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Effects of bilateral injection of GABA into the substantia nigra on spontaneous behavior and measures of analgesia.

Abstract：

:Bilateral injection of gamma-aminobutyric acid (GABA, 10-300 micrograms) into the substantia nigra (pars reticulata) of rats produced stereotyped sniffing and had an analgesic-like effect on the hot-plate but not on the tail-flick test. These effects of GABA (30 micrograms) were suppressed by simultaneous administration of a sub-convulsant dose of bicuculline methiodide (100 ng). Significant increases in locomotion occurred when GABA (300 micrograms) was injected along with the inhibitor of GABA-transaminase, d,l-gamma-vinyl-GABA (GVG; 5 micrograms) and the inhibitor of the uptake of GABA, 1-2,4-diaminobutyric acid (DABA; 5 micrograms). No other behavioral effects were observed following injection of GABA into the nigra, either alone or in combination with GVG and DABA. Bilateral injection of bicuculline (100-600 ng) into the nigra had strong convulsant actions. When injected simultaneously with bicuculline, GABA reduced bicuculline-induced seizures. These results are discussed in terms of their relevance to understanding the mechanisms that underlie the behavioral effects produced by injection of muscimol into the nigra.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Baumeister AA,Hawkins MF,Anderson-Moore LL,Anticich TG,Higgins TD,Griffin P

doi

10.1016/0028-3908(88)90097-4

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

817-21

issue

8

eissn

0028-3908

issn

1873-7064

journal_volume

27

pub_type

杂志文章

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