Dopamine D3 receptor-modulated neuroprotective effects of lisuride.


:Dopamine (DA) contributes to the regulation of voluntary movement, and a deficiency in DAergic neurons leads to movement disorders. The objective of this study was to examine the neuroprotective effect of DA D2-like receptor agonist, lisuride, and the role of DA receptors in this protection. Treatment with lisuride alleviated loss of tyrosine hydroxylase (TH) both direct and intraperitoneal injection in 6-hydroxydopamine (6-OHDA) mouse model. Similar results were obtained in primary neuronal cultures treated with lisuride. Lisuride protected TH expression against 6-OHDA-induced cytotoxicity in a concentration-dependent manner. Then, we evaluated the role of DA D2 and D3 receptor in neuroprotective effect of lisuride. Treatment of neuronal cultures with L-741,626, a DA D2 receptor-selective antagonist, did not alter neuroprotective effect of lisuride. However, protective effect of lisuride on TH expression was abolished when cells were treated with GR103691, a D3 receptor selective antagonist. Furthermore, whether lisuride can alleviate mitochondrial damage of DAergic neurons induced by 6-OHDA, we investigated the expression of the mitochondrial regulatory protein, paraplegin, and changes in mitochondria morphology. Treatment with lisuride countered a 6-OHDA-induced reduction in paraplegin and TH expression, and co-treatment with GR103691 blocked this effect of lisuride. Transmission electron microscopy confirmed the lisuride mitigation of 6-OHDA-induced damage to the mitochondrial membrane and cristae. These results suggest that the DA D3 receptor mediates the neuroprotective effects of lisuride by preventing mitochondrial damage.






Kim M,Lee S,Cho J,Kim G,Won C




Has Abstract


2017-05-01 00:00:00












  • Ethanol withdrawal seizure susceptibility is associated with upregulation of L- and P-type Ca2+ channel currents in rat inferior colliculus neurons.

    abstract::Calcium currents in the inferior colliculus (IC) are thought to play an important role in ethanol withdrawal hyperexcitability. Here, we report on the modulation of Ca(2+) channel currents in acutely dissociated IC neurons of rats, exhibiting higher incidence of audiogenic seizures when subjected to ethanol withdrawal...


    pub_type: 杂志文章


    authors: N'Gouemo P,Morad M

    更新日期:2003-09-01 00:00:00

  • Reducing the relative value of cigarettes: Considerations for nicotine and non-nicotine factors.

    abstract::Despite notable progress in recent decades, cigarette smoke persists as a leading cause of premature death and preventable disease. To weaken the link between nicotine reinforcement and the toxicity associated with combusted tobacco, the United States Food and Drug Administration is considering a product standard targ...


    pub_type: 杂志文章,评审


    authors: White CM,Hatsukami DK,Donny EC

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  • Zatosetron, a 5-HT3 receptor antagonist in a multicenter trial for acute migraine.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Chappell AS,Bay JM,Botzum GD,Cohen ML

    更新日期:1994-03-01 00:00:00

  • Different densities of 5-HT3 receptors are labeled by [3H]quipazine, [3H]GR 65630 and [3H]granisetron.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Krasowski MD,Nishikawa K,Nikolaeva N,Lin A,Harrison NL

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    pub_type: 杂志文章


    authors: Adell A,Casanovas JM,Artigas F

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  • NMDA NR1 subunit mRNA and glutamate NMDA-sensitive binding are differentially affected in the striatum and pre-frontal cortex of Parkinson's disease patients.

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    pub_type: 杂志文章


    authors: Meoni P,Bunnemann BH,Kingsbury AE,Trist DG,Bowery NG

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  • The effects of anxiolytic and anxiogenic benzodiazepine receptor ligands on motor activity and levels of ascorbic acid in the nucleus accumbens and striatum of the rat.

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    pub_type: 杂志文章


    authors: Brose N,O'Neill RD,Boutelle MG,Fillenz M

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    authors: Seely KA,Brents LK,Franks LN,Rajasekaran M,Zimmerman SM,Fantegrossi WE,Prather PL

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    authors: Gravius A,Barberi C,Schäfer D,Schmidt WJ,Danysz W

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  • Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.

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    pub_type: 杂志文章


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    更新日期:2003-10-01 00:00:00

  • Fractional occupancy of synaptic binding sites and the molecular plasticity of inhibitory synapses.

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    pub_type: 杂志文章,评审


    authors: Specht CG

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    pub_type: 杂志文章


    authors: Zarrindast MR,Hoghooghi V,Rezayof A

    更新日期:2008-03-01 00:00:00

  • Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Edwards FA,Robertson SJ,Gibb AJ

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  • Measures of anxiety, amygdala volumes, and hippocampal scopolamine phMRI response in elderly female rhesus macaques.

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    pub_type: 杂志文章


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    authors: Mostany R,Díaz A,Valdizán EM,Rodríguez-Muñoz M,Garzón J,Hurlé MA

    更新日期:2008-05-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Goldstein LB

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    pub_type: 杂志文章


    authors: Yao BB,Witte DG,Miller TR,Carr TL,Kang CH,Cassar S,Faghih R,Bennani YL,Surber BW,Hancock AA,Esbenshade TA

    更新日期:2006-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Rodrigues TM,Jerónimo-Santos A,Sebastião AM,Diógenes MJ

    更新日期:2014-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Wani WY,Gudup S,Sunkaria A,Bal A,Singh PP,Kandimalla RJ,Sharma DR,Gill KD

    更新日期:2011-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Kiguchi N,Uta D,Ding H,Uchida H,Saika F,Matsuzaki S,Fukazawa Y,Abe M,Sakimura K,Ko MC,Kishioka S

    更新日期:2020-06-15 00:00:00

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    abstract::The role in ligand recognition and receptor activation of two adjacent charged residues (lysine 195 and aspartate 196) in the first extracellular loop of the human VPAC(1) receptor was investigated in stably transfected CHO cells expressing the wild type or point mutated receptors.Replacement of lysine 195 by glutamin...


    pub_type: 杂志文章


    authors: Langer I,Vertongen P,Perret J,Waelbroeck M,Robberecht P

    更新日期:2003-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Mukhutdinova KA,Kasimov MR,Zakyrjanova GF,Gumerova MR,Petrov AM

    更新日期:2019-05-15 00:00:00

  • Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations.

    abstract::The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...


    pub_type: 杂志文章


    authors: Lopatář J,Dale N,Frenguelli BG

    更新日期:2015-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Safieh-Garabedian B,Dardenne M,Kanaan SA,Atweh SF,Jabbur SJ,Saadé NE

    更新日期:2000-07-10 00:00:00

  • Favorable amphiphilicity of nimodipine facilitates its interactions with brain membranes.

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    pub_type: 杂志文章


    authors: Herbette LG,Mason PE,Sweeney KR,Trumbore MW,Mason RP

    更新日期:1994-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Belardetti F,Ahn S,So K,Snutch TP,Phillips AG

    更新日期:2009-05-01 00:00:00

  • The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action.

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    pub_type: 杂志文章


    authors: Tan F,Guio-Aguilar PL,Downes C,Zhang M,O'Donovan L,Callaway JK,Crack PJ

    更新日期:2010-11-01 00:00:00