Behavioral and electrophysiological analyses of the effects of 2-o-chlorobenzoyl-4-chloro-n-methyl-n alpha-glycylglycinanilide hydrate (45-0088-S) in the CNS in cats and monkeys.

abstract：:In rats with cannulae permanently implanted into the third cerebral ventricle, the effects of different pharmacological manipulations affecting dopaminergic mechanisms, were studied on behaviour and electrocorticographic (ECoG) activity, continuously quantified in its spectrum power. The intraventricular injection (0....

journal_title：Neuropharmacology

authors： Bagetta G,Corasaniti MT,Strongoli MC,Sakurada S,Nisticò G

更新日期：1987-08-01 00:00:00

abstract：:Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important med...

journal_title：Neuropharmacology

authors： Pišlar A,Božić B,Zidar N,Kos J

更新日期：2017-03-01 00:00:00

abstract：:Rat striatal slices, preincubated with [3H]dopamine (DA) and [14C]choline, were superfused continuously. Detection of radioactivity was used to monitor the release of the neurotransmitters DA and acetylcholine (ACh). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (...

journal_title：Neuropharmacology

authors： Jin S

更新日期：1997-11-01 00:00:00

abstract：:After a focal ischemic lesion in the hand representation of the primary motor cortex in squirrel monkeys, manual skill was mildly and transiently impaired on a reach-and-retrieval task. Performance was significantly poorer during weeks 1 and 3 post-lesion, but was normal by week 4. An unusual behavioral event was also...

journal_title：Neuropharmacology

authors： Nudo RJ,Friel KM,Delia SW

更新日期：2000-03-03 00:00:00

abstract：:Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained uncertain. The fatty ac...

journal_title：Neuropharmacology

authors： Moreira FA,Kaiser N,Monory K,Lutz B

更新日期：2008-01-01 00:00:00

abstract：:Painful nerve injury disrupts Ca2+ signaling in primary sensory neurons by elevating plasma membrane Ca2+-ATPase (PMCA) function and depressing sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) function, which decreases endoplasmic reticulum (ER) Ca2+ stores and stimulates store-operated Ca2+ entry (SOCE). The extracell...

journal_title：Neuropharmacology

authors： Guo Y,Zhang Z,Wu HE,Luo ZD,Hogan QH,Pan B

更新日期：2017-05-01 00:00:00

abstract：:The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of vertebrate Cys-loop ligand-gated ion channels. It is activated by GABA, and this property, combined with its structural similarity to GABA(A) and other Cys-loop receptors, makes it potentially an excellent model to probe their structure and functi...

journal_title：Neuropharmacology

authors： Thompson AJ,Alqazzaz M,Ulens C,Lummis SC

更新日期：2012-09-01 00:00:00

abstract：:Under conditions in which NG-nitro-L-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS lev...

journal_title：Neuropharmacology

authors： Babey AM,Kolesnikov Y,Cheng J,Inturrisi CE,Trifilletti RR,Pasternak GW

更新日期：1994-11-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00

abstract：:The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a key regulator of the production of both neuroprotective (e.g. kynurenic and picolinic acid, and the essential cofactor NAD+) and neurotoxic metabolites (e.g. quinolinic acid, 3-hydroxykynurenine). The balance between the production o...

journal_title：Neuropharmacology

authors： Lovelace MD,Varney B,Sundaram G,Lennon MJ,Lim CK,Jacobs K,Guillemin GJ,Brew BJ

更新日期：2017-01-01 00:00:00

abstract：:High-frequency stimulation of afferents to the supraoptic nucleus (SON) results in a robust increase in the frequency and amplitude of pharmacologically isolated, tetrodotoxin-resistant, miniature excitatory postsynaptic currents (mEPSCs) lasting for 5-20 min. This increase in mEPSC frequency, termed short-term potent...

journal_title：Neuropharmacology

authors： Kombian SB,Hirasawa M,Matowe WC,Pittman QJ

更新日期：2001-10-01 00:00:00

abstract：:Memory reactivation has been shown to open a time window for memory modulation. The majority of the methodological or pharmacological approaches target disruption of reconsolidation to weaken aversive memories. However, methods to improve appetitive memory persistence through reconsolidation or to reverse drug-induced...

journal_title：Neuropharmacology

authors： Wang SH

更新日期：2018-10-01 00:00:00

abstract：:The autoradiographic distribution of binding sites for [3H]AMPA, [3H]kainate, [3H]MK-801 and [3H]L-glutamate and the in situ hybridization of GluR-A, GluR-B, GluR-C and GluR-D in rat spinal cord sections were determined. All of the radioligands had similar localisations with the dorsal horn being the most intensely la...

journal_title：Neuropharmacology

authors： Henley JM,Jenkins R,Hunt SP

更新日期：1993-01-01 00:00:00

abstract：:Agomelatine (S 20098) is a novel antidepressant drug with melatonin receptor agonist and 5-HT(2C) receptor antagonist properties, but actual mechanisms underlying its antidepressant action are unknown. Because functional desensitization of 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) occurs after chronic a...

journal_title：Neuropharmacology

authors： Hanoun N,Mocaër E,Boyer PA,Hamon M,Lanfumey L

更新日期：2004-09-01 00:00:00

abstract：:Chlorpromazine, given either subcutaneously (0.375 mg/kg) or unilaterally into the preoptic/anterior hypothalamic area through a chronically implanted cannula (20 micrograms), was found to enhance the hypothermic response to delta-9-tetrahydrocannabinol (THC; 5 mg/kg i.p.) in unrestrained adult male MF1 mice, kept at ...

