Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat.

abstract：:Limited information exists on the link between purinergic class P2X7 receptors (P2X7Rs) and calcium ion channels in epilepsy; no data has been reported regarding the interaction between P2X7Rs and T-type calcium ion channels in epilepsy. Thus, this study is an evaluation of the role that T-type calcium ion channels pl...

journal_title：Neuropharmacology

authors： Arslan G,Avci B,Kocacan SE,Rzayev E,Ayyildiz M,Agar E

更新日期：2019-05-01 00:00:00

abstract：:It has been hypothesized that Acetyl-L-Carnitine (ALC) contributes to mitochondrial ATP production through maintenance of key mitochondrial proteins and protects mitochondria against oxidative stress. We have investigated the role of ALC on the expression of two forms of synaptic plasticity in the striatum: (i) the ph...

journal_title：Neuropharmacology

authors： Bagetta V,Barone I,Ghiglieri V,Di Filippo M,Sgobio C,Bernardi G,Calabresi P,Picconi B

更新日期：2008-08-01 00:00:00

abstract：:Chronic nicotine administration in animals, and smoking in humans, causes up-regulation of α4β2* neuronal nicotinic receptors (nAChRs), which has been hypothesized to contribute to the addictive actions of nicotine. We used a rat model to test whether such up-regulatory effects differ in adolescents versus adults, and...

journal_title：Neuropharmacology

authors： Hoegberg BG,Lomazzo E,Lee NH,Perry DC

更新日期：2015-12-01 00:00:00

abstract：:Antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRI) act as indirect agonists of serotonin (5-HT) receptors. Although these drugs produce a rapid blockade of serotonin transporters (SERTs) in vitro, several weeks of treatment are necessary to observe clinical benefits. This paradox has not been solve...

journal_title：Neuropharmacology

authors： Deltheil T,Guiard BP,Cerdan J,David DJ,Tanaka KF,Repérant C,Guilloux JP,Coudoré F,Hen R,Gardier AM

更新日期：2008-11-01 00:00:00

abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

journal_title：Neuropharmacology

authors： Dourish CT,Herbert EN,Iversen SD

更新日期：1989-12-01 00:00:00

abstract：:Group III metabotropic glutamate receptors (mGluR4,7,8) are widely distributed in the basal ganglia. Injection of group III mGluR agonists into the striatopallidal complex alleviates parkinsonian symptoms in 6-hydroxydopamine-treated rats. In vitro rodent studies have suggested that this may be partly due to modulatio...

journal_title：Neuropharmacology

authors： Bogenpohl J,Galvan A,Hu X,Wichmann T,Smith Y

更新日期：2013-03-01 00:00:00

abstract：:Small doses of clonidine probably induce hypoactivity (a distinct form of sedation) by stimulating presynaptic alpha 2-adrenoceptors. This was attenuated by injection of 0.1-10 mg/kg of thyrotropin releasing hormone (TRH) or its biologically stable analogues, CG3509, CG3703 and RX77368, when these were given 10 min be...

journal_title：Neuropharmacology

authors： Heal DJ,Stoodley N,Elliott JM,Marsden CA,Bennett GW,Youdim MB

更新日期：1987-04-01 00:00:00

abstract：:The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-...

journal_title：Neuropharmacology

authors： Sanna MD,Ghelardini C,Thurmond RL,Masini E,Galeotti N

更新日期：2017-03-01 00:00:00

abstract：:Tilia species are well known around the world for their properties in traditional medicine. Antinociceptive activity of hexane, methanol and aqueous extracts from Tilia americana var. mexicana inflorescences was evaluated in the pain-induced functional impairment model in rats (PIFIR). A preliminar 300 mg/kg dosage of...

journal_title：Neuropharmacology

authors： Martínez AL,González-Trujano ME,Aguirre-Hernández E,Moreno J,Soto-Hernández M,López-Muñoz FJ

更新日期：2009-02-01 00:00:00

abstract：:In the present study, we investigated the effects of N(G)-nitro-L-arginine (L-NAME), an inhibitor of nitric oxide synthase, on repeated cerebral ischemia-induced impairment of spatial memory of the 8-arm radial maze in rats. Repeated ischemia (10 min ischemia x 2 times with 1 h interval) impaired the spatial memory in...

