Cholecystokinin octapeptide, caerulein and caerulein analogues: effects on thermoregulation in the mouse.

abstract：:The mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonergic (5-HT) toxicity remain unclear. It has been suggested that MDMA depletes 5-HT by increasing brain tyrosine levels, which via non-enzymatic hydroxylation leads to DA-derived free radical formation. Because this hypothesis assumes th...

journal_title：Neuropharmacology

authors： Goñi-Allo B,Puerta E,Mathúna BO,Hervias I,Lasheras B,de la Torre R,Aguirre N

更新日期：2008-04-01 00:00:00

abstract：:Trazodone is one of the most commonly prescribed medicines for treating depression and insomnia. However, the pharmacological mechanism of action underlying trazodone's unique effects is unclear. Despite its nanomolar affinity for 5HT(2A) receptors, histamine(1) receptors and alpha(1) adrenoceptors the drug is given a...

journal_title：Neuropharmacology

authors： Kraus RL,Li Y,Jovanovska A,Renger JJ

更新日期：2007-08-01 00:00:00

abstract：:Nerve growth factor (NGF) holds a pivotal role in brain development and maintenance, been also involved in the pathophysiology of neurodegenerative diseases. Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing pho...

journal_title：Neuropharmacology

authors： Pediaditakis I,Efstathopoulos P,Prousis KC,Zervou M,Arévalo JC,Alexaki VI,Nikoletopoulou V,Karagianni E,Potamitis C,Tavernarakis N,Chavakis T,Margioris AN,Venihaki M,Calogeropoulou T,Charalampopoulos I,Gravanis A

更新日期：2016-12-01 00:00:00

abstract：:Studies described here tested the hypothesis that phosphodiesterase 10A inhibition by a selective antagonist, MP-10, activates the dopamine D2 receptor expressing medium spiny neurons to a greater extent than the D1 receptor expressing neurons. We used regional pattern of c-Fos induction in the neostriatal subregions ...

journal_title：Neuropharmacology

authors： Wilson JM,Ogden AM,Loomis S,Gilmour G,Baucum AJ 2nd,Belecky-Adams TL,Merchant KM

更新日期：2015-12-01 00:00:00

abstract：:Anesthetics exposure to neonates leads to impairment of hippocampal synaptic plasticity and cognitive functions later in life. This phenomenon complies with the concept of metaplasticity: a priming stimulation can affect induction of synaptic plasticity mins or days later. We aimed to understand whether small conducta...

journal_title：Neuropharmacology

authors： Yu X,Zhang F,Shi J

更新日期：2018-10-01 00:00:00

abstract：:Chronic administration of desipramine resulted in a significant decrease in the degree of stimulation of production of cyclic AMP by noradrenaline, isoproterenol and forskolin in slices of the cerebral cortex of the rat. In preparations of membranes from similarly treated animals, GppNHp- and forskolin-stimulated aden...

journal_title：Neuropharmacology

authors： Newman ME,Lipot M,Lerer B

更新日期：1987-08-01 00:00:00

abstract：:Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...

journal_title：Neuropharmacology

authors： Sonsalla PK,Gibb JW,Hanson GR

更新日期：1986-11-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the control of cellular excitability. HCN2, a subgroup of the HCN family channels, are heavily expressed in small dorsal root ganglia (DRG) neurons and their activation seems to be important in the determination of pain intensity. In...

journal_title：Neuropharmacology

authors： Resta F,Masi A,Sili M,Laurino A,Moroni F,Mannaioni G

更新日期：2016-09-01 00:00:00

abstract：:The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest...

journal_title：Neuropharmacology

authors： Long SK,Evans RH,Cull L,Krijzer F,Bevan P

更新日期：1988-05-01 00:00:00

abstract：:The electrophysiological properties and cataleptogenicity of YM-09151-2 (N-[(2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl]-5-chloro-2-methoxy-4-methylaminobenzamide) were studied in the cat. This drug inhibited the EEG arousal response to electrical stimulation of the mesencephalic reticular formation with the same pote...

journal_title：Neuropharmacology

authors： Yamamoto M,Usuda S,Tachikawa S,Maeno H

更新日期：1982-10-01 00:00:00

abstract：:Tarantula Chilobrachys jingzhao is one of the most venomous species distributed in China. In this study, we have isolated and characterized a novel neurotoxin named Jingzhaotoxin-IX (JZTX-IX) from the venom of the tarantula. JZTX-IX is a C-terminally amidated peptide composed of 35 amino acid residues. The toxin shows...

journal_title：Neuropharmacology

authors： Deng M,Kuang F,Sun Z,Tao H,Cai T,Zhong L,Chen Z,Xiao Y,Liang S

更新日期：2009-08-01 00:00:00

abstract：:Receptor-mediated signal transduction is thought to play an important role in neuronal differentiation and the modification of synaptic connections during brain development. The intracellular signalling molecule phospholipase C-beta1 (PLC-beta1), which is activated via specific neurotransmitter receptors, has recently...

journal_title：Neuropharmacology

authors： Hannan AJ,Kind PC,Blakemore C

更新日期：1998-04-01 00:00:00

abstract：:Administration of 0.13% lead acetate solution as drinking fluid to breeding mice was without significant effect on the numbers of live or dead births or on weight of pups at 1 day. The appearance of fur was delayed and the body weights at 21 days and 31-38 weeks were smaller than in controls. On weaning, the treated o...

