Reduction of the amplitude of preovulatory LH and FSH surges and of the amplitude of the in vitro GnRH-induced LH release by substance P. Reversal of the effect by RP 67580.

abstract：:Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced in the lateral hypothalamus and zona incerta that increases food intake. The neuronal pathways and behavioral mechanisms mediating the orexigenic effects of MCH are poorly understood, as is the extent to which MCH-mediated feeding outcomes are ...

journal_title：Neuropharmacology

authors： Terrill SJ,Subramanian KS,Lan R,Liu CM,Cortella AM,Noble EE,Kanoski SE

更新日期：2020-11-01 00:00:00

abstract：:BMS-763534 is a potent (CRF(1) IC(50) = 0.4 nM) and selective (>1000-fold selectivity vs. all other sites tested) CRF(1) receptor antagonist (pA2 = 9.47 vs. CRF(1)-mediated cAMP production in Y79 cells). BMS-763534 accelerated the dissociation of (125)I-o-CRF from rat frontal cortex membrane CRF(1) receptors consisten...

journal_title：Neuropharmacology

authors： Lodge NJ,Lelas S,Li YW,Molski T,Grace J,Sivarao DV,Post-Munson D,Healy F,Bronson JJ,Hartz R,Macor JE,Zaczek R

更新日期：2013-04-01 00:00:00

abstract：:After a focal ischemic lesion in the hand representation of the primary motor cortex in squirrel monkeys, manual skill was mildly and transiently impaired on a reach-and-retrieval task. Performance was significantly poorer during weeks 1 and 3 post-lesion, but was normal by week 4. An unusual behavioral event was also...

journal_title：Neuropharmacology

authors： Nudo RJ,Friel KM,Delia SW

更新日期：2000-03-03 00:00:00

abstract：:The hypoactivity in rats induced by small doses of apomorphine, injected bilaterally into the nucleus accumbens area of the brain, could be antagonized by pretreatment with the neuroleptic-like neuropeptide des-enkephalin-gamma-endorphin (DE gamma E, beta-endorphin 6-17) as well as with the neuroleptic drugs haloperid...

journal_title：Neuropharmacology

authors： Van Ree JM,Caffé AR,Wolterink G

更新日期：1982-11-01 00:00:00

abstract：:The sleeping time induced by thiopentone in rats was markedly prolonged by the (-)-isomer of propranolol while the (+)-isomer was virtually without effect. Since the two isomers are equipotent in their membrane-stabilizing effects but the (-)-isomer is about seven to ten times more potent than the (+)-isomer in beta-b...

journal_title：Neuropharmacology

authors： Mason ST,Angel A

更新日期：1983-09-01 00:00:00

abstract：OBJECTIVES:To explore the role of 5' adenosine monophosphate-activated protein kinase/sirtuin1-sirtuin3 (AMPK/SIRT1-SIRT3) signaling pathway in behavioral and neuroinflammation/oxidative stress alterations in unpredictable chronic mild stress (UCMS) model mice. METHODS:Male ICR mice weighing 20-22 g were used in this ...

journal_title：Neuropharmacology

authors： Yu X,Hu Y,Huang W,Ye N,Yan Q,Ni W,Jiang X

更新日期：2020-03-15 00:00:00

abstract：:The effect of trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-benzene-acetamide methane sulfonate (U-50,488H), a kappa-opiate agonist-induced tolerance and abstinence on 5-HT1A receptors was determined in regions of the brain and spinal cord of the rat. The administration of U-50,488H (25 mg/kg, i....

journal_title：Neuropharmacology

authors： Reddy VP,Bhargava HN

更新日期：1992-12-01 00:00:00

abstract：:Intensive computerized auditory training results in improved cognition for schizophrenia patients, but participants show variation in their cognitive gains and the biological factors that affect the response to training are unknown. Single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene...

journal_title：Neuropharmacology

authors： Panizzutti R,Hamilton SP,Vinogradov S

更新日期：2013-01-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-...

journal_title：Neuropharmacology

authors： Sanna MD,Ghelardini C,Thurmond RL,Masini E,Galeotti N

更新日期：2017-03-01 00:00:00

abstract：:Of the ionotropic glutamatergic receptors, the NMDA receptor is clearly implicated in the acute and chronic effects of ethanol; however, the role of the AMPA receptor in mediating the effects of ethanol in vivo is as yet unclear. Using mice deficient in the AMPA receptor subunit GluR1 (GluR1-/- mice), we investigated ...

