The interaction between P2X7Rs and T-type calcium ion channels in penicillin-induced epileptiform activity.

abstract：:Disruptions in synaptic plasticity in the dorsal striatum may contribute to the pathophysiology underlying Parkinson's disease. Here we report a novel, chemically-induced form of plasticity induced by application of the potassium channel blocker tetraethylammonium (TEA) in the dorsolateral striatum of the adult rat. T...

journal_title：Neuropharmacology

authors： Norman ED,Egli RE,Colbran RJ,Winder DG

更新日期：2005-02-01 00:00:00

abstract：:Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...

journal_title：Neuropharmacology

authors： Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

更新日期：2009-03-01 00:00:00

abstract：:Glutamic acid is the major excitatory amino acid of the central nervous system which interacts with two receptor families, the ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGluRs) are coupled to G proteins and can be divided into three subgroups based on their sequence homolog...

journal_title：Neuropharmacology

authors： Emile L,Mercken L,Apiou F,Pradier L,Bock MD,Menager J,Clot J,Doble A,Blanchard JC

更新日期：1996-05-01 00:00:00

abstract：:The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although...

journal_title：Neuropharmacology

authors： Segi-Nishida E,Sukeno M,Imoto Y,Kira T,Sakaida M,Tsuchiya S,Sugimoto Y,Okuno Y

更新日期：2013-08-01 00:00:00

abstract：:The uptake of norepinephrine into cortical punches from the brain of the rat was studied in the presence of buffer and plasma from patients containing bupropion and its metabolites. Even though bupropion and its metabolite (compound II) were equipotent in inhibiting the uptake of NE in buffer, compound II was twice as...

journal_title：Neuropharmacology

authors： Perumal AS,Smith TM,Suckow RF,Cooper TB

更新日期：1986-02-01 00:00:00

abstract：:The loci coeruleus of freely moving cats were perfused bilaterally with acetylcholine at a dose of 0.001 microgram/microliter per min, while the animals were recorded polygraphically. The controls consisted of experiments in which no perfusions were done, and experiments in which the loci coeruleus were perfused bilat...

journal_title：Neuropharmacology

authors： Masserano JM,King C

更新日期：1982-11-01 00:00:00

abstract：:The present study evaluated whether hypolocomotion elicited by subcutaneous administration of the non-specific 5-HT/preferential 5-HT(2C) receptor agonist mCPP during novelty exposure was due to an enhanced anxiety-like state. The effects of mCPP on exploratory behavior during exposure to a new environment (novelty) w...

journal_title：Neuropharmacology

authors： Stiedl O,Misane I,Koch M,Pattij T,Meyer M,Ogren SO

更新日期：2007-03-01 00:00:00

abstract：:5-HT(1A) receptors are implicated in the modulation of cognitive processes including encoding of fear learning. However, their exact role has remained unclear due to contrasting contributions of pre- vs. postsynaptic 5-HT(1A) receptors. Therefore, their role in fear conditioning was studied in mice using the selective...

journal_title：Neuropharmacology

authors： Youn J,Misane I,Eriksson TM,Millan MJ,Ogren SO,Verhage M,Stiedl O

更新日期：2009-10-01 00:00:00

abstract：:Endocannabinoids are suggested to control pain, even though their clinical use is not fully validated and the underlying mechanisms are incompletely understood. To clarify the targets of endocannabinoid actions, we studied how activation of the endocannabinoid CB1 receptor (CB1R) affects neuronal responses in two in v...

journal_title：Neuropharmacology

authors： Eroli F,Loonen ICM,van den Maagdenberg AMJM,Tolner EA,Nistri A

更新日期：2018-03-15 00:00:00

abstract：:The effects of chronic treatment with haloperidol on [3H]PK 11195 binding and labelling of the peripheral-type benzodiazepine receptor (PBR) in the rat brain and peripheral tissues were investigated using an in vitro receptor binding technique. The intraperitoneal injection with haloperidol (0.3 or 1.0 mg/kg) for 21 d...

journal_title：Neuropharmacology

authors： Kurumaji A,Kaneko K,Toru M

更新日期：1996-01-01 00:00:00

abstract：:Electrophysiological studies suggest that 5-HT autoreceptor desensitization may be responsible for the delayed clinical efficacy of some antidepressant drugs, such as selective 5-HT reuptake inhibitors (SSRI) and certain MAO inhibitors (MAOI). In the present study we have used in vivo microdialysis to test this hypoth...

