Potent inhibitory GABAB receptors in stimulated guinea-pig taenia coli.

abstract：:Hippocampal volume reductions and functional impairments are reliable findings in posttraumatic stress disorder (PTSD) imaging studies. However, it is not clear if and how hippocampal dysfunction contributes to the etiology and maintenance of PTSD. Individuals with PTSD are often described as showing fear responses to...

journal_title：Neuropharmacology

authors： Acheson DT,Gresack JE,Risbrough VB

更新日期：2012-02-01 00:00:00

abstract：:Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked ...

journal_title：Neuropharmacology

authors： Hua XY,Jinno S,Back SM,Tam EK,Yaksh TL

更新日期：1994-10-01 00:00:00

abstract：:The central serotonin2B receptor (5-HT2BR) is currently considered as an interesting pharmacological target for improved treatment of drug addiction. In the present study, we assessed the effect of two selective 5-HT2BR antagonists, RS 127445 and LY 266097, on cocaine-induced hyperlocomotion and dopamine (DA) outflow ...

journal_title：Neuropharmacology

authors： Devroye C,Cathala A,Di Marco B,Caraci F,Drago F,Piazza PV,Spampinato U

更新日期：2015-10-01 00:00:00

abstract：:Participation of opiate, serotonergic and noradrenergic components in the antinociceptive action of intrathecally administered morphine was evaluated by measuring the ability of subcutaneously administered doses of naloxone, methysergide and phentolamine to alter analgesia. Morphine produced a dose-dependent elevation...

journal_title：Neuropharmacology

authors： Crisp T,Smith DJ

更新日期：1989-10-01 00:00:00

abstract：:This study was performed to investigate the effects of exercise on the synthesis of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the brain of the trained rat. The consequences on the relationships between these two systems were also examined. The sum of the levels of free 3,4-dihydroxyphenyl acetic acid (DOPAC) plu...

journal_title：Neuropharmacology

authors： Chaouloff F,Laude D,Merino D,Serrurrier B,Guezennec Y,Elghozi JL

更新日期：1987-08-01 00:00:00

abstract：:High concentrations of diazepam-binding inhibitor (DBI) mRNA have been detected in astrocytoma, suggesting that DBI-derived peptides may play a role in glial cell proliferation. In the present study, we have investigated the effect of a processing product of DBI, the octadecaneuropeptide ODN, on DNA synthesis in cultu...

journal_title：Neuropharmacology

authors： Gandolfo P,Patte C,Thoumas JL,Leprince J,Vaudry H,Tonon MC

更新日期：1999-05-01 00:00:00

abstract：:Over the last decade, robust human genetic findings have been instrumental in elucidating the heritable basis of nicotine addiction (NA). They highlight coding and synonymous polymorphisms in a cluster on chromosome 15, encompassing the CHRNA5, CHRNA3 and CHRNB4 genes, coding for three subunits of the nicotinic acetyl...

journal_title：Neuropharmacology

authors： Icick R,Forget B,Cloëz-Tayarani I,Pons S,Maskos U,Besson M

更新日期：2020-10-15 00:00:00

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:A unique type of limbic seizures, maximal dentate activation, was used to examine the effects of cholinergic and adrenergic agents on the processes involved in epileptogenesis. The time to onset of maximal dentate activation was used to monitor the initiation of seizures while the duration of maximal dentate activatio...

journal_title：Neuropharmacology

authors： Stringer JL,Lothman EW

更新日期：1991-01-01 00:00:00

abstract：:Benzodiazepines (BZDs) and barbiturates exert their CNS actions by binding to GABA-A receptors (GABARs). The structural mechanisms by which these drugs allosterically modulate GABAR function, to either enhance or inhibit GABA-gated current, are poorly understood. Here, we used the substituted cysteine accessibility me...

journal_title：Neuropharmacology

authors： Sancar F,Czajkowski C

更新日期：2011-02-01 00:00:00

abstract：:Many studies in preclinical animal models have described fear-reducing effects of the neuropeptide oxytocin in the central nucleus of the amygdala. However, recent studies have refined the role of oxytocin in the central amygdala, which may extend to the selection of an active defensive coping style in the face of imm...