journal_title：Neuropharmacology

authors： Cowen MS,Schroff KC,Gass P,Sprengel R,Spanagel R

更新日期：2003-09-01 00:00:00

abstract：:Midazolam, which induces anaesthesia in humans at intravenous doses of 0.3 mg/kg, did not anaesthetize cats at doses of 20 mg/kg. Nevertheless, intravenous doses as small as 0.3 mg/kg enhanced spinal primary afferent depolarization and presynaptic inhibition of spinal monosynaptic reflexes, and both intravenous and mi...

journal_title：Neuropharmacology

authors： Leah JD,Malik R,Curtis DR

更新日期：1983-12-01 00:00:00

abstract：:Dichlorvos is a synthetic insecticide that belongs to the family of chemically related organophosphate (OP) pesticides. It can be released into the environment as a major degradation product of other OPs, such as trichlorfon, naled, and metrifonate. Dichlorvos exerts its toxic effects in humans and animals by inhibiti...

journal_title：Neuropharmacology

authors： Wani WY,Gudup S,Sunkaria A,Bal A,Singh PP,Kandimalla RJ,Sharma DR,Gill KD

更新日期：2011-12-01 00:00:00

abstract：:The mechanisms underlying the neuroprotective effects of cannabidiol (CBD) were studied in vivo using a hypoxic-ischemic (HI) brain injury model in newborn pigs. One- to two-day-old piglets were exposed to HI for 30 min by interrupting carotid blood flow and reducing the fraction of inspired oxygen to 10%. Thirty minu...

journal_title：Neuropharmacology

authors： Pazos MR,Mohammed N,Lafuente H,Santos M,Martínez-Pinilla E,Moreno E,Valdizan E,Romero J,Pazos A,Franco R,Hillard CJ,Alvarez FJ,Martínez-Orgado J

更新日期：2013-08-01 00:00:00

abstract：:Despite evidence from psychiatry and psychology clinics pointing to altered cognition and decision making following the consumption of cannabis, the effects of cannabis derivatives are still under dispute and the mechanisms of cannabinoid effects on cognition are not known. In this study, we used effort-based and dela...

journal_title：Neuropharmacology

authors： Fatahi Z,Reisi Z,Rainer G,Haghparast A,Khani A

更新日期：2018-05-01 00:00:00

abstract：:In the present study, we investigated the effect of ACPT-I [(1S, 3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid], a blood-brain-barrier permeable agonist of group III mGlu receptor, against oxygen-glucose deprivation (OGD)-evoked neuronal cell death in primary neuronal cell cultures and in the model of transient ...

journal_title：Neuropharmacology

authors： Domin H,Przykaza Ł,Jantas D,Kozniewska E,Boguszewski PM,Śmiałowska M

更新日期：2016-03-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) through the activation of its receptor (TrkB-FL) exert well-described neuroprotective effects playing a major role in hippocampal synaptic transmission and plasticity such as long-term potentiation (LTP), a molecular surrogate for learning and memory. Impairments in BDNF signal...

journal_title：Neuropharmacology

authors： Jerónimo-Santos A,Batalha VL,Müller CE,Baqi Y,Sebastião AM,Lopes LV,Diógenes MJ

更新日期：2014-08-01 00:00:00

abstract：:The intravenous administration of L-5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), p-chloroamphetamine (PCA), LSD and methysergide to acute spinal rats, transected at C1, stimulated the flexor reflexes induced by electrical stimulation applied to the skin of the toe. The enhancement produced...

journal_title：Neuropharmacology

authors： Ono H,Miyamoto M,Kobayashi M,Fukuda H

更新日期：1987-09-01 00:00:00

abstract：:The effect of drugs which down-regulate the function of GABA at the level of the GABA/benzodiazepine receptor complex was studied on the conflict test in the rat. The GABA receptor antagonist, bicuculline, and the blockers of the GABA-receptor-coupled chloride channel, picrotoxin and pentylenetetrazol, produced a dose...

