Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract.

abstract：:Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly...

journal_title：Neuropharmacology

authors： Iwakabe H,Katsuura G,Ishibashi C,Nakanishi S

更新日期：1997-02-01 00:00:00

abstract：:Convection-enhanced delivery (CED) of GDNF and NTN was employed to determine the tissue clearance of these factors from the rat striatum and the response of the dopaminergic system to a single infusion. Two doses of GDNF (15 and 3 microg) and NTN (10 microg and 2 microg) were infused into the rat striatum. Animals wer...

journal_title：Neuropharmacology

authors： Hadaczek P,Johnston L,Forsayeth J,Bankiewicz KS

更新日期：2010-06-01 00:00:00

abstract：:Anxiety disorders contribute to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The hippocampus is important for anxiety modulation. However, the mechanisms that control the neuronal activity of the hippocampus in anxiety are still not clear. We found that E...

journal_title：Neuropharmacology

authors： Chen M,Shu S,Yan HH,Pei L,Wang ZF,Wan Q,Bi LL

更新日期：2017-05-15 00:00:00

abstract：:The psychostimulant drug amphetamine increases extracellular monamines in the brain acting on neurotransmitter transporters, especially the dopamine transporter. Mediated by this plasmalemmal pump, amphetamine does not only induce release but also charge transfer which might be involved in the release mechanism. To st...

journal_title：Neuropharmacology

authors： Pifl C,Rebernik P,Kattinger A,Reither H

更新日期：2004-02-01 00:00:00

abstract：:We evaluated the anticonvulsant efficacy of the antiepileptic drugs (AEDs) lamotrigine (LTG) and felbamate (FBM) in amygdala kindled rats that had been preselected with respect to their response to phenytoin. Anticonvulsant response was tested by determining the afterdischarge threshold (ADT), i.e., a sensitive measur...

journal_title：Neuropharmacology

authors： Ebert U,Reissmüller E,Löscher W

更新日期：2000-07-24 00:00:00

abstract：:Zatosetron (13 mg or 0.19 mg/kg), a potent and selective 5-HT3 receptor antagonist was studied with a 30 min infusion in a crossover double-blind placebo-controlled trial for acute migraine therapy. Groups receiving zatosetron and placebo were demographically similar and zatosetron was well-tolerated in all patients w...

journal_title：Neuropharmacology

authors： Chappell AS,Bay JM,Botzum GD,Cohen ML

更新日期：1994-03-01 00:00:00

abstract：:The mechanisms underlying improvement of neuromuscular transmission deficits by glucocorticoids are still a matter of debate despite these compounds have been used for decades in the treatment of autoimmune myasthenic syndromes. Besides their immunosuppressive action, corticosteroids may directly facilitate transmitte...

journal_title：Neuropharmacology

authors： Oliveira L,Costa AC,Noronha-Matos JB,Silva I,Cavalcante WL,Timóteo MA,Corrado AP,Dal Belo CA,Ambiel CR,Alves-do-Prado W,Correia-de-Sá P

更新日期：2015-02-01 00:00:00

abstract：:Central administration of corticotropin-like peptides generally blocks the analgesic action of opiate ligands, yet it is unclear whether this is due to an independent hyperalgesic action of corticotropin or to some other mechanism. Single cells in the ventromedial medulla of the anaesthetized rat were characterized as...

journal_title：Neuropharmacology

authors： Smock T

更新日期：1987-12-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...

journal_title：Neuropharmacology

authors： Lamont JS,Kula NS,Baldessarini RJ

更新日期：1987-06-01 00:00:00

abstract：:The metabotropic glutamate receptor 5 (mGluR5) is a target for drug development and for imaging studies of the glutamate system in neurological and psychiatric disorders. [11C]AZD9272 is a selective mGluR5 PET radioligand that is structurally different from hitherto applied mGluR5 radioligands. In the present investig...

journal_title：Neuropharmacology

authors： Varnäs K,Juréus A,Finnema SJ,Johnström P,Raboisson P,Amini N,Takano A,Stepanov V,Halldin C,Farde L

更新日期：2018-06-01 00:00:00

abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

journal_title：Neuropharmacology

authors： Dourish CT,Herbert EN,Iversen SD

更新日期：1989-12-01 00:00:00

abstract：:PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the physiological role of PDE10A in the central nervous system, PDE10A knockout mice (PDE10A(-/-)) were characterized both behaviorally and neurochemically. PDE10A(-/-...

journal_title：Neuropharmacology

authors： Siuciak JA,McCarthy SA,Chapin DS,Fujiwara RA,James LC,Williams RD,Stock JL,McNeish JD,Strick CA,Menniti FS,Schmidt CJ

更新日期：2006-08-01 00:00:00

abstract：:Recently, the presence of two high affinity binding sites for phencyclidine were described in guinea pig brain, with one site coupled to the glutamate excitatory amino acid receptor, specifically activated by N-methyl-D-aspartate (NMDA) (site 1) and the other site associated with the dopamine (DA) reuptake carrier (si...

journal_title：Neuropharmacology

authors： Reid AA,Mattson MV,de Costa BR,Thurkauf A,Jacobson AE,Monn JA,Rice KC,Rothman RB

更新日期：1990-09-01 00:00:00

abstract：:Basic neurobiological studies have led to great progress in our understanding of the mechanisms of action of drugs of abuse. Much has been learned about the brain response from the moment a psychoactive drug enters the organism onwards, including the psychological, neurobiological and peripheral effects of repeated dr...