journal_title：Neuropharmacology

authors： van den Burg EH,Hegoburu C

更新日期：2020-08-15 00:00:00

abstract：:Rat striatal slices, preincubated with [3H]dopamine (DA) and [14C]choline, were superfused continuously. Detection of radioactivity was used to monitor the release of the neurotransmitters DA and acetylcholine (ACh). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (...

journal_title：Neuropharmacology

authors： Jin S

更新日期：1997-11-01 00:00:00

abstract：:After a focal ischemic lesion in the hand representation of the primary motor cortex in squirrel monkeys, manual skill was mildly and transiently impaired on a reach-and-retrieval task. Performance was significantly poorer during weeks 1 and 3 post-lesion, but was normal by week 4. An unusual behavioral event was also...

journal_title：Neuropharmacology

authors： Nudo RJ,Friel KM,Delia SW

更新日期：2000-03-03 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR, M1 - M5, which are expressed throughout the central nervous system (CNS) on numerous cell types and represent promising treatment targets fo...

journal_title：Neuropharmacology

authors： Lebois EP,Thorn C,Edgerton JR,Popiolek M,Xi S

更新日期：2018-07-01 00:00:00

abstract：:Putative kappa binding was investigated in homogenates of the brain of the rat using [3H]ethylketocylazocine and [3H]diprenorphine under conditions where mu and delta sites were blocked. Under blocked conditions, the binding of [3H]ethylketocyclazocine labelled a single site, as defined by kinetic and equilibrium anal...

journal_title：Neuropharmacology

authors： Weyhenmeyer JA,Mack KJ

更新日期：1985-02-01 00:00:00

abstract：:Reductions in the capacity of the human choline transporter (SLC5A7, CHT) have been hypothesized to diminish cortical cholinergic neurotransmission, leading to risk for cognitive and mood disorders. To determine the acetylcholine (ACh) release capacity of cortical cholinergic projections in a mouse model of cholinergi...

journal_title：Neuropharmacology

authors： Paolone G,Mallory CS,Cherian AK,Miller TR,Blakely RD,Sarter M

更新日期：2013-12-01 00:00:00

abstract：:Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, alt...

journal_title：Neuropharmacology

authors： Yamamoto K,Sawada T,Utsumi S,Naito Y,Koshida H

更新日期：1982-05-01 00:00:00

abstract：:The nomenclature system used to characterize 5-hydroxytryptamine receptor subtypes remains controversial. To date, the majority of nomenclature systems have been on the differential pharmacological properties of the receptors. However, the availability of molecular biological data allows for a nomenclature system base...

journal_title：Neuropharmacology

authors： Peroutka SJ

更新日期：1992-07-01 00:00:00

abstract：:The objective of this study was to compare nAChR-mediated neurotransmitter release from slices of rat striatum, frontal cortex and hippocampus following chronic (-)-nicotine (Nic) administration (tartrate salt, 2 mg/kg twice daily for 10 days). Binding studies were also conducted to measure changes in receptor density...

journal_title：Neuropharmacology

authors： Jacobs I,Anderson DJ,Surowy CS,Puttfarcken PS

更新日期：2002-10-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, ALS) to symptomatic treatment (e.g. epilepsy, Parkinson's ...

journal_title：Neuropharmacology

authors： Parsons CG,Danysz W,Quack G

更新日期：1999-06-01 00:00:00

abstract：:The overexpression of Kir3.2, a subunit of the G protein-gated inwardly rectifying K(+) channel, is implicated in some of the neurological phenotypes of Down syndrome (DS). Chemical compounds that block Kir3.2 are expected to improve the symptoms of DS. The purpose of this study is to develop a cell-based screening sy...

journal_title：Neuropharmacology

authors： Kawada H,Inanobe A,Kurachi Y

更新日期：2016-10-01 00:00:00

abstract：:Depolarizing, hyperpolarizing and biphasic muscarinic responses have been described in hippocampal inhibitory interneurons, but the receptor subtypes and activity patterns required to synaptically activate muscarinic responses in interneurons have not been completely characterized. Using optogenetics combined with who...