journal_title：Neuropharmacology

authors： Donald JM,Cutler MG,Moore MR,Bradley M

更新日期：1986-02-01 00:00:00

abstract：:The patterns of spontaneous firing recorded from 25 cells in slice preparations of rat cerebral cortex were characterised using inter-spike interval plots (ISI). Histograms of the ISI showed two peaks having modal values of 20 and 82ms, corresponding to episodes of high frequency bursts of action potentials, and a low...

journal_title：Neuropharmacology

authors： Bagust J,Nagi I,Kerkut GA

更新日期：1985-06-01 00:00:00

abstract：:The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...

journal_title：Neuropharmacology

authors： Lopatář J,Dale N,Frenguelli BG

更新日期：2015-06-01 00:00:00

abstract：:The bed nucleus of the stria terminalis was first described nearly a century ago and has since emerged as a region central to motivated behavior and affective states. The last several decades have firmly established a role for the BNST in drug-associated behavior and implicated this region in addiction-related process...

journal_title：Neuropharmacology

authors： Vranjkovic O,Pina M,Kash TL,Winder DG

更新日期：2017-08-01 00:00:00

abstract：:The kainate-type of ionotropic glutamate receptors are assembled from a combination of five different pore-forming subunits (GluK1-5), which confer distinct functional and pharmacological properties. These receptors are also modulated by co-assembly with the auxiliary subunits Neto1 and Neto2. To determine the impact ...

journal_title：Neuropharmacology

authors： Fisher JL

更新日期：2015-12-01 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:The effect of neurotrophic factors on apoptosis induced by ionomycin, a potent Ca2+ ionophore, was investigated using cultured cortical neurons from embryonic rats. Brain-derived neurotophic factor (BDNF) and neurotrophin-3 (NT-3) prevented the ionomycin-mediated cell death in a dose-dependent manner. In contrast to t...

journal_title：Neuropharmacology

authors： Takei N,Tanaka O,Endo Y,Lindholm D,Hatanaka H

更新日期：1999-02-01 00:00:00

abstract：:Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexa...

journal_title：Neuropharmacology

authors： Barthó L,Holzer P,Lembeck F

更新日期：1987-11-01 00:00:00

abstract：:In this study, we investigated whether resveratrol could protect against ischemic injury by improving brain energy metabolism and alleviating oxidative stress. Male rats were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol treatment (resveratrol-treated group, 30 m...

journal_title：Neuropharmacology

authors： Li H,Yan Z,Zhu J,Yang J,He J

更新日期：2011-02-01 00:00:00

abstract：:Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...

journal_title：Neuropharmacology

authors： Lamont JS,Kula NS,Baldessarini RJ

更新日期：1987-06-01 00:00:00

abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

journal_title：Neuropharmacology

authors： Dafny N

更新日期：1983-05-01 00:00:00

abstract：:Prenatal hypoxia ischemia is a major cause of neurodevelopmental impairment in the newborn, associated with risk for motor, behavioral and cognitive impaired outcomes. We used an established mouse model of maternal hypoxia to examine the immediate molecular responses of signaling pathways associated with both cell dea...

journal_title：Neuropharmacology

authors： Golan MH,Mane R,Molczadzki G,Zuckerman M,Kaplan-Louson V,Huleihel M,Perez-Polo JR

更新日期：2009-10-01 00:00:00

abstract：:Disruptions in synaptic plasticity in the dorsal striatum may contribute to the pathophysiology underlying Parkinson's disease. Here we report a novel, chemically-induced form of plasticity induced by application of the potassium channel blocker tetraethylammonium (TEA) in the dorsolateral striatum of the adult rat. T...

journal_title：Neuropharmacology

authors： Norman ED,Egli RE,Colbran RJ,Winder DG

更新日期：2005-02-01 00:00:00

abstract：:Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pat...

journal_title：Neuropharmacology

authors： Ren Z,Sahir N,Murakami S,Luellen BA,Earnheart JC,Lal R,Kim JY,Song H,Luscher B

更新日期：2015-01-01 00:00:00

abstract：:Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be particularly susceptible to cravings and other components of the disease. While many brain regions are involved in AUD etiology, proper prefrontal cortex (PFC) function is particularly important for top-down craving management and the m...

journal_title：Neuropharmacology

authors： Joffe ME,Winder DG,Conn PJ

更新日期：2020-11-01 00:00:00

abstract：:We have previously demonstrated that an acute dose of Δ9-tetrahydrocanninbinol (THC), administered prior to extinction learning, facilitates later recall of extinction learning and modulates the underlying neural circuitry, including the ventromedial prefrontal cortex (vmPFC), hippocampus (HPC), and amygdala (AMYG). I...

journal_title：Neuropharmacology

authors： Rabinak CA,Peters C,Marusak HA,Ghosh S,Phan KL

更新日期：2018-12-01 00:00:00

abstract：:Rats were pretreated twice daily for six consecutive days with either saline or 1.0, 5.0, or 10.0 mg/kg (+)-amphetamine. On the following day, single-unit recording techniques were used to identify serotonin-containing neurons in the dorsal raphe nucleus (DRN). Pretreatment with amphetamine did not alter the mean spon...

journal_title：Neuropharmacology

authors： Heidenreich BA,Basse-Tomusk AE,Rebec GV

更新日期：1987-07-01 00:00:00

abstract：:Epidemiological studies have reported that cigarette smoking may protect from neurodegenerative diseases such as Parkinson's disease. These protective effects are thought to be mediated by nicotine. Recent data showed that nicotine significantly decreases respiratory control ratio (RCR) and superoxide anion generation...

journal_title：Neuropharmacology

authors： Cormier A,Morin C,Zini R,Tillement JP,Lagrue G

更新日期：2003-04-01 00:00:00