journal_title：Neuropharmacology

authors： Hjorth S,Auerbach SB

更新日期：1994-03-01 00:00:00

abstract：:Group III metabotropic glutamate receptors (mGluR4,7,8) are widely distributed in the basal ganglia. Injection of group III mGluR agonists into the striatopallidal complex alleviates parkinsonian symptoms in 6-hydroxydopamine-treated rats. In vitro rodent studies have suggested that this may be partly due to modulatio...

journal_title：Neuropharmacology

authors： Bogenpohl J,Galvan A,Hu X,Wichmann T,Smith Y

更新日期：2013-03-01 00:00:00

abstract：:Mice were injected bilaterally into the septum with 6-hydroxydopamine and 6 weeks later the hippocampi were assayed for activity of choline acetyltransferase, muscarinic receptor binding capabilities and for formation of inositol phosphate in response to direct (carbachol) or presynaptically elicited (K+) stimulation ...

journal_title：Neuropharmacology

authors： Yanai J,Rogel-Fuchs Y,Pick CG,Slotkin T,Seidler FJ,Zahalka EA,Newman ME

更新日期：1993-02-01 00:00:00

abstract：:Anxiety and depression are considered as stress-related disorders, which present considerable sex differentiation. In animal models of anxiety and depression sex differences have been described and linked to the sexually dimorphic hypothalamus-pituitary-adrenals (HPA) axis. The present study aimed to adjust corticoste...

journal_title：Neuropharmacology

authors： Kokras N,Dalla C,Sideris AC,Dendi A,Mikail HG,Antoniou K,Papadopoulou-Daifoti Z

更新日期：2012-01-01 00:00:00

abstract：:Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and LY2365109 {[2-(4-benzo[1,3]dioxol-5-yl-2-tert-butylphenoxy)ethyl]-methylamino}-acetic acid in...

journal_title：Neuropharmacology

authors： Perry KW,Falcone JF,Fell MJ,Ryder JW,Yu H,Love PL,Katner J,Gordon KD,Wade MR,Man T,Nomikos GG,Phebus LA,Cauvin AJ,Johnson KW,Jones CK,Hoffmann BJ,Sandusky GE,Walter MW,Porter WJ,Yang L,Merchant KM,Shannon HE,S

更新日期：2008-10-01 00:00:00

abstract：:A major mouse model widely adopted in recent years to induce pronounced ethanol intake is the ethanol vapor model known as "CIE" or "Chronic Intermittent Ethanol." One critical question concerning this model is whether the rapid induction of high blood ethanol levels for such short time periods is sufficient to induce...

journal_title：Neuropharmacology

authors： Renteria R,Maier EY,Buske TR,Morrisett RA

更新日期：2017-01-01 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8), caerulein and seven out of ten analogues of caerulein produced in mice, after subcutaneous administration, a dose-dependent drop in rectal temperature. For the hypothermic effect, i.e. a decrease in temperature by at least 1.5 degree C, ED50's were estimated with these peptides and...

journal_title：Neuropharmacology

authors： Zetler G

更新日期：1982-08-01 00:00:00

abstract：:We have recently reported that intraperitoneal (i.p.) injection of thymulin at low doses (50 ng) resulted in thermal and mechanical hyperalgesia and upregulation of the level of interleukin-1beta in the liver. In this study, we demonstrate that such injections of thymulin result in a significant elevation in the level...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Dardenne M,Kanaan SA,Atweh SF,Jabbur SJ,Saadé NE

更新日期：2000-07-10 00:00:00

abstract：:The content of authentic 3H-spiroperidol and of its metabolites was measured in brain regions of rat, guinea pig and mouse receiving tracer doses of 3H-spiroperidol intravenously (0.2 to 0.5 micrograms/kg). The time course of the 3H-spiroperidol content of various brain regions shows that a steady state was maintained...

journal_title：Neuropharmacology

authors： Ferrero P,Vaccarino F,Guidotti A,Costa E,Di Chiro G

更新日期：1983-06-01 00:00:00

abstract：:There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the long-term consequences of anesthetic ketamine on rats' non-spatial and spatial recognition memory; b...

journal_title：Neuropharmacology

authors： Pitsikas N,Boultadakis A

更新日期：2009-07-01 00:00:00

abstract：:Dopamine (DA)-replacement therapy utilizing l-DOPA is the gold standard symptomatic treatment for Parkinson's disease (PD). A critical complication of this therapy is the development of l-DOPA-induced dyskinesia (LID). The endogenous opioid peptides, including enkephalins and dynorphin, are co-transmitters of dopamine...

