New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats.

abstract：:Transmission at the parallel fibre-Purkinje neurone synapse of the cerebellum can be depressed by a number of presynaptic receptors: endocannabinoid (CB1), metabotropic glutamate (mGluR4), adenosine (A1) and GABA (GABA(B)), which have been implicated in both short- and long-term synaptic plasticity. Stimulation of par...

journal_title：Neuropharmacology

authors： Bellamy TC

更新日期：2007-02-01 00:00:00

abstract：:To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...

journal_title：Neuropharmacology

authors： Nesil T,Kanit L,Collins AC,Pogun S

更新日期：2011-07-01 00:00:00

abstract：:Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...

journal_title：Neuropharmacology

authors： Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

更新日期：2016-04-01 00:00:00

abstract：:Adenosine A(2A) agonists are known to induce catalepsy and inhibit dopamine mediated motor hyperactivity. An antagonistic interaction between adenosine A(2A) and dopamine D(2) receptors is known to regulate GABA-mediated neurotransmission in striatopallidal neurons. Stimulation of adenosine A(2A) and dopamine D(2) rec...

journal_title：Neuropharmacology

authors： Khisti RT,Chopde CT,Abraham E

更新日期：2000-04-03 00:00:00

abstract：BACKGROUND:After neonatal ventral hippocampal lesions (NVHLs), adult rats exhibit evidence of neural processing deficits relevant to schizophrenia, including reduced prepulse inhibition (PPI) of acoustic startle and impaired sensory processing. In intact rats, the regulation of PPI by the ventral hippocampus (VH) is me...

journal_title：Neuropharmacology

authors： Swerdlow NR,Powell SB,Breier MR,Hines SR,Light GA

更新日期：2013-12-01 00:00:00

abstract：:Dopamine (DA) contributes to the regulation of voluntary movement, and a deficiency in DAergic neurons leads to movement disorders. The objective of this study was to examine the neuroprotective effect of DA D2-like receptor agonist, lisuride, and the role of DA receptors in this protection. Treatment with lisuride al...

journal_title：Neuropharmacology

authors： Kim M,Lee S,Cho J,Kim G,Won C

更新日期：2017-05-01 00:00:00

abstract：:In this study, the P2 receptor-mediated modulation of [3H]glutamate and [3H]noradrenaline release were examined in rat spinal cord slices. Adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), and 2-methylthioadenosine 5'-diphosphate (2-MeSADP) decreased the electrical stimulation-evoked [3H]glutamate efflu...

journal_title：Neuropharmacology

authors： Heinrich A,Kittel A,Csölle C,Sylvester Vizi E,Sperlágh B

更新日期：2008-02-01 00:00:00

abstract：:The pathogenesis of Alzheimer's disease (AD) is characterized by cerebral deposits of amyloid beta-peptides (A beta) and neurofibrillary tangles which are surrounded by inflammatory cells. Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays the onset of the dise...

journal_title：Neuropharmacology

authors： Hirohata M,Ono K,Naiki H,Yamada M

更新日期：2005-12-01 00:00:00

abstract：:The role of orexin receptors in the nucleus accumbens shell in rat turning behaviour of rats was studied. Unilateral injection of neither the orexin 1 and 2 receptor agonist orexin A (2 microg) nor the orexin 1 receptor antagonist SB 334867 (20 ng) into the nucleus accumbens shell elicited turning behaviour. Unilatera...

journal_title：Neuropharmacology

authors： Kotani A,Ikeda H,Koshikawa N,Cools AR

更新日期：2008-03-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00

abstract：:Clinically, amantadine and memantine are drugs whose therapeutic utility is linked to their ability to block N-methyl-D-aspartate receptors (NMDARs) in a voltage-dependent manner. Nevertheless many studies that have characterized the pharmacological actions of amantadine and memantine have done so in the absence of ph...

