Effect of organochlorine insecticides on nicotinic acetylcholine receptor-rich membranes.

abstract：:The role of the stress-induced increase in the uptake of tryptophan in brain in opioid-induced analgesia was investigated by modifying the uptake of amino acid in brain with injections of competing amino acids. Blockade of analgesia by valine (200 mg/kg, i.p.) alone, and by valine and tyrosine (100 mg/kg, i.p.), but n...

journal_title：Neuropharmacology

authors： Kelly SJ,Franklin KB

更新日期：1985-11-01 00:00:00

abstract：:Chronic activity perturbations in neurons induce homeostatic plasticity through modulation of synaptic strength or other intrinsic properties to maintain the correct physiological range of excitability. Although similar plasticity can also occur at the population level, what molecular mechanisms are involved remain un...

journal_title：Neuropharmacology

authors： Jewett KA,Lee KY,Eagleman DE,Soriano S,Tsai NP

更新日期：2018-08-01 00:00:00

abstract：:In the solitary tract nucleus, neuronal responsiveness to synaptic input from peripheral afferent fibres has been found to decrease as the frequency of that input is increased. The present study investigated the possibility that glycine and gamma-aminobutyric acid (GABA) are (1) involved in this phenomenon of "frequen...

journal_title：Neuropharmacology

authors： Feldman PD,Felder RB

更新日期：1991-03-01 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH) and an analog of this hormone, MK-771, were determined on body shaking behavior and on biochemical estimates of the activity of dopamine (DA) neurons in the rat. Both compounds elicited dose-related episodes of "wet-dog shakes". A dose of TRH (20 mg/kg, i.p.) which ca...

journal_title：Neuropharmacology

authors： Yamada K,Demarest KT,Moore KE

更新日期：1984-07-01 00:00:00

abstract：:Selective inhibitors of the glycine transporter 1 (GlyT1) have been implicated in central nervous system disorders related to hypoglutamatergic function such as schizophrenia. The selective GlyT1 inhibitors ALX5407 (NFPS) and LY2365109 {[2-(4-benzo[1,3]dioxol-5-yl-2-tert-butylphenoxy)ethyl]-methylamino}-acetic acid in...

journal_title：Neuropharmacology

authors： Perry KW,Falcone JF,Fell MJ,Ryder JW,Yu H,Love PL,Katner J,Gordon KD,Wade MR,Man T,Nomikos GG,Phebus LA,Cauvin AJ,Johnson KW,Jones CK,Hoffmann BJ,Sandusky GE,Walter MW,Porter WJ,Yang L,Merchant KM,Shannon HE,S

更新日期：2008-10-01 00:00:00

abstract：:Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capabilit...

journal_title：Neuropharmacology

authors： Parker CC,Chen H,Flagel SB,Geurts AM,Richards JB,Robinson TE,Solberg Woods LC,Palmer AA

更新日期：2014-01-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, ALS) to symptomatic treatment (e.g. epilepsy, Parkinson's ...

journal_title：Neuropharmacology

authors： Parsons CG,Danysz W,Quack G

更新日期：1999-06-01 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:Following intraperitoneal administration, the selective cAMP phosphodiesterase (PDE) inhibitors rolipram, ICI 63 197 and Ro 20-1724 were investigated in mice in comparison with imipramine for their effectiveness in two classical test models for prediction of clinical antidepressant activity: antagonism of reserpine-in...

journal_title：Neuropharmacology

authors： Wachtel H

更新日期：1983-03-01 00:00:00

abstract：:Mice were found to exhibit a marked suppression of motor activity when placed into the same experimental chamber in which they had previously received electrical shocks. This suppression was found to be a stable response when mice, 6-8 weeks of age, received shocks of frequencies of 1/10 or 1/30 Hz, and their motility...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1982-12-01 00:00:00

abstract：:Cannabinoid CB(1) receptors mediate, in part, the neuroprotectant properties of endocannabinoids, and altered signalling via the CB(1) receptor may contribute to the pathogenesis of diabetic neuropathy. We investigated CB(1) receptor function in PC12 cells differentiated into a neuronal phenotype with nerve growth fac...

