T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.

abstract：:Methylphenidate (MPH, Ritalin©) is widely used in the treatment of Attention Deficit Hyperactivity Disorder and recently as a drug of abuse. Although the effect of MPH has been studied in brain regions such as striatum and prefrontal cortex (PFC), the hippocampus has received relatively little attention. It is known t...

journal_title：Neuropharmacology

authors： Rozas C,Carvallo C,Contreras D,Carreño M,Ugarte G,Delgado R,Zeise ML,Morales B

更新日期：2015-12-01 00:00:00

abstract：:Agomelatine (S 20098) is a novel antidepressant drug with melatonin receptor agonist and 5-HT(2C) receptor antagonist properties, but actual mechanisms underlying its antidepressant action are unknown. Because functional desensitization of 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) occurs after chronic a...

journal_title：Neuropharmacology

authors： Hanoun N,Mocaër E,Boyer PA,Hamon M,Lanfumey L

更新日期：2004-09-01 00:00:00

abstract：:Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene, represents a compelling novel drug target for the treatment of schizophrenia. mGluR5 is a postsynaptic G-protein coupled glutamate receptor strongly linked with several critical cellular processes that are reported to be disrupted in schizop...

journal_title：Neuropharmacology

authors： Matosin N,Fernandez-Enright F,Lum JS,Newell KA

更新日期：2017-03-15 00:00:00

abstract：:It has been shown that endogenous adenosine 5'-triphosphate (ATP) as well as its exogenously applied structural analogue, 2-methylthio ATP (2-MeSATP), facilitate the release of dopamine from axon terminals in the rat nucleus accumbens (NAc) by activating ATP-sensitive P2 receptors. In the present study, reversed micro...

journal_title：Neuropharmacology

authors： Krügel U,Kittner H,Franke H,Illes P

更新日期：2001-06-01 00:00:00

abstract：:Up to 80% of cancer patients are affected by the cancer anorexia-cachexia syndrome (CACS), which leads to excessive body weight loss, reduced treatment success and increased lethality. The area postrema/nucleus of the solitary tract (AP/NTS) region emerged as a central nervous key structure in this multi-factorial pro...

journal_title：Neuropharmacology

authors： Navarro I Batista K,Schraner M,Riediger T

更新日期：2020-12-01 00:00:00

abstract：:Anti-emetic drugs such as the tachykinin NK(1) receptor antagonists are useful to control emesis induced by diverse challenges. Evidence suggests pungent capsaicin-like TRPV1 activators also have broad inhibitory anti-emetic activity. However, pungent compounds are associated with undesirable effects including adverse...

journal_title：Neuropharmacology

authors： Chu KM,Ngan MP,Wai MK,Yeung CK,Andrews PL,Percie du Sert N,Rudd JA

更新日期：2010-02-01 00:00:00

abstract：:Intrathecal (IT) injection of neostigmine (a cholinesterase inhibitor) has been reported to produce a significant anti-nociceptive effect in a number of inflammatory pain models. However, a potential anti-inflammatory effect of IT neostigmine in these models has not been investigated. In the present study, we have exa...

journal_title：Neuropharmacology

authors： Yoon SY,Kwon YB,Kim HW,Roh DH,Kang SY,Kim CY,Han HJ,Kim KW,Yang IS,Beitz AJ,Lee JH

更新日期：2005-09-01 00:00:00

abstract：:Trace amines are biological compounds that are still awaiting identification of their role in neuronal function. Using intracellular electrophysiological recordings, we investigated the depressant action of two trace amines (beta-phenylethylamine and tyramine) on the firing activity of dopaminergic neurons of the subs...

journal_title：Neuropharmacology

authors： Geracitano R,Federici M,Prisco S,Bernardi G,Mercuri NB

更新日期：2004-05-01 00:00:00

abstract：:The effect of in vivo administration of the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on striatal and extrastriatal D-1 and D-2 dopamine (DA) receptors was investigated in the rat. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline treatment reduced specific [3H]SCH 23390 (7-chloro-8-hydroxy-2...

journal_title：Neuropharmacology

authors： Gnanalingham KK,Hunter AJ,Jenner P,Marsden CD

更新日期：1994-05-01 00:00:00

abstract：:Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously shown to be effective for nicotine cessation and obesity. However, studies using rimonabant were discontinued as it was associated with an incre...

