Abstract：
:Discovered and crystallized over sixty years ago, serotonin's important functions in the brain and body were identified over the ensuing years by neurochemical, physiological and pharmacological investigations. This 2008 M. Rapport Memorial Serotonin Review focuses on some of the most recent discoveries involving serotonin that are based on genetic methodologies. These include examples of the consequences that result from direct serotonergic gene manipulation (gene deletion or overexpression) in mice and other species; an evaluation of some phenotypes related to functional human serotonergic gene variants, particularly in SLC6A4, the serotonin transporter gene; and finally, a consideration of the pharmacogenomics of serotonergic drugs with respect to both their therapeutic actions and side effects. The serotonin transporter (SERT) has been the most comprehensively studied of the serotonin system molecular components, and will be the primary focus of this review. We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Murphy DL,Fox MA,Timpano KR,Moya PR,Ren-Patterson R,Andrews AM,Holmes A,Lesch KP,Wendland JRdoi
10.1016/j.neuropharm.2008.08.034subject
Has Abstractpub_date
2008-11-01 00:00:00pages
932-60issue
6eissn
0028-3908issn
1873-7064pii
S0028-3908(08)00380-8journal_volume
55pub_type
历史文章,杂志文章,评审abstract：:Human studies suggest that a variety of prenatal stressors are related to high risk for cognitive and behavioral abnormalities associated with psychiatric illness (Markham and Koenig, 2011). Recently, a downregulation in the expression of GABAergic genes (i.e., glutamic acid decarboxylase 67 and reelin) associated wit...
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doi：10.1016/j.neuropharm.2012.04.013
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2008.05.021
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pub_type： 杂志文章
doi：10.1016/j.neuropharm.2019.01.021
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journal_title：Neuropharmacology
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pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1988-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2018.06.011
更新日期：2018-08-01 00:00:00