journal_title：Neuropharmacology

authors： Zhang F,Challapalli SC,Smith PJ

更新日期：2009-08-01 00:00:00

abstract：:The possible synergism between caffeine and muscarinic antagonists to inhibit haloperidol-induced catalepsy was investigated with the bar test in rats. Pretreatment with low doses of caffeine (1-3 mg/kg), a non-selective adenosine antagonist, dose dependently reduced the intensity and increased the onset latency of ca...

journal_title：Neuropharmacology

authors： Moo-Puc RE,Góngora-Alfaro JL,Alvarez-Cervera FJ,Pineda JC,Arankowsky-Sandoval G,Heredia-López F

更新日期：2003-09-01 00:00:00

abstract：:The effects of pretreatment of rats with an intrahypothalamic injection of 6-hydroxydopamine on the thermal responses induced by intrahypothalamic injection of noradrenaline, prostaglandin E2, thyrotropin-releasing hormone or beta-endorphin were assessed. Administration of either noradrenaline (2-10 micrograms), prost...

journal_title：Neuropharmacology

authors： Lin MT,Chern YF,Chen SY

更新日期：1985-11-01 00:00:00

abstract：:mGlu7 receptors are coupled to Gi/Go-proteins and activate multiple transduction pathways, including inhibition of adenylyl cyclase activity and stimulation of ERK1/2 and JNK pathways. mGlu7 receptors play an important role in cognition and emotion and are involved in stress-related disorders such as anxiety and depre...

journal_title：Neuropharmacology

authors： Iacovelli L,Felicioni M,Nisticò R,Nicoletti F,De Blasi A

更新日期：2014-02-01 00:00:00

abstract：:Since its characterisation in 2001, the mGlu8-selective agonist DCPG has been widely used to explore the potential functional role of this group III mGlu receptor within the central nervous system. This research has implicated mGlu8 receptors in a number of disease states and conditions such as epilepsy and anxiety, s...

journal_title：Neuropharmacology

authors： Mercier MS,Lodge D,Fang G,Nicolas CS,Collett VJ,Jane DE,Collingridge GL,Bortolotto ZA

更新日期：2013-04-01 00:00:00

abstract：:Pyrantel is an anthelmintic which acts as an agonist of nicotinic receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Here we explore at the single-channel level the action of pyrantel at mammalian muscle AChR. AChR currents are elicited by pyrantel. However, openi...

journal_title：Neuropharmacology

authors： Rayes D,De Rosa MJ,Spitzmaul G,Bouzat C

更新日期：2001-08-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) receptor-expressing (GRPR)+ neurons have a central role in the spinal transmission of itch. Because their fundamental regulatory mechanisms are not yet understood, it is important to determine how such neurons are excited and integrate itch sensation. In this study, we investigated the ...

journal_title：Neuropharmacology

authors： Kiguchi N,Uta D,Ding H,Uchida H,Saika F,Matsuzaki S,Fukazawa Y,Abe M,Sakimura K,Ko MC,Kishioka S

更新日期：2020-06-15 00:00:00

abstract：:In the prostatic portion of rat vas deferens, the non-selective adenosine receptor agonist NECA (0.1-30 microM), but not the A(2A) agonist CGS 21680 (0.001-10 microM), caused a facilitation of electrically evoked noradrenaline release (up to 43 +/- 4%), when inhibitory adenosine A(1) receptors were blocked. NECA-elici...

journal_title：Neuropharmacology

authors： Queiroz G,Quintas C,Talaia C,Gonçalves J

更新日期：2004-08-01 00:00:00

abstract：:We previously reported that elevated pressure induces axonal swelling and facilitates the synthesis of the neurosteroid, allopregnanolone (AlloP), in the ex vivo rat retina. Exogenously applied AlloP attenuates the axonal swelling, suggesting that the neurosteroid plays a neuroprotective role against glaucomatous pres...

