Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.

abstract：:The homotrimeric P2X3 subtype, one of the seven members of the ATP-gated P2X receptor family, plays a role in sensory neurotransmission, including nociception. To overcome the bias resulting from fast desensitization of the P2X3 receptor in dose-response analyses, a non-desensitizing P2X2-X3 receptor chimera has been ...

journal_title：Neuropharmacology

authors： Hausmann R,Bahrenberg G,Kuhlmann D,Schumacher M,Braam U,Bieler D,Schlusche I,Schmalzing G

更新日期：2014-04-01 00:00:00

abstract：:The effects of nefiracetam on GABA-induced chloride currents were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. The dose-response curve for GABA-induced currents was shifted by 16 microM to lower concentrations by 10 microM nefiracetam while the maximal re...

journal_title：Neuropharmacology

authors： Huang CS,Ma JY,Marszalec W,Narahashi T

更新日期：1996-01-01 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidity with other psychiatric and somatic disorders. Commonly used treatments, such as selective serotonin reuptake inhibit...

journal_title：Neuropharmacology

authors： Samuels BA,Leonardo ED,Gadient R,Williams A,Zhou J,David DJ,Gardier AM,Wong EH,Hen R

更新日期：2011-09-01 00:00:00

abstract：:Our recent studies have shown that the neuronal nitric oxide synthase (nNOS) gene is required for the development and persistence of psychomotor sensitization to cocaine in adult but not adolescent male mice (Balda, M.A., Anderson, K.L., Itzhak, Y., 2008. Differential role of the nNOS gene in the development of behavi...

journal_title：Neuropharmacology

authors： Balda MA,Anderson KL,Itzhak Y

更新日期：2009-03-01 00:00:00

abstract：:The effect of sumatriptan, a selective 5-HT1D receptor agent, on extracellular levels of 5-HT in the frontal cortex of the guinea pig was measured by intracerebral dialysis. A constant infusion of sumatriptan (10(-8)-10(-7) M) dose-dependently reduced extracellular levels of 5-HT (e.g. 80 +/- 2% decrease from control ...

journal_title：Neuropharmacology

authors： Sleight AJ,Cervenka A,Peroutka SJ

更新日期：1990-06-01 00:00:00

abstract：:Over the last decade, robust human genetic findings have been instrumental in elucidating the heritable basis of nicotine addiction (NA). They highlight coding and synonymous polymorphisms in a cluster on chromosome 15, encompassing the CHRNA5, CHRNA3 and CHRNB4 genes, coding for three subunits of the nicotinic acetyl...

journal_title：Neuropharmacology

authors： Icick R,Forget B,Cloëz-Tayarani I,Pons S,Maskos U,Besson M

更新日期：2020-10-15 00:00:00

abstract：:In rat brain, the number of beta-adrenoceptors and activity of noradrenaline-dependent adenylate cyclase were examined after treatment with desipramine (7.5 mg kg-1 day-1) for three days alone or in combination with the alpha 2-adrenoceptor antagonist, yohimbine (2 mg kg-1 12 hr-1), or with phenoxybenzamine (7.5 mg kg...

journal_title：Neuropharmacology

authors： Campbell IC,McKernan RM,Smokcum RW,Stephenson JD,Weeramanthri TB

更新日期：1984-12-01 00:00:00

abstract：:Administration of serotonin-enhancing drugs induces a distinctive behavioral syndrome in rodents. We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug. In the current studies, we assessed the drug-induced s...

journal_title：Neuropharmacology

authors： Fox MA,Jensen CL,Gallagher PS,Murphy DL

更新日期：2007-10-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:The antagonist effects of the 4-carboxyphenylglycines: (S)-4-carboxy-3hydroxyphenylglycine (4C3HPG), (S)-4-carboxyphenylglycine (4CPG) and (+)-alpha-methyl-4-carboxyphenylglycine (M4CPG) were compared on functional responses of human metabotropic glutamate receptor (mGluR) subtypes mGluR1 alpha and mGluR5a. These rece...