journal_title：Neuropharmacology

authors： Pertwee RG,Hedley D,McQueen AS,Gentleman SM

更新日期：1988-02-01 00:00:00

abstract：:Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. Male Wistar rats were exposed to an l-try...

journal_title：Neuropharmacology

authors： Koot S,Zoratto F,Cassano T,Colangeli R,Laviola G,van den Bos R,Adriani W

更新日期：2012-03-01 00:00:00

abstract：:Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...

journal_title：Neuropharmacology

authors： Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

更新日期：2020-07-01 00:00:00

abstract：:Long-term memory formation requires the coordinated regulation of gene expression. Until recently nucleosome remodeling, one of the major epigenetic mechanisms for controlling gene expression, had been largely unexplored in the field of neuroscience. Nucleosome remodeling is carried out by chromatin remodeling complex...

journal_title：Neuropharmacology

authors： Vogel-Ciernia A,Wood MA

更新日期：2014-05-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuropr...

journal_title：Neuropharmacology

authors： Zhou T,Zu G,Zhang X,Wang X,Li S,Gong X,Liang Z,Zhao J

更新日期：2016-02-01 00:00:00

abstract：:For a number of years it has been known that the CNS convulsant picrotoxin inhibits the GABA(A) receptor, an anion-selective member of the ligand-gated ion channel (LGIC) superfamily. PTX also inhibits other anion-selective LGIC members, such as GABA(C), glycine and glutamate-gated Cl(-) channels. In the present repor...

journal_title：Neuropharmacology

authors： Das P,Bell-Horner CL,Machu TK,Dillon GH

更新日期：2003-03-01 00:00:00

abstract：:Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, ...

journal_title：Neuropharmacology

authors： del Castillo C,Morales L,Alguacil LF,Salas E,Garrido E,Alonso E,Pérez-García C

更新日期：2009-07-01 00:00:00

abstract：:Although there is much evidence for a role of GABAB receptors in the pathophysiology of anxiety, the underlying neuronal mechanisms are largely unclear. The GABAB receptor allosteric positive modulator, GS39783, exerts anxiolytic effects without interfering with GABAB-mediated modulation of body temperature, cognitive...

journal_title：Neuropharmacology

authors： Pizzo R,O'Leary OF,Cryan JF

更新日期：2018-07-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained on a working and reference memory task in an eight ar...

journal_title：Neuropharmacology

authors： Zou LB,Yamada K,Tanaka T,Kameyama T,Nabeshima T

更新日期：1998-01-01 00:00:00

abstract：:Benzodiazepine drugs (BZ) are used for anxiety, insomnia, and seizures. They worsen memory, especially in large doses, but the mechanism of this action is uncertain. In micromolar concentrations, benzodiazepines have been shown to reduce long-term potentiation (LTP), which could be a cellular basis for their amnesic a...

journal_title：Neuropharmacology

authors： Evans MS,Viola-McCabe KE

更新日期：1996-03-01 00:00:00

abstract：:Cannabinoid CB2 receptors (CB2Rs) are emerging as important therapeutic targets in brain disorders that typically involve neurometabolic alterations. We here addressed the possible role of CB2Rs in the regulation of glucose uptake in the mouse brain. To that aim, we have undertaken 1) measurement of (3)H-deoxyglucose ...

journal_title：Neuropharmacology

authors： Köfalvi A,Lemos C,Martín-Moreno AM,Pinheiro BS,García-García L,Pozo MA,Valério-Fernandes Â,Beleza RO,Agostinho P,Rodrigues RJ,Pasquaré SJ,Cunha RA,de Ceballos ML

更新日期：2016-11-01 00:00:00

abstract：:Depolarizations provoked by acetylcholine (ACh) and three dicholines, succinylcholine (SCh), glutarylcholine (GCh) and azelainylcholine (AzCh) were measured in normal and 3-7 days denervated muscles of adult, and in normal muscles of 0-27 days old mice and rats. Soleus and flexor digitorum superficialis muscles were m...

journal_title：Neuropharmacology

authors： Lorković H

更新日期：1989-04-01 00:00:00

abstract：:The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-08-01 00:00:00

abstract：:Previously, we have found that activation of mGlu receptors using a group I-specific mGlu receptor agonist, (RS)-3,5-DHPG, can induce long-term depression (LTD) in the CA1 region of the hippocampus and that, once established, this synaptic depression can be reversed by application of the mGlu receptor antagonist, (S)-...

journal_title：Neuropharmacology

authors： Schnabel R,Kilpatrick IC,Collingridge GL

更新日期：1999-10-01 00:00:00

abstract：:Vortioxetine is a multimodal drug that blocks serotonin (5-HT) reuptake and directly modulates 5-HT receptors. The effects of subacute and long-term administration of vortioxetine on various aspects of catecholamine and glutamate systems were investigated using single-unit extracellular recordings and microiontophores...

journal_title：Neuropharmacology

authors： Ebrahimzadeh M,El Mansari M,Blier P

更新日期：2018-01-01 00:00:00

abstract：:Methylphenidate (MPD), or Ritalin, is a psychostimulant that is prescribed for an extended period of time to children and adolescents with attention deficit hyperactivity disorder. Adolescence is a time of critical brain maturation and development, and the drug exposure during this time could lead to lasting changes i...

journal_title：Neuropharmacology

authors： Lee MJ,Yang PB,Wilcox VT,Burau KD,Swann AC,Dafny N

更新日期：2009-09-01 00:00:00