journal_title：Neuropharmacology

authors： Balla A,Dong B,Shilpa BM,Vemuri K,Makriyannis A,Pandey SC,Sershen H,Suckow RF,Vinod KY

更新日期：2018-03-15 00:00:00

abstract：:A large body of evidence indicates that ligand-gated channels may open spontaneously, exhibiting a basal activity in the absence of the neurotransmitter. In the present work, we were interested in studying the Ca(2+)-induced modulation of the basal channel activity of unliganded human L248Talpha7 receptors expressed i...

journal_title：Neuropharmacology

authors： Tonini R,Renzi M,Eusebi F

更新日期：2004-04-01 00:00:00

abstract：:The mechanisms underlying improvement of neuromuscular transmission deficits by glucocorticoids are still a matter of debate despite these compounds have been used for decades in the treatment of autoimmune myasthenic syndromes. Besides their immunosuppressive action, corticosteroids may directly facilitate transmitte...

journal_title：Neuropharmacology

authors： Oliveira L,Costa AC,Noronha-Matos JB,Silva I,Cavalcante WL,Timóteo MA,Corrado AP,Dal Belo CA,Ambiel CR,Alves-do-Prado W,Correia-de-Sá P

更新日期：2015-02-01 00:00:00

abstract：:Behavioural studies can help to validate, modify and refine schemes for classifying receptors that are developed from electrophysiological and biochemical experiments. Drug discrimination constitutes one family of behavioural techniques that is being extensively used for studying subtypes of receptors, mainly because ...

journal_title：Neuropharmacology

authors： Stolerman IP,Stephenson JD,Rauch RJ

更新日期：1987-07-01 00:00:00

abstract：:Adenosine A(2A) agonists are known to induce catalepsy and inhibit dopamine mediated motor hyperactivity. An antagonistic interaction between adenosine A(2A) and dopamine D(2) receptors is known to regulate GABA-mediated neurotransmission in striatopallidal neurons. Stimulation of adenosine A(2A) and dopamine D(2) rec...

journal_title：Neuropharmacology

authors： Khisti RT,Chopde CT,Abraham E

更新日期：2000-04-03 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the control of cellular excitability. HCN2, a subgroup of the HCN family channels, are heavily expressed in small dorsal root ganglia (DRG) neurons and their activation seems to be important in the determination of pain intensity. In...

journal_title：Neuropharmacology

authors： Resta F,Masi A,Sili M,Laurino A,Moroni F,Mannaioni G

更新日期：2016-09-01 00:00:00

abstract：:Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum. Downregulation of CRF in limbic brain regions is essential for appropriate maternal behavior and an adaptive anxiety response. Here, we focus our attention on arguably the most important brain regi...

journal_title：Neuropharmacology

authors： Klampfl SM,Schramm MM,Gaßner BM,Hübner K,Seasholtz AF,Brunton PJ,Bayerl DS,Bosch OJ

更新日期：2018-05-01 00:00:00

abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

journal_title：Neuropharmacology

authors： Dafny N

更新日期：1983-05-01 00:00:00

abstract：:In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% ...

journal_title：Neuropharmacology

authors： Hauger R,Hulihan-Giblin B,Paul SM

更新日期：1986-03-01 00:00:00

abstract：:The effects of phospholipase A2, cyclooxygenase-1, cyclooxygenase-2, and 5-lipoxygenase inhibitors on acute opiate withdrawal induced by selective mu, kappa and delta receptor agonists was investigated in vitro. After a 4 min in vitro exposure to D-Ala2-N-methyl-Phe-Gly5-ol)enkephalin (DAMGO; a highly selective mu ago...

journal_title：Neuropharmacology

authors： Capasso A

更新日期：1999-06-01 00:00:00

abstract：:The ability of specific dopamine (DA) receptor agonists and antagonists to modify the release and metabolism of DA in the ventrolateral striatum of awake rats was assessed using in vivo microdialysis. The specific DA D2 receptor antagonist, raclopride (0.1, 0.5 and 2.0 mg/kg, i.p.), dose-dependently increased release ...