journal_title：Neuropharmacology

authors： Flores AJ,Bartlett MJ,Root BK,Parent KL,Heien ML,Porreca F,Polt R,Sherman SJ,Falk T

更新日期：2018-10-01 00:00:00

abstract：:In this study, we analysed the implication of superoxide (O2-.) and nitric oxide (NO.) free radicals and their resulting product peroxynitrite (ONOO-) in the neuronal death induced by the activation of the glutamatergic receptor of the N-methyl-D-aspartate (NMDA) subtype using cultured cerebellar granule cells. The NO...

journal_title：Neuropharmacology

authors： Lafon-Cazal M,Culcasi M,Gaven F,Pietri S,Bockaert J

更新日期：1993-11-01 00:00:00

abstract：:6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array...

journal_title：Neuropharmacology

authors： Witkin JM,Li J,Gilmour G,Mitchell SN,Carter G,Gleason SD,Seidel WF,Eastwood BJ,McCarthy A,Porter WJ,Reel J,Gardinier KM,Kato AS,Wafford KA

更新日期：2017-11-01 00:00:00

abstract：:Participation of opiate, serotonergic and noradrenergic components in the antinociceptive action of intrathecally administered morphine was evaluated by measuring the ability of subcutaneously administered doses of naloxone, methysergide and phentolamine to alter analgesia. Morphine produced a dose-dependent elevation...

journal_title：Neuropharmacology

authors： Crisp T,Smith DJ

更新日期：1989-10-01 00:00:00

abstract：:An infusion of dopamine for 13 days into the nucleus accumbens of rat caused biphasic peaks of hyperactivity responding during infusion and an enhanced locomotor responsiveness to the dopamine agonist (-)N-n-propylnorapomorphine [(-)NPA] after the infusion when rats where initially preselected as low activity responde...

journal_title：Neuropharmacology

authors： Costall B,Domeney AM,Naylor RJ

更新日期：1985-03-01 00:00:00

abstract：:We generated transgenic (Thy1alpha6) mice in which the GABA(A) receptor alpha6 subunit, whose expression is usually confined to granule cells of cerebellum and cochlear nuclei, is ectopically expressed under the control of the pan-neuronal Thy-1.2 promoter. Strong Thy1alpha6 subunit expression occurs, for example, in ...

journal_title：Neuropharmacology

authors： Wisden W,Cope D,Klausberger T,Hauer B,Sinkkonen ST,Tretter V,Lujan R,Jones A,Korpi ER,Mody I,Sieghart W,Somogyi P

更新日期：2002-09-01 00:00:00

abstract：:Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clustered at the edges of postsynaptic densities of excitatory ...

journal_title：Neuropharmacology

authors： Meera P,Dodson PD,Karakossian MH,Otis TS

更新日期：2005-11-01 00:00:00

abstract：:JAK4D, a first-in-class thyrotropin-releasing hormone (TRH)-based compound, is a prospective therapeutic candidate offering a multifaceted approach to treating neurodegeneration and other CNS conditions. The purpose of these studies was to determine the ability of JAK4D to bind to TRH receptors in human brain and to e...

journal_title：Neuropharmacology

authors： Kelly JA,Boyle NT,Cole N,Slator GR,Colivicchi MA,Stefanini C,Gobbo OL,Scalabrino GA,Ryan SM,Elamin M,Walsh C,Vajda A,Goggin MM,Campbell M,Mash DC,O'Mara SM,Brayden DJ,Callanan JJ,Tipton KF,Della Corte L,Hunter J,

更新日期：2015-02-01 00:00:00

abstract：:Dopamine (DA) efflux from terminals of the mesocorticolimbic system is linked to incentive motivation, drug dependency and schizophrenia. Strategies for modulating dopaminergic activity have focused on transmitter receptors or the DA transporter, not on DA release, largely due to lack of systemically available drugs a...

journal_title：Neuropharmacology

authors： Belardetti F,Ahn S,So K,Snutch TP,Phillips AG

更新日期：2009-05-01 00:00:00

abstract：:GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GABA binding site affects this transition. However, description of flippi...

journal_title：Neuropharmacology

authors： Kisiel M,Jatczak M,Brodzki M,Mozrzymas JW

更新日期：2018-03-15 00:00:00