journal_title：Neuropharmacology

authors： Mishima K,Pu F,Kaneko T,Egashira N,Iwasaki K,Fujiwara M

更新日期：2003-03-01 00:00:00

abstract：:3,4-Methlylenedioxymethamphetamine (MDMA) administration (4 x 15 mg/kg) on a single day has been shown to cause path integration deficits in rats. While most animal experiments focus on single binge-type models of MDMA use, many MDMA users take the drug on a recurring basis. The purpose of this study was to compare th...

journal_title：Neuropharmacology

authors： Skelton MR,Able JA,Grace CE,Herring NR,Schaefer TL,Gudelsky GA,Vorhees CV,Williams MT

更新日期：2008-12-01 00:00:00

abstract：:Extracts of the skin of Pseudophryne coriacea displayed a powerful stimulant action on the leech helical muscle, both in vitro and in vivo. In the isolated dorsal muscle, the extract caused the appearance of vigorous phasic movements, accompanied by rapid increase in tonus, up to intense spasm. Hyoscine, physostigmine...

journal_title：Neuropharmacology

authors： Falconieri Erspamer G,Farruggia G

更新日期：1986-08-01 00:00:00

abstract：:Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We have developed a novel hydantoin compound (HA) using comparative molecular field analysis (CoMFA) and evaluated its effects on hNa(v)1.2 channels. Both DPH and HA demonstrated affinity for rest...

journal_title：Neuropharmacology

authors： Lenkowski PW,Batts TW,Smith MD,Ko SH,Jones PJ,Taylor CH,McCusker AK,Davis GC,Hartmann HA,White HS,Brown ML,Patel MK

更新日期：2007-03-01 00:00:00

abstract：:A functional balance between excitatory and inhibitory control over dopamine (DA)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin(2C) receptor (5-HT(2C)R) located within the ventral tegmental area and the nucleus accumbens (NAc). The 5-HT(2C)R located in the medial prefrontal cor...

journal_title：Neuropharmacology

authors： Leggio GM,Cathala A,Moison D,Cunningham KA,Piazza PV,Spampinato U

更新日期：2009-02-01 00:00:00

abstract：:In the rat subthalamic nucleus, which plays a critical role in the control of motor behaviour, specific binding of [3H]-prazosin was detected by radioligand binding to homogenates and by autoradiography in slices. [3H]-Prazosin binding to homogenates (Bmax 71 +/- 5 fmol/mg protein; Kd 0.27 +/- 0.05 nM) was competed fo...

journal_title：Neuropharmacology

authors： Arcos D,Sierra A,Nuñez A,Flores G,Aceves J,Arias-Montaño JA

更新日期：2003-12-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a crucial signaling molecule involved in several physiological and pathological processes. Nonetheless, the role of this gasotransmitter in the pathogenesis and treatment of neuropathic pain is controversial. The aim of the present study was to investigate the pain relieving profile of a seri...

journal_title：Neuropharmacology

authors： Di Cesare Mannelli L,Lucarini E,Micheli L,Mosca I,Ambrosino P,Soldovieri MV,Martelli A,Testai L,Taglialatela M,Calderone V,Ghelardini C

更新日期：2017-07-15 00:00:00

abstract：:Drugs that alter the function of gamma-aminobutyric acid (GABA) neurotransmission seem to reduce cocaine reinforcement, and as such may be useful in pharmacologically treating cocaine addiction. In the present experiment, the anti-cocaine effects of CGP 44532, a phosphinic acid analogue of GABA, and a highly selective...

journal_title：Neuropharmacology

authors： Dobrovitsky V,Pimentel P,Duarte A,Froestl W,Stellar JR,Trzcińska M

更新日期：2002-04-01 00:00:00

abstract：:Adolescence is a critical period for postnatal brain maturation and a time during which there is increased susceptibility to developing emotional and cognitive-related disorders. Exercise during adulthood has been shown to increase hippocampal plasticity and enhance cognition. However, the impact of exercise initiated...

journal_title：Neuropharmacology

authors： O'Leary JD,Hoban AE,Cryan JF,O'Leary OF,Nolan YM

更新日期：2019-02-01 00:00:00

abstract：:Amphetamine-type stimulants (ATS) are the second most consumed illicit drug worldwide and lack good treatments for associated substance use disorders, lagging behind other addictive drugs. For this reason, a deeper understanding of the pharmacodynamics of ATS is required. The present study seeks to determine amphetami...

