Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors.

abstract：:Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp down the KP. Flux is the major determinant of kynurenine metabolite formation and is more effective than induction of hepatic Trp 2,3-dioxygen...

journal_title：Neuropharmacology

authors： Badawy AA

更新日期：2017-01-01 00:00:00

abstract：:Palatability driven feeding and voluntary physical activity are mediated by and influence similar neural mechanisms, notably through the actions of opioids within the nucleus accumbens. Recent studies suggest that access to a voluntary running wheel results in sex dependent behavioral and physiological adaptations rel...

journal_title：Neuropharmacology

authors： Lee JR,Tapia MA,Weise VN,Bathe EL,Vieira-Potter VJ,Booth FW,Will MJ

更新日期：2019-09-01 00:00:00

abstract：:The homotrimeric P2X3 receptor, one of the seven members of the ATP-gated P2X receptor family, plays a crucial role in sensory neurotransmission. P2X3 receptor antagonists have been identified as promising drugs to treat chronic cough and are suggested to offer pain relief in chronic pain such as neuropathic pain. Her...

journal_title：Neuropharmacology

authors： Obrecht AS,Urban N,Schaefer M,Röse A,Kless A,Meents JE,Lampert A,Abdelrahman A,Müller CE,Schmalzing G,Hausmann R

更新日期：2019-11-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor beta/delta (PPAR-β/δ), a nuclear receptor acting as a transcription factor, was shown to be protective in various models of neurological diseases. However, there is no information about the role of PPAR-β/δ as well as its molecular mechanisms in neonatal hypoxia...

journal_title：Neuropharmacology

authors： Gamdzyk M,Doycheva DM,Malaguit J,Enkhjargal B,Tang J,Zhang JH

更新日期：2018-09-15 00:00:00

abstract：:Neural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote aversion, while dopamine was viewed as interacting with reward behavior, and KOR acti...

journal_title：Neuropharmacology

authors： Pirino BE,Spodnick MB,Gargiulo AT,Curtis GR,Barson JR,Karkhanis AN

更新日期：2020-12-15 00:00:00

abstract：:The contribution of central PGE(2) levels to the nociceptive response in rats was assessed and the effects of the selective cPLA(2)α inhibitor efipladib, and pain therapies of different classes on these responses was determined. An inflammatory pain model was optimized in rats so that PGE(2) levels in the cerebrospina...

journal_title：Neuropharmacology

authors： Nickerson-Nutter CL,Goodwin D,Shen MW,Damphousse C,Duan W,Samad TA,McKew JC,Lee KL,Zaleska MM,Mollova N,Clark JD

更新日期：2011-03-01 00:00:00

abstract：:The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-08-01 00:00:00

abstract：:The aim of the present study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, ad...

journal_title：Neuropharmacology

authors： Ingram N,Martin S,Wang JH,van der Laan S,Loiacono R,van den Buuse M

更新日期：2005-01-01 00:00:00

abstract：:SB-204269 (trans-(+)-6-acetyl-4S-(4-fluorobenzoylamino)-3, 4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3R-ol) shows anticonvulsant activity in a range of animal seizure models, with a high therapeutic index and a lack of side-effects. We have previously reported the characterisation of a novel binding site for [(3)H]-SB-2...

journal_title：Neuropharmacology

authors： Herdon HJ,Godfrey FM,Chan WN

更新日期：2000-09-01 00:00:00

abstract：:The aim of this study was to determine the effects of sex, corticosterone and oestradiol-17 beta on the hypothermia and motor behavioural syndrome induced by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. The hypothermia, but not the behavioural syndrome induced by 8-OH-DPAT...

journal_title：Neuropharmacology

authors： Young AH,Dow RC,Goodwin GM,Fink G

更新日期：1993-07-01 00:00:00

abstract：:We have previously demonstrated that an acute dose of Δ9-tetrahydrocanninbinol (THC), administered prior to extinction learning, facilitates later recall of extinction learning and modulates the underlying neural circuitry, including the ventromedial prefrontal cortex (vmPFC), hippocampus (HPC), and amygdala (AMYG). I...

journal_title：Neuropharmacology

authors： Rabinak CA,Peters C,Marusak HA,Ghosh S,Phan KL

更新日期：2018-12-01 00:00:00

abstract：:Human studies suggest that a variety of prenatal stressors are related to high risk for cognitive and behavioral abnormalities associated with psychiatric illness (Markham and Koenig, 2011). Recently, a downregulation in the expression of GABAergic genes (i.e., glutamic acid decarboxylase 67 and reelin) associated wit...

journal_title：Neuropharmacology

authors： Matrisciano F,Tueting P,Dalal I,Kadriu B,Grayson DR,Davis JM,Nicoletti F,Guidotti A

更新日期：2013-05-01 00:00:00

abstract：:In this study, we investigated whether resveratrol could protect against ischemic injury by improving brain energy metabolism and alleviating oxidative stress. Male rats were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol treatment (resveratrol-treated group, 30 m...

journal_title：Neuropharmacology

authors： Li H,Yan Z,Zhu J,Yang J,He J

更新日期：2011-02-01 00:00:00

abstract：:The pathogenesis of Alzheimer's disease (AD) is characterized by cerebral deposits of amyloid beta-peptides (A beta) and neurofibrillary tangles which are surrounded by inflammatory cells. Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays the onset of the dise...

