当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines.

Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines.

Abstract：

:In the rat brain, gamma-hydroxybutyric-acid (GHB) increases the concentrations of 3alpha-hydroxy,5alpha-pregnan-20-one (allopregnanolone, 3alpha,5alpha-THP) and 3alpha,21-dihydroxy,5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone/3alpha,5alphaTHDOC), two neurosteroids acting as positive allosteric modulators of gamma-aminobutyric acid (GABA)(A) receptors. This study was aimed at assessing whether neurosteroids play a role in GHB-induced loss of righting reflex (LORR). Basal and GHB-stimulated brain concentrations of endogenous 3alpha,5alpha-THP and 3alpha,5alpha-THDOC were analyzed in two rat lines, GHB-sensitive (GHB-S) and GHB-resistant (GHB-R), selectively bred for opposite sensitivity to GHB-induced sedation/hypnosis. Basal neurosteroid concentrations were similar in brain cortex of the two rat lines. However, in male GHB-S rats, administration of GHB (1000 mg/kg, i.p., 30 min) increased brain cortical concentrations of 3alpha,5alpha-THP and 3alpha,5alpha-THDOC 7- and 2.5-fold, respectively, whilst male GHB-R animals displayed only a 4- and 2-fold increase, respectively. In GHB-S rats this increase lasted up to 90 min and declined 180 min following GHB administration, a time course that matches LORR onset and duration. In contrast, in GHB-R rats, which failed to show GHB-induced LORR, brain cortical 3alpha,5alpha-THP and 3alpha,5alpha-THDOC had returned to control values within 90 min. At onset of LORR, a similar increase in brain cortical levels of 3alpha,5alpha-THP and 3alpha,5alpha-THDOC (2-3-fold) was observed in GHB-S female rats and in the few female GHB-R rats that lost the righting reflex after GHB administration, but not in female GHB-R rats failing to show LORR. Sub-hypnotic doses (7.5 and 12.5 mg/kg, i.p.) of pregnanolone, administered 10 min before GHB, dose-dependently facilitated the expression of GHB-induced LORR in GHB-R male rats. These results suggest that the GHB-induced increases of brain 3alpha,5alpha-THP and 3alpha,5alpha-THDOC concentrations are implicated in the eliciting of the sedative/hypnotic action of GHB.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Barbaccia ML,Carai MA,Colombo G,Lobina C,Purdy RH,Gessa GL

doi

10.1016/j.neuropharm.2005.01.026

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

48-58

issue

1

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(05)00067-5

journal_volume

49

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

    abstract：:Parasympathetic preganglionic cardiac vagal neurons (CVNs) which dominate the control of heart rate are located within the nucleus ambiguus (NA). Serotonin (5HT), and in particular 5HT2 receptors, play an important role in cardiovascular function in the brainstem. However, there is a lack of information on the mechani...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2008.02.016

    authors： Dergacheva O,Wang X,Kamendi H,Cheng Q,Pinol RM,Jameson H,Gorini C,Mendelowitz D

    更新日期：2008-06-01 00:00:00

  • Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.

    abstract：:It has been hypothesized that Acetyl-L-Carnitine (ALC) contributes to mitochondrial ATP production through maintenance of key mitochondrial proteins and protects mitochondria against oxidative stress. We have investigated the role of ALC on the expression of two forms of synaptic plasticity in the striatum: (i) the ph...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2008.05.015

    authors： Bagetta V,Barone I,Ghiglieri V,Di Filippo M,Sgobio C,Bernardi G,Calabresi P,Picconi B

    更新日期：2008-08-01 00:00:00

  • Molecular and neuronal mechanisms underlying the effects of adolescent nicotine exposure on anxiety and mood disorders.

    abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2020.108411

    authors： Laviolette SR

    更新日期：2021-02-15 00:00:00

  • Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract.

    abstract：:Metabotropic glutamate (mGlu) receptors in the basal ganglia motor loop may increase cell excitability (Group I) or modulate neurotransmitter release (Group I, II and III). Nigrostriatal tract degeneration in Parkinson's disease (PD) produces downstream pathological disturbances in glutamate and GABA transmission. The...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00090-4

    authors： Messenger MJ,Dawson LG,Duty S

    更新日期：2002-08-01 00:00:00

  • Environmental novelty causes stress-like adaptations at nucleus accumbens synapses: implications for studying addiction-related plasticity.