journal_title：Neuropharmacology

authors： Corda MG,Biggio G

更新日期：1986-05-01 00:00:00

abstract：:It has been shown that endogenous adenosine 5'-triphosphate (ATP) as well as its exogenously applied structural analogue, 2-methylthio ATP (2-MeSATP), facilitate the release of dopamine from axon terminals in the rat nucleus accumbens (NAc) by activating ATP-sensitive P2 receptors. In the present study, reversed micro...

journal_title：Neuropharmacology

authors： Krügel U,Kittner H,Franke H,Illes P

更新日期：2001-06-01 00:00:00

abstract：:miRNA-137 is an extremely abundant miRNA in the central nervous system and is thought to be closely related to synaptic plasticity. Here, we report a previously unrecognized role of miRNA-137 in epilepsy. The expression of miRNA-137 was decreased both in patients with temporal lobe epilepsy (TLE) and in two different ...

journal_title：Neuropharmacology

authors： Wang W,Guo Y,He L,Chen C,Luo J,Ma Y,Li J,Yang Y,Yang Q,Du C,Zhang Y,Li Z,Xu X,Tian X,Wang X

更新日期：2018-08-01 00:00:00

abstract：:Research on the nicotinic cholinergic system function in the brain was previously mainly derived from animal studies, yet, research in humans is growing. Up to date, findings allow significant advances on the understanding of nicotinic cholinergic effects on human cognition, emotion and behavior using a range of funct...

journal_title：Neuropharmacology

authors： Nees F

更新日期：2015-09-01 00:00:00

abstract：:The antiepileptic drug, gamma-vinyl GABA (GVG, vigabatrin), is an irreversible inhibitor of GABA-transaminase, the enzyme responsible for the breakdown of GABA. In hippocampal slices prepared from rats pretreated with either an anticonvulsant dose of GVG (1500 mg/kg) or saline, electrophysiological recordings were per...

journal_title：Neuropharmacology

authors： Jackson MF,Esplin B,Capek R

更新日期：2000-01-01 00:00:00

abstract：:Transgenic mice that accumulate Aβ peptides in the CNS are commonly used to interrogate functional consequences of Alzheimer's disease-associated amyloidopathy. In addition to changes to synaptic function, there is also growing evidence that changes to intrinsic excitability of neurones can arise in these models of am...

journal_title：Neuropharmacology

authors： Kerrigan TL,Brown JT,Randall AD

更新日期：2014-04-01 00:00:00

abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

journal_title：Neuropharmacology

authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

更新日期：2020-09-15 00:00:00

abstract：:Bilateral injection of gamma-aminobutyric acid (GABA, 10-300 micrograms) into the substantia nigra (pars reticulata) of rats produced stereotyped sniffing and had an analgesic-like effect on the hot-plate but not on the tail-flick test. These effects of GABA (30 micrograms) were suppressed by simultaneous administrati...

journal_title：Neuropharmacology

authors： Baumeister AA,Hawkins MF,Anderson-Moore LL,Anticich TG,Higgins TD,Griffin P

更新日期：1988-08-01 00:00:00

abstract：:In the present studies, an attempt was made to elucidate the role of endogenous opioid inputs to the depressor region of the caudal ventrolateral medulla in the tonic regulation of arterial pressure and to examine the subtype(s) of receptor underlying any observed effects by use of receptor-specific antagonists. The d...

journal_title：Neuropharmacology

authors： Drolet G,Morilak DA,Chalmers J

更新日期：1991-04-01 00:00:00

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:Stress-related psychiatric disorders, including anxiety, are complex diseases that have genetic, and environmental causes. Stressful experiences increase the release of prefrontal amygdala neurotransmitters, a response that is relevant to cognitive, emotional, and behavioral coping. Moreover, exposure to stress elicit...

journal_title：Neuropharmacology

authors： Andolina D,Di Segni M,Bisicchia E,D'Alessandro F,Cestari V,Ventura A,Concepcion C,Puglisi-Allegra S,Ventura R

更新日期：2016-08-01 00:00:00

abstract：:The monosynaptic reflex (MSR), recorded in vitro from the neonatal rat spinal cord, was depressed by 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists. The results, together with our previous findings, indicate an apparent rank order of potency: 5-carboxamidotryptamine (5-CT) > sumatriptan > methysergide > 5-HT > ...

journal_title：Neuropharmacology

authors： Crick H,Manuel NA,Wallis DI

更新日期：1994-07-01 00:00:00