journal_title：Neuropharmacology

authors： Kabbaj M,Evans S,Watson SJ,Akil H

更新日期：2004-01-01 00:00:00

abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

journal_title：Neuropharmacology

authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

更新日期：2013-10-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:The presence of ethanol, 100 microM, in the superfusate enhanced the spontaneous release of previously uptaken [3H]-dopamine from slices of rat corpus striatum, but produced a small inhibition of K+-stimulated release. The concomitant presence of picrotoxin, 10 microM, in the superfusate prevented the enhancement of s...

journal_title：Neuropharmacology

authors： Samuel D,Lynch MA,Littleton JM

更新日期：1983-12-01 00:00:00

abstract：:The United States is in the midst of an opiate epidemic, with abuse of prescription and illegal opioids increasing steadily over the past decade. While it is clear that there is a genetic component to opioid addiction, there is a significant portion of heritability that cannot be explained by genetics alone. The curre...

journal_title：Neuropharmacology

authors： Vassoler FM,Oliver DJ,Wyse C,Blau A,Shtutman M,Turner JR,Byrnes EM

更新日期：2017-02-01 00:00:00

abstract：:The gender difference in behavioral and hormonal response to stress is well known, but the underlying mechanism remains elusive. Arginine-vasopressin (AVP) and corticotrophin-releasing hormone (CRH) are two major regulatory peptides in the brain involved in stress regulation. Their response to stress has been shown to...

journal_title：Neuropharmacology

authors： Huang Q,Zhu H,Fischer DF,Zhou JN

更新日期：2008-06-01 00:00:00

abstract：:Dopaminergic innervation of the extended amygdala regulates anxiety-like behavior and stress responsivity. A portion of this dopamine input arises from dopamine neurons located in the ventral lateral periaqueductal gray (vlPAG) and rostral (RLi) and caudal linear nuclei of the raphe (CLi). These neurons receive substa...

journal_title：Neuropharmacology

authors： Williams MA,Li C,Kash TL,Matthews RT,Winder DG

更新日期：2014-11-01 00:00:00

abstract：:As postsynaptic metabotropic subtype 1 (mGlu1) receptors are present in the thalamus, we have investigated the effect of potentiating and antagonising mGlu1 receptors on responses of thalamic neurones to noxious sensory stimulation. Extracellular recordings were made in vivo with multi-barrel iontophoretic electrodes ...

journal_title：Neuropharmacology

authors： Salt TE,Jones HE,Copeland CS,Sillito AM

更新日期：2014-04-01 00:00:00

abstract：:The guinea-pig substantia nigra receives a 5-hydroxytryptaminergic (5-HT ergic) projection from the dorsal raphé nucleus. In this study we have attempted to identify the 5-HT receptor subtype mediating release of acetylcholinesterase (AChE) from nigral neurones, measured by assay of perfusate obtained via chronically ...

journal_title：Neuropharmacology

authors： Dickie BG,Greenfield SA

更新日期：1995-09-01 00:00:00

abstract：:A cDNA encoding the human metabotropic glutamate receptor type 4 (hmGluR4) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR4 probes. The deduced amino acid sequence of human mGluR4 consists of 912 residues and shows a sequence identity of 96% to the amino acid sequence of rat mGluR4. ...

journal_title：Neuropharmacology

authors： Flor PJ,Lukic S,Rüegg D,Leonhardt T,Knöpfel T,Kuhn R

更新日期：1995-02-01 00:00:00

abstract：:The effects of the anxiolytic benzodiazepine flurazepam and the anxiogenic beta-carboline N-methyl-beta-carboline-3-carboxylate (FG 7142) were measured in unanaesthetised rats. Changes in motor activity, using a Doppler-shift microwave device, and in the extracellular concentration of ascorbate in the striatum and nuc...

journal_title：Neuropharmacology

authors： Brose N,O'Neill RD,Boutelle MG,Fillenz M

更新日期：1989-05-01 00:00:00

abstract：:The cyclic octapeptide, CYN-154806, inhibited specific [(125)I]-[Tyr(11)]-SRIF binding to CHO-K1 cell membranes expressing human recombinant somatostatin (SRIF) sst(2) receptors (pIC(50) 8. 58) or rat sst(2(a)) and rat sst(2(b)) receptors (pIC(50) 8.35 and 8. 10, respectively). The affinity of CYN-154806 at other huma...

journal_title：Neuropharmacology

authors： Feniuk W,Jarvie E,Luo J,Humphrey PP

更新日期：2000-06-08 00:00:00

abstract：:Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important med...

journal_title：Neuropharmacology

authors： Pišlar A,Božić B,Zidar N,Kos J

更新日期：2017-03-01 00:00:00

abstract：:Different neurotransmitter systems are involved in behavioural and molecular responses to morphine. The brain stress system is activated by acute administration of drugs of abuse, being CRF the main neuropeptide of this circuitry. In this study we have studied the role of CRF1R in the rewarding effects of morphine usi...

journal_title：Neuropharmacology

authors： Lasheras MC,Laorden ML,Milanés MV,Núñez C

更新日期：2015-08-01 00:00:00

abstract：:Prenatal hypoxia ischemia is a major cause of neurodevelopmental impairment in the newborn, associated with risk for motor, behavioral and cognitive impaired outcomes. We used an established mouse model of maternal hypoxia to examine the immediate molecular responses of signaling pathways associated with both cell dea...

journal_title：Neuropharmacology

authors： Golan MH,Mane R,Molczadzki G,Zuckerman M,Kaplan-Louson V,Huleihel M,Perez-Polo JR

更新日期：2009-10-01 00:00:00

abstract：:Seldom does a single individual have such a profound effect on the development of a scientific discipline as Erminio Costa had on neuropharmacology. During nearly sixty years of research, Costa and his collaborators helped established many of the basic principles of the pharmacodynamic actions of psychotherapeutics. H...

journal_title：Neuropharmacology

authors： Enna SJ

更新日期：2011-06-01 00:00:00