activated by a wide range of stimuli, including drugs. Here we report that in male rats, a dose of sodium butyrate (NaBu) that is typically used to inhibit histone deacetylation (1200 mg/kg) increased the peripheral levels of HPA hormones and glucose. In a further exper...

journal_title：Neuropharmacology

authors： Gagliano H,Delgado-Morales R,Sanz-Garcia A,Armario A

更新日期：2014-04-01 00:00:00

abstract：:To compare the actions of prototypic drugs which are selective for phencyclidine and sigma receptors, the electrophysiological effects of phencyclidine (PCP),3-[3-hydroxyphenyl]-N-(1-propyl)piperidine [+)3-PPP), and 1,3-di(2-tolyl)guanidine (DTG) on CA1 hippocampal pyramidal neurons were examined. A wide range of conc...

journal_title：Neuropharmacology

authors： Malouf AT,Swearengen E,Chavkin C

更新日期：1988-11-01 00:00:00

abstract：:Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, alt...

journal_title：Neuropharmacology

authors： Yamamoto K,Sawada T,Utsumi S,Naito Y,Koshida H

更新日期：1982-05-01 00:00:00

abstract：:Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexa...

journal_title：Neuropharmacology

authors： Barthó L,Holzer P,Lembeck F

更新日期：1987-11-01 00:00:00

abstract：:Gene-environment interactions drive experience-dependent changes in the brain that alter cognition, emotion and behaviour. Positive engagement with the environment, through novel experience and physical activity, can improve brain function, although the mechanisms mediating such experience-dependent plasticity remain ...

journal_title：Neuropharmacology

authors： Rogers J,Renoir T,Hannan AJ

更新日期：2019-02-01 00:00:00

abstract：:4-Alkylated analogues of homoibotenic acid (HIBO) have previously shown high potency and selectivity at ionotropic and metabotropic glutamic acid receptor (iGluR and mGluR) subtypes. Compounds with different selectivity profiles are valuable pharmacological tools for neuropharmacological studies, and the series of 4-a...

journal_title：Neuropharmacology

authors： Madsen U,Pickering DS,Nielsen B,Bräuner-Osborne H

更新日期：2005-01-01 00:00:00

abstract：:We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid (3-MATIDA) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a, mGlu2, mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist-induced depolarizations in mouse cortical w...

journal_title：Neuropharmacology

authors： Moroni F,Attucci S,Cozzi A,Meli E,Picca R,Scheideler MA,Pellicciari R,Noe C,Sarichelou I,Pellegrini-Giampietro DE

更新日期：2002-05-01 00:00:00

abstract：:Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...

journal_title：Neuropharmacology

authors： Sonsalla PK,Gibb JW,Hanson GR

更新日期：1986-11-01 00:00:00

abstract：:Intraperitoneal administration of 5-10 mg/kg of THIP (4,5,6,7 tetrahydroxyisoxazolo (4,5,c) pyridine 3-ol) induced a transient, reliable model of bilaterally synchronous spikes and waves in rats. The paroxysmal bursts elicited by THIP had similar topographical distribution to the spontaneously-occurring spike and wave...

journal_title：Neuropharmacology

authors： Fariello RG,Golden GT

更新日期：1987-02-01 00:00:00

abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

journal_title：Neuropharmacology

authors： Dourish CT,Herbert EN,Iversen SD

更新日期：1989-12-01 00:00:00

abstract：:Two peptide fragments of native Protein Kinase A inhibitor (PKI), PKI-(6-22)-amide and PKI-(Myr-14-22)-amide, significantly reversed low-level morphine antinociceptive tolerance in mice. The inhibition of Protein Kinase A (PKA) activity by both peptide fragments was then measured in specific brain regions (thalamus, p...

journal_title：Neuropharmacology

authors： Dalton GD,Smith FL,Smith PA,Dewey WL

更新日期：2005-04-01 00:00:00

abstract：:Nitric oxide synthase (NOS) enzyme activity was determined in a comprehensive selection of regions of the rat brain. The effects of lateral ventricular administration of N omega-nitro-L-arginine (L-NA, 30 micrograms) and its methyl ester (L-NAME, 3-100 micrograms) on NOS activity were examined in the ipsilateral and c...

journal_title：Neuropharmacology

authors： Salter M,Duffy C,Garthwaite J,Strijbos PJ

更新日期：1995-06-01 00:00:00

abstract：:Centrally-administered opioid peptides produce elevations in levels of catecholamines in plasma in conscious rats. To investigate the opioid receptor involved in mediating this response, morphine (3.5-105 nmol), [D-Ala2-D-Leu5]enkephalin (DADL, 1.05-35 nmol) and U50, 488H (35-1160 nmol), relatively selective ligands f...

journal_title：Neuropharmacology

authors： Conway EL,Brown MJ,Dollery CT

更新日期：1984-11-01 00:00:00

abstract：:Purines are ubiquitous endogenous metabolites, and their roles as signalling molecules, especially in the case of adenosine and ATP, are well documented. The release of purines is increased when cells are highly activated, stressed or damaged, and this is known to have profound effects on various organ systems. Recent...

journal_title：Neuropharmacology

authors： Chow SC,Kass GE,Orrenius S

更新日期：1997-09-01 00:00:00

abstract：:The hippocampus may be functionally differentiated along its dorsoventral axis. In contrast to the wealth of data available on synaptic plasticity mechanisms in the dorsal hippocampus, little is known about synaptic plasticity processes in the intermediate hippocampus. Behavioral data suggest that this structure may p...

journal_title：Neuropharmacology

authors： Kenney J,Manahan-Vaughan D

更新日期：2013-11-01 00:00:00

abstract：:The Mouse Defense Test Battery (MDTB) has been designed to investigate defensive responses of Swiss-Webster mice confronted with a natural predator, a rat. These behaviors include flight, avoidance, defensive threat/attack responses, and risk assessment activities. Previous studies with the MDTB have suggested that th...

journal_title：Neuropharmacology

authors： Griebel G,Blanchard DC,Jung A,Lee JC,Masuda CK,Blanchard RJ

更新日期：1995-12-01 00:00:00