journal_title：Neuropharmacology

authors： Kingston AE,Burnett JP,Mayne NG,Lodge D

更新日期：1995-08-01 00:00:00

abstract：:Behavioral flexibility is in close proximity to dentate gyrus (DG) function and long-term depression (LTD), but the role of DG LTD in behavioral flexibility has hitherto been unexplored. Although the functions of alpha-Ca2+/calmodulin-dependent protein kinase II (CaMKII) have been studied extensively, the role of βCaM...

journal_title：Neuropharmacology

authors： Yin P,Xu H,Wang Q,Wang J,Yin L,Xu M,Xie Z,Liu W,Cao X

更新日期：2017-04-01 00:00:00

abstract：:Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the "therapeutic window" may be widened beyond the first few hour after stroke and an e...

journal_title：Neuropharmacology

authors： Goldstein LB

更新日期：2000-03-03 00:00:00

abstract：:Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. The regional quantification of mGlu(2) and mGlu(3) receptors remains unknown. A selective and structurally novel mGlu(2/3) receptor agonist, 2-amino-4-flu...

journal_title：Neuropharmacology

authors： Wright RA,Johnson BG,Zhang C,Salhoff C,Kingston AE,Calligaro DO,Monn JA,Schoepp DD,Marek GJ

更新日期：2013-03-01 00:00:00

abstract：:Brief exposure to an elevated plus-maze has been shown to induce antinociception in male mice, a reaction that is not attenuated by manipulations of opiate receptors but which is fully blocked by diazepam. The present study examined the effects of the benzodiazepine receptor antagonist, flumazenil (5-20 mg/kg), on beh...

journal_title：Neuropharmacology

authors： Lee C,Rodgers RJ

更新日期：1991-12-01 00:00:00

abstract：:In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio). Release of DA per surviving neurone was assesse...

journal_title：Neuropharmacology

authors： Hefti F,Enz A,Melamed E

更新日期：1985-01-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or 0.9% saline, was administered to a group of common marmosets initially treated with the toxin 12-18 months previously. Initial treatment had consisted of a cumulative dose of 6-22 mg/kg (i.p.) which caused marked parkinsonism. Subsequently, the animals gradually ...

journal_title：Neuropharmacology

authors： Ueki A,Chong PN,Albanese A,Rose S,Chivers JK,Jenner P,Marsden CD

更新日期：1989-10-01 00:00:00

abstract：:Different neurotransmitter systems are involved in behavioural and molecular responses to morphine. The brain stress system is activated by acute administration of drugs of abuse, being CRF the main neuropeptide of this circuitry. In this study we have studied the role of CRF1R in the rewarding effects of morphine usi...

journal_title：Neuropharmacology

authors： Lasheras MC,Laorden ML,Milanés MV,Núñez C

更新日期：2015-08-01 00:00:00

abstract：:Trace amines are biological compounds that are still awaiting identification of their role in neuronal function. Using intracellular electrophysiological recordings, we investigated the depressant action of two trace amines (beta-phenylethylamine and tyramine) on the firing activity of dopaminergic neurons of the subs...

journal_title：Neuropharmacology

authors： Geracitano R,Federici M,Prisco S,Bernardi G,Mercuri NB

更新日期：2004-05-01 00:00:00

abstract：:NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular source driving the working memory deficits caused by NMDAr hypofunc...

journal_title：Neuropharmacology

authors： Sokolenko E,Nithianantharajah J,Jones NC

更新日期：2020-07-01 00:00:00

abstract：:In the human genome, 22 genes are coding for the class C G protein-coupled receptors that are receptors for the two main neurotransmitters glutamate and γ-aminobutyric acid, for Ca(2+) and for sweet and amino acid taste compounds. In addition to the GPCR heptahelical transmembrane domain responsible for G-protein acti...

journal_title：Neuropharmacology

authors： Rondard P,Goudet C,Kniazeff J,Pin JP,Prézeau L

更新日期：2011-01-01 00:00:00

abstract：:The effects of the putative dopamine agonist, ciladopa hydrochloride (AY 27,110) a non-ergot compound, were investigated in animal models of dopaminergic activity to evaluate its possible role in the treatment of Parkinson's disease. Ciladopa induced stereotyped behavior in both rats and guinea pigs. Unlike apomorphin...