journal_title：Neuropharmacology

authors： Otton HJ,Lawson McLean A,Pannozzo MA,Davies CH,Wyllie DJ

更新日期：2011-02-01 00:00:00

abstract：:Alcohol damages the developing brain and can lead to fetal alcohol syndrome. One of alcohol's most important neuropathologic effects is neuronal death. As neurons mature, they become less vulnerable to alcohol-induced death because they acquire a protective signaling pathway, mediated by nitric oxide (NO). This pathwa...

journal_title：Neuropharmacology

authors： Bonthius DJ,Luong T,Bonthius NE,Hostager BS,Karacay B

更新日期：2009-03-01 00:00:00

abstract：:JAK4D, a first-in-class thyrotropin-releasing hormone (TRH)-based compound, is a prospective therapeutic candidate offering a multifaceted approach to treating neurodegeneration and other CNS conditions. The purpose of these studies was to determine the ability of JAK4D to bind to TRH receptors in human brain and to e...

journal_title：Neuropharmacology

authors： Kelly JA,Boyle NT,Cole N,Slator GR,Colivicchi MA,Stefanini C,Gobbo OL,Scalabrino GA,Ryan SM,Elamin M,Walsh C,Vajda A,Goggin MM,Campbell M,Mash DC,O'Mara SM,Brayden DJ,Callanan JJ,Tipton KF,Della Corte L,Hunter J,

更新日期：2015-02-01 00:00:00

abstract：:The elevation of extracellular 5-HT after systemic administration of 5-HT reuptake inhibiting drugs is strongly potentiated by agents capable of blocking 5-HT1A autoreceptors in the midbrain raphe. The present in vivo microdialysis study was aimed at assessing the relative importance of 5-HT reuptake inhibition versus...

journal_title：Neuropharmacology

authors： Hjorth S,Westlin D,Bengtsson HJ

更新日期：1997-04-01 00:00:00

abstract：:Compound IG20 is a newly synthesised sulphated glycolipid that promotes neuritic outgrowth and myelinisation, at the time it causes the inhibition of glial proliferation and facilitates exocytosis in chromaffin cells. Here we have shown that IG20 at 0.3-10 μM afforded neuroprotection in rat hippocampal slices stressed...

journal_title：Neuropharmacology

authors： Punzón E,García-Alvarado F,Maroto M,Fernández-Mendívil C,Michalska P,García-Álvarez I,Arranz-Tagarro JA,Buendia I,López MG,León R,Gandía L,Fernández-Mayoralas A,García AG

更新日期：2017-04-01 00:00:00

abstract：:A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

journal_title：Neuropharmacology

authors： Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

更新日期：2019-03-01 00:00:00

abstract：:The effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-HT1A, 5-HT1B, 5-HT2A and 5-HT3, in various brain regions in the rat. In addition, t...

journal_title：Neuropharmacology

authors： Gozlan H,Laporte AM,Thibault S,Schechter LE,Bolaños F,Hamon M

更新日期：1994-03-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00

abstract：:Research on the nicotinic cholinergic system function in the brain was previously mainly derived from animal studies, yet, research in humans is growing. Up to date, findings allow significant advances on the understanding of nicotinic cholinergic effects on human cognition, emotion and behavior using a range of funct...

journal_title：Neuropharmacology

authors： Nees F

更新日期：2015-09-01 00:00:00

abstract：:We have recently reported that intraperitoneal (i.p.) injection of thymulin at low doses (50 ng) resulted in thermal and mechanical hyperalgesia and upregulation of the level of interleukin-1beta in the liver. In this study, we demonstrate that such injections of thymulin result in a significant elevation in the level...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Dardenne M,Kanaan SA,Atweh SF,Jabbur SJ,Saadé NE

更新日期：2000-07-10 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) mania patients exhibit poor cognition and reward-seeking/hypermotivation, negatively impacting a patient's quality of life. Current treatments (e.g., lithium), do not treat such deficits. Treatment development has been limited due to a poor understanding of the neural mechanisms underly...

journal_title：Neuropharmacology

authors： Milienne-Petiot M,Kesby JP,Graves M,van Enkhuizen J,Semenova S,Minassian A,Markou A,Geyer MA,Young JW