    abstract：:Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system. Here, we show that exposure to a novel environment produces functional synaptic adaptations in the nucleus accumbens (NAc) that mirror the effect of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2011.01.038

    authors： Rothwell PE,Kourrich S,Thomas MJ

    更新日期：2011-12-01 00:00:00

  • The effects of a photosensitive nitric oxide donor on basal and electrically-stimulated dopamine efflux from the rat striatum in vitro.

    abstract：:The reported effects of nitric oxide (NO) on dopamine release from the striatum are variable and its precise effect on striatal nerve terminals is unclear. In the present study a novel method of applying NO to brain tissue in situ was employed. Photo-activation of Roussin's Black Salt (RBS), retained in isolated perfu...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(94)90037-x

    authors： Black MD,Matthews EK,Humphrey PP

    更新日期：1994-11-01 00:00:00

  • Dual-acting agents for improving cognition and real-world function in Alzheimer's disease: Focus on 5-HT6 and D3 receptors as hubs.

    abstract：:To date, there are no interventions that impede the inexorable progression of Alzheimer's disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N-Methyl-d-Aspartate receptor antagonist, memantine, offer only modest symptomatic benefit. Moreover, a range of mechanistically-diverse agents ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2020.108099

    authors： Millan MJ,Dekeyne A,Gobert A,Brocco M,Mannoury la Cour C,Ortuno JC,Watson D,Fone KCF

    更新日期：2020-10-15 00:00:00

  • MK-801 impairs working memory on the Trial-Unique Nonmatch-to-Location test in mice, but this is not exclusively mediated by NMDA receptors on PV+ interneurons or forebrain pyramidal cells.

    abstract：:NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular source driving the working memory deficits caused by NMDAr hypofunc...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108103

    authors： Sokolenko E,Nithianantharajah J,Jones NC

    更新日期：2020-07-01 00:00:00

  • Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo.

    abstract：:Using the technique of microelectrophoresis on spinal neurones in pentobarbitone-anaesthetized rats, (1S,3R)-1-aminocyclo-pentane-1,3-dicarboxylate (1S,3R-ACPD) reversibly and dose-dependently enhanced responses to alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA), kainate, N-methyl-D-aspartate (NMDA) and L...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(95)00046-9

    authors： Bond A,Lodge D

    更新日期：1995-08-01 00:00:00

  • Remifentanil produces cross-desensitization and tolerance with morphine on the mu-opioid receptor.

    abstract：:Remifentanil is a powerful mu-opioid (MOP) receptor agonist used in anaesthesia with a very short half-life. However, per-operative perfusion of remifentanil was shown to increase morphine consumption during post-operative period to relieve pain. In the present study, we aimed to describe the cellular mechanisms respo...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.06.010

    authors： Nowoczyn M,Marie N,Coulbault L,Hervault M,Davis A,Hanouz JL,Allouche S

    更新日期：2013-10-01 00:00:00

  • Toll-like receptor signalling as a cannabinoid target in Multiple Sclerosis.

    abstract：:Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery is a pivotal player in the ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2016.04.009

    authors： Fitzpatrick JK,Downer EJ

    更新日期：2017-02-01 00:00:00

  • The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors.

    abstract：:For a number of years it has been known that the CNS convulsant picrotoxin inhibits the GABA(A) receptor, an anion-selective member of the ligand-gated ion channel (LGIC) superfamily. PTX also inhibits other anion-selective LGIC members, such as GABA(C), glycine and glutamate-gated Cl(-) channels. In the present repor...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(03)00032-7

    authors： Das P,Bell-Horner CL,Machu TK,Dillon GH

    更新日期：2003-03-01 00:00:00

  • Effects of the enkephalinase inhibitor SCH 34826 on the sleep-waking cycle and EEG activity in the rat.

