A potent factor in extracts of the skin of the Australian frog, Pseudophryne coriacea--II. Stimulation of the leech helical muscle in vitro and in vivo.

abstract：:Nicotine elicits several behavioural effects on mood as well as on stress and anxiety processes. Recently, it was found that the higher order components of the sensory cortex, such as the secondary auditory cortex Te2, are essential for the long-term storage of remote fear memories. Therefore, in the present study, we...

journal_title：Neuropharmacology

authors： Cambiaghi M,Grosso A,Renna A,Concina G,Sacchetti B

更新日期：2015-12-01 00:00:00

abstract：:Similar to patients with ventromedial prefrontal cortex (VMPC) lesions, substance abusers show altered decision-making, characterized by a tendency to choose the immediate reward, at the expense of negative future consequences. The somatic marker model proposes that decision-making depends on neural substrates that re...

journal_title：Neuropharmacology

authors： Verdejo-García A,Bechara A

更新日期：2009-01-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the long-term consequences of anesthetic ketamine on rats' non-spatial and spatial recognition memory; b...

journal_title：Neuropharmacology

authors： Pitsikas N,Boultadakis A

更新日期：2009-07-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of histamine in chloral anaesthetized rats exposed to an ambient temperature of 22 C elicited a rise in their colonic temperature associated with a shivering. This effect was shared by the H2 receptor agonists dimaprit and impromidine. Impromidine is, in this respect, a ...

journal_title：Neuropharmacology

authors： Colboc O,Protais P,Costentin J

更新日期：1982-01-01 00:00:00

abstract：:A functional balance between excitatory and inhibitory control over dopamine (DA)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin(2C) receptor (5-HT(2C)R) located within the ventral tegmental area and the nucleus accumbens (NAc). The 5-HT(2C)R located in the medial prefrontal cor...

journal_title：Neuropharmacology

authors： Leggio GM,Cathala A,Moison D,Cunningham KA,Piazza PV,Spampinato U

更新日期：2009-02-01 00:00:00

abstract：:Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment of generalized anxiety disorder in Humans. However, because only few animal models display overt anxious-like behavior, detailed preclinical studies of the anxiolytic properties of antidepressants are still lacking. Here, we stu...

journal_title：Neuropharmacology

authors： Guilloux JP,David DJ,Xia L,Nguyen HT,Rainer Q,Guiard BP,Repérant C,Deltheil T,Toth M,Hen R,Gardier AM

更新日期：2011-09-01 00:00:00

abstract：:The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was ev...

journal_title：Neuropharmacology

authors： Higgs J,Wasowski C,Loscalzo LM,Marder M

更新日期：2013-09-01 00:00:00

abstract：:To identify the enzymes involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at CA1 synapses of two-week-old rats we have tested various kinase inhibitors. Surprisingly, given the large body of evidence supporting a role for calcium/calmodulin-dependent protein kinas...

journal_title：Neuropharmacology

authors： Wikström MA,Matthews P,Roberts D,Collingridge GL,Bortolotto ZA

更新日期：2003-11-01 00:00:00

abstract：:Calcium currents in the inferior colliculus (IC) are thought to play an important role in ethanol withdrawal hyperexcitability. Here, we report on the modulation of Ca(2+) channel currents in acutely dissociated IC neurons of rats, exhibiting higher incidence of audiogenic seizures when subjected to ethanol withdrawal...

journal_title：Neuropharmacology

authors： N'Gouemo P,Morad M

更新日期：2003-09-01 00:00:00

abstract：:It has been reported that application of 1S,3R-1-aminocyclopentane 1,3-dicarboxylic acid (ACPD) in vitro triggers a slow-onset potentiation in the hippocampal CA1 region. This study examined the effect of ACPD in the CA1 of freely moving rats. No effect on fEPSP baseline recordings occurred at 40 and 400 microM/5 micr...

journal_title：Neuropharmacology

authors： Manahan-Vaughan D,Reymann KG

更新日期：1995-08-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:Guinea-pigs, chronically exposed to simulated high altitude of 6000 m, showed alterations in some, but not all, neurotransmitter-receptor systems. Thus, peripheral (cardiac) beta-adrenergic receptors were decreased in numbers (Bmax) with an increased affinity although no alterations in endogenous cardiac norepinephrin...

journal_title：Neuropharmacology

authors： Light KE,Dick TE,Hughes MJ

更新日期：1984-02-01 00:00:00

abstract：:In rat brain, the number of beta-adrenoceptors and activity of noradrenaline-dependent adenylate cyclase were examined after treatment with desipramine (7.5 mg kg-1 day-1) for three days alone or in combination with the alpha 2-adrenoceptor antagonist, yohimbine (2 mg kg-1 12 hr-1), or with phenoxybenzamine (7.5 mg kg...

journal_title：Neuropharmacology

authors： Campbell IC,McKernan RM,Smokcum RW,Stephenson JD,Weeramanthri TB

更新日期：1984-12-01 00:00:00

abstract：:Intrapritoneal injection of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) to rats significantly reduced the density of alpha 1- and alpha 2-adrenoceptors in the cerebral cortex, without affecting beta-adrenoceptors. A single dose of EEDQ markedly accelerated the development of downregulation of beta-adrenocept...

journal_title：Neuropharmacology

authors： Pilc A,Vetulani J

更新日期：1990-05-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the dopamine D(2)/D(3) receptor agonist, PD128,907 (0.16 mg/kg, i.p.), which suppressed frontocortical release of dopamine (DA) but not 5-HT. The selective 5-HT1A receptor agonists, 8-OH-DPAT and flesinoxan, dose-dependently generalized to PD128...