更新日期：2017-02-01 00:00:00

abstract：:The contribution of metabotropic glutamate receptors (mGluRs) to the modulation of nociception by the periaqueductal gray (PAG) matter was investigated in mice. Intra-PAG microinjection of (IS,3R)-ACPD, an agonist of groups I and II mGluRs, as well as (S)-3,5-DHPG, a selective agonist of group I mGluRs, increased the ...

journal_title：Neuropharmacology

authors： Maione S,Marabese I,Leyva J,Palazzo E,de Novellis V,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:We have previously demonstrated that an acute dose of Δ9-tetrahydrocanninbinol (THC), administered prior to extinction learning, facilitates later recall of extinction learning and modulates the underlying neural circuitry, including the ventromedial prefrontal cortex (vmPFC), hippocampus (HPC), and amygdala (AMYG). I...

journal_title：Neuropharmacology

authors： Rabinak CA,Peters C,Marusak HA,Ghosh S,Phan KL

更新日期：2018-12-01 00:00:00

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:Small doses of clonidine probably induce hypoactivity (a distinct form of sedation) by stimulating presynaptic alpha 2-adrenoceptors. This was attenuated by injection of 0.1-10 mg/kg of thyrotropin releasing hormone (TRH) or its biologically stable analogues, CG3509, CG3703 and RX77368, when these were given 10 min be...

journal_title：Neuropharmacology

authors： Heal DJ,Stoodley N,Elliott JM,Marsden CA,Bennett GW,Youdim MB

更新日期：1987-04-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA, half-maximal inhibitory concentration, IC50 = 9.9 microM) and (-)-baclofen (IC50 = 4.5 microM) but not 10(-4) M muscimol, exerted a presynaptic inhibitory effect on cholinergic transmission in field-stimulated guinea-pig taenia coli preparations, in vitro. The antagonism by 10(-5) M (1S,...

journal_title：Neuropharmacology

authors： Rónai AZ,Kardos J,Simonyi M

更新日期：1987-11-01 00:00:00

abstract：:Neurotrophins jointly exert various functions in the nervous system, including neuronal differentiation, survival, and regulation of synaptic plasticity. However, the functional interactions of neurotrophins or mechanisms through which neurotrophins regulate each other are still not clear. In the present study, brain-...

journal_title：Neuropharmacology

authors： Xiong H,Futamura T,Jourdi H,Zhou H,Takei N,Diverse-Pierluissi M,Plevy S,Nawa H

更新日期：2002-06-01 00:00:00

abstract：:Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation provides a potential therapeutic strategy for cognitive disorders involving aberrant neuroplastic...

journal_title：Neuropharmacology

authors： Fass DM,Reis SA,Ghosh B,Hennig KM,Joseph NF,Zhao WN,Nieland TJ,Guan JS,Kuhnle CE,Tang W,Barker DD,Mazitschek R,Schreiber SL,Tsai LH,Haggarty SJ

更新日期：2013-01-01 00:00:00

abstract：:Stress-related psychiatric disorders, including anxiety, are complex diseases that have genetic, and environmental causes. Stressful experiences increase the release of prefrontal amygdala neurotransmitters, a response that is relevant to cognitive, emotional, and behavioral coping. Moreover, exposure to stress elicit...

journal_title：Neuropharmacology

authors： Andolina D,Di Segni M,Bisicchia E,D'Alessandro F,Cestari V,Ventura A,Concepcion C,Puglisi-Allegra S,Ventura R

更新日期：2016-08-01 00:00:00

abstract：:The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have previously been identified in the genetically epilepsy-prone rat (GEPR) brain. In vitro binding of [3H]8-OH-DPAT (0.16-10.3 nM) to 5-HT1A receptor sites was foun...

journal_title：Neuropharmacology

authors： Statnick MA,Dailey JW,Jobe PC,Browning RA

更新日期：1996-01-01 00:00:00