    abstract：:The sedative effect of SCH 34826, an enkephalinase inhibitor, was evaluated by studying electroencephalographic (EEG) activity, behaviour and the sleep-waking cycle in the rat. The reference opioid, morphine, was used for comparison. After administration of morphine (10 mg/kg s.c.) the rats were motionless and stuporo...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(90)90002-9

    authors： Trampus M,Conti A,Marzanatti M,Monopoli A,Ongini E

    更新日期：1990-03-01 00:00:00

  • Effect of organochlorine insecticides on nicotinic acetylcholine receptor-rich membranes.

    abstract：:The so-called generalized polarization (GP) of the fluorescent probe Laurdan and the steady-state fluorescence anisotropy of the probe diphenylhexatriene (DPH) and its phenylpropionic derivative (PA-DPH) were used to study the effects of several organochlorine insecticides of the chlorophenylethane, chlorinated cycloh...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00194-x

    authors： Massol RH,Antollini SS,Barrantes FJ

    更新日期：2000-04-03 00:00:00

  • P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone.

    abstract：:Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and immunocytochemistry demonstrated the presence of P2X7 receptor mRNA and immunoreactivity in cultured neural progenitor cells (NPCs) prepared from the adult mouse subventricular...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2013.05.017

    authors： Messemer N,Kunert C,Grohmann M,Sobottka H,Nieber K,Zimmermann H,Franke H,Nörenberg W,Straub I,Schaefer M,Riedel T,Illes P,Rubini P

    更新日期：2013-10-01 00:00:00

  • Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation.

    abstract：:Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important med...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.11.019

    authors： Pišlar A,Božić B,Zidar N,Kos J

    更新日期：2017-03-01 00:00:00

  • Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes.

    abstract：:Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of side effects has hampered clinical progression. As separate inhibitio...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108414

    authors： Paes D,Xie K,Wheeler DG,Zook D,Prickaerts J,Peters M

    更新日期：2021-02-15 00:00:00

  • Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes.

    abstract：:The antagonist effects of the 4-carboxyphenylglycines: (S)-4-carboxy-3hydroxyphenylglycine (4C3HPG), (S)-4-carboxyphenylglycine (4CPG) and (+)-alpha-methyl-4-carboxyphenylglycine (M4CPG) were compared on functional responses of human metabotropic glutamate receptor (mGluR) subtypes mGluR1 alpha and mGluR5a. These rece...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(95)00069-i

    authors： Kingston AE,Burnett JP,Mayne NG,Lodge D

    更新日期：1995-08-01 00:00:00

  • The effects of anxiolytic and anxiogenic benzodiazepine receptor ligands on motor activity and levels of ascorbic acid in the nucleus accumbens and striatum of the rat.

    abstract：:The effects of the anxiolytic benzodiazepine flurazepam and the anxiogenic beta-carboline N-methyl-beta-carboline-3-carboxylate (FG 7142) were measured in unanaesthetised rats. Changes in motor activity, using a Doppler-shift microwave device, and in the extracellular concentration of ascorbate in the striatum and nuc...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90087-7

    authors： Brose N,O'Neill RD,Boutelle MG,Fillenz M

    更新日期：1989-05-01 00:00:00

  • Modulation of the GABAA-like autoreceptor by barbiturates but not by steroids.

    abstract：:In slices of cerebral cortex from rat preloaded with [3H]GABA, muscimol produced a concentration-related inhibition of K(+)-evoked release of tritium with a pIC25 value of 7.80 +/- 0.39. Dimethylbarbituric acid (10 and 100 microM) and pentobarbitone (100 microM) significantly increased this value to 8.31 +/- 0.09, 9.9...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(93)90156-w

    authors： Ennis C,Minchin MC

    更新日期：1993-04-01 00:00:00

  • Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol.

    abstract：:Alcohol use disorder (AUD) is a serious public health problem that results in tremendous social, legal and medical costs to society. Unlike other addictive drugs, there is no specific molecular target for ethanol (EtOH). Here, we report a novel molecular target that mediates EtOH effects at concentrations below those ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.01.021

    authors： Gao F,Chen D,Ma X,Sudweeks S,Yorgason JT,Gao M,Turner D,Eaton JB,McIntosh JM,Lukas RJ,Whiteaker P,Chang Y,Steffensen SC,Wu J

    更新日期：2019-05-01 00:00:00

  • The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.