journal_title：Neuropharmacology

authors： Koller WC,Fields JZ,Gordon JH,Perlow MJ

更新日期：1986-09-01 00:00:00

abstract：:Prenatal exposure to the CB1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone) mesylate (WIN) at a daily dose of 0.5 mg/kg, and Delta9-tetrahydrocannabinol (Delta9-THC) at a daily dose of 5 mg/kg, reduced dialysate glutamate levels in ...

journal_title：Neuropharmacology

authors： Castaldo P,Magi S,Gaetani S,Cassano T,Ferraro L,Antonelli T,Amoroso S,Cuomo V

更新日期：2007-09-01 00:00:00

abstract：:Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors at synapses within the nucleus accumbens. Exposure to cocaine can lead to protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and this phosphorylation event ...

journal_title：Neuropharmacology

authors： Briand LA,Deutschmann AU,Ellis AS,Fosnocht AQ

更新日期：2016-12-01 00:00:00

abstract：:The long held view is cocaine's pharmacological effects are mediated by monoamine reuptake inhibition. However, drugs with rapid brain penetration like sibutramine, bupropion, mazindol and tesofensine, which are equal to or more potent than cocaine as dopamine reuptake inhibitors, produce no discernable subjective eff...

journal_title：Neuropharmacology

authors： Heal DJ,Gosden J,Smith SL

更新日期：2014-12-01 00:00:00

abstract：:Pyrantel is an anthelmintic which acts as an agonist of nicotinic receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Here we explore at the single-channel level the action of pyrantel at mammalian muscle AChR. AChR currents are elicited by pyrantel. However, openi...

journal_title：Neuropharmacology

authors： Rayes D,De Rosa MJ,Spitzmaul G,Bouzat C

更新日期：2001-08-01 00:00:00

abstract：:Methylazoxymethanol (MAM)-treated pregnant rat at gestation day (GD) 17 has been shown to be a valuable developmental animal model for schizophrenia. Yet, this model remains to be established in mice. In the present study, we examined behavioral, cytoarchitectural, and neurochemical changes in the offspring of MAM-tre...

journal_title：Neuropharmacology

authors： Takahashi K,Nakagawasai O,Sakuma W,Nemoto W,Odaira T,Lin JR,Onogi H,Srivastava LK,Tan-No K

更新日期：2019-05-15 00:00:00

abstract：:The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although...

journal_title：Neuropharmacology

authors： Segi-Nishida E,Sukeno M,Imoto Y,Kira T,Sakaida M,Tsuchiya S,Sugimoto Y,Okuno Y

更新日期：2013-08-01 00:00:00

abstract：:The United States is in the midst of an opiate epidemic, with abuse of prescription and illegal opioids increasing steadily over the past decade. While it is clear that there is a genetic component to opioid addiction, there is a significant portion of heritability that cannot be explained by genetics alone. The curre...

journal_title：Neuropharmacology

authors： Vassoler FM,Oliver DJ,Wyse C,Blau A,Shtutman M,Turner JR,Byrnes EM

更新日期：2017-02-01 00:00:00

abstract：:The in vivo striatal binding of [3H]SCH 23390, an antagonist of the D1 dopamine receptors, was investigated in mice submitted to pretreatment to either decrease (gammabutyrolactone 750 mg/kg, i.p.) or, increase (3,4-dihydroxyphenylalanine (L-DOPA) 200 mg/kg i.p. plus dexamphetamine 4 mg/kg, s.c.) dopaminergic transmis...

journal_title：Neuropharmacology

authors： Thibaut F,Vaugeois JM,Bonnet JJ,Costentin J

更新日期：1996-03-01 00:00:00

abstract：:The activity of tianeptine (2.5 and 5.0 mg/kg twice daily, i.p.) and of sertraline (5.0 mg/kg, twice daily, i.p.) were assessed in three animal models of depression. In the Behavioural Despair Test, acute treatment with sertraline or tianeptine (5.0 mg/kg) significantly reduced the immobility time. In the olfactory bu...

journal_title：Neuropharmacology

authors： Kelly JP,Leonard BE

更新日期：1994-08-01 00:00:00