journal_title：Neuropharmacology

authors： Ishikawa M,Yoshitomi T,Covey DF,Zorumski CF,Izumi Y

更新日期：2016-12-01 00:00:00

abstract：:The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Development of selective mGlu₅ agonists has been difficult, but several different...

journal_title：Neuropharmacology

authors： Gilmour G,Broad LM,Wafford KA,Britton T,Colvin EM,Fivush A,Gastambide F,Getman B,Heinz BA,McCarthy AP,Prieto L,Shanks E,Smith JW,Taboada L,Edgar DM,Tricklebank MD

更新日期：2013-01-01 00:00:00

abstract：:This study confirms and extends an earlier report that acute administration of the serotonin (5-HT) antagonist, mianserin, caused a marked decrease in the density of 5-HT2 binding sites in brain of the rat (Blackshear and Sanders-Bush, 1982). Using [3H]ketanserin, a selective ligand for the 5-HT2 site, the present stu...

journal_title：Neuropharmacology

authors： Blackshear MA,Martin LL,Sanders-Bush E

更新日期：1986-11-01 00:00:00

abstract：:Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their pathogenic processes. Most of these diseases still lack effective treatment and are hampered by a shortfall in the development of novel medicines. Clearly new ...

journal_title：Neuropharmacology

authors： Chan F,Lax NZ,Davies CH,Turnbull DM,Cunningham MO

更新日期：2016-03-01 00:00:00

abstract：:Non-invasive brain stimulation has shown its potential to modulate brain plasticity in humans. Endeavour has been made to utilize brain stimulation in neurological diseases to enhance adaptive processes and prevent potential maladaptive ones. In stroke for instance both sensorimotor and higher cognitive impairment, su...

journal_title：Neuropharmacology

authors： Schulz R,Gerloff C,Hummel FC

更新日期：2013-01-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are highly conserved between humans and non-human primates. Conservation exists at the level of genomic structure, protein structure and epigenetics. Overall homology of nAChRs at the protein level is 98% in macaques versus 89% in mice, which is highly relevant for evaluating...

journal_title：Neuropharmacology

authors： Shorey-Kendrick LE,Ford MM,Allen DC,Kuryatov A,Lindstrom J,Wilhelm L,Grant KA,Spindel ER

更新日期：2015-09-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are considered to be viable targets to enhance cognition in patients diagnosed with schizophrenia. Activation of nAChRs with selective nicotinic receptor agonists may provide effective means to pharmacologically treat cognitive deficits observed in schizophrenia. Cognitive fl...

journal_title：Neuropharmacology

authors： Wood C,Kohli S,Malcolm E,Allison C,Shoaib M

更新日期：2016-06-01 00:00:00

abstract：:How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated i...

journal_title：Neuropharmacology

authors： Auerbach A

更新日期：2015-09-01 00:00:00

abstract：:The identification and characterization of amyloid-beta (Abeta) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD. In the last decade, research in this area has focused on developing a better understanding of the principles that go...

journal_title：Neuropharmacology

authors： Tarawneh R,Holtzman DM

更新日期：2010-09-01 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR, M1 - M5, which are expressed throughout the central nervous system (CNS) on numerous cell types and represent promising treatment targets fo...

journal_title：Neuropharmacology

authors： Lebois EP,Thorn C,Edgerton JR,Popiolek M,Xi S

更新日期：2018-07-01 00:00:00

abstract：:Up to 80% of cancer patients are affected by the cancer anorexia-cachexia syndrome (CACS), which leads to excessive body weight loss, reduced treatment success and increased lethality. The area postrema/nucleus of the solitary tract (AP/NTS) region emerged as a central nervous key structure in this multi-factorial pro...

journal_title：Neuropharmacology

authors： Navarro I Batista K,Schraner M,Riediger T

更新日期：2020-12-01 00:00:00