    abstract：:Alterations in motor functions are well-characterized features observed in humans and experimental animals with thyroid hormone dysfunctions during development. We have previously suggested the implication of the endocannabinoid system in the hyperlocomotor phenotype observed in developmentally induced hypothyroidism ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.12.018

    authors： Giné E,Echeverry-Alzate V,Lopez-Moreno JA,Rodriguez de Fonseca F,Perez-Castillo A,Santos A

    更新日期：2017-04-01 00:00:00

  • Serotonin depletion in the dorsal and ventral hippocampus: effects on locomotor hyperactivity, prepulse inhibition and learning and memory.

    abstract：:We present an overview of our studies on the differential role of serotonergic projections from the median raphe nucleus (MRN) and dorsal raphe nucleus (DRN) in behavioural animal models with relevance to schizophrenia. Stereotaxic microinjection of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the M...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2008.06.035

    authors： Adams W,Kusljic S,van den Buuse M

    更新日期：2008-11-01 00:00:00

  • Neuroprotective effects of novel small peptides in vitro and after brain injury.

    abstract：:Thyrotropin-releasing hormone (TRH) and TRH analogues have been reported to be neuroprotective in experimental models of spinal cord injury and head injury. We have previously shown that a diketopiperazine structurally related to the TRH metabolite cyclo-his-pro reduces neuronal cell death in vitro and in vivo. Here w...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.04.001

    authors： Faden AI,Movsesyan VA,Knoblach SM,Ahmed F,Cernak I

    更新日期：2005-09-01 00:00:00

  • Neuronal activity associated with cocaine preference: Effects of differential cocaine intake.

    abstract：:Differences in overall cocaine intake can directly affect neuroadaptations, and this relationship can make it difficult to interpret neurobiological changes seen in drug-choice studies, since drug intake varies between subjects. Herein, a choice procedure that controls for cocaine intake was utilized to explore if neu...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108441

    authors： Chow JJ,Hofford RS,Beckmann JS

    更新日期：2021-02-15 00:00:00

  • The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action.

    abstract：:Although sigma 1 (σ(1)) receptors and mitogen-activated protein kinases (MAPKs) are known modulators of neuroprotection, a role for MAPK signaling pathways in σ receptor-mediated neuroprotection has not been investigated in detail.The present study aims to investigate the possible link between σ(1) receptors and MAPKs...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2010.05.014

    authors： Tan F,Guio-Aguilar PL,Downes C,Zhang M,O'Donovan L,Callaway JK,Crack PJ

    更新日期：2010-11-01 00:00:00

  • Inhibition of rat brain monoamine oxidase activity by cerebral anti-ischemic agent, ifenprodil.

    abstract：:Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(91)90190-m

    authors： Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

    更新日期：1991-07-01 00:00:00

  • Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.

    abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small molecule morantel (Mor...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2014.11.027

    authors： Short CA,Cao AT,Wingfield MA,Doers ME,Jobe EM,Wang N,Levandoski MM

    更新日期：2015-04-01 00:00:00

  • Non-opiate beta-endorphin fragments and dopamine--III. gamma-Type endorphins and various neuroleptics counteract the hypoactivity elicited by injection of apomorphine into the nucleus accumbens.

    abstract：:The hypoactivity in rats induced by small doses of apomorphine, injected bilaterally into the nucleus accumbens area of the brain, could be antagonized by pretreatment with the neuroleptic-like neuropeptide des-enkephalin-gamma-endorphin (DE gamma E, beta-endorphin 6-17) as well as with the neuroleptic drugs haloperid...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(82)90168-x

    authors： Van Ree JM,Caffé AR,Wolterink G

    更新日期：1982-11-01 00:00:00

  • A potent factor in extracts of the skin of the Australian frog, Pseudophryne coriacea--II. Stimulation of the leech helical muscle in vitro and in vivo.

    abstract：:Extracts of the skin of Pseudophryne coriacea displayed a powerful stimulant action on the leech helical muscle, both in vitro and in vivo. In the isolated dorsal muscle, the extract caused the appearance of vigorous phasic movements, accompanied by rapid increase in tonus, up to intense spasm. Hyoscine, physostigmine...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90001-8

    authors： Falconieri Erspamer G,Farruggia G

    更新日期：1986-08-01 00:00:00