journal_title：Neuropharmacology

authors： Dekeyne A,Rivet JM,Gobert A,Millan MJ

更新日期：2001-06-01 00:00:00

abstract：:We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be us...

journal_title：Neuropharmacology

authors： Bussey TJ,Holmes A,Lyon L,Mar AC,McAllister KA,Nithianantharajah J,Oomen CA,Saksida LM

更新日期：2012-03-01 00:00:00

abstract：:Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...

journal_title：Neuropharmacology

authors： Simon OR,Schramm LP

更新日期：1983-03-01 00:00:00

abstract：:Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exert beneficial effects in models of cardiac and renal disease, as well as hemorrhagic stroke. Here, we hypothesize that C21 may exer...

journal_title：Neuropharmacology

authors： Joseph JP,Mecca AP,Regenhardt RW,Bennion DM,Rodríguez V,Desland F,Patel NA,Pioquinto DJ,Unger T,Katovich MJ,Steckelings UM,Sumners C

更新日期：2014-06-01 00:00:00

abstract：:The effects of increased membrane cholesterol on the potentiation of GABA(A) currents by pregnanolone (5beta-pregnan-3alpha-ol-20-one), allopregnanolone (5alpha-pregnan-3alpha-ol-20-one), alphaxalone (5alpha-pregnan-3alpha-ol-11,20-dione) and propofol were investigated in acutely dissociated rat hippocampal neurones u...

journal_title：Neuropharmacology

authors： Sooksawate T,Simmonds MA

更新日期：1998-09-01 00:00:00

abstract：:The ability of specific dopamine (DA) receptor agonists and antagonists to modify the release and metabolism of DA in the ventrolateral striatum of awake rats was assessed using in vivo microdialysis. The specific DA D2 receptor antagonist, raclopride (0.1, 0.5 and 2.0 mg/kg, i.p.), dose-dependently increased release ...

journal_title：Neuropharmacology

authors： See RE,Sorg BA,Chapman MA,Kalivas PW

更新日期：1991-12-01 00:00:00

abstract：:Administration of stimulant and non-stimulant drugs that inhibit monoamine reuptake is known to improve cognitive and behavioral symptoms of attention deficit hyperactivity disorder (ADHD). Although this may reflect acute actions of these drugs, clinical observations suggest that prolonged treatment with these agents ...

journal_title：Neuropharmacology

authors： Seu E,Jentsch JD

更新日期：2009-12-01 00:00:00

abstract：:The effect of the D1 dopamine receptor antagonist SCH 23390 on sleep patterns was studied in rats by means of the electroencephalographic (EEG) technique. Haloperidol, an established D2 antagonist neuroleptic, was used for comparison. Over a very small dose range (0.003-0.03 mg/kg, subcutaneously), SCH 23390 significa...

journal_title：Neuropharmacology

authors： Trampus M,Ongini E

更新日期：1990-10-01 00:00:00

abstract：:A neuronal nicotinic acetylcholine receptor (nAChR) subunit, Dalpha4, has been identified and cloned from the fruit fly Drosophila melanogaster, together with several alternatively spliced transcripts. Intron-exon boundaries within the gene encoding Dalpha4 (nAcRalpha-80B) have been identified by comparison of cDNA an...

journal_title：Neuropharmacology

authors： Lansdell SJ,Millar NS

更新日期：2000-10-01 00:00:00

abstract：:Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring spike and wave discharges (SWDs) in the WAG/Rij rat model of absence e...

journal_title：Neuropharmacology

authors： D'Amore V,Santolini I,van Rijn CM,Biagioni F,Molinaro G,Prete A,Conn PJ,Lindsley CW,Zhou Y,Vinson PN,Rodriguez AL,Jones CK,Stauffer SR,Nicoletti F,van Luijtelaar G,Ngomba RT

更新日期：2013-03-01 00:00:00

abstract：:Nerve growth factor (NGF) holds a pivotal role in brain development and maintenance, been also involved in the pathophysiology of neurodegenerative diseases. Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing pho...

journal_title：Neuropharmacology

authors： Pediaditakis I,Efstathopoulos P,Prousis KC,Zervou M,Arévalo JC,Alexaki VI,Nikoletopoulou V,Karagianni E,Potamitis C,Tavernarakis N,Chavakis T,Margioris AN,Venihaki M,Calogeropoulou T,Charalampopoulos I,Gravanis A

更新日期：2016-12-01 00:00:00

abstract：:Upon retrieval, an aversive memory can undergo destabilization and reconsolidation. A traumatic-like memory, however, may be resistant to this process. The present study sought to contribute with a strategy to overcome this potential issue by investigating whether generalized fear retrieval is susceptible to destabili...

journal_title：Neuropharmacology

authors： Marin FN,Franzen JM,Troyner F,Molina VA,Giachero M,Bertoglio LJ

更新日期：2020-12-15 00:00:00

abstract：:The role of monamine oxidase (MAO), type A and B, on the deamination of dopamine in the striatum, nucleus accumbens and frontal cortex of the rat was studied. Levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) tissue were quantified by means of high pressure liquid chromatography wi...

journal_title：Neuropharmacology

authors： Garrett MC,Soares-da-Silva P

更新日期：1990-10-01 00:00:00

abstract：:Effective medical treatment for impulsive aggression and several impulse control disorders is needed. Disinhibited, impulsive behavior of e.g. murderers, arsonists, suicidal patients, and patients suffering from antisocial personality or substance abuse disorders has been associated with signs of a deficiency in brain...

journal_title：Neuropharmacology

authors： Söderpalm B,Svensson AI

更新日期：1999-12-01 00:00:00