journal_title：Neuropharmacology

authors： See RE,Sorg BA,Chapman MA,Kalivas PW

更新日期：1991-12-01 00:00:00

abstract：:Intraperitoneal administration of 5-10 mg/kg of THIP (4,5,6,7 tetrahydroxyisoxazolo (4,5,c) pyridine 3-ol) induced a transient, reliable model of bilaterally synchronous spikes and waves in rats. The paroxysmal bursts elicited by THIP had similar topographical distribution to the spontaneously-occurring spike and wave...

journal_title：Neuropharmacology

authors： Fariello RG,Golden GT

更新日期：1987-02-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. Using rat striatal synaptosomes loaded with [3H]dopamine, we have characterized the action of the selective nicotinic agonist, (+/-)anatoxin-a, with respect to [3H]dopamine release, in order to explore the mecha...

journal_title：Neuropharmacology

authors： Soliakov L,Gallagher T,Wonnacott S

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:After neonatal ventral hippocampal lesions (NVHLs), adult rats exhibit evidence of neural processing deficits relevant to schizophrenia, including reduced prepulse inhibition (PPI) of acoustic startle and impaired sensory processing. In intact rats, the regulation of PPI by the ventral hippocampus (VH) is me...

journal_title：Neuropharmacology

authors： Swerdlow NR,Powell SB,Breier MR,Hines SR,Light GA

更新日期：2013-12-01 00:00:00

abstract：:Serotonin (5-HT) dysfunction has been involved in both movement and behavioral disorders. Serotonin pharmacology improves dyskinetic movements as well as depressive, anxious, aggressive and anorexic symptoms. Animal models have been useful to investigate more precisely to what extent 5-HT is involved and whether drugs...

journal_title：Neuropharmacology

authors： Beaudoin-Gobert M,Sgambato-Faure V

更新日期：2014-06-01 00:00:00

abstract：:The effects of the glycine derivative, CP 1552-S (2-N-pentylaminoacetamide hydrochloride) were evaluated for potential anticonvulsant activity in rats which were cortically- or amygdaloid-kindled. Large doses (300-600 mg/kg, i.p.) of CP 1552 given 30 min before stimulation resulted in significant reductions in duratio...

journal_title：Neuropharmacology

authors： Albertson TE,Stark LG,Joy RM

更新日期：1984-08-01 00:00:00

abstract：:Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression of various cancers. However, the molecular mechanism and pathological role of bradykinin recept...

journal_title：Neuropharmacology

authors： Liu YS,Hsu JW,Lin HY,Lai SW,Huang BR,Tsai CF,Lu DY

更新日期：2019-01-01 00:00:00

abstract：:The combination of the selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotic drugs shows better therapeutic efficacy than SSRI monotherapy in the treatment of depression. However, the underlying mechanisms responsible for the augmenting effects of olanzapine are not fully understood. Here, we repo...

journal_title：Neuropharmacology

authors： Asaoka N,Nagayasu K,Nishitani N,Yamashiro M,Shirakawa H,Nakagawa T,Kaneko S

更新日期：2015-08-01 00:00:00

abstract：:Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...

journal_title：Neuropharmacology

authors： Hiramatsu N,Ago Y,Hasebe S,Nishimura A,Mori K,Takuma K,Matsuda T

更新日期：2013-12-01 00:00:00

abstract：:FK1706, a derivative of FK506, is a non-immunosuppressive immunophilin ligand with significant neurotrophic activity mediated via FKBP-52 and the RAS/RAF/MAPK signaling pathway. Here, we tested the effect of FK1706 on painful diabetic neuropathy in rat model of diabetes induced by streptozotocin (STZ). FK1706 ameliora...

journal_title：Neuropharmacology

authors： Yamazaki S,Yamaji T,Murai N,Yamamoto H,Price RD,Matsuoka N,Mutoh S

更新日期：2008-12-01 00:00:00

abstract：:Recent observations from synaptosome preparations have questioned the tetrodotoxin (TTX) insensitivity of nicotine-evoked release in the striatum, a characteristic previously considered diagnostic of presynaptically located nicotinic acetylcholine receptors (nAChRs). Therefore, we have undertaken a comparison of nicot...

journal_title：Neuropharmacology

authors： Marshall D,Soliakov L,Redfern P,Wonnacott S

更新日期：1996-01-01 00:00:00