journal_title：Neuropharmacology

authors： Bell LA,Bell KA,McQuiston AR

更新日期：2013-10-01 00:00:00

abstract：:In the cerebellum of juvenile mice or rats, endocannabinoids are shown to mediate depolarization-induced suppression of excitation (DSE) and retrograde suppression induced by activation of type 1 metabotropic glutamate receptor (mGluR1) at parallel fiber (PF) to Purkinje cell (PC) synapses. However, recent studies sho...

journal_title：Neuropharmacology

authors： Tanimura A,Kawata S,Hashimoto K,Kano M

更新日期：2009-08-01 00:00:00

abstract：:Neurons in thalamic midline and paraventricular nuclei (PVT) display a unique slow afterhyperpolarizing potential (sAHP) following the low threshold spike (LTS) generated by activation of their low voltage Ca(2+) channels. We evaluated the conductances underlying this sAHP using whole-cell patch-clamp recordings in ra...

journal_title：Neuropharmacology

authors： Kolaj M,Zhang L,Renaud LP

更新日期：2014-11-01 00:00:00

abstract：:Tau hyperphosphorylation and memory deficit are characteristic alterations of Alzheimer's disease (AD), and glycogen synthase kinase-3 (GSK-3) plays a crucial role in these AD-like changes. We have reported that activation of GSK-3 through ventricular injection of wortmannin and GF-109203X (WT/GFX, 100 microM each) in...

journal_title：Neuropharmacology

authors： Peng JH,Zhang CE,Wei W,Hong XP,Pan XP,Wang JZ

更新日期：2007-06-01 00:00:00

abstract：:Amphetamine (AMPH) acts as a substrate of the dopamine transporter (DAT) and causes a dramatic increase in extracellular dopamine (DA). Upon entering DA neurons, AMPH promotes DA efflux via DAT through a mechanism implicating depletion of DA from vesicular stores, activation of kinase pathways and transporter phosphor...

journal_title：Neuropharmacology

authors： Runegaard AH,Dencker D,Wörtwein G,Gether U

更新日期：2019-12-15 00:00:00

abstract：:The objectives of this study, conducted on neonatal rat spinal cord and dorsal roots in vitro, were to characterise the actions of a range of willardiine analogues on GluR5-containing kainate receptors present in dorsal roots, to determine whether GluR5-containing receptors are also present on motoneurones, and to dif...

journal_title：Neuropharmacology

authors： Thomas NK,Hawkins LM,Miller JC,Troop HM,Roberts PJ,Jane DE

更新日期：1998-10-01 00:00:00

abstract：:Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation provides a potential therapeutic strategy for cognitive disorders involving aberrant neuroplastic...

journal_title：Neuropharmacology

authors： Fass DM,Reis SA,Ghosh B,Hennig KM,Joseph NF,Zhao WN,Nieland TJ,Guan JS,Kuhnle CE,Tang W,Barker DD,Mazitschek R,Schreiber SL,Tsai LH,Haggarty SJ

更新日期：2013-01-01 00:00:00

abstract：:Remifentanil is a powerful mu-opioid (MOP) receptor agonist used in anaesthesia with a very short half-life. However, per-operative perfusion of remifentanil was shown to increase morphine consumption during post-operative period to relieve pain. In the present study, we aimed to describe the cellular mechanisms respo...

journal_title：Neuropharmacology

authors： Nowoczyn M,Marie N,Coulbault L,Hervault M,Davis A,Hanouz JL,Allouche S

更新日期：2013-10-01 00:00:00

abstract：:The influence of naloxone (a narcotic antagonist), bicuculline (a GABA antagonist), phentolamine (an alpha-blocking agent), propranolol (a beta-adrenergic blocking agent), haloperidol (a dopaminergic blocking agent), methysergide (a serotonergic blocking agent) and atropine (a muscarinic blocking agent), on the antino...

journal_title：Neuropharmacology

authors： Foong FW,Satoh M

更新日期：1984-06-01 00:00:00