journal_title：Neuropharmacology

authors： Garton DR,Ross SG,Maldonado-Hernández R,Quick M,Lasalde-Dominicci JA,Lizardi-Ortiz JE

更新日期：2019-01-01 00:00:00

abstract：:The influence of naloxone (a narcotic antagonist), bicuculline (a GABA antagonist), phentolamine (an alpha-blocking agent), propranolol (a beta-adrenergic blocking agent), haloperidol (a dopaminergic blocking agent), methysergide (a serotonergic blocking agent) and atropine (a muscarinic blocking agent), on the antino...

journal_title：Neuropharmacology

authors： Foong FW,Satoh M

更新日期：1984-06-01 00:00:00

abstract：:Methamphetamine is a neurotoxic drug of abuse known to cause cell death both in vitro and in vivo. Nevertheless, the molecular and cellular mechanisms involved in this process remain to be clarified. Herein, we show that methamphetamine-induced apoptosis is associated with early (2 h) overexpression of bax, decreases ...

journal_title：Neuropharmacology

authors： Deng X,Cai NS,McCoy MT,Chen W,Trush MA,Cadet JL

更新日期：2002-05-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:Based on significant amount of evidence, it is now generally believed, that one underlying cause for neurodegenerative diseases, could be dysregulation in inflammatory processes. The actual mechanisms involved are not yet well understood. Several studies have demonstrated the potent analgesic and anti-inflammatory act...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Jabbur SJ,Dardenne M,Saadé NE

更新日期：2011-02-01 00:00:00

abstract：:Nitric oxide synthase (NOS) enzyme activity was determined in a comprehensive selection of regions of the rat brain. The effects of lateral ventricular administration of N omega-nitro-L-arginine (L-NA, 30 micrograms) and its methyl ester (L-NAME, 3-100 micrograms) on NOS activity were examined in the ipsilateral and c...

journal_title：Neuropharmacology

authors： Salter M,Duffy C,Garthwaite J,Strijbos PJ

更新日期：1995-06-01 00:00:00

abstract：:The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine...

journal_title：Neuropharmacology

authors： Nabeshima T,Hiramatsu M,Furukawa H,Kameyama T

更新日期：1985-08-01 00:00:00

abstract：:Heterogeneous binding interactions of cerebellar GABA(A) receptors were investigated with GABA agonists and neurosteroids. GABA(A) receptors of rat cerebellum were labelled with [(3)H]ethynylbicycloorthobenzoate (EBOB), a convulsant radioligand. Saturation analysis revealed a homogenous, nanomolar population of [(3)H]...

journal_title：Neuropharmacology

authors： Maksay G,Bíró T

更新日期：2005-09-01 00:00:00

abstract：:In low cerveau isolé transected rats, the effects of microiontophoretic application of putative serotonin 5-HT1A and 5-HT1B agonists on the spontaneous firing rate of CA1 pyramidal cells were compared to those of 5-HT. In contrast to the large current-dependent suppression of unit activity observed with 5-HT, the 5-HT...

journal_title：Neuropharmacology

authors： Sprouse JS,Aghajanian GK

更新日期：1988-07-01 00:00:00

abstract：:The hippocampal slice is a popular model system in which to study the cellular properties of long-term potentiation (LTP). Synaptogenesis induced by exposure to ice-cold artificial cerebrospinal fluid (ACSF), however, raises the concern that morphological correlates of LTP might be obscured, especially in mature slice...

journal_title：Neuropharmacology

authors： Bourne JN,Kirov SA,Sorra KE,Harris KM

更新日期：2007-01-01 00:00:00

abstract：:The properties of central ATP-mediated synaptic currents were studied using whole-cell patch-clamp recording in rat medial habenula slices. Release was shown to be calcium dependent with a Hill coefficient of approximately 2. The voltage dependence of synaptic current amplitudes was approximately linear. Some reductio...

journal_title：Neuropharmacology

authors： Edwards FA,Robertson SJ,Gibb AJ

更新日期：1997-09-01 00:00:00

abstract：:Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation ...

journal_title：Neuropharmacology

authors： Yanai J,Rogel-Fuchs Y,Pick CG,Slotkin T,Seidler FJ,Zahalka EA,Newman ME

更新日期：1993-02-01 00:00:00