journal_title：Neuropharmacology

authors： Hirohata M,Ono K,Naiki H,Yamada M

更新日期：2005-12-01 00:00:00

abstract：:Vasopressin V1a receptors in the rat brain have been studied for their role in modulating aggression and anxiety. In the current study blood-oxygen-level-dependent (BOLD) functional MRI was used to test whether V1a receptors modulate neural processing in the maternal brain when dams are exposed to a male intruder. Pri...

journal_title：Neuropharmacology

authors： Caffrey MK,Nephew BC,Febo M

更新日期：2010-01-01 00:00:00

abstract：:The role of AMPA receptors in cochlear synaptic transmission and excitotoxicity was investigated by comparing the actions of a selective AMPA antagonist GYKI 53784 (LY303070) with additional AMPA/kainate antagonists, GYKI 52466 and DNQX, and the NMDA antagonist, D-AP5, in several electrophysiological, neurotoxicologic...

journal_title：Neuropharmacology

authors： Ruel J,Bobbin RP,Vidal D,Pujol R,Puel JL

更新日期：2000-08-23 00:00:00

abstract：:Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (alpha(2)-AR) subtypes in these functions is not clear. We investigated the role of alpha(2C)-ARs in the modulation of baseline cortical EEG activity and EEG responses to the alpha(2)-AR selective agonist, de...

journal_title：Neuropharmacology

authors： Puoliväli J,Björklund M,Holmberg M,Ihalainen JA,Scheinin M,Tanila H

更新日期：2002-12-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small molecule morantel (Mor...

journal_title：Neuropharmacology

authors： Short CA,Cao AT,Wingfield MA,Doers ME,Jobe EM,Wang N,Levandoski MM

更新日期：2015-04-01 00:00:00

abstract：:A unique type of limbic seizures, maximal dentate activation, was used to examine the effects of cholinergic and adrenergic agents on the processes involved in epileptogenesis. The time to onset of maximal dentate activation was used to monitor the initiation of seizures while the duration of maximal dentate activatio...

journal_title：Neuropharmacology

authors： Stringer JL,Lothman EW

更新日期：1991-01-01 00:00:00

abstract：:Slow excitatory postsynaptic currents (EPSCs) mediated by metabotropic glutamate receptors (mGlu receptors) have been reported in several neuronal subtypes, but their presence in hippocampal pyramidal neurons remains elusive. Here we find that in CA1 pyramidal neurons a slow EPSC is induced by repetitive stimulation w...

journal_title：Neuropharmacology

authors： Sheng N,Yang J,Silm K,Edwards RH,Nicoll RA

更新日期：2017-03-15 00:00:00

abstract：:Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intr...

journal_title：Neuropharmacology

authors： Gareri P,Condorelli D,Belluardo N,Russo E,Loiacono A,Barresi V,Trovato-Salinaro A,Mirone MB,Ferreri Ibbadu G,De Sarro G

更新日期：2004-12-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:In this study, a high throughput screening system was set up to identify D5 receptor agonists-027075. Then, a series of behavior tests were used to evaluate the beneficial effects of 027075 in Aβ1-42-induced mice model including morris water maze, passive avoidance, active avoidance, open field and step-down test. The...

journal_title：Neuropharmacology

authors： Shen L,Yan M,He L

更新日期：2016-06-01 00:00:00

abstract：:Desensitization of the nicotinic acetylcholine receptor (nAChR) containing the β2 subunit is a potentially critical mechanism underlying the body weight (BW) reducing effects of nicotine. The purpose of this study was a) to determine the α subunit(s) that partners with the β2 subunit to form the nAChR subtype that end...

journal_title：Neuropharmacology

authors： Dezfuli G,Olson TT,Martin LM,Keum Y,Siegars BA,Desai A,Uitz M,Sahibzada N,Gillis RA,Kellar KJ

更新日期：2020-04-01 00:00:00

abstract：:Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors. This form of neural inhibition was presumed to be mediated by synaptic receptors, however recent evidence has highlighted a previously unappreciated role for extrasynaptic GABA(A) receptors...

journal_title：Neuropharmacology

authors： Wafford KA,van Niel MB,Ma QP,Horridge E,Herd MB,Peden DR,Belelli D,Lambert JJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Atypical antipsychotic drugs, particularly olanzapine, represent a mainstay in the treatment of psychoses; however, their use is commonly associated with weight gain and diabetes. The aim of this study was to determine whether combined administration of olanzapine and zonisamide can be used to prevent olanza...

journal_title：Neuropharmacology

authors： Stefanidis A,Watt MJ,Cowley MA,Oldfield BJ

更新日期：2017-09-01 00:00:00

abstract：:Morphine alters affective states in humans and produces reinforcement in humans and animal subjects. Therefore, the present study was designed to determine whether morphine affected the functional activity in brain structures involved in emotion and motivation. Since opioid-induced analgesia largely reflects an influe...

journal_title：Neuropharmacology

authors： Cohen SR,Kimes AS,London ED

更新日期：1991-02-01 00:00:00

abstract：:Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pat...

journal_title：Neuropharmacology

authors： Ren Z,Sahir N,Murakami S,Luellen BA,Earnheart JC,Lal R,Kim JY,Song H,Luscher B

更新日期：2015-01-01 00:00:00