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Inhibitors of neuropeptide peptidases engaged in pain and drug dependence.

Abstract：

:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of native peptides. These enzymes, in turn, are regulated by inhibitors, which play integral role in controlling many metabolic pathways. Thus, the search for selective inhibitors and detailed knowledge on the mechanisms of binding of these substances to enzymes, could be of importance for designing new pharmacological approaches. The aim of this review is to summarize the current knowledge on the inhibitors of enzymes that convert selected groups of neuropeptides, such as dynorphins, enkephalins, substance P and NPFF fragments. The importance of these substances in pathophysiological processes involved in pain and drug addiction, have been discussed. This article is part of the special issue on Neuropeptides.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Hartman K,Mielczarek P,Smoluch M,Silberring J

doi

10.1016/j.neuropharm.2020.108137

subject

Has Abstract

pub_date

2020-09-15 00:00:00

pages

108137

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(20)30205-7

journal_volume

175

pub_type

杂志文章,评审

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